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Clean sterile high-barrier medical rubber plug and preparation method thereof

A high-barrier, rubber stopper technology, applied in the field of medical rubber accessories, can solve the problems of harming human health and difficulty in preparing medical rubber stopper products, so as to improve safety and quality assurance, ensure biological safety, and improve heat and oxygen aging resistance performance effect

Active Publication Date: 2015-04-08
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the various additives in the above-mentioned traditional vulcanized pistons are easy to decompose into harmful chemical components during high-temperature processing. Once in contact with medicines and body fluids, it is very likely to damage human health; it is still difficult to prepare medical rubber plug products that meet high-quality standards.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A clean and sterile high-barrier medical rubber stopper and a preparation method thereof are prepared by using the following raw materials and methods:

[0023] Raw materials: Guangdong Maoming butadiene rubber (br9000) 100g; medical grade nano montmorillonite 5g; stearic acid 2g; petrolatum 3g; natural aloe extract powder 0.1g.

[0024] The preparation method is as follows: the raw rubber rubber is mixed in a mixer at 55 r / min and 60° C., stearic acid and petrolatum are added after 2 minutes, montmorillonite is added for 5 minutes, and the material is mixed for 10 minutes. After compression molding, radiation vulcanization, remodeling, drying and other processes, medical rubber plugs are made. Among them, radiation vulcanization is to use high-energy electron beams generated by a high-energy electron accelerator to vulcanize the rubber profile under normal temperature and pressure (15-25°C, 0.1Mpa) conditions, and the radiation dose is 200kGy.

Embodiment 2

[0026] A clean and sterile high-barrier medical rubber stopper and a preparation method thereof are prepared by using the following raw materials and methods:

[0027] Raw materials: 100g of Japanese Zeon isoprene rubber (2200); 30g of medical grade clay; 2g of stearic acid; 3g of petrolatum; 5g of radiation sensitizer TMPTA; 1.0g of natural aloe extract powder.

[0028] The preparation method is as follows: raw rubber rubber and radiation sensitizer are mixed in a mixer at 55 r / min and 60° C., stearic acid and petrolatum are added after 2 minutes, clay is added for 5 minutes, and the material is mixed for 10 minutes. After compression molding, radiation vulcanization, remodeling, drying and other processes, medical rubber plugs are made. Among them, radiation vulcanization is to use high-energy electron beams generated by a high-energy electron accelerator to vulcanize the rubber profile under normal temperature and pressure (15-25°C, 0.1Mpa) conditions, and the radiation dose is ...

Embodiment 3

[0030] A clean and sterile high-barrier medical rubber stopper and a preparation method thereof are prepared by using the following raw materials and methods:

[0031] Raw materials: Guangdong Maoming butadiene rubber (br9000) 100g; medical grade clay 15g; medical grade montmorillonite 5g; stearic acid 2g; petrolatum 3g; radiation sensitizer TMPTA 10g; natural aloe extract powder 2.0g.

[0032] The preparation method is as follows: the raw rubber rubber and the radiation sensitizer are mixed in a mixer at 55r / min, 60℃, stearic acid and petrolatum are added in 2 minutes, clay and montmorillonite are added in 5 minutes, and mixed for 10 minutes Discharge. After compression molding, radiation vulcanization, remodeling, drying and other processes, medical rubber plugs are made. The radiation vulcanization is the application of high-energy electron beams generated by a high-energy electron accelerator to radiation vulcanization of the rubber profile under normal temperature and pressur...

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PUM

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Abstract

The invention discloses a clean sterile high-barrier medical rubber plug and a preparation method thereof, and relates to a medical rubber plug which is free of potential toxicity on medicines and human tissues and has bacteria restraining and sterilizing performance and high barrier performance and a preparation method thereof, belonging to the technical field of medical rubber accessories. The preparation method for the clean sterile high-barrier medical rubber plug comprises the following steps: performing processes such as mixing medical raw rubber, natural aloe extract powder, medical-level sheet micro nano filler, processing auxiliaries and a radiation sensitizer in proportion, performing mould base pressing and molding, radiation vulcanizing, trimming, and drying, thereby preparing the medical rubber plug. The sterile high-barrier medical rubber plug is simple in formula system, adopts normal-temperature radiation vulcanization, is free of high-temperature decomposition products and free of potential toxicity on medicines and human tissues, and can be used for medical rubber accessories such as a medical injector rubber piston and a medical rubber plug which directly contact with the medicines.

Description

Technical field [0001] The invention belongs to the field of medical rubber accessories, and specifically relates to a medical rubber stopper with cleaning, antibacterial and sterilization functions, high barrier properties and a preparation method thereof. Background technique [0002] Traditional medical rubber stoppers are mostly natural rubber or synthetic rubber that is cross-linked by traditional vulcanization methods under high temperature and high pressure under the action of complex sulfur vulcanization system, peroxide vulcanization system, resin vulcanization system or metal oxide vulcanization system. Become. Patent CN101724180 provides a natural rubber or isoprene rubber in a sulfur vulcanization system at 150-180°C to prepare a disposable sterile syringe rubber piston. Patent CN102585389 relates to the use of chlorinated butyl rubber instead of natural rubber under high temperature and high pressure conditions, and vulcanization molding of tert-octylphenol formalde...

Claims

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Application Information

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IPC IPC(8): C08L9/00C08L7/00C08L9/06C08K13/02C08K3/34C08K3/22C08K5/01C08K5/09C08K5/103B29C43/02B29C35/08
CPCC08L9/00B29C35/08C08K2201/011C08L2203/02C08L91/06C08K13/02C08K3/346C08K5/09C08K5/0058
Inventor 王庆国肖晓周雪
Owner QINGDAO UNIV OF SCI & TECH
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