The invention provides a filling machine integrated with blanking, bottle blowing, cleaning, filling and sealing, comprising a blanking system, a heating system, a bottle blowing system, a cleaning system, a filling system, a sealing system, a covering system and a delivery system wich connects the blanking system, the heating system, the bottle blowing system, the cleaning system, the filling system, the sealing system and the covering system sequentially together; by adopting the filling machine integrated with blanking, bottle blowing, cleaning, filling and sealing, the problem that when the bottle blowing system is used, compression air for blowing bottle can be mixed with particles to pollute the bottle by using the blanking-bottle blowing-filling-sealing four-in-one machine manufactured by Hunan CHINASUN pharmaceutical machinery Co.,Ltd. is solved, thereby achieving the effect that the manufactured bottle is clean.