Method for preventing deformation of polypropylene transfusion bottle during sterilization

A polypropylene bottle and polypropylene technology, applied in the field of medicine, can solve problems affecting the quality of medicines, easy deformation of the bottle body, etc., and achieve the effect of ensuring the quality of medicine liquid

Active Publication Date: 2011-08-24
SHANXI NUOCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a polypropylene bottled medicinal solution with no deformation of the bottle body, stable medicinal quality and high product qualification rate in v

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A method for preventing sterilization and deformation of polypropylene infusion bottles, comprising the following steps:

[0016] 1) Embryo injection: computerized injection molding machine with a clamping force of 3800t / m 2 , The injection volume is 20%, the injection temperature is 250°C, the melting zone temperature is 240°C, the mold core temperature is 40°C, the mold cavity temperature is 60°C, the injection pressure is 1500bar, and the holding pressure is 1200bar. At 95% of the full stroke, turn to hold pressure, and inject polypropylene particles into preforms under the condition that the hold pressure time is 5;

[0017] 2) Blowing: Rotating preforms are used to heat the inside of the preform to 100°C and the outside of the preform to 110°C under the heating condition of eight-layer electric heating lamps: then use 1.8MPa pressure air to blow the heated preform Blow into 1000mL polypropylene bottle;

[0018] 3) Bottle washing: adopt ion wind cleaning technolog...

Embodiment 2

[0023] A method for preventing sterilization and deformation of polypropylene infusion bottles, comprising the following steps:

[0024] 1) Embryo injection: use a computerized injection molding machine with a clamping force of 4000t / m 2 , The injection volume is 60%, the injection temperature is 265°C, the melting zone temperature is 250°C, the mold core temperature is 45°C, the mold cavity temperature is 65°C, the injection pressure is 1650bar, and the holding pressure is 1350bar. Turn to hold pressure at 95% of the full stroke, and inject polypropylene particles into preforms under the condition that the hold time is 10 seconds;

[0025] 2) Bottle blowing: use rotating preforms, heat the inside of the preform to 120°C and the outside of the preform to 120°C under heating conditions: then use 2MPa pressure air to blow the heated preform into a 1000mL polypropylene bottle;

[0026] 3) Bottle washing: use ionic wind cleaning technology to clean the polypropylene bottle made a...

Embodiment 3

[0031] A method for preventing sterilization and deformation of polypropylene infusion bottles, comprising the following steps:

[0032] 1) Embryo injection: computerized injection molding machine with a clamping force of 4200t / m 2 , The injection volume is 85%, the injection temperature is 280°C, the melting zone temperature is 260°C, the mold core temperature is 50°C, the mold cavity temperature is 70°C, the injection pressure is 1800bar, and the holding pressure is 1500bar. Turn to hold pressure at 95% of the full stroke, and inject polypropylene particles into preforms under the condition that the hold time is 15 seconds;

[0033] 2) Bottle blowing: use rotating preforms to heat the inside of the preform to 150°C and the outside of the preform to 130°C under heating conditions: then use 2.2MPa pressure air to blow the heated preform into a polypropylene bottle;

[0034] 3) Bottle washing: use ionic wind cleaning technology to clean the polypropylene bottle made according ...

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PUM

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Abstract

The invention belongs to the technical field of medicaments and in particular relates to a method for preventing deformation of a polypropylene transfusion bottle during sterilization. The invention aims to solve the problems of deformation of the bottle and influence on medicament quality when the polypropylene transfusion bottle is used for accommodating medicinal liquid. The method for preventing deformation of the polypropylene transfusion bottle during sterilization comprises the following steps of: 1) injecting blanks, namely setting certain parameters by using a computer injection molding machine, preserving pressure when the whole stroke reaches 95 percent and injecting polypropylene particles into bottle blanks; 2) blowing bottles, namely heating internal part and external part of each bottle blank respectively to different temperatures by rotating the bottle blank and blowing the bottle blank by using air with a certain pressure into a polypropylene bottle; 3) washing the bottle, namely washing the polypropylene bottle by an ion wind washing technique and according to the conventional method; 4) performing encapsulation; 5) sealing; and 6) performing sterilization, namely performing sterilization by using a water bath sterilizer, and then performing light detection, labeling and packaging. During sterilization, the transfusion bottle is not deformed, so that quality stability of the medicinal liquid is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a method for preventing sterilization and deformation of polypropylene infusion bottles. Background technique [0002] Polypropylene infusion bottle is a new type of packaging material in the large infusion market at present. It is made of polypropylene pellets after processing. Using this infusion bottle to pack medicine in clinical use can avoid nurses' operation errors or other reasons. The bottle mouth is damaged, and there are glass shavings in the medicinal liquid. During the intravenous infusion, the glass shavings will enter the human body, causing additional damage to the patient's body, and avoiding the breaking of the medicinal liquid during transportation. But because the production method is not perfect, the bottle body is often deformed during sterilization, which affects the appearance of the bottle body, and also brings a certain degree of hidden dan...

Claims

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Application Information

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IPC IPC(8): B67C7/00B29C49/06
Inventor 张润成
Owner SHANXI NUOCHENG PHARMA
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