290results about How to "Excellent photothermal performance" patented technology

The invention provides a cellulose/two-dimensional layered material composite hydrogel. The composite hydrogel comprises a cellulose three-dimensional network structure and a two-dimensional materialsupported in the cellulose three-dimensional network structure, wherein the two-dimensional layered material is a two-dimensional transition metal carbide, nitride, or carbonitride. According to the composite hydrogel provided by the invention, the two-dimensional layered material can be stably supported in the composite hydrogel system and is not easy to agglomerate; and the composite hydrogel has good compatibility with a biological fluid, and the advantages of full biodegradability and high biological safety, and can be used in the field of biomedicines. The invention also provides a preparation method of the composite hydrogel.

The invention relates to a preparation method for polydopamine-coated polyethyleneimine-stablized gold-nanometer-star photothermal treatment agent. The preparation method comprises the following steps: preparing a gold seed solution from chloroauric acid and sodium citrate; activating mercaptoacetic acid with EDC, then adding an aqueous PEI solution and carrying out a reaction, dialysis, cooling and drying so as to obtain PEI-SH; adding dopamine hydrochloride into a Tris buffer so as to obtain dopamine Tris buffer; adding the gold seed solution into a chloroauric acid solution, adding a AgNO3 solution and an ascorbic acid solution under stirring, adding PEI-SH after stirring reaction and carrying out a reaction so as to obtain AuNSs-PEI; and adding AuNSs-PEI into the dopamine Tris buffer and carrying out stirring and centrifugation so as to obtain the photothermal treatment agent. The preparation method has the advantages of simplicity, mild reaction conditions, easy operation and industrialization prospects; and the prepared star-like nanometer agent has application potential in the fields of CT imaging diagnosis and photothermal treatment of cancers.

The invention provides a membranous layer composite structure of toughened low-radiation coated glass with a double-silver composite structure; toughening processing technique can be carried out after coating without influence on quality of products; silicon nitride (Si3N4) + ZnO is used as a composite dielectric layer of a base layer; one or more of tin oxide (SnO2), titanium oxide (TiO2), silicon nitride (Si3N4), and an absorbing layer of niobium oxide (Kb2O5) with ZnO are selected to form a composite dielectric layer of a middle layer; and the thicknesses and membranous components of other layers are reasonably selected, so as to prepare the toughened low-radiation coated glass with the double-silver composite structure which can undergo high-temperature heat processing.

The invention discloses a MnO2 wrapped polydopamine nano-particle, a preparation method and application. The nano-particle has a shell-core structure which is formed in the manner of acquiring a photo-thermal core by oxidizing the self-polymerized polydopamine nano-particle by dopamine hydrochloride under an alkali condition and in situ reducing the polydopamine nano-particle surface by manganesedioxide. The nano-particle has a photo-thermal effect and an acid-sensitive magnetic resonance imaging function. The nano-particle has the beneficial effects that the tumor tissue and the normal tissue can be more accurately distinguished, a more accurate guidance is supplied for clinic tumor treatment, and meanwhile, the material has a thermo-optical property and the diagnosis and treatment integration of the tumor can be realized.

The invention provides a targeted photothermal black phosphorus nano-preparation, which is prepared from a black phosphorus nano-slice, polyethylene glycol absorbed on the surface of the black phosphorus nano-slice by means of electrostatic attraction, and folic acid connected to the polyethylene glycol by means of an amide bond, wherein one end of the polyethylene glycol is amino, and the other end of the polyethylene glycol is imino; nitrogen atom of the imino and carbonyl carbon atom of the folic acid are connected with each other so as to form the amide bond; the folic acid is exposed at the outermost layer of the nano-preparation. The targeted photothermal black phosphorus nano-preparation is high in stability, good in target recognition ability and excellent in light-heat property, is capable of effectively killing cancer cells, and can be used for performing targeted photothermal treatment on cancers at the cellular level. The invention also provides a preparation method and application of the targeted photothermal black phosphorus nano-preparation.

The invention discloses a Cu3BiS3 ternary sulfur nano material and a preparation method thereof, belonging to the field of inorganic nano materials. The Cu3BiS3 ternary sulfur nano material is nano particles which are prepared by adopting a high-temperature pyrolysis method by taking oleic acid, oleylamine and octadecene as reaction solvents, Cu(NO3)2.3H2O and Bi(NO3)3.5H2O as raw materials and sodium diethyldithiocarbamate as a complexing agent and a sulfur source. The Cu3BiS3 nano particles have better absorbability in an ultraviolet/visible light area, and are proved to have a good photo-thermal effect; besides, the Cu3BiS3 ternary sulfur nano particles can be used for performing CT (computed tomography) imaging, so that the nano particles can be well applied in the field of biomedicine. Moreover, the preparation method of the Cu3BiS3 ternary sulfur nano material has many advantages of simple operation, low raw material cost, availability and the like, and is suitable for industrial production and application.

The invention discloses a preparation method of poly(N-isopropyl acrylamide)/oxidized graphene hydrogel. The preparation method comprises the following steps: at first, oxidizing graphite to obtain oxidized graphite; and then subjecting the oxidized graphite to radiation polymerization under a radiation source with a temperature of 60 DEG C to obtain the poly(N-isopropyl acrylamide)/oxidized graphene hydrogel. According to the preparation method, graphene oxide (GO) is dispersed into a water solution of (N-isopropyl acrylamide) NIPAM monomers and then the mixture is subjected to radiation polymerization to prepare the hydrogel. Multi-step reactions and organic solvent are not needed. The preparation method is simple and direct and is easy to control. The product is more pure and is more suitable for being used as a biological material. By changing the content of GO before polymerization, the amount of GO loaded on hydrogel can be easily controlled. Moreover, GO has excellent optical and thermal properties, and thus the poly(N-isopropyl acrylamide)/oxidized graphene hydrogel has an excellent light and heat sensitive property.

The invention discloses novel photo-irradiation induced self-repairing precious metal nano composite hydrogel. According to the hydrogel, a dynamic precious metal-sulfur coordination bond serves as a self-healing body which has a uniform mesh structure, that is, monomer has uniform polymerization reaction in the polymerization process, and accordingly the hydrogel has good stretchability and strength. The hydrogel has good notch sensitivity prevention capacity, that is, when notches or cracks exist in the surface of the hydrogel, hydrogel still has good stretchability. By means of the precious metal-sulfur coordination bond and good light-heat properties of precious metal, the hydrogel shows good self-repairing performance under stimulation of infrared laser.

The invention provides novel energy-saving toughened three-silver-layer low-radiation coated glass, which is characterized in that: a film structure of the glass sequentially consists of the following layers from a glass substrate to the outside: the glass substrate, a first composite dielectric medium layer (11), a first reflection deduction layer (12), a first silver layer (13), a first protective layer (14), a second dielectric medium layer (21), a second reflection deduction layer (22) plus a second silver layer (23), a second protective layer (24), a third dielectric medium layer (31), a third reflection deduction layer (32), a third silver layer (33), a third protective layer (34), a fourth composite dielectric medium layer (35) and a fourth protective layer (36). The novel energy-saving toughened three-silver-layer low-radiation coated glass has the advantages that: an infrared reflection capacity is higher than that of a double-silver-layer low-radiation film with the same visible light transmission value, the radiation rate on the surface of the film layer is low, the shading coefficient is much lower, and the reflection rate is low; and the film has high hardness and high oxidation resistance, and different cold processing and hot treatment can be carried out after the film coating.

The invention provides a conductive photo-thermal self-healing composite hydrogel dressing as well as a preparation method and application thereof.The preparation method comprises the following steps:grafting acrylic acid on chitosan to obtain an N-carboxyethyl chitosan polymer; the preparation method comprises the following steps: grafting p-hydroxybenzaldehyde on a triblock copolymer to obtainan aldehyde-terminated polymer (PF127-CHO); the preparation method comprises the following steps: preparing an aldehyde-terminated polymer into a solution, adding carbon nanotubes into the polymer solution, and carrying out ultrasonic treatment in an ice bath to obtain an aldehyde-terminated/carbon nanotube dispersion liquid; the preparation method comprises the following steps: preparing an N-carboxyethyl chitosan polymer into a solution, mixing the solution with an aldehyde group-terminated/carbon nanotube dispersion liquid, and carrying out mutual crosslinking at 20-45 DEG C for 5-400 seconds to obtain the conductive, adhesive, self-healing, photo-thermal and nano composite hydrogel. The hydrogel has excellent adhesion, self-healing, pH response, biocompatibility and hemostatic performance, can show a photo-thermal behavior after being exposed to a near-infrared (NIR) region, causes physical damage to bacteria, and has huge potential for treating infected wounds.

The invention relates to a folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

The invention provides a rare earth nano-material with both up/down conversion fluorescence emission and photothermal properties, and a synthesis method thereof. The rare earth nano-material has a multi-level core-shell structure with a controllable size (30-50nm). The innermost layer is NaGdF4:0.3%Nd<3+> with the best down conversion fluorescence property. The layer outside the innermost layer is inert NaGdF4. From the inert NaGdF4 layer to the outside, there are three shell layers which are NaNdF4:10%Yb<3+>/1%Er<3+>, NaGdF4:10%Yb<3+>, and NaNdF4:10%Yb<3+>. Under 808nm near-infrared laser irradiation, the material has both 500-700nm up conversion fluorescence emission and 850-920nm down conversion fluorescence emission. The two fluorescence emissions do not interfere with each other. Also, considerable photothermal effect is produced. According to the invention, for a first time, up/down conversion fluorescence mechanisms and photothermal effect are realized in a same material.

The invention relates to the technical field of biological medicine and discloses a targeting multifunctional nanoparticle wrapping IR780. The targeting multifunctional nanoparticle comprises a polylactic acid-glycolic acid copolymer PLGA shell and the IR780 iodide embedded into the polylactic acid-glycolic acid copolymer PLGA shell, wherein a cyclic arginyl-glycyl-aspartic acid cRGD targeting peptide fragment is connected to the polylactic acid-glycolic acid copolymer PLGA shell. By the targeting multifunctional nanoparticle, the problems that tumor is prone to relapse and the treatment effect is poor due to the fact that the nanoparticles are not uniformly distributed on a tumor part in the prior art are solved.

The invention discloses a reparation method of a copper sulfide nanowire, relating to a copper sulfide nanomaterial. The preparation method comprises the following steps: putting CuCl2.2H2O and oleylamine into a three-necked bottle, and under the protection of N2 atmosphere, heating and maintaining constant temperature, so that CuCl2.2H2O is entirely dissolved in oleylamine to obtain a solution A; dissolving (C2H5)2NCSSNa.3H2O into oleylamine to obtain a solution B; adding the solution B into the solution A for reacting, to obtain a copper sulfide solution with hydrophobic property, then performing centrifugal separation, washing with cyclohexane, then dissolving chloroform to obtain a hydrophobic nano copper sulfide product; mixing and stirring the obtained hydrophobic nano copper sulfide product together with polyethylene glycol monoethylether 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE-PEG) and chloroform, putting the obtained product into a rotary evaporator, then performing vacuum drying and rotary drying, dispersing into H2O, to obtain the copper sulfide nanowire.

The invention relates to the field of medical polymers, and discloses a preparation method of a controlled-release hydrogel with photo-thermal treatment and wound repair functions. The method comprises the following steps of: firstly, modifying dopamine on alginic acid to ensure that an o-diphenol side group is arranged on a molecular chain of the alginic acid, and simultaneously preparing coppersulfide @ melanin-PEG @ dopamine nanoparticles with good photo-thermal performance and radiotherapy effect; and then adding the copper sulfide @ dopamine nanoparticles into a dopamine-modified alginicacid solution, adding astragaloside with the function of promoting wound healing into the solution at the same time, and forming gel through a catalytic cross-linking system of horseradish peroxidaseand hydrogen peroxide. The hydrogel has good controlled release performance and can play a role in reducing administration dosage and reducing or avoiding toxic and side effects. The hydrogel prepared by the method has good biocompatibility, can be used for treating cancer cells by utilizing photo-thermal performance and radiotherapy, and can be combined with the astragaloside for promoting postoperative wound healing.

The invention provides a carbon-based photo-thermal converting thin film, a preparation method and application thereof and a photo-thermal converting device. According to the preparation method, expanded carbon black is prepared through microwave treatment, so that photo-thermal converting performance of the expanded carbon black is improved; then a crosslinking agent is utilized to enable carboxy groups on the surface of the expanded carbon black and amino groups on the surface of mixed cellulose to generate crosslinking reaction to generate amido bonds, so that chemical bond connection between the expanded carbon black and a mixed cellulose filter membrane is achieved; thus, mechanical stability of the carbon-based photo-thermal converting thin film is improved, and the carbon-based photo-thermal converting thin film can be used repeatedly. When the carbon-based photo-thermal converting thin film disclosed by the invention is assembled into the photo-thermal converting device, a photo-thermal converting efficiency of the obtained photo-thermal converting device can reach 85% under 1kW/m<2> illumination condition, and the obtained photo-thermal converting device can still keep stable photo-thermal performance after 14 times of repeated tests.

The invention belongs to the field of preparing inorganic oxide nanometer functional materials, and specifically relates to a preparation method of a Fe3O4 nanometer aggregate which has both photothermal property and superparamagetism. The method comprises firstly preparing Fe3O4 particles modified by oleic acid and oleylamine, then constructing units for the particles, and constructing the Fe3O4 nanometer aggregate having controllable size, photothermal property and superparamagnetism by regulating the interaction between nanometer particle surface ligand and solvent. The preparation method of the Fe3O4 nanometer particle aggregate is simple and convenient in operation, good in repeatability; with an easily regulated size, the nanometer particle aggregate has superparamagnetism and photothermal property better than Fe3O4 particles, as well as good stability; it is easy to react with biomolecules and can be applied to the fields such as targeted photothermal therapy of tumors.

The invention discloses a multifunctional nanoprobe for targeting SERS (surface enhanced Raman scattering) imaging of tumor cells and a preparation method thereof. The probe comprises gold nanoparticles, thiosalicylic acid, polypeptide and bovine serum albumin sequentially from inside to outside, the gold nanoparticles are wrapped with a layer of thiosalicylic acid molecules and then connected with the polypeptide through an amido bond, and finally the surface is wrapped with a layer of the bovine serum albumin to enclose the exposed area of the surface of the probe to obtain the nanoprobe; the gold nanoparticles are star-like gold nanoparticles. The preparation method includes: firstly, preparing the star-like gold nanoparticles high in near-infrared absorption performance, secondly, modifying the surfaces of the gold nanoparticles with Raman molecules, and thirdly, further binding the polypeptide capable of specifically binding the tumor cells. The probe integrates multiple functions, has targeting SERS imaging performance and a photothermal therapy function, can effectively recognize the tumor cells in a directional manner, performs tumor imaging, and utilizes the photothermal therapy to kill the tumor cells.

The invention relates to a biological ceramic scaffold with a surface micro-nano structure and a preparation method and application of the biological ceramic scaffold with the surface micro-nano structure. The biological ceramic scaffold with the surface micro-nano structure comprises a Ca7Si2P2O16 biological ceramic scaffold body and a micro-nano structured polydopamine/Ca-P nano layer formed on the surface of the Ca7Si2P2O16 biological ceramic scaffold body. By means of forming the micro-nano structured polydopamine/Ca-P nano layer on the surface of the Ca7Si2P2O16 biological ceramic scaffold body, adhesion, proliferation and differentiation of bone mesenchymal stem cells on the surface of the scaffold can be facilitated to promote in-vivo osteogenesis, and therefore the biological ceramic scaffold (or dopamine-induced biological ceramic scaffold) with the surface micro-nano structure prepared herein can repair bones and treat bone tumors.

The invention discloses a preparation method and application of a photothermal antibacterial agent polypeptide/Au/Fe3O4, and belongs to the field of preparation of materials. The preparation method mainly comprises the following steps: (1) preparing Fe3O4-NPs; (2) preparing a Au/Fe3O4 core-shell composite material; (3) preparing a peptide/Au/Fe3O4 core-shell composite material; and (4) performing photothermal sterilization. The Fe3O4 serves as a core, so that the composite material has good photothermal effect, can be recovered and reutilized easily through a strong magnet, greatly increases the utilization rate and saves energy. The outer layer has bacterial selectivity polypeptide, so the composite material can target bacteria well and reduce damage to the peripheral normal cells.

The invention provides a stannous sulfide nanosheet based drug delivery system. The stannous sulfide nanosheet based drug delivery system comprises a stannous sulfide nanosheet, folic acid modified polyethylene glycol coated on the surface of the stannous sulfide nanosheet, and an anti-cancer drug loaded on the stannous sulfide nanosheet. The drug delivery system takes the stannous sulfide nanosheet as a carrier to load the anti-cancer drug, the cost of the carrier is low, the carrier is easy to prepare, the excellent photothermal effect is achieved, so that the drug delivery system has the effect of photothermally killing the tumors of the stannous sulfide nanosheet and the effect of chemotherapeutically treating the tumors of a chemotherapeutic drug, and has a very high clinical value for the treatment of the cancers. The invention further provides a preparation method of the stannous sulfide nanosheet based drug delivery system.

The invention discloses an ultra-fast preparation method of Bi nanoparticles and surface defects co-modified BiOCl nanosheets. The preparation method comprises the following steps: (1) adding the prepared BiOCl nanosheets and a certain amount of NaN3 into deionized water, magnetically stirring the mixture for 30 minutes for uniform mixing, slowly pouring the mixture into liquid nitrogen for rapidfreezing, and carrying out freeze-drying; and (2) after the drying is finished, placing a BiOCl and NaN3 mixture in a closed high-temperature reaction kettle, filling the kettle with nitrogen protection gas, carrying out a deflagration reaction on the NaN3 by adopting a heating wire heating mode, repeatedly cleaning products by using the deionized water after the reaction is finished, carrying outdrying, and finally obtaining the Bi nanoparticles and surface defects co-modified BiOCl nanosheets. The preparation method has the advantages of short reaction time, simultaneous completion of formation of BiOCl oxygen defects and doping of Bi nanoparticles, controllable defect and doping amount, high yield and the like; and moreover, the method is simple, the operation is simple and convenient,the universality is good, and the method can be used for preparing other advanced materials.

The invention discloses application of ferroferric oxide as a photo-thermal sensitive material. According to the application, ferroferric oxide is radiated by near-infrared light to generate heat and is irradiated by laser with the wavelength of 700-2000nm; Fe3O4 is found to have a favorable photo-thermal effect for the first time and is a potential photo-thermal sensitive agent; the Fe3O4 has a certain application prospect in the aspect of photo-thermal conversion, in particular to the aspect of biological therapy; in addition, the Fe3O4 has remarkable photo-thermal effect and biological therapy effect; specific cytotoxicity of tumor can be realized by irradiating the Fe3O4 for five minutes; after treatment, the tumor is completely removed; the Fe3O4 has no remarkable influence on normal tissues; relative to treatment methods such as operation and chemotherapy, the Fe3O4 is remarkable in curative effect and small in toxic or side effect; and meanwhile, the Fe3O4 integrates various special functions such as magnetic targeting and magnetic resonance imaging, so that the Fe3O4 has broad application prospect in aspects of clinical diagnosis and treatment.

The invention relates to a preparation method of bamboo-like nitrogen-doped carbon nanotubes loaded with metal monoatoms and nanoparticles. The method comprises the following steps of: adding 2-methylimidazole, metal salt, a zinc-containing compound and grinding balls into a ball milling tank, and carrying out ball milling for 2-8 hours to obtain a mixture containing ZIFs single crystals; and placing the mixture containing ZIFs single crystals in a quartz boat, heating the mixture to 800-1100 DEG C from room temperature at a speed of 2-5 DEG C min <-1 > in a tubular furnace, maintaining the temperature for 1-3 hours, and naturally cooling to room temperature to finally obtain bamboo-like nitrogen-doped carbon nanotubes loaded with metal monoatoms and nanoparticles. The steps of washing, separating and the like are not needed, the method has huge potential application value in the fields of photo-thermal catalysis, concerted catalysis and the like, and the application range of the method in the catalysis field is widened.

The invention relates to the field of medicines, and discloses a preparation method of antimonene-based tumor targeted drug-loaded nanoparticles. Firstly, antimonene nanoparticles are obtained through a liquid phase mechanical stripping method and differential centrifugation, then the surface of AMNPs with negative charges is coated with chitosan and adriamycin with positive charges through the electrostatic adsorption effect, and finally the surface of chitosan is coated with hyaluronic acid with negative charges; and the photo-thermal/chemotherapy drug-loaded nanoparticles capable of realizing tumor targeting, drug sustained release and multi-modal imaging are obtained. The drug-loaded nanoparticles have important development prospects in the aspects of anti-tumor photo-thermal photodynamic therapy, drug nano-carriers and the like.