Preparation method of antimonene-based tumor targeted drug-loaded nanoparticles
A drug-loaded nano- and tumor-targeted technology, applied in the field of medicine, can solve the problems of difficult chemical modification, poor product stability, and few AM surface active groups
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Embodiment 1
[0035] (1) Chitosan solution preparation: Weigh 20 mg chitosan and dissolve it in 20 ml acetic acid to prepare a 1 mg / mL chitosan solution, and store it in a refrigerator at 4°C.
[0036] (2) Preparation of hyaluronic acid solution: Weigh 20 mg of hyaluronic acid and dissolve it in 20 ml of deionized water to prepare a 1 mg / mL hyaluronic acid solution, and store it in a refrigerator at 4°C.
[0037] (3) Preparation of doxorubicin doxorubicin solution: Weigh 10 mg of ICG and dissolve in 10 ml of deionized water to prepare a 1 mg / mL doxorubicin solution, wrap it in tin foil and store it in a refrigerator at 4°C.
[0038](4) Preparation of AMNPs: Disperse 2g of antimony powder in a clean beaker containing 40ml of NMP at room temperature, seal it with plastic wrap, and use a φ6 ultrasonic probe to sonicate in an ice bath for 8h under an ultrasonic cell disruptor, with a power of 1000w, and stop for 1s every 3s. Stir the dispersion with a glass rod every 30 minutes to make it evenl...
Embodiment 2
[0044] (1) Chitosan solution preparation: Weigh 20 mg chitosan and dissolve it in 10 ml acetic acid to prepare a 2 mg / mL chitosan solution, and store it in a refrigerator at 4°C.
[0045] (2) Preparation of hyaluronic acid solution: Weigh 20 mg of hyaluronic acid and dissolve it in 10 ml of deionized water to prepare a 2 mg / mL hyaluronic acid solution, and store it in a refrigerator at 4°C.
[0046] (3) Preparation of doxorubicin doxorubicin solution: Weigh 20 mg of ICG and dissolve in 10 ml of deionized water to prepare a 2 mg / mL ICG solution, wrap it in tin foil and store it in a refrigerator at 4°C.
[0047] (4) Preparation of AMNPs: Disperse 4 g of antimony powder in a clean beaker containing 80 ml of NMP at room temperature, seal it with plastic wrap, and use a φ6 ultrasonic probe to sonicate in an ice bath for 10 h under an ultrasonic cell disruptor, with a power of 1000 W, and stop for 1 s every 3 s. Stir the dispersion with a glass rod every 30 minutes to make it evenl...
Embodiment 3
[0052] (1) Preparation of chitosan solution: Weigh 15 mg of chitosan and dissolve it in 10 ml of acetic acid to prepare a 1.5 mg / mL chitosan solution, and store it in a refrigerator at 4°C.
[0053] (2) Preparation of hyaluronic acid solution: Weigh 15 mg of hyaluronic acid and dissolve it in 10 ml of deionized water to prepare a 1.5 mg / mL hyaluronic acid solution, and store it in a refrigerator at 4°C.
[0054] (3) Preparation of doxorubicin doxorubicin solution: Weigh 15 mg of ICG and dissolve in 10 ml of deionized water to prepare a 1.5 mg / mL doxorubicin solution, wrap it in tin foil and store it in a refrigerator at 4°C.
[0055] (4) Preparation of AMNPs: Disperse 3g of antimony powder in a clean beaker containing 50ml of NMP at room temperature, seal it with plastic wrap, and use a φ6 ultrasonic probe to sonicate in an ice bath for 8.5h under an ultrasonic cell disruptor, with a power of 1000w, and stop for 1s every 3s , use a glass rod to stir the dispersion every 30 min...
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