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Fe3O4 nanometer particle aggregate and preparation method thereof

A nanoparticle and aggregate technology, applied in the field of Fe3O4 nanoparticle aggregates and its preparation, can solve problems such as side effects and increased risks, difficulty in meeting clinical application needs, etc., to achieve enhanced near-infrared absorption, improved photothermal performance, and improved The effect of stability

Inactive Publication Date: 2016-08-31
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Fe 3 o 4 The absorption of nanoparticles near the near-infrared region is generally relatively weak. In order to obtain ideal photothermal therapy effects, high-power lasers or large injection doses are required, which increases the related side effects and risks, making it difficult to meet the needs of clinical applications.

Method used

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  • Fe3O4 nanometer particle aggregate and preparation method thereof

Examples

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Effect test

example 1

[0018] Add 2 mmol oleic acid, 2 mmol oleylamine, 2 mmol iron acetylacetonate, and 10 mmol 1, 2-hexadecanediol into 20 mL dibenzyl ether, stir well under nitrogen protection, and heat to 200°C. React for 1 hour, then raise the temperature to 300°C, react for 1 hour, cool to room temperature, wash with magnetism three times, and disperse into 15 mL of chloroform, the solution concentration is about 20 mg / mL. Take 1 mLFe 3 o 4 Nanoparticle solution, add 65 mM 1 mL dedecyltrimethylammonium bromide aqueous solution, blow nitrogen gas for 5 minutes under the condition of water bath at 40 ℃, add 2 mM 5 mL polyvinylpyrrolidone ethylene glycol solution, heat to 80 °C under nitrogen protection ℃, stirred for 6 hours, cooled to room temperature, centrifuged at 5000 rpm for 15 minutes, added ethanol to disperse, magnetically washed three times, and finally dispersed into 5 mL of water to obtain Fe with a size of about 450 nm. 3 o 4 Nanoparticle aggregate solution.

example 2

[0020] The dedecyltrimethylammonium bromide in Example 1 is replaced by dodecyltrimethylammonium bromide, and the rest of the reaction process and reaction conditions are unchanged, and Fe with a size of about 388 nm can be obtained. 3 o 4 Nanoparticle aggregate solution.

example 3

[0022] The dedecyltrimethylammonium bromide in Example 1 is replaced by tetradecyltrimethylammonium bromide, and the rest of the reaction process and reaction conditions are unchanged, and Fe with a size of about 329 nm can be obtained. 3 o 4 Nanoparticle aggregate solution.

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Abstract

The invention belongs to the field of preparing inorganic oxide nanometer functional materials, and specifically relates to a preparation method of a Fe3O4 nanometer aggregate which has both photothermal property and superparamagetism. The method comprises firstly preparing Fe3O4 particles modified by oleic acid and oleylamine, then constructing units for the particles, and constructing the Fe3O4 nanometer aggregate having controllable size, photothermal property and superparamagnetism by regulating the interaction between nanometer particle surface ligand and solvent. The preparation method of the Fe3O4 nanometer particle aggregate is simple and convenient in operation, good in repeatability; with an easily regulated size, the nanometer particle aggregate has superparamagnetism and photothermal property better than Fe3O4 particles, as well as good stability; it is easy to react with biomolecules and can be applied to the fields such as targeted photothermal therapy of tumors.

Description

technical field [0001] The invention belongs to the technical field of preparation of inorganic oxide nano functional materials, in particular to a kind of Fe with photothermal properties and superparamagnetism 3 o 4 Nanoparticle aggregates and methods for their preparation. Background technique [0002] In recent years, the incidence of malignant tumors has been increasing, and it has become the second most frequently occurring disease after brain diseases. The commonly used methods for clinical treatment of malignant tumors are mainly surgical resection, radiotherapy and chemotherapy, but these methods usually have relatively high toxicity and side effects. While killing tumor cells, they are likely to cause damage to normal tissues and organs around the tumor, destroy the immune system, and cure the disease. rates are generally low. Photothermal therapy is an emerging tumor treatment technology. It mainly uses photothermal conversion agents to convert the light energy ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00B82Y30/00B82Y40/00
CPCA61K41/0052B82Y30/00B82Y40/00
Inventor 洪霞刘益春于渤丛铁
Owner NORTHEAST NORMAL UNIVERSITY
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