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Conductive photo-thermal self-healing composite hydrogel dressing as well as preparation method and application thereof

A composite hydrogel, self-healing technology, applied in pharmaceutical formulations, drug combinations, medical preparations with inactive ingredients, etc. Good water solubility and cell compatibility, good biodegradability, good biocompatibility

Active Publication Date: 2020-06-05
THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the antibacterial activity and self-healing of the hydrogel are the inherent properties of the raw material itself. Although the healing and antibacterial capabilities are significant but limited, and the treatment effect on infected wounds is not good, therefore, there is an urgent need for a hydrogel that can be used on full-thickness skin. Bactericidal, antibacterial, self-healing and better healing dressings in wound infection models

Method used

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  • Conductive photo-thermal self-healing composite hydrogel dressing as well as preparation method and application thereof
  • Conductive photo-thermal self-healing composite hydrogel dressing as well as preparation method and application thereof
  • Conductive photo-thermal self-healing composite hydrogel dressing as well as preparation method and application thereof

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preparation example Construction

[0069] The invention provides a preparation method of a conductive photothermal self-healing composite hydrogel dressing, the steps of which include:

[0070] S1: Preparation of N-carboxyethyl chitosan polymer: 1) Suspend chitosan in deionized water to obtain chitosan dispersion, then add acrylic acid drop by drop while stirring continuously, and stir at 30-80°C 24-96 hours to obtain the reaction solution; 2) adding sodium hydroxide aqueous solution to the reaction solution to adjust the pH of the reaction solution to 8-12, then dialyzing the reaction solution with distilled water, repeatedly changing the water for 3-5 days, and then freeze-drying, Obtain N-carboxyethyl chitosan polymer; wherein, the mass ratio of chitosan and acrylic acid is (2~6):(1~8), and the concentration of chitosan dispersion is 15mg / mL~25mg / mL , the concentration of sodium hydroxide aqueous solution is 0.5mol / L~2mol / L;

[0071] S2: Aldehyde terminated The preparation of F127 polymer (PF127-CHO): 1) ...

Embodiment 1

[0092] S1: Preparation of CEC (N-carboxyethyl chitosan, N-carboxyethyl chitosan) polymer: first suspend 4.0g chitosan in 200mL deionized water, stir continuously, then add 5.84mL acrylic acid dropwise to the In the suspension, continue to stir at 50°C for 72 hours. After the reaction, adjust the pH of the reaction mixture to 8-12 with 1mol / L aqueous sodium hydroxide solution, dialyze the mixture with distilled water (MWCO 8000), and change the water repeatedly for 3 days , and then lyophilized to obtain pure CEC polymer;

[0093] S2: PF127-CHO (Benzaldehyde-terminated PF127, aldehyde-terminated F127) Preparation of polymers:

[0094] 1) Add 25g After the F127 polymer was sealed in a three-necked flask with nitrogen gas for 30 minutes, it was vacuum-dried at 80°C for 12 hours, then 240 mL of dry dichloromethane was added, and 2.772 mL of dry triethylamine was added in an ice bath at 0°C, and stirred thoroughly for 10 minutes, then dissolve 1.584 mL of dry methanesulfonyl c...

Embodiment 2

[0099] With the aldehyde capped in step S3 The final concentration of carbon nanotubes (CNTs) in the F127 / carbon nanotube dispersion was controlled at 8 mg / mL, and other conditions were the same as in Example 1 to obtain a CEC / PF / CNT2 hydrogel.

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Abstract

The invention provides a conductive photo-thermal self-healing composite hydrogel dressing as well as a preparation method and application thereof.The preparation method comprises the following steps:grafting acrylic acid on chitosan to obtain an N-carboxyethyl chitosan polymer; the preparation method comprises the following steps: grafting p-hydroxybenzaldehyde on a triblock copolymer to obtainan aldehyde-terminated polymer (PF127-CHO); the preparation method comprises the following steps: preparing an aldehyde-terminated polymer into a solution, adding carbon nanotubes into the polymer solution, and carrying out ultrasonic treatment in an ice bath to obtain an aldehyde-terminated / carbon nanotube dispersion liquid; the preparation method comprises the following steps: preparing an N-carboxyethyl chitosan polymer into a solution, mixing the solution with an aldehyde group-terminated / carbon nanotube dispersion liquid, and carrying out mutual crosslinking at 20-45 DEG C for 5-400 seconds to obtain the conductive, adhesive, self-healing, photo-thermal and nano composite hydrogel. The hydrogel has excellent adhesion, self-healing, pH response, biocompatibility and hemostatic performance, can show a photo-thermal behavior after being exposed to a near-infrared (NIR) region, causes physical damage to bacteria, and has huge potential for treating infected wounds.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a conductive photothermal self-healing composite hydrogel dressing, a preparation method and application thereof. Background technique [0002] The largest organ of the human body is the skin tissue, which acts as the first barrier to the external environment against dehydration, chemical / radiation damage, and microbial invasion. However, after severe damage (including surgery, burns, skin diseases, etc.), the barrier loses its basic protective mechanism and eventually creates a wound. Once the damaged tissue loses its main function as a protective barrier, microorganisms can easily invade and colonize the wound site during this period, leading to infection and further chronic wounds. Wounds infected by bacteria will seriously affect people's quality of life, and even threaten the lives of patients. In addition, it will place a heavy burden o...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L71/02C08L5/08C08K3/04C08B37/08A61K9/06A61K31/722A61K41/00A61K47/10A61K47/36A61L26/00A61P17/02A61P31/04
CPCA61K9/06A61K31/722A61K41/0052A61K47/10A61K47/36A61L26/0004A61L26/0019A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/108A61L2300/232A61L2300/404A61P17/02A61P31/04C08B37/003C08J3/075C08J3/24C08J2371/02C08J2405/08C08K2201/001C08K2201/011C08K3/041C08L71/02C08L5/08A61K2300/00
Inventor 薛力郭保林贺佳辉
Owner THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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