59 results about "P-hydroxybenzaldehyde" patented technology

The invention discloses a Schiff base epoxy oligomer chain extender as well as a preparation method and application thereof. The preparation method of the Schiff base epoxy oligomer chain extender comprises the following steps: adding p-hydroxybenzaldehyde and p-hydroxyaniline into ethanol, reacting at 30-70 DEG C for 2-5 hours, and performing suction filtration to obtain a 4-((4-hydroxybenzylidene) amino) phenol intermediate; and mixing the 4-((4-hydroxybenzylidene) amino) phenol intermediate, epoxy chloropropane and a catalyst, reacting at 80-100 DEG C for 3-7 hours, cooling to 50-70 DEG C, dropwise adding a strong alkali solution, reacting for 4-8 hours after dropwise adding, washing with deionized water, retaining an organic layer, and carrying out rotary evaporation on the organic layer to obtain the product. The rigidity, toughness and heat resistance of the modified nylon 6 prepared by applying the Schiff base epoxy oligomer chain extender are improved, and the modified nylon 6 still has processability similar to that of nylon 6.

The invention discloses a flame-retardant corrosion-resistant coating and a preparation method thereof, and relates to the technical field of fluorocarbon resin powder coatings. The flame-retardant corrosion-resistant coating comprises the following raw materials in parts by weight: 15-25 parts of fluorocarbon resin, 40-50 parts of epoxy resin, 3-5 parts of a curing agent, 5-7 parts of a reinforcing agent, 4-6 parts of a corrosion inhibitor, 6-8 parts of filler, 1-2 parts of a flatting agent and 0.5-1 part of benzoin. The preparation method comprises the following steps: reacting phosphonitrilic chloride trimer with p-hydroxybenzaldehyde to generate an intermediate 1, reacting the intermediate 1 with p-aminobenzoic acid to generate an intermediate 2, and reacting the intermediate 2 with 2-heptyl ethylene oxide to generate the reinforcing agent. The flame-retardant corrosion-resistant coating prepared by the invention has excellent mechanical properties, corrosion resistance, aging resistance and flame retardance.

The invention relates to the field of pipes, and discloses a heat-resistant high-strength MPP cable protection pipe and a preparation method thereof.The cable protection pipe comprises polypropylene resin, composite filler, modified layered lanthanum phenylphosphonate and auxiliaries; the composite filler is prepared by carrying out amino functional covalent modification on halloysite nanotubes by using a modified silane coupling agent, then carrying out protonation treatment and carrying out cation exchange on nano montmorillonite grafted with the modified silane coupling agent, and the modified silane coupling agent is prepared by reacting gamma-methacryloxypropyltrimethoxysilane with polyether amine; the modified layered lanthanum phenylphosphonate is prepared by grafting and modifying the surface of the layered lanthanum phenylphosphonate by using a cyclotriphosphazene substitute, the cyclotriphosphazene substitute is prepared by reacting 4-amino-1, 2, 4-triazole with p-hydroxybenzaldehyde and then substituting with phosphonitrilic chloride trimer, and the prepared MPP cable protection tube has the advantages of good tensile property, high impact resistance, high heat resistance, good flame retardancy, good flame retardancy and good flame retardancy. Meanwhile, excellent flame retardance and antibacterial effect are achieved.

The present application relates to the technical field of pesticides, and discloses a chromene aryl hydrazide derivative, a preparation method and application thereof, a structural general formula of the chromene aryl hyydrazide derivative is as formula (I); the preparation method is as follows: taking p-hydroxybenzaldehyde as raw material, and obtaining the chromene aryl hydrazide compound through substitution reaction, cyclization reaction, oxidation reaction, acylation reaction and hydrazinolysis reaction. The chromene aryl hydrazide compound is used for preparing an agricultural bacteriostatic agent. The present application combines aryl hydrazine and chromene skeleton by using the pharmacophore splicing principle in medicinal chemistry, and designs and synthesizes a series of chromene aryl hydrazide compounds. The bacteriostatic activity test result shows that the compounds have excellent bacteriostatic activity, and can be used as active ingredients for preparing a plant pathogenic fungus fungicide.

The application relates to the field of biological medicine, and discloses an active oxygen response thione aldehyde linker as well as a preparation method and application thereof. The thione aldehyde linker structure is a thione aldehyde structure with a p-hydroxyphenyl as a center. The thione aldehyde carbon atom is connected with two -CH2CH2COOH groups through a sulfur atom. The preparation method of the active oxygen response thione aldehyde linker comprises the following steps: dissolving 3-mercapto propionic acid and p-hydroxybenzaldehyde in ethyl acetate, adding trifluoroacetic acid as a catalyst, stirring and reacting at room temperature, and after the reaction is completed, the thione aldehyde linker is obtained through separation and purification. The thione aldehyde linker can respond to the increased ROS level in a tumor microenvironment, is broken under a high ROS condition, and thus realizes the release of a drug molecule connected therewith, which is beneficial to realizing the specific release of the drug at a tumor site.

The invention discloses asymmetric ester group-containing dicarboxylic acid, polyarylester, a preparation method and application. The asymmetric ester group-containing dicarboxylic acid is prepared from 4-formylbenzoic acid or a derivative thereof and p-hydroxybenzaldehyde or a derivative thereof through an esterification reaction and an aldehyde group oxidation reaction in sequence; the polyarylester is obtained by copolymerizing asymmetric ester group-containing dicarboxylic acid and aromatic amine; the main chain structure of the polyarylester contains heteroaromatic rings, so that the interaction force among polyarylester molecules is remarkably enhanced, the glass transition temperature and the thermal decomposition temperature of the polyarylester are greatly improved, and the polyarylester has excellent thermal stability and high-temperature-resistant application prospects, is remarkably higher than those of existing polyarylester materials, and shows certain toughness; meanwhile, the polyarylester has excellent gas separation performance after film formation, particularly has good selectivity to hydrogen, and is obviously superior to that of traditional polyarylester.

The invention provides a method for preparing p-hydroxystyrene, which comprises the following steps: reacting a raw material p-hydroxybenzaldehyde with a raw material dimethylacetamide in an organic solvent in a reactor under the catalysis of a basic catalyst to generate p-hydroxystyrene, wherein the method does not include reacting p-hydroxybenzaldehyde with malonic acid to produce p-hydroxystyrene.

The invention discloses a high-strength modified polypropylene composite material and a preparation process thereof, and relates to the technical field of polypropylene composite materials. The high-strength modified polypropylene composite material comprises the following raw materials in parts by weight: 60-70 parts of polypropylene, 15-18 parts of modified glass fibers and 5-6 parts of a thiazolyl phosphorus-containing flame retardant. The preparation method comprises the following steps: sequentially reacting phosphorus oxychloride with p-hydroxybenzaldehyde and 2-aminothiazole to obtain a thiazolyl phosphorus-containing flame retardant; the preparation method comprises the following steps: sequentially reacting glass fibers with 3-chloropropyltriethoxysilane and tetraethylenepentamine to prepare aminated glass fibers; and carrying out a reaction on the aminated glass fiber, acrylate-based hindered phenol and 2-[3-(2H-benzotriazole-2-yl)-4-hydroxyphenyl] ethyl 2-methacrylate to prepare the modified glass fiber. The modified glass fiber and the thiazolyl phosphorus-containing flame retardant are added into polypropylene, so that the polypropylene composite material is endowed with excellent flame retardance, weather resistance and mechanical properties.

The invention provides p-hydroxybenzaldehyde (PHBA) modified macroporous chloromethylated polystyrene (CMPs) as well as a preparation method and application thereof, and belongs to the technical field of adsorbents. The preparation method comprises the following steps: introducing an oxygen-containing aromatic functional compound PHBA to modify CMPs, firstly carrying out a nucleophilic substitution reaction, and then carrying out a Friedel-Crafts alkylation reaction to prepare the super-crosslinked resin PHBA-HCPs. Due to the good specific surface area and the introduction of aromatic hydrocarbon functional groups containing heteroatoms (especially oxygen-enriched groups), the adsorption performance of the polymer on aniline in an aqueous solution is greatly improved.

The invention discloses a synthesis method of an antibody-coupled drug connexon with an aldehyde group, and belongs to the technical field of chemical synthesis of drugs. The preparation method comprises the following steps: synthesizing 4-(4-formylphenoxy) butyric acid by taking p-hydroxybenzaldehyde as an initial raw material, then carrying out amidation reaction on the 4-(4-formylphenoxy) butyric acid and Boc-ethylenediamine to generate 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide, and carrying out acidic deprotection reaction to remove Boc groups, thereby obtaining the 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide. According to the present invention, with the method, the basis is provided for the variety expansion of the antibody-coupled drug connexon, and the good application prospect is provided.

The invention relates to the technical field of organic synthesis, and particularly discloses a preparation method of 4-isopropenylphenol, which comprises the following steps: hydroxyl protection: under the action of stirring, adding p-hydroxyacetophenone or p-hydroxybenzaldehyde into a solvent A, then adding a hydroxyl protective agent and alkaline ion exchange resin, carrying out heat preservation reaction at 10-15 DEG C for 3-4 hours, filtering, washing, and drying to obtain 4-isopropenylphenol; filtering, extracting and concentrating to obtain an intermediate 1; grignard reaction: under the stirring action, adding the intermediate 1 into a solvent B, heating to 35-45 DEG C, then dropwise adding a Grignard reagent, continuously carrying out heat preservation reaction for 5-6 hours, after the reaction is finished, adding a hydrochloric acid solution, standing for phase separation, and concentrating to obtain an intermediate 2; the Grignard reagent is isopropyl magnesium chloride or methyl magnesium chloride. According to the preparation method provided by the invention, the 4-isopropenylphenol with the yield being greater than or equal to 60% and the purity being greater than or equal to 98% can be obtained, the reaction operation is simple, and large-scale industrial production is facilitated.

The invention relates to the technical field of manganese oxide catalysts, in particular to a SiO2-loaded rare earth-doped Mn oxide catalyst as well as preparation and application thereof. The SiO2 loaded rare earth doped Mn oxide catalyst provided by the invention has a large number of surface oxygen holes, and can convert herbal lignin into high value-added aromatic aldehydes such as p-hydroxybenzaldehyde, vanillin and the like at high selectivity and high conversion rate under mild conditions; rare earth elements and Mn in the crystal structure of the catalyst interact to improve the activity of the catalyst, and furthermore, insufficient exposure of an active center caused by agglomeration of the catalyst is avoided through loading of SiO2, so that the reaction selectivity is effectively ensured, and the reaction efficiency is improved.

The invention provides a halogen-free phosphorus flame retardant as well as a preparation method and application thereof, and belongs to the technical field of flame retardants. The preparation method comprises the following steps: mixing a hydroxyl-containing compound, an acid-binding agent and an organic solvent to obtain a mixed solution; dropwise adding pyrophosphoryl chloride into the mixed solution, and reacting to obtain a reaction product; and carrying out post-treatment on the reaction product to obtain the halogen-free phosphorus flame retardant. The hydroxyl-containing compound comprises one or more of epoxy butanol, glycidol, syringaldehyde, vanillin and p-hydroxybenzaldehyde. The halogen-free phosphorus-based flame retardant disclosed by the invention is a flame retardant with a new structure and has an epoxy group capable of participating in a co-curing reaction of epoxy resin; the preparation method of the flame retardant is simple, the flame retardant is prepared from hydroxyl-containing compounds such as glycidol and pyrophosphoryl chloride under the action of an organic solvent and an acid-binding agent through a one-step synthesis method, and a target object can be conveniently and rapidly prepared.

The present application relates to a kind of phosphorus of p-hydroxybenzaldehyde PPHBA compound and its auxiliary preparation octreotide method, belong to organic synthesis technical field.The present application also provides a kind of phosphorus of p-hydroxybenzaldehyde PPHBA compound in preparation octreotide application, and a kind of phosphorus of p-hydroxybenzaldehyde compound auxiliary preparation octreotide method.The present application is with diphenylphosphine acyl oxy benzaldehyde DPOBA as carrier auxiliary octreotide phase synthesis method, using the auxiliary precipitation effect of DPOBA carrier, through liquid phase reaction with equivalent amino acid coupling and the strategy of Fmoc protection, optimize and simplify the preparation method of octreotide, verify the recyclability and reusability of DPOBA carrier.

The application discloses a kind of fire-retardant corrosion-resistant coating and preparation method thereof, it is related to fluorocarbon resin powder coating technical field.The fire-retardant corrosion-resistant coating includes the following weight parts of raw materials: fluorocarbon resin 15-25 parts, epoxy resin 40-50 parts, curing agent 3-5 parts, reinforcing agent 5-7 parts, corrosion inhibitor 4-6 parts, filler 6-8 parts, leveling agent 1-2 parts, benzoin 0.5-1 part.The application is generated by the reaction of hexachlorocyclotriphosphazene and p-hydroxybenzaldehyde intermediate 1, intermediate 1 is generated by the reaction of p-aminobenzoic acid and intermediate 2, and intermediate 2 is generated by the reaction of 2-heptyl oxirane and reinforcing agent.The fire-retardant corrosion-resistant coating prepared by the application has excellent mechanical properties, corrosion resistance, aging resistance and fire-retardant performance.

The application belongs to the technical field of polyurethane elastomer preparation, and discloses a water-resistant and self-repairing polyurethane elastomer, a preparation method thereof and application of the polyurethane elastomer in a humidity sensor. The method comprises the following steps: S1, dissolving 4,4'-diaminodiphenyl methane and p-hydroxybenzaldehyde in anhydrous ethanol to generate a small molecule MDOH with an imine bond structure through Schiff base reaction, and the small molecule MDOH is used as a chain extender of polyurethane; S2, reacting hydroxyl-terminated polybutadiene and isophorone diisocyanate at 60 DEG C to generate a prepolymer, and adding MDOH and glycerol monostearate into the obtained prepolymer to extend the chain; the introduction of MDOH can make the material have excellent self-repairing capability, and the glycerol monostearate is beneficial to further improve the self-repairing capability and water resistance. In addition, the humidity sensor based on the polyurethane elastomer can exhibit good sensing performance.

The invention relates to the technical field of high-performance coatings, and discloses a wear-resistant coating, a preparation method and application of the wear-resistant coating to an alumite color layer. The preparation method of the wear-resistant coating comprises the following steps: reacting 1, 6-dibromohexane with p-hydroxybenzaldehyde to obtain an intermediate product A; reacting the intermediate product A with p-phenylenediamine to obtain an intermediate product B; modifying the surface modified silicon carbide / silicon dioxide composite material with the intermediate product B to obtain an organic-inorganic hybrid filler; treating the organic-inorganic hybrid filler with N-methyldiethanolamine to obtain a modified organic-inorganic hybrid filler; the preparation method comprises the following steps: preparing a waterborne polyurethane acrylate emulsion by taking a multifunctional modifier, a modified organic-inorganic hybrid filler and tetrakis (3-mercaptopropionic acid) pentaerythritol ester as raw materials; and mixing the waterborne polyurethane acrylate emulsion with other auxiliaries to obtain the wear-resistant coating. The wear-resistant coating provided by the invention has good mechanical properties, wear resistance, heat resistance and antibacterial properties, and can be used in an alumite color layer.

The invention discloses a 2-hydroxy-3-pinonyl difluoro borane complex ratio type fluorescent probe for detecting H2O2 as well as a preparation method and application of the 2-hydroxy-3-pinonyl difluoro borane complex ratio type fluorescent probe. The preparation method comprises the following steps: by taking 2-hydroxy-3-pinone as a raw material, carrying out aldol condensation reaction on the 2-hydroxy-3-pinone and p-hydroxybenzaldehyde to prepare a compound DP; the compound DP and boron trifluoride diethyl etherate are subjected to a complexation reaction, and a compound DPO is prepared; the compound DPO and 4-bromomethyl phenylboronic acid pinacol ester are subjected to an etherification reaction, and the fluorescent probe DPBO is prepared. The probe DPBO can specifically recognize H2O2, under irradiation of 385nm ultraviolet light, after H2O2 is added into a DMSO / PBS solution of the probe DPBO, the fluorescence color of the solution gradually changes from blue-green to yellow, and the lowest detection limit is 0.09 [mu] M. The probe has the advantages of being simple and convenient to synthesize, good in selectivity, high in sensitivity, good in biocompatibility, low in toxicity and the like, and has a good application prospect.

The present invention provides a method for preparing p-hydroxystyrene, the method comprising reacting p-hydroxybenzaldehyde in an organic solvent with dimethylacetamide in a reactor under the catalysis of an alkaline catalyst to produce p-hydroxystyrene, wherein the method does not involve reacting p-hydroxybenzaldehyde with malonic acid to produce p-hydroxystyrene.

The invention relates to the technical field of industrial wastewater treatment, and discloses a modified attapulgite adsorbent for treating p-hydroxybenzaldehyde wastewater and a use method thereof.The adsorbent is prepared by treating an attapulgite raw material with a modifier, the modifier is a surfactant or a silane coupling agent, and the modifier is a modified attapulgite adsorbent. The attapulgite raw material is selected from at least one of attapulgite activated clay, attapulgite filter cakes, attapulgite raw ore and attapulgite extraction leftover materials, the surfactant is a quaternary ammonium salt type cationic surfactant, specifically, hexadecyl trimethyl ammonium bromide, and the concentration of a surfactant aqueous solution used in the modification process is 0.05-0.2 mol / L. The attapulgite raw material is modified by adopting a single surfactant or a silane coupling agent, a complex multi-step composite modification route in the prior art is abandoned, and the modification process is simplified and easy to operate; the attapulgite raw material is wide in selectable range, and related byproducts or leftover materials of mineral resources can be fully utilized, so that comprehensive utilization of the resources is realized, and the cost of the raw materials is reduced.

This invention relates to a strain of *Pseudomonas proteus* PHBA133 and its applications, belonging to the field of bioengineering. The strain, classified as *Pseudomonas proteus* coglossicida PHBA133, was deposited at the China General Microbiological Culture Collection Center on December 26, 2022, with accession number CGMCC No. 26275. The *Pseudomonas proteus* PHBA133 provided by this invention exhibits strong genetic stability and a broad substrate spectrum. It can ferment and convert p-hydroxycinnamic acid and its derivatives into corresponding aldehydes, with a conversion concentration of p-hydroxybenzaldehyde as high as 3.4 g / L, demonstrating potential for industrial application. The production process is simple, mild, green, and safe, avoiding the problems of long reaction times, high energy consumption, and environmental pollution faced by traditional chemical methods. Furthermore, it produces fewer byproducts, facilitating extraction and separation operations.

The present application belongs to the field of catalyst preparation technology, specifically a catalyst for the oxidation of p-cresol to prepare p-hydroxybenzaldehyde and its use method, the catalyst is a composite metal oxide catalyst, the carrier is γ-Al2O3, the active component is a bimetallic oxide, the auxiliary agent is one or more metal oxides of variable valence metals Ce, Mn, Au, La, and the metal element in the bimetallic catalyst contains at least one of Cu and Co. The catalyst disclosed in the present application has high catalytic activity and strong stability, and the preparation method of the catalyst is simple and the catalytic conditions are mild, which solves the problems of high cost, complex preparation process and harsh reaction process conditions of traditional oxidation catalysts; the CuCoM-Al2O3 (M=Ce, Mn, Au, La) catalyst prepared by the deposition precipitation method in the present application has a p-cresol conversion rate of 80% and a p-hydroxybenzaldehyde selectivity of 99%.

The invention relates to a method for preparing aromatic aldehyde by degrading lignin, which comprises the following steps: firstly, extracting lignin from different sources by an organic solvent method, dissolving the lignin in an organic solvent containing an acidic additive, introducing ozone to carry out ozone oxidative degradation, and then reducing ozone oxide by adopting a reducing agent aqueous solution to obtain the aromatic aldehyde. Finally, the lignin is converted into aromatic aldehyde compounds such as p-hydroxy benzaldehyde, vanillin and syringaldehyde. Compared with the prior art, the method has the advantages that the operation is simple and convenient, the reaction condition is mild, and the method is green and environment-friendly; acid is added into a reaction system, so that the lignin conversion rate and the aromatic aldehyde selectivity are effectively improved. The invention provides a new thought for efficient utilization of lignin, and also provides a feasible technical route for production of high-added-value chemicals.

The invention provides a method for preparing p-hydroxystyrene, which comprises the following steps: reacting a raw material p-hydroxybenzaldehyde with a raw material dimethylacetamide in an organic solvent in a reactor under the catalysis of a basic catalyst to generate p-hydroxystyrene, wherein the method does not include reacting p-hydroxybenzaldehyde with malonic acid to produce p-hydroxystyrene.

The invention discloses a strain of Levilicibacillus zyma capable of producing a sour bamboo shoot characteristic flavor substance p-cresol through fermentation, and belongs to the technical field of microorganisms. According to the invention, a strain of Levibacillus zyma CCFM1420 is screened, and is preserved in the Guangdong Microbial Culture Collection Center on October 31, 2024, and the preservation number is GDMCC No: 65378. The strain screened by the invention can convert p-hydroxybenzyl alcohol and p-hydroxybenzaldehyde in fresh bamboo shoots into characteristic flavor substance p-cresol in sour bamboo shoots under facultative anaerobic conditions, and can be used as a flavor substance to provide a new strain resource for industrial production of sour bamboo shoots.

The invention discloses an improved TR beta selective thyroid hormone GC-1 preparation method, and relates to the field of pharmaceuticals, p-hydroxybenzaldehyde and 3, 5-dimethyl-4-bromophenol are used as starting raw materials, and the TR beta selective thyroid hormone GC-1 is obtained through eight-step reactions of Friedel-Crafts alkylation, phenolic hydroxyl group protection, aldehyde addition reaction, alcoholic hydroxyl group protection, selective deprotection, phenol alkylation, acid catalytic hydrogenation and the like. The Sobetirome is synthesized by the method with the total yield of 54%. Compared with the prior art, the method has the advantages that a protecting group is easy to remove, the product stability is improved, and the yield is high.

The invention provides a method for preparing p-hydroxystyrene, which comprises the following steps: reacting a raw material p-hydroxybenzaldehyde with a raw material dimethylacetamide in an organic solvent in a reactor under the catalysis of a basic catalyst to generate p-hydroxystyrene, wherein the method does not include reacting p-hydroxybenzaldehyde with malonic acid to produce p-hydroxystyrene.

The invention relates to the technical field of electronic products, in particular to a prepreg for an electronic product shell and a preparation method of the prepreg. Glass fiber cloth is subjected to plasma treatment and phosphorus-containing polysiloxane precursor liquid treatment; carrying out phenol amine modification on the heat-conducting filler, and then grafting an aldehyde benzophenone derivative to obtain a composite heat-conducting filler; mixing epoxy resin, the composite heat-conducting filler, a curing agent, an auxiliary agent and a solvent to obtain an epoxy dipping solution; coating the modified glass fiber cloth with the epoxy dipping liquid to obtain a prepreg; the preparation method comprises the following steps: by taking titanium dioxide modified hexagonal boron nitride as a heat-conducting filler, co-depositing catechol and polyethyleneimine on the surface of the heat-conducting filler, and then grafting an aldehyde benzophenone derivative prepared from p-hydroxybenzaldehyde, isophorone diisocyanate and 2-aminobenzophenone as raw materials by utilizing a Schiff base reaction, so as to prepare the heat-conducting material. The prepreg is endowed with long-term aging resistance and corrosion resistance, and the service life of the prepreg is prolonged.

The application discloses a preparation method of a cyclotriphosphazene Schiff base carboxylic acid rare earth complex and application of the cyclotriphosphazene Schiff base carboxylic acid rare earth complex in preparation of a flame-retardant high polymer material, which is prepared by reacting raw materials including p-hydroxybenzaldehyde, anhydrous potassium carbonate, hexachlorocyclotriphosphazene, p-aminobenzoic acid and a rare earth chloride salt with seven waters, and is obtained directly. The cyclotriphosphazene Schiff base carboxylic acid rare earth complex prepared by the application plays a role of catalyzing carbonization and capturing free radicals based on the joint action of rare earth elements and phosphorus elements, plays a high-efficiency flame-retardant role, and has a small adding amount, so that the total adding amount of the flame retardant can be effectively reduced when the flame retardant is compounded with other halogen-free flame retardants.

The invention discloses a preparation method of methyl p-methoxycinnamate and p-methoxycinnamic acid, and belongs to the technical field of chemical synthesis. The preparation method of methyl p-methoxycinnamate comprises the following steps: S1, stirring and mixing sodium ethoxide and acetic acid formic acid, then cooling to 10 DEG C or below, then adding p-hydroxybenzaldehyde, and then stirring to obtain methyl p-hydroxycinnamate; and S2, stirring and mixing the methyl p-hydroxycinnamate, sodium hydroxide and methyl acetate, dropwise adding dimethyl sulfate at 0-5 DEG C, and reacting at 20-30 DEG C to obtain the methyl p-methoxycinnamate. In addition, the invention also provides a preparation method of the p-methoxycinnamic acid, which comprises the following steps: mixing the methyl p-methoxycinnamate prepared by the preparation method with a sodium hydroxide solution, and then reacting to obtain the p-methoxycinnamic acid. The method realizes synthesis of methyl p-methoxycinnamate from simple and low-price raw materials.