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Folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as preparation method and application thereof

A technology of mesoporous silica and nanocomposite particles, which is applied in the direction of nanotechnology, nanotechnology, and nanotechnology for sensing, to achieve good nuclear magnetic imaging, simple synthesis process, and low cost

Inactive Publication Date: 2016-09-07
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing cancer treatment methods mainly include surgery, chemotherapy, and radiotherapy, all of which have drawbacks

Method used

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  • Folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as preparation method and application thereof
  • Folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as preparation method and application thereof
  • Folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A Fe3O4 / mesoporous silica / copper sulfide nanocomposite particle coupled with folic acid targeting, including Fe 3 o 4 @mSiO 2 core-shell structure nanoparticles, the core-shell structure nanoparticles with Fe 3 o 4 The nanoparticle is the core, the mesoporous silica is the shell, a part of the surface of the shell is grafted with folic acid, the other part is loaded with copper sulfide nanoparticles, and the outer surface of the copper sulfide nanoparticles is grafted with polyethylene glycol.

[0039] In the nanocomposite particles, Fe 3 o 4 The mass ratio of nanoparticles, mesoporous silicon dioxide, copper sulfide nanoparticles, folic acid and polyethylene glycol is 4:10-40:0.3-14:2-30:1-100.

[0040] The preparation method of the folic acid-targeted ferric oxide / mesoporous silicon dioxide / copper sulfide nanocomposite particles comprises the following steps:

[0041] (1) Fe 3 o 4 Preparation of nanocrystals: 4.80 g FeCl 3 ·6H 2 O and 2.02 g FeCl 2 4H 2 O ...

Embodiment 2

[0053] A Fe3O4 / mesoporous silica / copper sulfide nanocomposite particle coupled with folic acid targeting, including Fe 3 o 4 @mSiO 2 core-shell structure nanoparticles, the core-shell structure nanoparticles with Fe 3 o 4Nano particles are the core, mesoporous silicon dioxide is the shell, a part of the surface of the shell is grafted with folic acid, the other part is loaded with copper sulfide nanoparticles, and the outer surface of the copper sulfide nanoparticles is grafted with polyethylene glycol. In the nanocomposite particles, Fe 3 o 4 The mass ratio of nanoparticles, mesoporous silicon dioxide, copper sulfide nanoparticles, folic acid and polyethylene glycol is 4:10-40:0.3-14:2-30:1-100.

[0054] Fe in the nanocomposite particles 3 o 4 @mSiO 2 The diameter of the core-shell nanoparticle is 40nm, the diameter of the core is 30nm, and the thickness of the shell is 5nm.

[0055] The preparation method of the folic acid-targeted ferric oxide / mesoporous silicon di...

Embodiment 3

[0062] A Fe3O4 / mesoporous silica / copper sulfide nanocomposite particle coupled with folic acid targeting, including Fe 3 o 4 @mSiO 2 core-shell structure nanoparticles, the core-shell structure nanoparticles with Fe 3 o 4 Nano particles are the core, mesoporous silicon dioxide is the shell, a part of the surface of the shell is grafted with folic acid, the other part is loaded with copper sulfide nanoparticles, and the outer surface of the copper sulfide nanoparticles is grafted with polyethylene glycol. In the nanocomposite particles, Fe 3 o 4 The mass ratio of nanoparticles, mesoporous silicon dioxide, copper sulfide nanoparticles, folic acid and polyethylene glycol is 4:10-40:0.3-14:2-30:1-100.

[0063] Fe in the nanocomposite particles 3 o 4 @mSiO 2 The diameter of the core-shell nanoparticle is 100nm, the diameter of the core is 10nm, and the thickness of the shell is 45nm.

[0064] The preparation method of the folic acid-targeted ferric oxide / mesoporous silicon...

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Abstract

The invention relates to a folic acid coupled targeted ferriferrous oxide / mesoporous silica / copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

Description

technical field [0001] The invention belongs to the technical field of an anticancer drug carrier, in particular to a ferric oxide / mesoporous silicon dioxide / copper sulfide nanocomposite particle (Fe 3 o 4 @mSiO 2 -FA-CuS-PEG) and its preparation method and application. Background technique [0002] In recent years, with the intensification of environmental pollution and the impact of changes in people's lifestyles, the growth rate of cancer cases has accelerated. Existing cancer treatment methods mainly include surgical therapy, chemotherapy and radiotherapy, etc., and these methods all have drawbacks. At the same time, the development of nanotechnology and its exciting achievements in the application of biomedicine have promoted the emergence and development of the emerging research field of "nanomedicine". Designing and controlling the structure and properties of nanoparticles, and further developing their applications in biomedicine have rapidly become the focus of r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/48A61K49/08A61K49/18B82Y5/00B82Y15/00A61K31/704A61P35/00
CPCA61K31/704A61K41/0052A61K49/08A61K49/1818B82Y5/00B82Y15/00A61K2300/00
Inventor 高志方刘锡建王烨颖王帆任兰芳陆杰
Owner SHANGHAI UNIV OF ENG SCI
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