Application of ferroferric oxide as photo-thermal sensitive material

A technology of ferroferric oxide and sensitive materials, which is applied in the direction of medical preparations containing active ingredients, wave energy or particle radiation treatment materials, preparations for in vivo tests, etc., to achieve remarkable curative effect, obvious photothermal effect, and toxic and side effects small effect

Inactive Publication Date: 2013-04-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] About Fe 3 o 4 There are many reports on the application, but for Fe 3 o 4 Research on photothermal conversion and as a NIR photothermal sensitizer has not been reported yet, although some studies have made Fe 3 o 4 Prepare composites with carbon nanotubes, graphene, gold nanoparticles, etc., and use them as photothermal sensitizers, but the substance that generates heat is not Fe 3 o 4 , but carbon nanotubes, graphene, gold nanoparticles, etc., Fe 3 o 4 The main role in it is as a magnetic targeting and magnetic resonance contrast agent (see: Kai Yang, Lilei Hu, Xingxing Ma, et al. Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles. Adv. Mater. 2012 , 24, 1868–1872. Wenjie Dong, Yongsheng Li, Dechao Niu, et al. Facile Synthesis of Monodisperse Superparamagnetic Fe 3 o 4 CorehybridAu Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy. Adv. Mater. 2011, 23, 5392–5397. )

Method used

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  • Application of ferroferric oxide as photo-thermal sensitive material
  • Application of ferroferric oxide as photo-thermal sensitive material
  • Application of ferroferric oxide as photo-thermal sensitive material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Fe 3 o 4 preparation of

[0028] Weigh 1.35g FeCl 3 ·6H 2 O. Dissolve 0.4g of sodium citrate in 70mL of ethylene glycol, add 3.85g of ammonium acetate, stir for 1h, transfer to a 100mL reaction kettle, react at 200°C for 10h, take it out and separate it using a magnetic field, and wash it with water for 3 times to obtain Fe 3 o 4 Powder, spare.

Embodiment 2

[0029] Example 2 Fe 3 o 4 The near-infrared absorption of the solution

[0030] Fe prepared by embodiment 1 3 o 4 The powder was prepared with normal saline to prepare Fe with concentration C of 5, 10, 25, 50, 75, 100, 150 and 300 μg / mL 3 o 4 Solution, utilize ultraviolet spectrophotometer to measure its absorbance A at 808nm place, the result sees figure 1 shown. Fe 3 o 4 The solution has a certain absorption at 808nm and has good linearity. The linear regression equation is A= 0.0051C + 0.0119, R 2 =0.9998.

Embodiment 3

[0031] Example 3 Fe 3 o 4 Photothermal conversion effect of solution

[0032] Fe prepared by embodiment 1 3 o 4 The powder was prepared with normal saline with Fe concentrations of 30, 75, 150 and 300 μg / mL 3 o 4 solution, 0.5 mL of each concentration was placed in a 2mL centrifuge tube, and water was used as a reference, and 808nm laser (2 W / cm 2 ) at room temperature for 5 minutes, measure the temperature every 30s, see the results figure 2 , 3 shown.

[0033] From figure 2 It can be seen that Fe 3 o 4 Has good photothermal conversion effect, 150 μg / mL and 300 μg / mLFe 3 o 4 The temperatures of the solutions reached 71°C and 83°C after irradiation for 5 minutes, and the transformation effect increased with the increase of the concentration. From image 3 It can be seen that Fe 3 o 4 After the solution is irradiated, due to the temperature rise, the water vapor forms water droplets on the bottle wall, but after the water undergoes the same irradiation, no wat...

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Abstract

The invention discloses application of ferroferric oxide as a photo-thermal sensitive material. According to the application, ferroferric oxide is radiated by near-infrared light to generate heat and is irradiated by laser with the wavelength of 700-2000nm; Fe3O4 is found to have a favorable photo-thermal effect for the first time and is a potential photo-thermal sensitive agent; the Fe3O4 has a certain application prospect in the aspect of photo-thermal conversion, in particular to the aspect of biological therapy; in addition, the Fe3O4 has remarkable photo-thermal effect and biological therapy effect; specific cytotoxicity of tumor can be realized by irradiating the Fe3O4 for five minutes; after treatment, the tumor is completely removed; the Fe3O4 has no remarkable influence on normal tissues; relative to treatment methods such as operation and chemotherapy, the Fe3O4 is remarkable in curative effect and small in toxic or side effect; and meanwhile, the Fe3O4 integrates various special functions such as magnetic targeting and magnetic resonance imaging, so that the Fe3O4 has broad application prospect in aspects of clinical diagnosis and treatment.

Description

(1) Technical field [0001] The invention relates to a photothermal sensitive material and its application, in particular to the application of ferric iron tetroxide as a photothermal sensitive material. (2) Background technology [0002] Photothermal sensitizers refer to a class of substances that absorb electromagnetic waves of a certain wavelength, usually near infrared light (NIR) and generate heat. At present, there are three main categories of substances used as photothermal sensitizers: the first category is organic compounds, such as indocyanine green, polyaniline, etc., which have good photothermal conversion efficiency, but poor photothermal stability, and It has a serious photobleaching effect; the second largest category is carbon nanomaterials, mainly including carbon nanotubes, graphene, C60, etc., which have good light stability and high heating efficiency, but their preparation process and functional modification are extremely complicated, and It is difficult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61P35/00
Inventor 金一沈松吴琳王成润
Owner ZHEJIANG UNIV
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