Stannous sulfide nanosheet based drug delivery system and preparation method thereof

A technology of stannous sulfide and drug delivery system, applied in the field of tumor treatment, can solve the problem of high price of black phosphorus, and achieve the effects of high clinical value, good light absorption, and simple preparation

Active Publication Date: 2018-06-05
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But black phosphorus is expensive and very easy to oxidize

Method used

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  • Stannous sulfide nanosheet based drug delivery system and preparation method thereof
  • Stannous sulfide nanosheet based drug delivery system and preparation method thereof
  • Stannous sulfide nanosheet based drug delivery system and preparation method thereof

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Embodiment 1

[0039] A preparation method of a drug delivery system based on stannous sulfide nanosheets, comprising the following steps:

[0040] (1) After the stannous sulfide block was ground for 30 minutes, it was dispersed in isopropanol to obtain a dispersion with a concentration of 1 mg / mL; the above-mentioned dispersion was ultrasonicated for 5 hours by a probe, and the probe power of the ultrasonic probe was 360w , the temperature of the probe is maintained at 5-20°C during the ultrasonic process, and when the temperature rises during the period, an ice pack is used to cool down; then the dispersion is ultrasonicated in a water bath for 10 hours to obtain the ultrasonic dispersion, and the water bath ultrasonic Keep the temperature at 15-25°C. When the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 15-25°C; after centrifuging the ultrasonic dispersion, centrifuge at a speed of 5000 rpm for 0.5 h, take th...

Embodiment 2

[0045] A preparation method of a drug delivery system based on stannous sulfide nanosheets, comprising the following steps:

[0046] (1) After the stannous sulfide block was ground for 40 minutes, it was dispersed in nitrogen-methylpyrrolidone to obtain a dispersion with a concentration of 1 mg / mL; the above-mentioned dispersion was ultrasonicated for 6 hours by a probe, and the probe power of the ultrasonic probe was 360w, the temperature of the probe is maintained at 10-15°C during the ultrasonic process, and when the temperature rises during the period, use an ice pack to cool down; then the dispersion liquid is ultrasonicated in a water bath for 12 hours to obtain the ultrasonic dispersion liquid, and the water bath ultrasonic Keep the temperature of the water bath at 15-25°C. When the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 15-25°C; centrifuge the ultrasonically dispersed liquid at a spee...

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Abstract

The invention provides a stannous sulfide nanosheet based drug delivery system. The stannous sulfide nanosheet based drug delivery system comprises a stannous sulfide nanosheet, folic acid modified polyethylene glycol coated on the surface of the stannous sulfide nanosheet, and an anti-cancer drug loaded on the stannous sulfide nanosheet. The drug delivery system takes the stannous sulfide nanosheet as a carrier to load the anti-cancer drug, the cost of the carrier is low, the carrier is easy to prepare, the excellent photothermal effect is achieved, so that the drug delivery system has the effect of photothermally killing the tumors of the stannous sulfide nanosheet and the effect of chemotherapeutically treating the tumors of a chemotherapeutic drug, and has a very high clinical value for the treatment of the cancers. The invention further provides a preparation method of the stannous sulfide nanosheet based drug delivery system.

Description

technical field [0001] The invention relates to the technical field of tumor treatment, in particular to a drug delivery system based on stannous sulfide nanosheets and a preparation method thereof. Background technique [0002] Chemotherapy is a commonly used treatment method in cancer treatment, but currently commonly used therapeutic drugs such as doxorubicin (DOX), paclitaxel, etc. often have the disadvantages of poor specificity and high toxicity, and will kill many normal cells while treating cancer. cells, side effects are relatively large. In order to solve this problem, people try to use nanomaterials as drug carriers to enhance their targeting. However, the traditional drug loading system often has problems such as low drug loading rate and poor drug control release effect. [0003] Using two-dimensional materials as carriers to carry anticancer drugs is a new anticancer technology developed in recent years. This technology uses two-dimensional materials to carr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/02A61K47/22A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K47/22A61K2300/00
Inventor 张晗范涛健谢中建
Owner SHENZHEN UNIV
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