Biological ceramic scaffold with surface micro-nano structure and preparation method and application of biological ceramic scaffold with surface micro-nano structure

A technology of micro-nano structure and bioceramics, applied in the direction of medical preparations containing active ingredients, drug combinations, tissue regeneration, etc., can solve the problems of non-degradability, toxicity, etc., achieve good photothermal performance, promote adhesion, and inhibit tumors The effect of growth

Active Publication Date: 2017-01-04
南京吾岳道医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most photothermal agents face long-term safety issues such as non-degradable or potential toxicity[4-6]

Method used

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  • Biological ceramic scaffold with surface micro-nano structure and preparation method and application of biological ceramic scaffold with surface micro-nano structure
  • Biological ceramic scaffold with surface micro-nano structure and preparation method and application of biological ceramic scaffold with surface micro-nano structure
  • Biological ceramic scaffold with surface micro-nano structure and preparation method and application of biological ceramic scaffold with surface micro-nano structure

Examples

Experimental program
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Effect test

preparation example Construction

[0045] Preparation of dopamine-Tris-HCl solution. Dissolve the dopamine in the Tris-HCl solution, stir until completely dissolved, and prepare a dopamine-Tris-HCl solution with a concentration of 2-6 mg / mL.

[0046] Soak the Nagel bioceramic stent in the dopamine-Tris-HCl solution, control the pH of the dopamine-Tris-HCl solution to be 8.4-8.6, and soak at 20-60° C. for 1-3 days. Wherein the dopamine concentration in the dopamine-Tris-HCl solution is 2-6mg / mL, and the dopamine concentration is too low, which is not conducive to the formation of surface micro-nano structures. By controlling the concentration of dopamine solution and / or immersion time, the content of polydopamine and the structure of nanometer layer generated on the surface of Nagel bioceramic scaffold can be controlled.

[0047] The present invention characterizes the functionalized scaffold through optical microscope and SEM. The micro-nano structure on the surface is specifically manifested as a nano-layer ...

Embodiment 1

[0060] Mix 3g of pure Nagel powder with 0.165g of sodium alginate and 1.65g of F127, and then use three-dimensional printing technology to prepare the stent blank;

[0061] Calcinate the printed stent blank at 1350°C for 3 hours to obtain pure Nagel ceramics;

[0062] Soak the pure Nagel stent in 2 mg / mL dopamine-Tris-HCl solution for 3 days at 20°C;

[0063] At 0.42W / cm 2 Ultra-low-power near-infrared light was irradiated for 10 minutes, and the tumor cell death rate was measured, and then the biological activity, osteogenesis and in vivo anti-tumor performance were evaluated, which were the same as the performance evaluation in the summary of the invention.

Embodiment 2

[0065] 3g of pure Nagel powder, mixed with 0.15g of sodium alginate and 1.5g of F127, was prepared by three-dimensional printing technology;

[0066] Calcinate the printed stent blank at 1400°C for 3 hours to obtain pure Nagel ceramics;

[0067] Soak the pure Nagel stent in 4 mg / mL dopamine-Tris-HCl solution for 3 days at 40°C;

[0068] At 0.38W / cm 2 Ultra-low-power near-infrared light was irradiated for 10 minutes, and the tumor cell death rate was measured, and then the biological activity, osteogenesis and in vivo anti-tumor performance were evaluated, which were the same as the performance evaluation in the summary of the invention. The dopamine-induced Ca prepared in this example 7 Si 2 P 2 o 16 The thickness of the polydopamine / Ca-P nano layer on the surface of the bioceramic scaffold is 618nm.

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Abstract

The invention relates to a biological ceramic scaffold with a surface micro-nano structure and a preparation method and application of the biological ceramic scaffold with the surface micro-nano structure. The biological ceramic scaffold with the surface micro-nano structure comprises a Ca7Si2P2O16 biological ceramic scaffold body and a micro-nano structured polydopamine/Ca-P nano layer formed on the surface of the Ca7Si2P2O16 biological ceramic scaffold body. By means of forming the micro-nano structured polydopamine/Ca-P nano layer on the surface of the Ca7Si2P2O16 biological ceramic scaffold body, adhesion, proliferation and differentiation of bone mesenchymal stem cells on the surface of the scaffold can be facilitated to promote in-vivo osteogenesis, and therefore the biological ceramic scaffold (or dopamine-induced biological ceramic scaffold) with the surface micro-nano structure prepared herein can repair bones and treat bone tumors.

Description

technical field [0001] The present invention relates to dopamine-induced Ca 7 Si 2 P 2 o 16 A bioceramic support and its application in bone repair and photothermal treatment of bone tumors belong to the field of biomaterials. Background technique [0002] The current clinical treatment of bone cancer is a combination of surgery and chemotherapy. However, surgery results in a large bone defect with residual tumor cells [1]. Radiotherapy and chemotherapy have problems such as drug resistance and severe side effects. Therefore, it is of great practical significance to prepare a biomaterial that can treat bone tumors and repair bone defects. Photothermal therapy has attracted more and more attention because of its low toxic and side effects and the characteristics of targeted therapy[2-3]. However, most photothermal agents face long-term safety issues such as non-degradable or potential toxicity [4-6]. [0003] references [0004] [1] A. Luetke, P.A. Meyers, I. Lewis, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/32A61L27/34A61L27/50A61L27/54A61K41/00A61P35/00
CPCA61K41/0052A61L27/12A61L27/32A61L27/34A61L27/50A61L27/54A61L2300/416A61L2420/04A61L2430/02C08L79/02
Inventor 吴成铁马红石常江
Owner 南京吾岳道医疗科技发展有限公司
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