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Fe@Fe3O4 nanoparticles having photothermal function, and preparation method and application thereof

A nanoparticle and functional technology, which is applied in the field of composite FeFe3O4 nanoparticles, can solve the problem of inability to accurately locate lesions, and achieve the effect of obvious photothermal effect, good dispersion and stability, and uniform particle size

Active Publication Date: 2013-10-09
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important thing is that the above two materials are non-magnetic materials, which cannot accurately locate the lesion through magnetic targeting

Method used

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  • Fe@Fe3O4 nanoparticles having photothermal function, and preparation method and application thereof
  • Fe@Fe3O4 nanoparticles having photothermal function, and preparation method and application thereof
  • Fe@Fe3O4 nanoparticles having photothermal function, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 10 mL of octadecene, add 0.3 mL of oleylamine, and stir. Exhaust the air and pass nitrogen to the device, then raise the temperature of the reactant, the temperature rises to 180°C, and quickly inject 0.35mL Fe(CO) 5 , reacted for 1h, then added 6mg of (CH 3 ) 3 NO, quickly raise the temperature to 250°C, react for 0.5h, and centrifuge after the reaction. You can get FeFe 3 o 4 Core-shell nanospheres. When modifying, dissolve 200 mg of polyethylene glycol monocarboxylic acid, 30 mg of N-hydroxysuccinimide, and 8 mg of dopamine in pyridine, and add 30 mg of 1-ethyl-(3-dimethylaminopropyl) carbon dicarboxylate After the imine hydrochloride was stirred magnetically for 30 minutes at room temperature, it was added to FeFe 3 o 4 For oily nanomaterials, shake overnight on a shaker, centrifuge after the reaction, and disperse the obtained samples in water, using 0.5W / cm 2 808nm laser, test its light-to-heat conversion performance.

Embodiment 2

[0033] Take 20 mL of octadecene, add 0.3 mL of oleylamine, and stir. Ventilate the device with nitrogen, then raise the temperature of the reactant, the temperature rises to 180°C, and quickly inject 0.7mL Fe(CO) 5 , reacted for 1h, then added 6mg of (CH 3 ) 3NO, quickly raise the temperature to 250°C, react for 0.5h, and centrifuge after the reaction. You can get FeFe 3 o 4 Core-shell nanospheres. When modifying, dissolve 200 mg of polyethylene glycol monocarboxylic acid, 30 mg of N-hydroxysuccinimide, and 8 mg of dopamine in pyridine, and add 30 mg of 1-ethyl-(3-dimethylaminopropyl) carbon dicarboxylate After the imine hydrochloride was stirred magnetically for 30 minutes at room temperature, it was added to FeFe 3 o 4 For oily nanomaterials, shake overnight on a shaker, centrifuge after the reaction, and disperse the obtained samples in water, using 0.5W / cm 2 808nm laser, test its light-to-heat conversion performance.

Embodiment 3

[0035] Take 20 mL of octadecene, add 0.3 mL of oleylamine, and stir. Ventilate the device with nitrogen, then raise the temperature of the reactant, the temperature rises to 180°C, and quickly inject 0.7mL Fe(CO) 5 , reacted for 0.5h, then added 6mg of (CH 3 ) 3 NO, quickly raise the temperature to 250°C, react for 0.5h, and centrifuge after the reaction. You can get FeFe 3 o 4 Core-shell nanospheres. When modifying, dissolve 200 mg of polyethylene glycol monocarboxylic acid, 30 mg of N-hydroxysuccinimide, and 8 mg of dopamine in pyridine, and add 30 mg of 1-ethyl-(3-dimethylaminopropyl) carbon dicarboxylate After the imine hydrochloride was stirred magnetically for 30 minutes at room temperature, it was added to FeFe 3 o 4 For oily nanomaterials, shake overnight on a shaker, centrifuge after the reaction, and disperse the obtained samples in water, using 0.5W / cm 2 808nm laser, test its light-to-heat conversion performance.

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Abstract

The invention discloses Fe@Fe3O4 nanoparticles having a photothermal function, and a preparation method and an application thereof, and belongs to the field of medical science materials. The preparation method is significantly characterized by comprising: firstly, utilizing octadecene as a solvent, utilizing Fe(CO)5 as an iron source, utilizing oleyl amine as a surfactant and a stabilizer, and preparing an Fe nanomaterial having good dispersity by high temperature pyrolysis; sequentially, adding (CH3)3NO at the high temperature for oxidization to form one layer of Fe3O4 shell on the surface layer of each Fe nanoparticle, and then improving water solubility by a ligand exchange method to obtain the Fe@Fe3O4 composite material as a photothermal reagent and having high magnetization strength. The composite material has the advantages of uniform particle size, high saturation magnetization strength, and controllable morphology, and has excellent dispersion and excellent stability in aqueous solution. The reaction time is short, the raw materials are easy to get, and operation processes are convenient. On the basis of the raw materials, the Fe@Fe3O4 nanoparticles are developed to connect PEG to the surface of the material, so that the Fe@Fe3O4 nanoparticles can be applied to biological bodies. The invention provides the application of the Fe@Fe3O4 nanoparticles in the field of tumor photothermal therapy.

Description

technical field [0001] The invention discloses a composite material FeFe with photothermal function 3 o 4 Nanoparticles, their preparation method and their application in tumor photothermal therapy. The invention belongs to the fields of magnetic nanometer materials, medical materials, near-infrared photothermal conversion materials and near-infrared hyperthermia. Background technique [0002] Photothermal therapy technology is an important minimally invasive treatment technology. This technology uses photothermal conversion reagents to convert the light energy of laser light into heat energy, so as to achieve the purpose of killing cells at high temperature. Its characteristics include accurate positioning and killing of diseased cells or tissues. Among the many hyperthermia technologies, near-infrared hyperthermia has attracted more attention. At present, the more researched near-infrared photothermal conversion reagents are mainly divided into noble metal nanomaterials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61K47/34B82Y40/00A61P35/00A61K47/12A61K47/18
Inventor 杨仕平孙亚楠周治国沈金超王俊王力
Owner SHANGHAI NORMAL UNIVERSITY
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