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MnO2 wrapped polydopamine nano-particle, preparation method and application

A technology of polydopamine and nanoparticles, which is applied in the field of functional nanomaterials and its preparation, can solve the problems of poor biocompatibility of inorganic materials, restrictions on the application of photothermal preparations, and the enrichment of organic photosensitive molecules with short blood half-lives. Effects of biocompatibility and photothermal performance

Active Publication Date: 2018-02-06
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the photothermal preparations that can be used for tumors are some organic photosensitive molecules or some inorganic materials, but there are certain shortcomings, such as organic photosensitive molecules have a short blood half-life and cannot be selectively enriched in the tumor area, and inorganic materials also have biological Poor compatibility and other shortcomings, which restrict the application of existing photothermal preparations

Method used

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  • MnO2 wrapped polydopamine nano-particle, preparation method and application
  • MnO2 wrapped polydopamine nano-particle, preparation method and application
  • MnO2 wrapped polydopamine nano-particle, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Preparation of polydopamine (PDA) nanoparticles:

[0026] (1) Dissolve 180 mg of dopamine hydrochloride in 90 mL of water, bathe in water at 50°C for 20 minutes, quickly add 760 μL of aqueous sodium hydroxide solution with a concentration of 1 mol / L, and stir at 50°C for 5 hours;

[0027] (2) Centrifuge the above system at 15000rpm for 10min, discard the supernatant, ultrasonically disperse the precipitate in water, centrifuge at 15000rpm for 10min, and repeat 3 times to obtain polydopamine (PDA) nanoparticles.

Embodiment 2

[0029] Manganese dioxide-coated polydopamine (PDA@MnO 2 ) Preparation of nanoparticles:

[0030] (1) Disperse 20mg of PDA nanoparticles in 20mL of water, and adjust the system to be neutral with 0.1mol / L dilute hydrochloric acid;

[0031] (2) Take 20 mg of potassium permanganate, dissolve it in 5 mL of water, and slowly add it dropwise into the system of (1) under ultrasonic conditions;

[0032] (3) Put the system of (2) in a 40°C water bath, and stir it magnetically for 4 hours;

[0033] (4) Centrifuge the above system at 15000rpm for 10min, discard the supernatant, ultrasonically disperse the precipitate in water, centrifuge at 15000rpm for 10min, and repeat 3 times to obtain polydopamine (PDA@MnO2) wrapped in manganese dioxide 2 ) nanoparticles.

Embodiment 3

[0035] TEM characterization of the material:

[0036] refer to figure 1 , 1mg / L of PDA@MnO 2 The sample aqueous solution was dropped on the copper grid, and the sample was completely dried for transmission electron microscope characterization. In the figure, A is a transmission electron microscope photo of PDA nanoparticles, and it can be seen that the particle size is about 100nm; B is PDA@MnO 2 The transmission electron microscope photo shows that 2-5nm MnO is reduced on the surface of the material. 2 The layer is monodisperse; Figures C, D, and E are the element mapping white field, manganese element, and oxygen element photos, showing that the surface of the material contains manganese element and oxygen element.

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Abstract

The invention discloses a MnO2 wrapped polydopamine nano-particle, a preparation method and application. The nano-particle has a shell-core structure which is formed in the manner of acquiring a photo-thermal core by oxidizing the self-polymerized polydopamine nano-particle by dopamine hydrochloride under an alkali condition and in situ reducing the polydopamine nano-particle surface by manganesedioxide. The nano-particle has a photo-thermal effect and an acid-sensitive magnetic resonance imaging function. The nano-particle has the beneficial effects that the tumor tissue and the normal tissue can be more accurately distinguished, a more accurate guidance is supplied for clinic tumor treatment, and meanwhile, the material has a thermo-optical property and the diagnosis and treatment integration of the tumor can be realized.

Description

technical field [0001] The invention belongs to the technical field of functional nanomaterials and their preparation, and specifically relates to the preparation of a novel functional nanomaterial with a shell-core structure that can produce magnetic resonance imaging performance under acidic conditions and can be used for tumor photothermal treatment. The nanomaterial has acid-sensitive magnetic resonance imaging performance and good photothermal conversion effect, and can be used for photothermal treatment of tumors. Background technique [0002] Tumor is currently one of the biggest killers threatening human life and health, and its morbidity and mortality are still rising. Almost 22% of new cases and 27% of cancer deaths in the world occur in China. Facing such a severe situation, accurate and effective cancer diagnosis and treatment methods are particularly important. At present, the commonly used clinical tumor treatment methods are surgical resection, chemotherapy, ...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K41/00A61K9/51A61P35/00
CPCA61K9/5115A61K41/0052A61K49/12A61K49/1878
Inventor 俞磊刘秧贾宗翔南丽娟赵世民王昊闫志强王镜朱建中王依婷
Owner EAST CHINA NORMAL UNIVERSITY
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