36 results about "Dopamine hcl" patented technology

The invention relates to an electrolyte functional additive, a preparation method thereof, an electrolyte containing the electrolyte functional additive and a sodium ion battery. The electrolyte functional additive is prepared from dopamine hydrochloride, imidazolium salt and fluorine-containing anion salt according to a specific mass ratio through the processes of auto-polymerization, heating and stirring, grafting and solvent removal.

The invention relates to the technical field of alloys, in particular to a preparation method of a high-wear-resistance hard alloy for geomines. The method comprises the following steps: taking nickel-based corrosion-resistant alloy powder with specific components as a binding phase instead of cobalt, carrying out wet ball-milling mixing, forming, dewaxing and pre-sintering on the binding phase and hard phase powder such as tungsten carbide, and then carrying out vacuum-back pressure pulse treatment on a pre-sintered body by adopting an infiltration solution containing polyacrylic acid, branched polyethyleneimine and dopamine hydrochloride; and carrying out vacuum final sintering and hot isostatic pressing densification treatment to obtain a final product. Through material system innovation and process optimization, the wear resistance, corrosion resistance and toughness of the hard alloy under the underground severe working condition are remarkably improved, and the problems that a traditional cobalt-based alloy binding phase is prone to corrosion, and the service life of a tool is short are effectively solved.

A process for producing oxide particles coated with amino groups comprises the following steps: introducing a plurality of first LLZO particles and methanol into a wet mixer for mixing to form a first slurry; then introducing a tris(tris(hydroxymethyl)aminomethane) material and a tris(hydroxymethyl)aminomethane hydrochloride into the wet mixer for grinding and stirring to form a second slurry and to cause an outer surface of each of the first LLZO particles to be coated with a hydroxide ion layer; then introducing a dopamine hydrochloride into the wet mixer for mixing to form a third slurry and to cause a dopamine layer to be coated on an outer surface of the hydroxide ion layer on each of the first LLZO particles. A CTAB surfactant (cetyltrimethylammonium bromide) is added to the third slurry.

The invention discloses preparation and antibacterial application of a dopamine-heme copolymer nanosheet, and belongs to the field of biomedical high polymer materials. The preparation method comprises the following steps: preparing a mixed solvent of ultrapure water, absolute ethyl alcohol and stronger ammonia water, dissolving the hydroxyferriheme in the mixed solvent, and stirring to fully dissolve the hydroxyferriheme; the preparation method comprises the following steps: preparing a dopamine hydrochloride aqueous solution, rapidly dropwise adding the dopamine hydrochloride aqueous solution into a mixed solution of hydroxyferriheme, carrying out a stirring reaction under closed conditions, and carrying out centrifugal cleaning on a reaction product to obtain the dopamine-heme copolymer nanosheet. The preparation method of the dopamine-heme copolymer nanosheet is simple and convenient, the reaction solvent is green and environment-friendly, and the whole reaction process does not need additional energy supply. The dopamine-heme copolymer nanosheet prepared by the method has good dispersity in an aqueous solution, is extremely low in cytotoxicity and relatively good in biocompatibility, and has a very good sterilizing effect on staphylococcus aureus when the concentration is relatively low.

A method for manufacturing composite ceramic electrolyte particles with hydrophobic protective layers for a battery electrode includes the steps of: placing a plurality of first LLZO particles, a methanol and a plurality of hydrophobic particles into a wet mixer for mixing; then placing a tris material and a tris(hydroxymethyl)aminomethane hydrochloride into the wet mixer for stirring to cause each of the first LLZO particles and the hydrophobic particles is coated with a hydroxide ion layer; and then placing a dopamine hydrochloride into the wet mixer for mixing to cause dopamine molecules of the dopamine hydrochloride are co-polymerized to form a dopamine layer coated on the hydroxide ion layer on the corresponding first LLZO particle or hydrophobic particle, and the first LLZO particles having the dopamine layer are coated with corresponding hydrophobic particles having the dopamine layer to form composite LLZO particles.

The preparation method comprises the following steps: 1) dissolving polyoxyethylene polyoxypropylene in ethanol to prepare a template agent solution, adding a dopamine hydrochloride solution with the concentration of 0.5-20 mg / mL, mixing the two solutions, adding a pore-enlarging agent, carrying out ultrasonic treatment to form a uniform emulsion system, rapidly adding ammonia water drop by drop, carrying out ultrasonic treatment at the temperature of 60-80 DEG C, carrying out ultrasonic treatment at the temperature of 60-80 DEG C, and carrying out suction filtration; and continuously stirring at room temperature, reacting for 2-24 hours, centrifuging and washing to obtain the mPDA pesticide carrier. (2) dispersing the mPDA pesticide carrier obtained in the step (1) in ethanol and water, and carrying out ultrasonic treatment, so that the mPDA pesticide carrier is fully dispersed in the water to form a uniform and stable dispersion liquid; 3) adding a biopesticide into ethanol and pure water to completely dissolve the biopesticide to obtain a biopesticide solution, slowly dropwise adding the biopesticide solution into the dispersion liquid obtained in the step 2), and continuously stirring and reacting for 12-48 hours at room temperature; and 4) after the reaction is finished, collecting the precipitate, washing the precipitate with absolute ethyl alcohol, and drying the precipitate to obtain the mPDA pesticide preparation.

The invention relates to the technical field of degradable high polymer materials and disposable personal care products, and discloses a preparation process of a degradable high-barrier plastic film for a hair dyeing shawl, and the preparation process comprises the following steps: 1, preparing chitosan-dopamine grafted modified montmorillonite (CTS-DA-MMT): dispersing 5g of 20-30nm nano montmorillonite in a 2wt% acetic acid solution, and ultrasonically dispersing for 40 minutes by 200W; adding dopamine hydrochloride according to the ratio of montmorillonite to dopamine being 1: 0.2, adjusting the pH value to 8.5 by using 1mol / L NaOH, and carrying out stirring reaction at room temperature for 1 hour; adding chitosan according to the ratio of montmorillonite to chitosan being 1: 0.4, and stirring and reacting at the constant temperature of 50 DEG C for 3 hours; the pH is adjusted to 7.0 through 1 mol / L HCl, centrifugation is carried out for 15 min at the speed of 8000 r / min, washing is carried out three times through deionized water, vacuum drying is carried out for 8 h at the temperature of 60 DEG C, and the product is obtained. According to the preparation technology of the high-barrier plastic film for the degradable hair dyeing shawl, chemical grafting (instead of physical blending) of montmorillonite-dopamine-chitosan is achieved through catechol groups of dopamine, the problems of montmorillonite agglomeration and matrix compatibility are solved, and the degradable hair dyeing shawl is prepared. Meanwhile, through the dynamic adhesiveness of dopamine, the problem of barrier failure under dynamic stretching is solved.

The invention relates to the technical field of hydrophobic materials, and discloses a method for preparing a hydrophobic material and the hydrophobic material. The method comprises the following steps: forming a polydopamine coating layer on a matrix by using dopamine and / or dopamine hydrochloride, and then modifying by using an isocyanate compound and chain organic silicon respectively. According to the method disclosed by the invention, polydopamine is firstly adopted as a middle layer, then an isocyanate compound is adopted for functional modification, chain-shaped organic silicon is adopted for grafting, the hydrophobic material is prepared through a chemical modification method by utilizing the hydrophobicity of an organic silicon chain segment and the high reaction activity of isocyanato, and the hydrophobic material can be applied to waterproof, self-cleaning and other application scenes.

The application discloses a method for improving blood compatibility of PMP hollow fiber membranes for ECMO by using zwitterionic-nano silver antifouling and antibacterial coating, and the steps of the preparation method are as follows: (1) dissolving zwitterionic polymers and dopamine hydrochloride with different concentrations in PBS; (2) after cleaning the PMP membrane, the PMP membrane is soaked in the modified liquid obtained in step (1), so that the zwitterionic polymers are adhered to the membrane; (3) the above PMP hollow fiber membrane is sequentially immersed in AgNO3 solution, deionized water and NaBH4 solution, so that Ag + is fixed on the membrane surface, and silver nanoparticles are formed in situ on the membrane surface. Experiments prove that the method for improving blood compatibility of PMP hollow fiber membranes for ECMO by using zwitterionic-nano silver coating is simple and has strong universality, and the prepared PMP hollow fiber membrane has high hydrophilicity, excellent anti-platelet adsorption, anti-platelet adsorption and anti-protein adhesion performance, is beneficial to inhibiting thrombosis, and has good blood compatibility and biocompatibility.

This invention relates to a desensitizing drug for tooth enamel repair and its preparation method, belonging to the field of biomedical technology. The drug comprises a specific ratio of paeonol-dopamine modified chitosan quaternary ammonium salt, enzyme-responsive precursor mineral, polyethylene glycol didopamine modified hydroxyapatite, strontium nitrate, hyaluronic acid-maleimide, L-cysteine, and carbomer. The paeonol-dopamine modified chitosan quaternary ammonium salt is obtained by modifying chitosan quaternary ammonium salt with paeonol and dopamine hydrochloride under tyrosinase catalysis. The enzyme-responsive precursor mineral is obtained by coating nano-calcium pyrophosphate with ε-polylysine. The polyethylene glycol didopamine modified hydroxyapatite is obtained by surface adhesion modification of hydroxyapatite with polyethylene glycol didopamine. This invention yields a restorative desensitizing gel with strong adhesion and enzyme responsiveness. This gel can form a long-lasting protective layer on the tooth surface, simultaneously achieving the triple effects of physical sealing, nerve inhibition, and active mineralization.

The invention relates to a composite diaphragm for alkaline water electrolysis hydrogen production and a preparation method and application thereof, and the method comprises the following steps: (1) dopamine hydrochloride and first polyamine are subjected to a co-deposition reaction on the surface of the diaphragm to obtain the diaphragm with an adhesion layer; (2) carrying out polymerization reaction on second polyamine and a chlorine-containing reagent on the surface of the diaphragm with the adhesion layer; performing heat treatment on the diaphragm subjected to the polymerization reaction to obtain a composite diaphragm with an adhesion layer and a crosslinking layer; wherein the first polyamine and the second polyamine are the same or different; the chlorine-containing reagent comprises one or more of a chlorine cyanide compound and multi-element acyl chloride. The composite diaphragm disclosed by the invention has excellent hydrophilicity, good alkali resistance and stability and small surface resistance, and can improve the current density of hydrogen production by alkaline electrolysis of water and reduce the energy consumption of hydrogen production.

The application discloses application of N-beta-alanyldopamine or a salt thereof in preparation of a medicine for preventing and treating liver fibrosis, and belongs to the technical field of medicines. The application provides application of N-beta-alanyldopamine hydrochloride in preparation of a medicine for preventing and treating liver fibrosis. Experiments prove that, after N-beta-alanyldopamine hydrochloride is given, the content level of hydroxylysylpyridinoline (Pyr) is reduced, the hardness of a liver is reduced and the solubility of collagen is increased, thereby reducing collagen deposition in a liver tissue and relieving the symptom of liver fibrosis of a mouse induced by carbon tetrachloride (CCl4).

The application discloses a multifunctional wearable fabric heater and a preparation method thereof, and relates to the technical field of fabric heating, and has the technical scheme as follows: S1: pretreating the fabric; S2: adding trimethylol aminomethane into water to obtain a Tris solution, adjusting the pH value, then adding dopamine hydrochloride, placing the pretreated fabric in the Tris solution of dopamine hydrochloride to react so that a layer of polydopamine is grown on the surface of the fabric, and finally drying to obtain a polydopamine coated fabric; and S3: placing the polydopamine coated fabric obtained in S2 into a mixed solution containing a copper source and a sulfur source to perform water bath reaction, and drying after the reaction, thereby obtaining a multifunctional fabric heater loaded with copper sulfide. The fabric prepared by the preparation method has multiple heating modes, electromagnetic shielding, ultraviolet protection, antibacterial and flame-retardant functions.

The application belongs to the technical field of medicine, and discloses a nano-carrier capable of penetrating through the blood-brain barrier and improving brain delivery efficiency, and a preparation and application thereof. The preparation method comprises the following steps: 1) dopamine hydrochloride is deposited on the surface of nanoparticles through an oxidative self-polymerization reaction to obtain polydopamine modified particles; and 2) glucose functionalized polyethylene glycol and end-capped polyethylene glycol are reacted with the polydopamine modified particles to obtain the nano-carrier. The polydopamine coating is used to modify the nanoparticles, and the glucose functionalized polyethylene glycol is used to secondarily modify the polydopamine coating, so that the ability of the nanoparticles to penetrate through the BBB and enter brain tissues and brain gliomas is enhanced. The targeting effect of the glucose functionalized PEG and the synergistic effect of the PDA coating in enhancing cell uptake are combined in the application, so that the brain and brain tumor delivery capacity of the nano-carrier is enhanced. The nano-carrier is used for loading drugs.

The invention discloses a conductive adhesive based on polydopamine graft modified ionic liquid and a preparation method thereof, and relates to the technical field of adhesives, the conductive adhesive comprises dopamine hydrochloride, a mixture of acrylic acid and acrylate monomer, ionic liquid, an initiator, a cross-linking agent, an organic solvent and a curing agent. The obtained conductive adhesive is good in stability, high in conductivity and good in environmental adaptability.

The invention discloses a microporous carbon-coated core-shell nano composite material, a preparation method and application, and relates to the technical field of lithium batteries, and the preparation method comprises the following steps: uniformly dispersing silicon powder and graphite in a solvent to form a core material suspension; dopamine hydrochloride and hydrogen peroxide are added into the nuclear material suspension, polymerization reaction is carried out at the temperature of 60-85 DEG C, composite slurry is obtained, and the ratio of the total mass of the silicon powder and the graphite to the mass of the dopamine hydrochloride is 1: (0.1-0.5); carrying out spray drying treatment on the composite slurry to obtain precursor powder; sintering the precursor powder at high temperature to obtain a microporous carbon coated core-shell nano composite material; the microporous carbon-coated silicon / graphite core-shell nano composite material is prepared by adopting a polydopamine in-situ polymerization technology initiated by hydrogen peroxide and combining a subsequent spray drying and carbonization process, and the material has good rate capability, cycling stability, charge-discharge efficiency and low interface impedance.

This invention discloses a method for preparing a gradient elastic core-shell dual rare earth co-doped cerium oxide abrasive and its application, belonging to the field of mechanical polishing technology. The method includes the following steps: S1, reacting pyromellitic dianhydride with 4,4'-diaminodiphenyl ether and N,N-dimethylformamide to obtain PI microspheres; S2, adding buffer solution, dopamine hydrochloride, and KH560 to react the PI microspheres to obtain modified microspheres; S3, dispersing the modified microspheres and adding a shell material to react, adding a mixed solution, and grinding to obtain the core-shell abrasive; S4, dispersing the core-shell abrasive in anhydrous ethanol, adding polyethylene glycol monomethyl ether to react, and obtaining the abrasive. The abrasive prepared by this invention utilizes dual rare earth co-doping to construct highly efficient chemically active centers, achieving a material removal rate (MRR) of 200~230 nm / min, which is more than 67% higher than pure CeO2 abrasive and significantly higher than single Y... 3+ The CeO2 doping of abrasives increases polishing efficiency by more than 45%, resulting in a significant improvement in polishing efficiency.

The invention belongs to the technical field of implants, and discloses a dental implant for a hyperglycemia environment as well as a preparation method and application of the dental implant. The preparation method of the dental implant comprises the following steps: carrying out laser etching treatment on the surface of the metal matrix to form a plurality of micropores; placing the metal matrix subjected to laser etching treatment in an alkaline solution, carrying out heating treatment, then placing the metal matrix in a Tris buffer solution containing dopamine hydrochloride, and carrying out a reaction in a dark place to form a polydopamine adhesion layer; preparing a mixed solution containing glucose oxidase and sodium alginate, and forming a hydrogel coating on the polydopamine adhesion layer by the mixed solution through a dip-coating method; and spraying a magnesium salt solution on the hydrogel coating, purging by using a nitrogen gas knife, and carrying out vacuum drying to obtain the dental implant. The dental implant prepared by the preparation method disclosed by the invention is strong in interface bonding force, good in antibacterial property, capable of effectively regulating and controlling blood sugar and particularly suitable for patients with hyperglycemia or diabetes mellitus, and the coating is not easy to peel off.

The invention relates to an antibacterial and antiviral multifunctional filter screen and a preparation method thereof, and the preparation method comprises the following steps: S1, dissolving dopamine hydrochloride in a first solvent to obtain a first mixed solution; s2, adding an antibacterial and antiviral agent into the first mixed solution to obtain a second mixed solution; and S3, immersing the polypropylene filter screen in the second mixed solution for surface deposition treatment, and drying to obtain the antibacterial and antiviral multifunctional filter screen, compared with the prior art, dopamine is adopted as a bonding layer and a wrapping layer, dopamine molecules and an antibacterial and antiviral agent are treated to the surface of a PP net through a surface deposition method, a functional agent is wrapped while dopamine forms a polymerization reaction, and a core-shell structure is formed; the adhesive has the effects of adhering, fixing and slowly releasing the functional medicament, so that the problem that the antibacterial and antiviral agent is easy to lose in the prior art is solved.

The application belongs to the technical field of biological medicine and nanomaterials, and particularly relates to a nano system for targeted photothermal-chemotherapy synergistic treatment of abdominal aortic aneurysm as well as a preparation method and application thereof. The system is a mesoporous polydopamine-coated gold nanorod cluster (AuM) nanoparticle co-loaded with one or more traditional Chinese medicine ingredients and modified by c(RGDfK) cyclic peptide. The preparation comprises the following steps: taking chloroauric acid and dopamine hydrochloride as raw materials, synthesizing AuM in the presence of a reaming agent and a template agent by a one-step method; further loading a large amount of drugs in the mesopores to obtain drug-loaded nanoparticles; and finally grafting a targeting peptide on the surface of the nanoparticles to obtain the final product. The system has the characteristics of targeting macrophages and smooth muscle cells, NIR-Ⅱ photothermal conversion and photothermal response drug release. The in-vitro and in-vivo experimental results show that the system can realize local photothermal treatment and precise drug release under NIR-Ⅱ light, and inhibit aortic dilation through various cell behaviors, thereby providing a nano preparation with clinical transformation potential for precise treatment of abdominal aortic aneurysm.

This invention provides a method for manufacturing composite ceramic electrolyte particles for battery electrodes that are coated with a hydrophobic protective layer. [Solution] The method includes: step A, which involves putting a plurality of first LLZO particles, methanol, and a plurality of hydrophobic particles into a wet mixer and mixing and polishing them; step B, which involves adding tris(hydroxymethyl)aminomethane and tris(hydroxymethyl)aminomethane hydrochloride to the wet mixer and continuously stirring to form a hydroxide ion layer on the outer surface of the first LLZO particles and the hydrophobic particles; and step C, which involves adding dopamine hydrochloride to the wet mixer and continuously polishing and stirring to cause a dehydration polymerization reaction between the dopamine molecules of the dopamine hydrochloride and the hydroxide ion layer, and causing aggregation between the dopamine molecules, thereby forming a dopamine layer that coats the outside of the hydroxide ion layer of the corresponding first LLZO particles or hydrophobic particles. The hydrophobic particles having the dopamine layer coat the first LLZO particles having the dopamine layer, forming composite LLZO particles.

The present application relates to a kind of dual dynamic key crosslinking near-infrared light response liquid crystal elastomer and its preparation method, belong to liquid crystal elastomer technical field.The liquid crystal elastomer is by liquid crystal monomer, dopamine hydrochloride monomer, chain extender and crosslinking agent under the action of triethylamine by Michael addition polymerization, obtain the main chain type liquid crystal polymer containing catechol and thiolactone side group, liquid crystal polymer is by Fe 3+ The liquid crystal elastomer with dynamic crosslinking network formed by catechol coordination interaction.The present application realizes the pre-crosslinking of liquid crystal elastomer by Fe 3+ Catechol coordination interaction realizes the pre-crosslinking of liquid crystal elastomer while introducing photo-thermal effect, and the photo-thermal effect is excellent, and can enhance the mechanical properties of liquid crystal elastomer;Thiolactone side group is fixed by ring-opening crosslinking reaction with di-functional primary amine and the single-domain structure of liquid crystal elastomer, and the programming preparation method is simple and efficient.

The application discloses a preparation method and application of artificial melanin carbon aerogel with electromagnetic shielding property, and comprises the following steps: (1) preparing a mixed solution of dopamine hydrochloride and 5-hydroxyindole by using a mixture of ethanol and water as a mixed solvent; (2) adding an alkaline solution into the mixed solution, and keeping stirring at room temperature to obtain a yellow-green turbid solution; (3) centrifuging and washing the yellow-green turbid solution to obtain yellow artificial melanin nanofibers; (4) dispersing the artificial melanin nanofibers in deionized water, performing ultrasonic dispersion, and performing vacuum freeze-drying to obtain artificial melanin nanofiber aerogel; and (5) performing heat treatment on the artificial melanin nanofiber aerogel to obtain artificial melanin carbon aerogel. The preparation method is simple, green and environment-friendly, the prepared artificial melanin carbon aerogel has excellent electric conductivity and electromagnetic shielding performance, and has wide application in the field of electromagnetic shielding.

The invention provides a preparation method of a composite coating modified silicon-carbon material, which comprises the following steps: (1) carrying out surface activation treatment on the silicon-carbon material by using hydrogen peroxide to increase the hydroxyl density of the surface; (2) dissolving dopamine hydrochloride and acrylic acid in deionized water according to a molar ratio of 1: (1-10), and adjusting to be alkaline; (3) adding an initiator into the solution in the step (2), and carrying out free radical polymerization reaction to form a polydopamine-polyacrylic acid composite coating; and (4) purifying the coated material to obtain the composite coating modified silicon carbon material. According to the invention, a polymer layer is directly formed on the vapor-deposited silicon-carbon surface to coat the surface of the silicon-carbon material, so that the first effect and cycle performance of the material in the battery application process are improved.

The invention discloses a preparation method and application of a composite film with the surface modified with photosensitive carbon quantum dots, and belongs to the technical field of environmental treatment. According to the preparation method of the composite membrane, polydopamine serves as an adhesion medium, photosensitive carbon quantum dots are modified to the surface of the membrane, and the preparation method specifically comprises the following steps that dopamine hydrochloride is dissolved in a Tris buffer solution to prepare a solution A, an ultrafiltration membrane is soaked in the solution A, the ultrafiltration membrane is fully coated with the dopamine hydrochloride to form a polydopamine coating, and the polydopamine coating is dried to obtain the composite membrane. A polydopamine coating film is obtained; dispersing photosensitive carbon quantum dots in a Tris buffer solution to prepare a solution B, and immersing the polydopamine coating film into the solution B to modify the surface of the film with the photosensitive carbon quantum dots to obtain the composite film with the surface modified with the photosensitive carbon quantum dots. The composite membrane provided by the invention can be used in different fields including water treatment, biological medicine or chemical production and the like, particularly pollutant degradation in the water treatment process, photocatalytic preparation and separation of biological medicine products and the like.

The present disclosure relates to a pharmaceutical injectable solution comprising dopamine or a pharmaceutically acceptable salt thereof, preferably dopamine hydrochloride, dissolved in water for injection, wherein the solution has a pH between 3.0 and 5.5, and has an oxygen content equal to or lower than 0.008% (8 ppm), and uses thereof.

The application relates to the technical field of water treatment and separation membrane material modification, and discloses a modification process for coating the surface of a water purification membrane. A polyamide-based membrane is immersed in a buffer modification solution, the buffer modification solution contains 30-70 mmol / L of tris-hydroxymethyl aminomethane and 1.0-2.0 g / L of dopamine hydrochloride, and the pH value of the system is adjusted to carry out a mild immersion reaction under constant temperature conditions; and a complete polydopamine base anchoring layer is constructed on the membrane surface by using the oxidative self-polymerization of dopamine. The composite modified water purification membrane has excellent structural durability and long-acting antifouling efficiency, and highly meets the development requirements of complex water quality separation engineering and high-end water treatment materials.

This invention provides a method for producing oxide ceramic particles coated with aminated functional groups. [Solution] The method includes: step A, which involves adding a plurality of first LLZO particles and methanol to a wet mixer and mixing and polishing them; step B, which involves adding tris(hydroxymethyl)aminomethane and tris(hydroxymethyl)aminomethane hydrochloride to the wet mixer and polishing and stirring to form a hydroxide ion layer on the outer surface of the first LLZO particles; and step C, which involves adding dopamine hydrochloride to the wet mixer and continuously polishing and stirring to bind the dopamine molecules of the dopamine hydrochloride to the hydroxide ion layer of the first LLZO particles, thereby forming a dopamine layer on the outside of the hydroxide ion layer of the first LLZO particles and forming composite LLZO particles. A CTAB surfactant is further added to the wet mixer. In step C, after polishing and mixing, an alcohol-based solution containing carbon nanotubes is further added to form LLZO particles coated with carbon material.

This invention belongs to the field of coating technology, specifically disclosing a high-adhesion acrylic coating and its preparation method. The invention involves microwave irradiation of nano-silica in the presence of dopamine hydrochloride to obtain modified nano-silica, which is then mixed with an acrylic resin emulsion. A continuous flow process is then used to add isocyanate curing agent, titanium dioxide pigment, hydroxyl-terminated hyperbranched polyester, polycarboxylate ammonium salt dispersant, polysiloxane defoamer, and lithium magnesium silicate. After segmental curing, a coating with good adhesion, corrosion resistance, impedance, and low surface roughness is obtained, showing broad application prospects.

The application belongs to the technical field of nanomaterial synthesis and neurology, and particularly relates to a baicalein carbon dot as well as a preparation method and application thereof. The baicalein carbon dot is directly synthesized by hydrothermal reaction with baicalein as a main carbon source and a nitrogen-containing organic ligand (biotin, glutathione or dopamine hydrochloride). The baicalein carbon dot can efficiently penetrate the blood-brain barrier, scavenge reactive oxygen species and inhibit the aggregation of A beta protein. The baicalein carbon dot can be coupled with a transferrin-targeting derivative constructed by an EDC-NHS method. The baicalein carbon dot and the derivative prepared by the application have a wide application prospect in the preparation of drugs for preventing and / or treating Alzheimer's disease.