Preparation method of disinfectant capable of killing brucella

A technology of Brucella and disinfectant, which is applied in the field of disinfectant preparation, can solve the problems of few types of fungicides and poor killing effect, and achieve the effect of remarkable therapeutic effect, strong bactericidal power and high killing ability

Inactive Publication Date: 2020-03-27
JILIN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few types of special fungicides for Brucella, and the killing effect is not good. At present, there is no special killing drug

Method used

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  • Preparation method of disinfectant capable of killing brucella
  • Preparation method of disinfectant capable of killing brucella
  • Preparation method of disinfectant capable of killing brucella

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preparation example Construction

[0017] A preparation method of a disinfectant capable of killing Brucella, firstly adding a certain amount of solvent into an enamel kettle, heating the solvent at 20-40°, adding polyguanidine compound and bis(3-aminopropyl)alkane in proportion After the addition of base amine compounds, continue to stir for 5-30 minutes, use 15-30% hydrochloric acid to adjust the pH value to 4.5-7, and then stir for 5-15 minutes to obtain the disinfectant.

[0018] The polyguanidine compound is a guanidine polymer containing 4-6 methylene groups, the degree of polymerization n≥10, and its structural formula is

[0019] where (4≤m≤6; n≥10).

[0020] The structural formula of the two (3-aminopropyl) alkylamines is the following formula, wherein R is an alkyl group with 8-12 carbon atoms

[0021]

[0022] The content of the polyguanidine compound is 5-35 parts by weight, and the content of the bis(3-aminopropyl)alkylamine compound is 1-15 parts by weight.

[0023] The optimal weight ratio...

Embodiment 1

[0027] First, 35000 kg of medical deionized water is added to the enamel kettle, the solvent is heated to 40 °, 200 kg of polyguanidine compounds and 150 kg of bis (3-aminopropyl) alkylamine compounds are added in proportion, and the stirring is continued for 30 minutes after the feeding is completed. Use 30% medical hydrochloric acid to adjust the pH value to 4.5-7, preferably 5. Stir again for 15 minutes to obtain the disinfectant.

Embodiment 2

[0029] First, 40000kg of medical deionized water is added to the enamel kettle, the solvent is heated to 20 °, and 210kg of polyguanidine compounds and 140kg of bis(3-aminopropyl) alkylamine compounds are added in proportion, and the stirring is continued for 5 minutes after the feeding is completed. Adjust the pH value to 4.5 with 15% medical hydrochloric acid. Stir again for 10 minutes to obtain the disinfectant.

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Abstract

The invention relates to a preparation method of a disinfectant capable of killing brucella. The preparation method comprises the following steps of: adding a certain amount of a solvent into an enamel kettle, heating the solvent to a temperature of 20-40 DEG C, adding a poly guanidine compound and a bis(3-aminopropyl)alkylamine compound in proportion, continuing to stir for 5-30 minutes after feeding is completed, regulating the pH value to 4.5-7 with 15-30% of hydrochloric acid, and performing stirring for 5-15 minutes, thereby obtaining the disinfectant. According to the invention, polymethylene guanidine hydrochloride and bis(3-aminopropyl)alkylamine are used as main components, water is used as a solvent, and the prepared disinfectant can be applied to disinfection of various livestock farms. Especially, the disinfectant has high disinfection and killing capacity for brucella, has a good killing effect on hepatitis B virus, spores, fungi and germs, and also has a very remarkable treatment effect on foot-and-mouth disease, onychomycosis, crura cruralis and the like.

Description

technical field [0001] The invention relates to a veterinary or medical disinfectant, in particular to a preparation method of a disinfectant capable of killing Brucella. Background technique [0002] Modern chemical disinfectants have developed rapidly and are widely used since their inception. At present, there are roughly the following categories, namely acids, alcohols, halogens and gaseous volatile alkanes. The above-mentioned disinfectants have some common disadvantages, namely poor stability, high corrosiveness, and strong irritation to the human body, and some of them have certain toxicity and are harmful to humans and animals. Although the quaternary ammonium salt disinfectant that has appeared in recent years has a wide range of uses, it has poor quick-killing power, poor anti-interference ability of organic compounds, and high cost. Brucellosis, also known as undulate fever, is a zoonotic infectious disease caused by Brucella. In the past, the special disinfecta...

Claims

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Application Information

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IPC IPC(8): A01N47/44A01N33/04A01P1/00A01P3/00A61K31/155A61K31/131A61P31/14A61P31/10
CPCA01N33/04A01N47/44A61K31/131A61K31/155A61P31/10A61P31/14A61K2300/00
Inventor 李传碧韩爽刘春玲张首才
Owner JILIN NORMAL UNIV
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