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59results about How to "Strong killing effect" patented technology

Combined tumor targeted treatment system based on photodynamic therapy and chemotherapy

InactiveCN106924731ASolve the problem of highly efficient entrapped chemotherapy drugsSolving the photosensitizer conundrumOrganic active ingredientsEnergy modified materialsTumor targetPLA-PEG-PLA
The invention belongs to the field of medicinal preparations, and relates to a targeted nanometer delivery release system aiming at a multidrug resistant tumor and a preparation method of the targeted nanometer delivery release system. According to the system and the preparation method, the photosensitizer, namely, pyrophaeophorbide-a (PPA) is bonded to two ends of the copolymer, namely, hydroxylated-polylactic acid-polyglycolic acid (HO-PLA-PEG-PLA-OH) through a chemical bonding method, thus the product, namely, the photosensitizer-embedded polylactic acid-polyglycolic acid polymer (PPA-PLA-PEG-PLA-PPA) is obtained, then the chemotherapy medicine, namely, paclitaxel is encapsulated physically by adopting an emulsified solvent evaporation method, thus the binary-drug-loading nanometer delivery release system (PPA NP-PTX) is prepared, then F3 peptide with the specific targeting function and the cell penetrating function is modified on the surface of the system, and thus the photodynamic therapy and chemotherapy combined drug delivery nanometer delivery release system with the binary targeting property is prepared. The experiment proves that the delivery system has the strong lethal effect for drug resistant tumor cells, has the obvious in-vivo tumor targeting effect, and has the obvious treatment effect for the mice bearing the multidrug resistant tumor, and thus the combined drug delivery nanometer system has the clinical application prospect.
Owner:FUDAN UNIV

Preparation method and application of photosensitive magnetic nanoparticle system capable of inhibiting growth of breast cancer cells

The invention discloses a preparation method and application of a photosensitive magnetic nanoparticle system capable of inhibiting growth of breast cancer cells. The preparation method includes: performing amination treatment on magnetic nanoparticles Fe3O4-OA wrapped by oleic acid, and activating carboxyl on a photosensitizer; grafting the photosensitizer onto the surface of Fe3O4-OA through condensation reaction of amino and carboxyl to obtain the photosensitive magnetic nanoparticle system. The photosensitive magnetic nanoparticle system has effect of photodynamically treating breast cancer in the condition of illumination, realizes a combination of breast cancer targeting and folic acid cell targeting of a magnetic field, can effectively inhibit growth of the breast cancer cells in a targeted manner, has the characteristics of high slow release performance, stability, dispersity and uniformity and has the advantage of low toxic and side effect. The system is a novel administration path combining magnetic targeting with nano technology, is of great significance in fully utilizing drug to realize high-efficiency low-toxicity treatment effect and has good application prospect.
Owner:SOUTH CHINA NORMAL UNIVERSITY

Porcine compound astragalus polysaccharide injection and preparation method thereof

The invention discloses a porcine compound astragalus polysaccharide injection and a preparation method thereof. The invention aims to provide a compound astragalus polysaccharide injection which treats the diarrhea caused by compound infection of porcine bacteria and viruses, has quick response, treats both principal and secondary aspects of diseases, reduces the applied times of the medicament and has convenient medicament use, and a preparation method with simple process and easy realization. Each 100L of injection comprises 0.5 to 5kg of astragalus polysaccharide, 1 to 7kg of maquindox, 3 to 21kg of sodium salicylate, 2 to 10kg of colistin sulfate, 0.18kg of atropine sulfate, 30kg of propanediol, 5kg of 95 percent ethanol, and the balance of water for injection. The injection synchronously takes effect from many aspects through the reasonable proportioning of the consumption of various components of several medicaments, has quick response on the treatment of the diarrhea caused by the compound infection of the porcine bacteria and viruses, treats both principal and secondary aspects of diseases, reduces the drug resistance of bacteria, improves the resistance of organisms, and ensures that the recovery of pigs is accelerated. At the same time, a compound preparation of the invention is the injection and has convenient use.
Owner:TIANJIN SHENGJI GRP CO LTD

Application of demethylzeylasteral to preparation of medicine for treating pancreatic cancer

The invention relates to application of demethylzeylasteral to preparation of a medicine for treating pancreatic cancer. The application proves that the compound demethylzeylasteral has a significant killing effect on human pancreatic cancer cells, can induce tumor cell cycle arrest in a G0/G1 phase and achieves a pancreatic cancer resisting effect through induction of autophagic death and Caspase-3-dependent apoptosis of the cells; in combination with gemcitabine, the demethylzeylasteral can significantly reduce the IC50 of the gemcitabine, and through combined drug administration, a better inhibitory effect on the human pancreatic cancer cells is achieved; at low concentration, the demethylzeylasteral can induce the autophagic death of the cells so as to improve the antitumor effect of the gemcitabine, while at high concentration, the demethylzeylasteral improves the chemotherapeutic effect of the gemcitabine mainly through promotion of the apoptosis. On the basis of the application, the demethylzeylasteral can be applied to preparation of the medicine for treating the pancreatic cancer, and the prepared medicine is combined with the gemcitabine for use, or the demethylzeylasteral can be used for researching a cell autophagy or apoptosis mechanism.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV +1

2,3-epoxy-2-propyl sulfone-5,8-dimethoxy-1,4-naphthoquinone as well as preparation method thereof, and medicine containing same

The invention discloses 2,3-epoxy-2-propyl sulfone-5,8-dimethoxy-1,4-naphthoquinone as well as a preparation method thereof, and a medicine containing 2,3-epoxy-2-propyl sulfone-5,8-dimethoxy-1,4-naphthoquinone, and belongs to the technical field of medicines. The structural formula is as shown in the description. The method comprises the following steps: I, dissolving 5,8-dimethoxy-1,4-naphthoquinone in methyl alcohol, adding 1-propyl sulfhydrate for reaction at room temperature, then adding sodium bichromate and concentrated sulfuric acid for continuous reaction, carrying out extraction withdichloromethane and a saturated saline solution, drying the product with anhydrous sodium sulfate, filtering the product, and concentrating the product till the product is dry; II, dissolving the product in chloroform, continuously adding 3-chloroperoxybenzoic acid for reaction at room temperature, adding a NaHCO3 solution at the concentration of 5 percent after the reaction is completed to neutralize surplus metachloroperbenzoic acid in the reaction, then ending the reaction, carrying out extraction with the dichloromethane and the saturated saline solution, drying the product with the anhydrous sodium sulfate, filtering the product, and concentrating the product till the product is dry. The compound and a medicine composition can be applied to preparation of a medicine for treating a liver cancer.
Owner:HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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