115results about How to "Mitigation of lethality" patented technology

Ammunition which includes a bullet having an effective caliber that is larger than its nominal caliber, comprised of a bullet body with a longitudinal cavity in the forward end, and one or more bores extending from the cavity to bore openings on the exterior of the bullet. In use, target media is gathered in the cavity and ejected under force through the bore openings, increasing the damage done by the bullet. Preferably, the bullet cavity and bores are filled with a polymeric or elastomeric material.

A system and method for harvesting the kinetic energy of a fluid flow for power generation with a vertically oriented, aerodynamic wing structure comprising one or more airfoil elements pivotably attached to a mast. When activated by the moving fluid stream, the wing structure oscillates back and forth, generating lift first in one direction then in the opposite direction. This oscillating movement is converted to unidirectional rotational movement in order to provide motive power to an electricity generator. Unlike other oscillating devices, this device is designed to harvest the maximum aerodynamic lift forces available for a given oscillation cycle. Because the system is not subjected to the same intense forces and stresses as turbine systems, it can be constructed less expensively, reducing the cost of electricity generation. The system can be grouped in more compact clusters, be less evident in the landscape, and present reduced risk to avian species.

The invention relates to an oriented monitoring, preventing and controlling system for pests. The oriented monitoring, preventing and controlling system is characterized in that a pest sticking card, a camera, a computer feedback system device, a control switch and a deinsectization lamp are included, the camera is arranged above or beside the pest sticking card and connected with the input end of the computer feedback system device through an information transmission network, the output end of the computer feedback system device is connected with the control switch and the deinsectization lamp in sequence through control lines, and a photosensor is arranged on the control line between the control switch and the deinsectization lamp. The pest sticking card can attract one or more kinds of different female pests, the number of the different female pests is measured and calculated through the cooperation of the camera and the computer feedback system device, and the monitoring aim is achieved. When the number of the female pests of a certain kind reaches a set number, the computer feedback system device can automatically turn on the control switch, the deinsectization lamp with the corresponding wave length works, and the pests are trapped and killed. Through the added photosensor, the deinsectization lamp only works at night.

A system and method for harvesting the kinetic energy of a fluid flow for power generation with a vertically oriented, aerodynamic wing structure comprising one or more airfoil elements pivotably attached to a mast. When activated by the moving fluid stream, the wing structure oscillates back and forth, generating lift first in one direction then in the opposite direction. This oscillating movement is converted to unidirectional rotational movement in order to provide motive power to an electricity generator. Unlike other oscillating devices, this device is designed to harvest the maximum aerodynamic lift forces available for a given oscillation cycle. Because the system is not subjected to the same intense forces and stresses as turbine systems, it can be constructed less expensively, reducing the cost of electricity generation. The system can be grouped in more compact clusters, be less evident in the landscape, and present reduced risk to avian species.

Drug compositions for treatment of one or more inflammatory conditions can includes at least one of a θ-defensin, analog or derivative thereof. Inventive methods include researching θ-defensins, analogs or derivatives thereof for their efficacy with respect to anti-inflammatory effects, and providing such compositions to the marketplace for the purpose of treating inflammatory conditions. Of particular interest are drug compositions effective to produce clinically relevant inhibition of tumor necrosis factor alpha (TNF-α)-converting enzyme (TACE) or other proinflammatory proteases, and / or sheddases. it is contemplated that preferred compositions can be used to treat rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory diseases, autoimmune diseases, cancer, and Alzheimer's, osteoarthritis, inflammation-related neurodegenerative and other inflammation-related diseases.

Ammunition which includes a bullet having an effective caliber that is larger than its nominal caliber, comprised of a bullet body with a longitudinal cavity in the forward end, and one or more bores extending from the cavity to bore openings on the exterior of the bullet. In use, target media is gathered in the cavity and ejected under force through the bore openings, increasing the damage done by the bullet. Optional embodiments include filled, irritant payload, and jacketed embodiments.

The invention relates to an endoscopic system applicable to positioning and recognition of Barrett's esophagus. The endoscopic system is characterized by comprising a white light source, a Ti: sapphire mode-locked femtosecond laser, optical fibers, an acoustic optical modulator, photonic crystal fibers, an endoscope probe, a dichroscope, an imaging sensor, a filter, a detector and a computer control processing unit. The endoscopic system is reasonable in design, skillful in conception and provided with wide development prospect and great popularization significance.

The invention provides a compound having anticancer activity, which is obtained by cooperation of Norabieta cantharidin and platinum (IV) and modification of a piperazine derivative. The compound is characterized in that a Norabieta cantharidin piperazine derivative ligand is introduced, thereby cytotoxicity of a platinum (IV) compound is reduced, and high antineoplastic activity is provided. The result of the cytotoxicity experiments shows that the provided platinum (IV) compound has less destruction to normal mice fibroblast L929, but has good killing effect to cancer cells such as human breast cancer MCF-7 cell, human cervical carcinoma HeLa cell and human lung adenocarcinoma A549 cell, so that the compound having anticancer activity is capable of reducing the system toxicity and having equal anticancer activity with cisplatin. The compound having anticancer activity has good killing effect by aiming at cisplatin resistance human lung adenocarcinoma A549 / DDP cell. Therefore, the toxicity is reduced, the cisplatin resistance can be reversed, and anticancer effect of the platinum medicines can be increased.

The invention discloses melittin gene fission yeast engineering bacteria and a construction method and application thereof. The engineering bacteria are fission yeasts converted from recombinant expression vectors of melittin gene fission yeasts; the construction method comprises two steps of constructing the recombinant expression vectors of the melittin gene fission yeasts and converting the recombinant expression vectors of the melittin gene fission yeasts into the fission yeasts; a method for producing melittin by applying the engineering bacteria comprises two steps of expression of the melittin and separation and purification of the melittin; and the operation is simple and easy, the melittin has high expression level, easy separation and purification, and strong activity, and the method for production the melittin has short production period and low cost, makes up the shortages of the prior melittin preparation method, a prokaryotic expression system and other yeast expression systems, can ensure the native conformation and the activity of the melittin while reducing the lethality of the melittin to host cells, and solves the problems that the melittin is difficult to extract and purify, the synthesis cost is high and the like so as to provide a powerful tool for the fundamental research and the production application of the melittin.

The invention relates to a gene of an MLL leukemia targeted dual-specific chimeric antigen receptor and an application of the MLL leukemia targeted dual-specific chimeric antigen receptor. The dual-specific chimeric antigen receptor disclosed by the invention can be used for specifically recognizing two kinds of tumor associated antigens, i.e., CD19 and CD133 on surfaces of MLL leukemia cells. The dual-specific chimeric antigen receptor is expressed through recombining a TanCAR molecule to a virus vector and carrying out T lymphocyte series transfection, dual positive tumor cells, i.e., the CD19 and the CD133 can be specifically recognized and killed, the kill effect on non-tumor cells is relieved, and the probability of escape of tumor antigens is lowered. The MLL leukemia cells can be specifically killed by TanCAR(1linker)-Jurkat in case of a relatively low effector-target ratio, and toxic or side effects less occur in subsequent clinical use, for example cytokine storm and neurotoxicity. The dual-specific chimeric antigen receptor disclosed by the invention can be applied to the treatment of MLL leukemia and is used for clearing in-vivo tumors from patients and prolonging lifetime of the patients.

The invention provides a chitosan-chitosan derivative nanosphere product for loading an indissoluble medicament. The product has a porous structure with controllable aperture, thus being capable of controlling the medicament to be released relatively quickly and stably. When the nanosphere product is taken as an oral preparation, as a large number of positive charges exist on the surface of the nanosphere product, the adhesiveness and membrane permeability of the preparation on a small intestine part are improved greatly, and the oral bioavailability of the medicament is enhanced. Simultaneously, the product can be jointly loaded with medicaments with electronegativity or coupling targeting ligands to achieve the aim of coordinating administration or targeting administration. The chitosan-chitosan derivative nanosphere product not only can be used for improving the tolerance of a patient, but also has relatively low toxic and side effects. The invention also provides a preparation method of the chitosan-chitosan derivative nanosphere product for loading the indissoluble medicament. The grain size of the product prepared from the method is uniform. The preparation method is applicable to medicaments which are insoluble in water but soluble in fat, and can be used for controlling nanocrystallines of the indissoluble medicament to be uniformly distributed in the nanosphere in an in-situ crystallization way so as to improve the medicament loading efficiency.

The invention discloses a membrane-targeted photosensitizer capable of realizing photodynamic therapy as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. The preparation method comprises the following steps: preparing a C9 dichlorodipyridine bridge through reactions among dipyridine, ruthenium trichloride and lithium chloride; enabling the dichlorodipyridine bridge to react with a dipyridine auxiliary ligand b to obtain a ruthenium complex. The photosensitizer can specifically target the cell membrane of a cancer cell,and under irradiation of specific exciting light, generates reactive oxygen and damages the surface of the cell membrane to cause cell apoptosis finally; moreover, the photosensitizer realizes a goodphotodynamic therapy effect, thereby adding a new idea for photodynamic therapy. The membrane-targeted photosensitizer capable of realizing photodynamic therapy has a great potential in future biomedicine application.

The present invention discloses one kind of fusion protein with alpha-interferon activity and its coding gene, expression mode and application in preparing medicine for raising body's immunity. The fusion protein is human IFN-alpha-2b fusion protein with human IgG Fc-gamma-1 or human IgG Fc-gamma-2 connected to the carboxyl group end, the human IFN-alpha-2b has the amino acid residue sequence as shown in SEQ ID No. 13 of the sequence list, the human IgG Fc-gamma-1 is wild human IgG Fc-gamma-1 or its mutant, and the human IgG Fc-gamma-2 is wild human IgG Fc-gamma-2 or its mutant. The fusion protein has the following advantages: high alpha-interferon activity, long half life and small ADCC damaging effect. The present invention is significant and possesses wide application foreground in medicine and biomedicine preparing fields, especially in preparing medicine for raising immunity.

An extended range munition including a projectile having a generally cylindrical body includes a forward end and rearward end. The forward end includes a protruding member extending therefrom, thereby increasing the weight of said body and said forward end. The body is formed of a non-metallic material having a durometer hardness less than conventional metallic projectile.

The invention discloses a medicament for treating tumors. The medicament consists of a histone deacetylase inhibitor and a lysophosphatidic acid suppressant, wherein the lysophosphatidic acid suppressant is a substance for inhibiting lysophosphatidic acid from bonding with a lysophosphatidic acid receptor or a substance for inhibiting the lysophosphatidic acid from generating. The medicament indicates that the histone deacetylase inhibitor (HDACi) can up-regulate autotaxin (ATX) expression by inhibiting the activity of HDAC3 and HDAC7 in multiple tumor cells. The ATX generated by the induction of the HDACi generates the lysophosphatidic acid (LPA) by catalyzing lysophosphatidyl choline (LPC) and weakens the killing effect of the HDACi on the tumor cells. If the ATX expression is inhibited by a ribonucleic acid interference (RNAi) method or bromophosphonate-lysophosphatidic acid (BrP-LPA) serving as an ATX-LPA signal channel inhibitor is added to block an ATX-LPA signal, the killing effect of the HDACi on the tumor cells can be enhanced further. The study of the invention provides a new concept for treating the tumors by combing the lysophosphatidic acid suppressant and the HDACi. The medicament has wide application prospects in the treatment of the tumors.

The invention provides an application of a dihydromyricetin composition in preparation of medicines for inhibiting adriamycin cardiotoxicity. The composition is composed of dihydromyricetin and adriamycin; as shown by in vivo and in vitro experimental studies, the dihydromyricetin can inhibit cell apoptosis activated by the adriamycin and dependent to mitochondrial membrane potential so as to reduce lethality caused by adriamycin cardiotoxicity, and the composition provided by the invention has excellent protection effect on cardiotoxicity induced by adriamycin. The composition provided by the invention can be used for preventing and alleviating the cardiotoxicity educed by adriamycin and has clinical practicability.

The invention discloses application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin. Through the demonstration by in-vivo experiments, the Ferrostatin-1 reduces the lethality caused by adriamycin cardiotoxicity through inhibiting the ferroptosis process caused by the adriamycin; an obvious protection effect is achieved.

Embodiments of the present invention provide compounds and compositions thereof, which are effective for mitigating tissue damage or lethality induced by an agent, and methods of making and using the same.

The invention provides a bullet for shooting liquid ammunition and a device for shooting liquid ammunition. The bullet for shooting the liquid ammunition comprises a shell, a front end closed piece, a terminal closing piece and liquid ammunition, wherein the end of the shell is provided with an ignition device and propellant powder, the front end of the shell is opened, the front end closing piece is arranged at the opening, the liquid ammunition device is arranged between the propellant powder and the front end closing piece, and the terminal closing piece is arranged between the liquid ammunition and the propellant powder. The bullet and the device shoot liquid ammunition, are applicable to the short-distance shooting, and can cause large impact force on the target so as to restrict the movement of the target. Since the destruction of the liquid ammunition is weak, non-fatal attack is led to the target. At the same time, even being rebounded onto the human body, the liquid ammunition is free from injuring the human body, so the liquid ammunition is difficult to injure people surrounding the target by mistake.

The present invention relates to nanometer RE heterocyclic anticancer compound and its preparation process and application in inhibiting cancer cell. The compound has the chemical expression of RE(hq), where, RE is one or several selected from RE ions La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Er3+ and Y3+, and hq is 8-ydroxyquinoline, one-phenanthroline or pyridine. The nanometer RE heterocyclic anticancer compound has simple preparation process, low cost, high anticancer activity, small dosage, low toxicity, environment friendship and important anticancer application.

The invention provides a fluorescent super-molecular nano-particle, wherein a construction unit takes tetraphenyl ethylene tetra-bridged beta cyclodextrin as a main body and takes hyaluronic acid adamantane as an auxiliary body, and the main body and the auxiliary body are in inclusion complexation and interaction to construct a super-molecular assembly. The preparation method of the fluorescent super-molecular nano-particle comprises the following steps: dissolving tetraphenyl ethylene tetra-bridged beta cyclodextrin and hyaluronic acid adamantane in water and uniformly mixing to obtain a fluorescent super-molecular nano-particle solution. The fluorescent super-molecular nano-particle is used for loading an anti-cancer drug, namely adriamycin, into a super-molecular nano-particle. The fluorescent super-molecular nano-particle and the preparation method thereof have the advantages that the preparation method of the fluorescent super-molecular nano-particle is simple and convenient, the consumption of the main body and auxiliary body raw materials is less, the load rate to drugs is high, and a good active targeting property is achieved; and the fluorescent super-molecular nano-particle is used for loading the anti-cancer drug, namely adriamycin, and the adriamycin after loading has an obviously enhanced killing effect on cancer cells than single adriamycin but has an obviously reduced toxic effect on normal cells than single adriamycin, so that the fluorescent super-molecular nano-particle has wide application prospects in the fields of loading and targeting release of anti-cancer drugs.

The invention relates to an embedded composite wallboard of an earthquake proof construction, comprising a shell, and a corrugated ribbed slab and packing which are arranged in the shell, wherein the shell is made of a glass magnalium composite board; the corrugated ribbed slab is made of aluminum plastic glass fiber reinforced plastics; the packing is made of the mixture of perlite powder, kieselguhr and magnesite powder; and the corrugated ribbed slab in the packing and the shell outside the packing are solidified together by using mucilage glue. Since the composite wallboard takes the light high-strength glass magnalium composite board as the shell, the light high-strength aluminum plastic glass fiber reinforced plastics corrugated ribbed slab as a reinforcing rib and the light, heat-insulation, sound-insulation and insulated mixture of the perlite powder, the kieselguhr and the magnesite powder as the packing, and the shell, the corrugated ribbed slab and the packing are solidified together by using the mucilage glue, the embedded composite wallboard has the properties of firmness and light weight and the characteristics of heat preservation, fire prevention and noise insulation. Especially when the embedded composite wallboard is put in use in a mode of small area and a building is damaged once an earthquake happens, the antipersonnel force to people can be reduced a lot, and therefore, the embedded composite wallboard is an ideal building material for the traditional earthquake proof construction.

The present invention provides a process for the treatment of a composition comprising yeast cell walls comprising β-1,3-glucans which are insoluble when extracted with water and partially soluble when extracted with DMSO, the process comprising contacting said composition with laminaripentaose-producing-β-1,3-glucanase and inactivating the laminaripentaose-producing-β-1,3-glucanase to result in a composition comprising yeast cell walls wherein the β-1,3-glucans have an improved solubility in DMSO and the ratio of β-glucans soluble in DMSO compared to water is greater than or equal to 2.

The invention belongs to the field of pharmaceutical and chemical industry, and relates to dihydroquinozolinone antiport process blocking agent, and a preparation method and application thereof, in particular to a novel dihydroquinozolinone antiport process blocking agent compound, a medicinal salt, isomer, hydrate and solvate thereof, application of the compound and the medicinal salt, isomer, hydrate and solvate thereof to preparation of drugs for preventing and / or first aiding diseases caused by ribosome-inactivating proteins, and application of the compound and the medicinal salt, isomer,hydrate and solvate thereof to preparation of drugs for preventing and / or curing diseases caused by enterovirus, filoviridae or polyomavirus. The compound can effectively resist II-type ribosome-inactivating protein poisoning and / or the diseases caused by enterovirus, filoviridae or polyomavirus.

The invention provides preparation and applications of a pH and ATP response-type nano carrier. The pH and ATP response-type nano carrier comprises a nucleic acid nano carrier and an anti-tumor drug immobilized on the nucleic acid nano carrier; the anti-tumor drug is anthracycline antibiotics; and the nucleic acid nano carrier comprises an ATP aptamer double helix structure and an i-motif stem loop structure. The pH and ATP response-type nano carrier provided by the invention utilizes the characteristics of tumor cell high-concentration ATP to promote dissociation of aptamers and complementarysequences thereof; and utilizes the acidic environment of tumor cells to promote the i-motif conformational change and to realize the efficient and rapid release of drugs in cells.

The invention discloses an explosion-proof illuminating lamp device for modern traffic. The device structurally comprises a protection cover, a lamp body, a protection device and a cover plate; the lamp body is arranged in the protection device, the protecting cover sleeves the head portion of the lamp body, and the protecting cover is arranged at the bottom of the protecting device; the cover plate is fixedly connected to the top of the protecting device, and the protecting device is composed of a shell body, a power device, a closing mechanism, a locking device, a tensioning mechanism, a shrinking device, a guiding device and a supporting mechanism; the lamp body is arranged in the shell body, the bottom of the lamp body is hinged to the shell body through a supporting mechanism, guide devices are arranged on the two sides of the lamp body, and the lamp body is connected with the shrinking device; and the tensioning mechanism is arranged on the shrinking device, and closing mechanisms are arranged on the two sides of the lamp body. The explosion-proof illuminating lamp device for modern traffic has the beneficial effects that the protecting device can timely retract the lamp bodywhen being impacted, the closing plate is closed at the same time, the glass is prevented from splashing when the lamp body is broken, the killing force is reduced, the harm to the human body is reduced, and the use safety is improved.