115results about How to "Mitigation of lethality" patented technology

The invention relates to an oriented monitoring, preventing and controlling system for pests. The oriented monitoring, preventing and controlling system is characterized in that a pest sticking card, a camera, a computer feedback system device, a control switch and a deinsectization lamp are included, the camera is arranged above or beside the pest sticking card and connected with the input end of the computer feedback system device through an information transmission network, the output end of the computer feedback system device is connected with the control switch and the deinsectization lamp in sequence through control lines, and a photosensor is arranged on the control line between the control switch and the deinsectization lamp. The pest sticking card can attract one or more kinds of different female pests, the number of the different female pests is measured and calculated through the cooperation of the camera and the computer feedback system device, and the monitoring aim is achieved. When the number of the female pests of a certain kind reaches a set number, the computer feedback system device can automatically turn on the control switch, the deinsectization lamp with the corresponding wave length works, and the pests are trapped and killed. Through the added photosensor, the deinsectization lamp only works at night.

Drug compositions for treatment of one or more inflammatory conditions can includes at least one of a θ-defensin, analog or derivative thereof. Inventive methods include researching θ-defensins, analogs or derivatives thereof for their efficacy with respect to anti-inflammatory effects, and providing such compositions to the marketplace for the purpose of treating inflammatory conditions. Of particular interest are drug compositions effective to produce clinically relevant inhibition of tumor necrosis factor alpha (TNF-α)-converting enzyme (TACE) or other proinflammatory proteases, and/or sheddases. it is contemplated that preferred compositions can be used to treat rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory diseases, autoimmune diseases, cancer, and Alzheimer's, osteoarthritis, inflammation-related neurodegenerative and other inflammation-related diseases.

Ammunition which includes a bullet having an effective caliber that is larger than its nominal caliber, comprised of a bullet body with a longitudinal cavity in the forward end, and one or more bores extending from the cavity to bore openings on the exterior of the bullet. In use, target media is gathered in the cavity and ejected under force through the bore openings, increasing the damage done by the bullet. Optional embodiments include filled, irritant payload, and jacketed embodiments.

The invention discloses a chrysin amino acid derivative and a preparation method thereof. The preparation method using chrysin 7 sites to synthesize different series of chrysin derivatives specifically includes: allowing chrysin to have reaction with bromo-alkyl carboxylate, performing hydrolysis to obtain a 7-O-carboxyalkylated chrysin derivative, allowing the 7-O-carboxyalkylated chrysin derivative to have reaction with different types of amino acid alkyl ester, performing amide condensation to obtain a chrysin amino acid alkyl ester type compound, and performing hydrolysis to obtain the chrysin amino acid derivative. The preparation method has the advantages that amino acid is combined with chrysin molecules, and the solubility of the chrysin is improved while the killing effect on normal cells is reduced; the amino acid is the basic unit for forming protein, is an important active molecule in a human body, participates in various life activities and is harmless and nontoxic to the human body; the amino acid is good in solubility, and the demand quantity of tumor cells on the amino acid is higher than that of the normal cells.

The invention provides a compound having anticancer activity, which is obtained by cooperation of Norabieta cantharidin and platinum (IV) and modification of a piperazine derivative. The compound is characterized in that a Norabieta cantharidin piperazine derivative ligand is introduced, thereby cytotoxicity of a platinum (IV) compound is reduced, and high antineoplastic activity is provided. The result of the cytotoxicity experiments shows that the provided platinum (IV) compound has less destruction to normal mice fibroblast L929, but has good killing effect to cancer cells such as human breast cancer MCF-7 cell, human cervical carcinoma HeLa cell and human lung adenocarcinoma A549 cell, so that the compound having anticancer activity is capable of reducing the system toxicity and having equal anticancer activity with cisplatin. The compound having anticancer activity has good killing effect by aiming at cisplatin resistance human lung adenocarcinoma A549/DDP cell. Therefore, the toxicity is reduced, the cisplatin resistance can be reversed, and anticancer effect of the platinum medicines can be increased.

The present invention relates to a compound of formula (I):

or a pharmaceutically acceptable salt thereof, wherein R¹-R⁴, Q, Z, r, and p are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with FAK overexpression, including proliferative diseases.

The invention discloses a membrane-targeted photosensitizer capable of realizing photodynamic therapy as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. The preparation method comprises the following steps: preparing a C9 dichlorodipyridine bridge through reactions among dipyridine, ruthenium trichloride and lithium chloride; enabling the dichlorodipyridine bridge to react with a dipyridine auxiliary ligand b to obtain a ruthenium complex. The photosensitizer can specifically target the cell membrane of a cancer cell,and under irradiation of specific exciting light, generates reactive oxygen and damages the surface of the cell membrane to cause cell apoptosis finally; moreover, the photosensitizer realizes a goodphotodynamic therapy effect, thereby adding a new idea for photodynamic therapy. The membrane-targeted photosensitizer capable of realizing photodynamic therapy has a great potential in future biomedicine application.

The present invention discloses one kind of fusion protein with alpha-interferon activity and its coding gene, expression mode and application in preparing medicine for raising body's immunity. The fusion protein is human IFN-alpha-2b fusion protein with human IgG Fc-gamma-1 or human IgG Fc-gamma-2 connected to the carboxyl group end, the human IFN-alpha-2b has the amino acid residue sequence as shown in SEQ ID No. 13 of the sequence list, the human IgG Fc-gamma-1 is wild human IgG Fc-gamma-1 or its mutant, and the human IgG Fc-gamma-2 is wild human IgG Fc-gamma-2 or its mutant. The fusion protein has the following advantages: high alpha-interferon activity, long half life and small ADCC damaging effect. The present invention is significant and possesses wide application foreground in medicine and biomedicine preparing fields, especially in preparing medicine for raising immunity.

The invention discloses a medicament for treating tumors. The medicament consists of a histone deacetylase inhibitor and a lysophosphatidic acid suppressant, wherein the lysophosphatidic acid suppressant is a substance for inhibiting lysophosphatidic acid from bonding with a lysophosphatidic acid receptor or a substance for inhibiting the lysophosphatidic acid from generating. The medicament indicates that the histone deacetylase inhibitor (HDACi) can up-regulate autotaxin (ATX) expression by inhibiting the activity of HDAC3 and HDAC7 in multiple tumor cells. The ATX generated by the induction of the HDACi generates the lysophosphatidic acid (LPA) by catalyzing lysophosphatidyl choline (LPC) and weakens the killing effect of the HDACi on the tumor cells. If the ATX expression is inhibited by a ribonucleic acid interference (RNAi) method or bromophosphonate-lysophosphatidic acid (BrP-LPA) serving as an ATX-LPA signal channel inhibitor is added to block an ATX-LPA signal, the killing effect of the HDACi on the tumor cells can be enhanced further. The study of the invention provides a new concept for treating the tumors by combing the lysophosphatidic acid suppressant and the HDACi. The medicament has wide application prospects in the treatment of the tumors.

The invention provides an application of a dihydromyricetin composition in preparation of medicines for inhibiting adriamycin cardiotoxicity. The composition is composed of dihydromyricetin and adriamycin; as shown by in vivo and in vitro experimental studies, the dihydromyricetin can inhibit cell apoptosis activated by the adriamycin and dependent to mitochondrial membrane potential so as to reduce lethality caused by adriamycin cardiotoxicity, and the composition provided by the invention has excellent protection effect on cardiotoxicity induced by adriamycin. The composition provided by the invention can be used for preventing and alleviating the cardiotoxicity educed by adriamycin and has clinical practicability.

The invention provides a bullet for shooting liquid ammunition and a device for shooting liquid ammunition. The bullet for shooting the liquid ammunition comprises a shell, a front end closed piece, a terminal closing piece and liquid ammunition, wherein the end of the shell is provided with an ignition device and propellant powder, the front end of the shell is opened, the front end closing piece is arranged at the opening, the liquid ammunition device is arranged between the propellant powder and the front end closing piece, and the terminal closing piece is arranged between the liquid ammunition and the propellant powder. The bullet and the device shoot liquid ammunition, are applicable to the short-distance shooting, and can cause large impact force on the target so as to restrict the movement of the target. Since the destruction of the liquid ammunition is weak, non-fatal attack is led to the target. At the same time, even being rebounded onto the human body, the liquid ammunition is free from injuring the human body, so the liquid ammunition is difficult to injure people surrounding the target by mistake.

The invention provides a fluorescent super-molecular nano-particle, wherein a construction unit takes tetraphenyl ethylene tetra-bridged beta cyclodextrin as a main body and takes hyaluronic acid adamantane as an auxiliary body, and the main body and the auxiliary body are in inclusion complexation and interaction to construct a super-molecular assembly. The preparation method of the fluorescent super-molecular nano-particle comprises the following steps: dissolving tetraphenyl ethylene tetra-bridged beta cyclodextrin and hyaluronic acid adamantane in water and uniformly mixing to obtain a fluorescent super-molecular nano-particle solution. The fluorescent super-molecular nano-particle is used for loading an anti-cancer drug, namely adriamycin, into a super-molecular nano-particle. The fluorescent super-molecular nano-particle and the preparation method thereof have the advantages that the preparation method of the fluorescent super-molecular nano-particle is simple and convenient, the consumption of the main body and auxiliary body raw materials is less, the load rate to drugs is high, and a good active targeting property is achieved; and the fluorescent super-molecular nano-particle is used for loading the anti-cancer drug, namely adriamycin, and the adriamycin after loading has an obviously enhanced killing effect on cancer cells than single adriamycin but has an obviously reduced toxic effect on normal cells than single adriamycin, so that the fluorescent super-molecular nano-particle has wide application prospects in the fields of loading and targeting release of anti-cancer drugs.

The invention relates to an embedded composite wallboard of an earthquake proof construction, comprising a shell, and a corrugated ribbed slab and packing which are arranged in the shell, wherein the shell is made of a glass magnalium composite board; the corrugated ribbed slab is made of aluminum plastic glass fiber reinforced plastics; the packing is made of the mixture of perlite powder, kieselguhr and magnesite powder; and the corrugated ribbed slab in the packing and the shell outside the packing are solidified together by using mucilage glue. Since the composite wallboard takes the light high-strength glass magnalium composite board as the shell, the light high-strength aluminum plastic glass fiber reinforced plastics corrugated ribbed slab as a reinforcing rib and the light, heat-insulation, sound-insulation and insulated mixture of the perlite powder, the kieselguhr and the magnesite powder as the packing, and the shell, the corrugated ribbed slab and the packing are solidified together by using the mucilage glue, the embedded composite wallboard has the properties of firmness and light weight and the characteristics of heat preservation, fire prevention and noise insulation. Especially when the embedded composite wallboard is put in use in a mode of small area and a building is damaged once an earthquake happens, the antipersonnel force to people can be reduced a lot, and therefore, the embedded composite wallboard is an ideal building material for the traditional earthquake proof construction.

The present invention provides a process for the treatment of a composition comprising yeast cell walls comprising β-1,3-glucans which are insoluble when extracted with water and partially soluble when extracted with DMSO, the process comprising contacting said composition with laminaripentaose-producing-β-1,3-glucanase and inactivating the laminaripentaose-producing-β-1,3-glucanase to result in a composition comprising yeast cell walls wherein the β-1,3-glucans have an improved solubility in DMSO and the ratio of β-glucans soluble in DMSO compared to water is greater than or equal to 2.

The invention belongs to the field of pharmaceutical and chemical industry, and relates to dihydroquinozolinone antiport process blocking agent, and a preparation method and application thereof, in particular to a novel dihydroquinozolinone antiport process blocking agent compound, a medicinal salt, isomer, hydrate and solvate thereof, application of the compound and the medicinal salt, isomer, hydrate and solvate thereof to preparation of drugs for preventing and/or first aiding diseases caused by ribosome-inactivating proteins, and application of the compound and the medicinal salt, isomer,hydrate and solvate thereof to preparation of drugs for preventing and/or curing diseases caused by enterovirus, filoviridae or polyomavirus. The compound can effectively resist II-type ribosome-inactivating protein poisoning and/or the diseases caused by enterovirus, filoviridae or polyomavirus.

The invention provides preparation and applications of a pH and ATP response-type nano carrier. The pH and ATP response-type nano carrier comprises a nucleic acid nano carrier and an anti-tumor drug immobilized on the nucleic acid nano carrier; the anti-tumor drug is anthracycline antibiotics; and the nucleic acid nano carrier comprises an ATP aptamer double helix structure and an i-motif stem loop structure. The pH and ATP response-type nano carrier provided by the invention utilizes the characteristics of tumor cell high-concentration ATP to promote dissociation of aptamers and complementarysequences thereof; and utilizes the acidic environment of tumor cells to promote the i-motif conformational change and to realize the efficient and rapid release of drugs in cells.

The invention discloses an explosion-proof illuminating lamp device for modern traffic. The device structurally comprises a protection cover, a lamp body, a protection device and a cover plate; the lamp body is arranged in the protection device, the protecting cover sleeves the head portion of the lamp body, and the protecting cover is arranged at the bottom of the protecting device; the cover plate is fixedly connected to the top of the protecting device, and the protecting device is composed of a shell body, a power device, a closing mechanism, a locking device, a tensioning mechanism, a shrinking device, a guiding device and a supporting mechanism; the lamp body is arranged in the shell body, the bottom of the lamp body is hinged to the shell body through a supporting mechanism, guide devices are arranged on the two sides of the lamp body, and the lamp body is connected with the shrinking device; and the tensioning mechanism is arranged on the shrinking device, and closing mechanisms are arranged on the two sides of the lamp body. The explosion-proof illuminating lamp device for modern traffic has the beneficial effects that the protecting device can timely retract the lamp bodywhen being impacted, the closing plate is closed at the same time, the glass is prevented from splashing when the lamp body is broken, the killing force is reduced, the harm to the human body is reduced, and the use safety is improved.