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Nanometer RE heterocyclic anticancer compound and its prepn and application

A technology of heterocyclic compounds and nano rare earths, which is applied in the field of complexes with anticancer functions, can solve the problems of high price of anticancer compounds, easy environmental pollution, complicated preparation methods, etc., and achieves small killing effect on normal cells and anticancer ability. Powerful, easy-to-prepare effect

Inactive Publication Date: 2007-01-03
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The technical problem to be solved in the present invention is to provide a nano-rare-earth heterocyclic anticancer compound and its preparation method and application, so as to overcome the existing binary complexes with conventional particle size and no nano-particle size preparation method, And the disadvantages of complex preparation methods overcome the defects of existing anticancer compounds such as high price, large dosage, high toxicity, large side effects, and easy pollution to the environment

Method used

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  • Nanometer RE heterocyclic anticancer compound and its prepn and application
  • Nanometer RE heterocyclic anticancer compound and its prepn and application
  • Nanometer RE heterocyclic anticancer compound and its prepn and application

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Embodiment 1

[0036] Nano-rare earth heterocyclic binary anticancer complex and its preparation method 1: take 0.03mol 8-hydroxyquinoline, mix it with 0.01mol mixed rare earth chloride RECl 3 ·xH 2 O, (in advance by RE 2 o 3 prepared by reacting with hydrochloric acid), grind for ten minutes to one hour; filter with suction, wash with twice distilled water to remove chloride ions (Cl - ), dried in vacuum for 2 to 10 hours, and ground to the nanometer scale to obtain RE(hq) 2 . figure 1 ,3 , 4.

[0037] Note: hq is 8-hydroxyquinoline. RE can be La 3+ 、Ce 3+ 、Pr 3+ 、Nd 3+ 、Sm 3+ 、Eu 3+ 、Er 3+ or Y 3+ One of them can also be a combination of more than one, such as rare earth La 3+ and Ce 3+ 、Pr 3+ and Nd 3+ and Sm 3+ 、Eu 3+ and Er 3+ and Y 3+ 、Ce 3+ and Sm 3+ and Eu 3+ and Er 3+ and Y 3+ , even all 8 kinds of rare earth elements, n kinds of RECl 3 ·xH 2 When O is used as a raw material, 0.01 mol of each is mixed with 0.03×n mol of 8-hydroxyquinoline for reaction, an...

Embodiment 2

[0039] Nano-rare earth heterocyclic binary anti-cancer complex and its preparation method 2: take 0.03mol o-phenanthroline, mix it with 0.01mol mixed rare earth chloride RECl 3 ·xH 2 O, (in advance by RE 2 o 3 prepared by reacting with hydrochloric acid), grind for ten minutes to one hour; filter with suction, wash with twice distilled water to remove chloride ions (Cl - ), dried in vacuum for 2 to 10 hours, and ground to the nanometer scale to obtain RE(hq) 2 .

[0040] Note: hq is o-phenanthroline. RE can be La 3+ 、Ce 3+ 、Pr 3+ 、Nd 3+ 、Sm 3+ 、Eu 3+ 、Er 3+ or Y 3+ One of them can also be a combination of more than one, such as rare earth La 3+ and Ce 3+ 、Pr 3+ and Nd 3+ and Sm 3+ 、Eu 3+ and Er 3+ and Y 3+ 、Ce 3+ and Sm 3+ and Eu 3+ and Er 3+ and Y 3+ , even all 8 kinds of rare earth elements, n kinds of RECl 3 ·xH 2 When O is used as a raw material, 0.01 mol and 0.03×n mol of o-phenanthroline are mixed for reaction, and the reaction conditions and p...

Embodiment 3

[0042] Nano-rare earth heterocyclic binary anti-cancer complex and its preparation method three: take 0.03mol pyridine, mix it with 0.01mol mixed rare earth chloride RECl 3 ·xH 2 O, (in advance by RE 2 o 3 prepared by reacting with hydrochloric acid), grind for ten minutes to one hour; filter with suction, wash with twice distilled water to remove chloride ions (Cl - ), dried in vacuum for 2 to 10 hours, and ground to the nanometer scale to obtain RE(hq) 2 .

[0043] Note: hq is pyridine. RE can be La 3+ 、Ce 3+ 、Pr 3+ 、Nd 3+ 、Sm 3+ 、Eu 3+ 、Er 3+ or Y 3+ One of them can also be a combination of more than one, such as rare earth La 3+ and Ce 3+ 、Pr 3+ and Nd 3+ and Sm 3+ 、Eu 3+ and Er 3+ and Y 3+ 、Ce 3+ and Sm 3+ and Eu 3+ and Er 3+ and Y 3+ , even all 8 kinds of rare earth elements, n kinds of RECl 3 ·xH 2 When O is used as a raw material, 0.01 mol and 0.03×n mol of pyridine are mixed for reaction, and the reaction conditions and process are the same....

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Abstract

The present invention relates to nanometer RE heterocyclic anticancer compound and its preparation process and application in inhibiting cancer cell. The compound has the chemical expression of RE(hq), where, RE is one or several selected from RE ions La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Er3+ and Y3+, and hq is 8-ydroxyquinoline, one-phenanthroline or pyridine. The nanometer RE heterocyclic anticancer compound has simple preparation process, low cost, high anticancer activity, small dosage, low toxicity, environment friendship and important anticancer application.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and more specifically relates to a compound with anticancer function. Background technique [0002] Chemotherapy of cancer has developed rapidly in recent years, and new anticancer drugs are constantly emerging. The confirmation of the antitumor therapeutic effects of paclitaxel, camptothecin derivatives and retinoids was hailed as a major discovery in anticancer drug research in the 1990s. Reducing the incidence of cancer mainly depends on early detection and prevention. It is now known that tumor is a special disease. The transformation from normal tissue to cancer usually goes through the precancerous stage, and the treatment of precancerous diseases is an ideal target for drug prevention of cancer. . Therefore, anticancer drugs are not limited to traditional cytotoxic drugs, and the research and development of cancer prevention drugs has become a promising new field. In recent years, with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/72C07D213/06C07D471/04C07F5/00C07F11/00C07F19/00A61K31/555A61K33/24A61P35/02
Inventor 何其庄郑文捷闵惠陈琳
Owner SHANGHAI NORMAL UNIVERSITY
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