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Application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin

A technique for cardiotoxicity and ferroptosis, applied in drug combinations, antidote, antitumor drugs, etc., can solve the problems of affecting the quality of life of patients, incomplete understanding of myocardial injury mechanism, and limited clinical application of doxorubicin. Sexual and protective effects

Active Publication Date: 2017-08-04
ZHEJIANG UNIV
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  • Abstract
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Problems solved by technology

This not only greatly affects the quality of life of patients, but also greatly limits the clinical application of adriamycin.
[0003] The toxicity of doxorubicin to the heart is to cause myocardial damage in a cumulative and dose-dependent manner, but the mechanism of myocardial damage is still not fully understood

Method used

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  • Application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin
  • Application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin
  • Application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with specific examples, but the protection scope of the present invention is not limited thereto.

[0019] 1. Materials and Methods

[0020] 1.1 Experimental animals

[0021] Six-week-old SPF grade C57BL / 6 male mice were purchased from Shanghai Slack Experimental Animal Co., Ltd. and raised in SPF environment. Standard diet AIN-76A (iron content 50 mg / Kg, Research Diets, Inc) was adapted to feeding for 2 weeks, and randomly divided into groups according to body weight, with 6-8 animals in each group.

[0022] 1.2 Drugs and treatment

[0023] Compound monomer Fer-1 and doxorubicin (DOX) were purchased from Selleck Company. Doxorubicin was dissolved in physiological saline, Fer-1 was dissolved in physiological saline containing 2% (v / v) dimethyl sulfoxide DMSO, and the concentration of Fer-1 was 100 μg / ml. Doxorubicin was injected intraperitoneally once at 20 mg / kg body weight (lethal test) and 10 mg...

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Abstract

The invention discloses application of Ferrostatin-1 to preparation of medicine for inhibiting cardiotoxicity caused by adriamycin. Through the demonstration by in-vivo experiments, the Ferrostatin-1 reduces the lethality caused by adriamycin cardiotoxicity through inhibiting the ferroptosis process caused by the adriamycin; an obvious protection effect is achieved.

Description

technical field [0001] The invention relates to ferroptosis inhibitor Ferrostatin-1, which can significantly reduce cardiotoxicity caused by adriamycin when used in combination with antitumor drug adriamycin. Background technique [0002] Doxorubicin (DOX) belongs to anthracycline antitumor antibiotics. It has the characteristics of broad antitumor spectrum, strong antitumor effect and definite curative effect. It is widely used in the treatment of hematological malignancies and solid tumors, such as acute leukemia, lymph cancer, breast cancer, gastric cancer, soft tissue sarcoma and ovarian cancer. Similar to other antineoplastic drugs, doxorubicin has a strong damaging effect on cancerous cells on the one hand, and is also toxic to normal cells and tissues on the other hand, which can cause toxic side effects such as hair loss, bone marrow suppression, and cardiotoxicity. Among them, the biggest side effect of doxorubicin is irreversible cardiotoxicity. The mild clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/245A61K31/704A61P39/02A61P35/00
CPCA61K31/245A61K31/704A61K2300/00
Inventor 王福俤方学贤王浩闵军霞
Owner ZHEJIANG UNIV
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