Fluorescent super-molecular nano-particle and preparation method and application thereof

Abstract

The invention provides a fluorescent super-molecular nano-particle, wherein a construction unit takes tetraphenyl ethylene tetra-bridged beta cyclodextrin as a main body and takes hyaluronic acid adamantane as an auxiliary body, and the main body and the auxiliary body are in inclusion complexation and interaction to construct a super-molecular assembly. The preparation method of the fluorescent super-molecular nano-particle comprises the following steps: dissolving tetraphenyl ethylene tetra-bridged beta cyclodextrin and hyaluronic acid adamantane in water and uniformly mixing to obtain a fluorescent super-molecular nano-particle solution. The fluorescent super-molecular nano-particle is used for loading an anti-cancer drug, namely adriamycin, into a super-molecular nano-particle. The fluorescent super-molecular nano-particle and the preparation method thereof have the advantages that the preparation method of the fluorescent super-molecular nano-particle is simple and convenient, the consumption of the main body and auxiliary body raw materials is less, the load rate to drugs is high, and a good active targeting property is achieved; and the fluorescent super-molecular nano-particle is used for loading the anti-cancer drug, namely adriamycin, and the adriamycin after loading has an obviously enhanced killing effect on cancer cells than single adriamycin but has an obviously reduced toxic effect on normal cells than single adriamycin, so that the fluorescent super-molecular nano-particle has wide application prospects in the fields of loading and targeting release of anti-cancer drugs.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, in particular to a fluorescent supramolecular nano-particle and its preparation method and application. Background technique [0002] The use of nanotechnology to achieve targeted cancer therapy has great potential for the development of human health. Therefore, it is very important to construct a targeted drug delivery system to specifically kill cancer cells without affecting normal cells, see: K.Wang, D.S.Guo, X.Wang, Y.Liu.ACSnano.2011 , 5, 2880-2894. Since hyaluronic acid has some excellent properties, such as low toxicity, biocompatibility, biodegradability, high stability, good water solubility and easy chemical modification, the most important one is based on hyaluronic acid overexpressed on the surface of cancer cells. Receptor targeting, using hyaluronic acid to construct a targeted drug delivery system is a very popular research topic, see: A.Singh, M.Corvelli, ...

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Problems solved by technology

In recent years, people have built some hyaluronic acid-based nanoparticles through efforts, but there are problems such as the chemical modification process is too cumbersome or the constructed particles are too loose, which makes the drug easy to leak.

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