The invention provides a
magnetism, pH (potential of
hydrogen) and temperature co-stimulation response hydrogel pre-
radiation synthetic method, belongs to the technical field of nuclear
biology, and solves the technical problems of low existing nano-composite hydrogel environment stimulation response rate and the like. The synthetic method includes the steps: 1) injecting
temperature sensitive monomer solution into PE (
polyethylene) sealing bag, leading in N2, and performing pre-
radiation cross-linking reaction under
electron beams; 2) placing
macromolecule irradiation sensitizing agents, natural
polysaccharide, pH conditioning agents, magnetic nano-particles and
distilled water or deionized water into a
bottle, and the heating the
bottle; 3) slowly adding a
mixed solution system acquiredin the step 2) into the
temperature sensitive monomer solution acquired in the step 1), performing uniformly ultrasonic stirring, and leading in the N2; 4) injecting the mixed
system acquired in the step 3) into the PE sealing bag, and performing
radiation cross-linking reaction under
electron beams again. The method has the advantages that the comprehensive performances of nano-composite hydrogelare optimized and the like.