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Magnetism, pH (potential of hydrogen) and temperature co-stimulation response hydrogel pre-radiation synthetic method

A technology of synergistic stimulation and synthesis method, applied in the field of nuclear biology, can solve the problems of slow response rate of stimuli responsiveness, achieve the effect of non-toxic irradiation technology, maintain constant blood drug concentration, and reduce toxic and side effects

Inactive Publication Date: 2018-02-23
HUBEI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to address the above-mentioned problems existing in the existing technology, and to provide a magnetic, pH, and temperature synergistic stimulus response hydrogel pre-radiation synthesis method. The technical problem to be solved by the present invention is to realize the synthesis of nanocomposite hydrogel Performance optimization improves the sensitivity of magnetic, pH and temperature ternary synergistic stimuli responses, and effectively overcomes the shortcomings of traditional hydrogels, such as relatively single environmental stimuli responsiveness and slow response rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Inject a quantitative amount of N-ethylmorpholine methacrylate (MEMA) (20.0wt%) into a PE sealed bag (thickness about 2mm), pass nitrogen gas for 0.5h, and place it under an electron beam for radiation crosslinking reaction, The selected electron beam energy is 1MeV, the radiation dose is 5kGy, and the dose rate is 5kGy / pass, and the obtained product is the PMEMA prepolymer. Utilize ultrasound, according to a certain proportion of polyvinyl alcohol (PVA) (2.0wt%), carboxymethyl chitosan (CTS) (5.0wt%), iminodiacetic acid (0.1%), BiFeO 4 (0.5wt%) and deionized water were put into a three-necked flask, heated at 95°C, stirring at a rate of 150r / min, for 0.5h to form a uniform and stable solution system, and left to stand for about 2h to remove air bubbles. The resulting PVA, CTS, BiFeO 4 The mixed solution system was slowly added to the PMEMA prepolymer, and after ultrasonic stirring, the N 2For about 0.5 h, after static defoaming under negative pressure, inject it int...

Embodiment 2

[0028] Inject a quantitative amount of N,N-dimethylaminoethyl methacrylate (DMAEMA) (60.0wt%) into a PE sealed bag (thickness about 2mm), blow nitrogen for 2h, and place it under an electron beam for radiation crosslinking For the reaction, the selected electron beam energy is 1 MeV, the radiation dose is 40 kGy, and the dose rate is 20 kGy / pass, and the obtained product is PDMAEMA prepolymer. Using ultrasound, put a certain proportion of collagen (10.0wt%), sodium alginate (20.0wt%), triethanolamine (2.0wt%), CoFeO (0.5wt%) and deionized water into a three-necked bottle, Heat at 50°C, stir at 150r / min for 0.5h, make it uniform to form a stable solution system, and let it stand for about 2h to remove air bubbles. The mixed solution system of the obtained collagen, sodium alginate and CoFeO was slowly added to the PDMAEMA prepolymer, and after ultrasonic stirring, the N 2 For about 2 hours, after static defoaming under negative pressure, inject it into a PE sealed bag, and pla...

Embodiment 3

[0031] Inject a quantitative amount of N-isopropylacrylamide (NIPAAm) (40.0wt%) into a PE sealed bag (thickness about 2mm), pass nitrogen gas for 2h, and place it under an electron beam for radiation crosslinking reaction. Selected electron beam The energy is 1 MeV, the radiation dose is 20kGy, and the dose rate is 5kGy / pass, and the obtained product is NIPAAm prepolymer. Utilize ultrasonic waves, according to a certain proportion of polyvinyl alcohol (PVA) (5.0wt%), hydroxyhydroxypropyl cellulose (HHPC) (10.0wt%), disodium hydrogen phosphate (1.0wt%), Fe 3 o 4 (0.2wt%) and deionized water were put into a three-necked flask, heated at 85°C, stirring at a rate of 150r / min, for 1h to form a uniform and stable solution system, and left to stand for about 2h to remove air bubbles. The resulting PVA, HHPC, Fe 3 o 4 The mixed solution system of NIPAAm was slowly added to the NIPAAm prepolymer, and after ultrasonic stirring was uniform, N 2 For about 2 hours, after static defoam...

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PUM

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Abstract

The invention provides a magnetism, pH (potential of hydrogen) and temperature co-stimulation response hydrogel pre-radiation synthetic method, belongs to the technical field of nuclear biology, and solves the technical problems of low existing nano-composite hydrogel environment stimulation response rate and the like. The synthetic method includes the steps: 1) injecting temperature sensitive monomer solution into PE (polyethylene) sealing bag, leading in N2, and performing pre-radiation cross-linking reaction under electron beams; 2) placing macromolecule irradiation sensitizing agents, natural polysaccharide, pH conditioning agents, magnetic nano-particles and distilled water or deionized water into a bottle, and the heating the bottle; 3) slowly adding a mixed solution system acquiredin the step 2) into the temperature sensitive monomer solution acquired in the step 1), performing uniformly ultrasonic stirring, and leading in the N2; 4) injecting the mixed system acquired in the step 3) into the PE sealing bag, and performing radiation cross-linking reaction under electron beams again. The method has the advantages that the comprehensive performances of nano-composite hydrogelare optimized and the like.

Description

technical field [0001] The invention belongs to the technical field of nuclear biology, and relates to a pre-radiation synthesis method of magnetic, pH and temperature co-stimulus-responsive hydrogels. Background technique [0002] With the development of medical materials, the application of biomedical materials is becoming more and more extensive, and the requirements are getting higher and higher, which is of great interest to researchers in the field of medicine. For a long time, people need a long-acting, reliable, and side-effect-free drug to achieve effective and convenient therapeutic effects. An ideal drug controlled release system should be able to give full play to the drug effect, ensure that the blood drug concentration remains constant, and minimize drug exposure. Toxic side effects on the body. If the intelligent hydrogel is used to automatically sense the state in the body and control the speed of drug injection, it is expected to maintain a certain concentr...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08J3/28C08L33/14C08L5/08C08L29/04C08L89/00C08L5/04C08L1/28C08K3/24A61K9/06A61K47/32A61K47/36A61K47/38
CPCA61K9/0009A61K9/06A61K47/32A61K47/36A61K47/38C08J3/075C08J3/246C08J3/28C08J2333/14C08J2333/24C08J2401/28C08J2405/04C08J2405/08C08J2429/04C08J2489/00C08K3/24C08K2003/2275
Inventor 李月生
Owner HUBEI UNIV OF SCI & TECH
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