10results about How to "Obvious side effects" patented technology

The invention discloses a preparation method and application of a porous GelMA microneedle for delivering AIE molecules based on HSF derived exosome. The preparation method comprises the following steps: S1, preparing TTMN molecules; s2, dispersing DPPC and Chol in chloroform, performing water bath evaporation at 50 DEG C to form a thin film, hydrating the thin film in PBS, incubating to enable DPPC and Chol to form a liposome structure again, and uniformly dispersing TTMN molecules in the liposome structure to obtain TL; s3, extracting an exosome from the HSF cells; s4, loading the TL into the exosome by utilizing an electroporation technology, so as to obtain TE; s5, preparing the GelMA; and S6, mixing the GelMA with the TE, so that the TE is uniformly dispersed in the GelMA to obtain a mixed solution, injecting the mixed solution into a microneedle mold, and irradiating with 405nm laser to obtain the porous GelMA microneedle. According to the invention, high-efficiency treatment of hypertrophic scars is realized, and the system has a remarkable drug delivery effect, an innovative photodynamic therapy, a high-efficiency scar tissue remodeling effect and good biological safety and stability, and has important clinical application value and market prospect.

This invention provides a traditional Chinese medicine composition for treating renal edema, pyelonephritis with ascites, and nephritis. It consists of over 20 herbs including Atractylodes lancea, Areca catechu, Saposhnikovia divaricata, and Alisma plantago-aquatica (specific formulation details can be found in the original text). It can be prepared as pills, granules, or decoctions for oral administration. Core efficacy: 1. Promotes diuresis and reduces swelling, eliminating renal ascites; 2. Clears heat and detoxifies, anti-inflammatory and antibacterial (synergistic effect on fungal infections and cervical erosion); 3. Regulates renal function and improves abnormal uric acid metabolism. Treatment plan: Mild cases: Use five basic formulas (①-⑤) composed of Codonopsis pilosula, Poria cocos, etc., taken three times daily; Severe cases: Use a potent diuretic formula containing Akebia trifoliata and Euphorbia pekinensis (one spoonful of pills twice daily); Treatment course is approximately one month, with a follow-up examination after three months. Advantages: Cure rate reaches 90%, low recurrence rate – pure traditional Chinese medicine preparation, no significant toxic side effects; also treats complications (fungal infection, cervical lesions). This treatment plan has been clinically verified through three generations and has significant efficacy in treating renal edema, ascites, and nephritis.

The present invention provides a Chinese medicine composition for treating or preventing Alzheimer's disease, and its preparation method and application, wherein the Chinese medicine composition comprises the following raw materials in parts by mass: 10-20 parts of ginseng, 10-20 parts of polygala, 10-20 parts of calamus, 10-20 parts of tuckahoe, 10-20 parts of yam, 10-20 parts of polygonatum, 10-20 parts of green tea pigments and 10-20 parts of quercetin, and optionally comprises 0.1-0.5 parts of black pepper. The Chinese medicine composition of the present invention has a significant therapeutic effect on 5XFAD transgenic AD mice, which is specifically manifested in that daily oral administration of the Chinese medicine composition of the present invention improves the spatial learning and memory disorders of dementia mice, reduces the deposition of amyloid plaques in the dentate gyrus of the hippocampus of mice, and significantly inhibits the generation of Aβ without causing liver and kidney toxicity and weight loss. Therefore, the Chinese medicine composition of the present invention is a safe and effective method for treating AD.

The invention discloses an external traditional Chinese medicine composition for treating breast yin syndrome and half-yin and half-yang syndrome swelling and ulcer as well as a preparation method and application thereof, the traditional Chinese medicine composition provided by the invention comprises 9 warm medicines and 3 cold medicines, the cold and warm medicines are taken into account and warm is taken as a main part, the whole formula does not contain pure tonifying medicines or pure discharging medicines, and the traditional Chinese medicine composition has the effects of warming, dispelling cold coagulation, removing stagnation and activating blood. The external traditional Chinese medicine ointment prepared from the traditional Chinese medicine composition is clear in clinical curative effect on breast yin syndrome and half-yin and half-yang syndrome swelling and ulcer, free of obvious toxic and side effects, free of traumatic damage, low in recurrence rate, good in patient compliance and worthy of being vigorously popularized and applied clinically.

The invention belongs to the technical field of biological medicines, and particularly relates to application of dipyridamole in preparation of a medicine for preventing and / or treating periodontitis. Experiments prove that when dipyridamole is used in a Pg-LPS induced cell model and a ligation induced animal model, the expression level of Pg-LPS induced inflammatory factors such as IL-1beta, IL-6, TNF-alpha and iNOS can be remarkably reduced, meanwhile, alveolar bone resorption of ligation induced periodontitis model rats can be improved, periodontal tissue attachment loss is reduced, and the ligation induced periodontitis model rats can be used for treating periodontitis. The compound can inhibit the expression of periodontal tissue inflammatory factors and relieve inflammatory cell infiltration, does not generate obvious toxic and side effects on the body, and has a good application prospect in treatment of periodontitis.

The present application relates to the fields of microbial technology and tumor biological therapy, and particularly relates to a bacillus pumilus and application thereof, a protein preparation and a microbial preparation. The bacillus pumilus is named bacillus pumilus BP01, is isolated from the oral cavity of healthy people, and is preserved in China Center for Type Culture Collection on April 2, 2026, with a preservation number of CCTCC NO: M2026574. The 16S rRNA gene sequence of the bacillus pumilus is SEQ ID NO: 1. Compared with the prior art, the bacillus pumilus of the present application is derived from the normal oral cavity of people and has high safety. The culture product of the bacillus pumilus can significantly inhibit the proliferation and clonogenic ability of hepatocarcinoma, hepatoblastoma, colorectal cancer, bladder cancer and endometrial cancer cells. In an in vivo animal model, the bacillus pumilus shows stable anti-tumor effect and does not cause obvious toxic side effects. The bacillus pumilus can be used as a live bacterial preparation, and can also play an anti-tumor role through culture supernatant or metabolic products, and has flexible application forms. The bacillus pumilus has good clinical transformation and industrial application prospects.

The present application relates to the use of a cyclic heptapeptide in the preparation of a medicament for reducing body weight. Specifically, the present application discloses a new use of a cyclic heptapeptide Cyclo-[TYVPKAF] or a pharmaceutically acceptable salt thereof in the preparation of a medicament for reducing body weight, preventing or treating a body weight related disease. The body weight related disease includes obesity, overweight, metabolic syndrome, type 2 diabetes, fatty liver, cardiovascular disease or osteoarthritis, etc. The present application first discovers that the specific cyclic heptapeptide has clear and convenient body weight control activity, and in particular, its orally effective characteristics provide a new choice for long-term body weight management.

The invention relates to application of alkaloid in preparation of a T cell immunosuppressor, and belongs to the technical field of application of natural products. The invention discloses an application of a natural product alkaloid of zephyranthes candida in preparation of a T cell immunosuppressor, especially a medicine for acute rejection in allogeneic transplantation, and more particularly a medicine for acute rejection in allogeneic heart transplantation. The alkaloid is used for inhibiting proliferation of T lymphocytes and reducing secretion of inflammatory factors, wherein the T lymphocytes are CD3 + T lymphocytes; the inflammatory factors are a Th1 type inflammatory factor, a Th2 type inflammatory factor and / or a Th17 type inflammatory factor, and the Th1 type inflammatory factor is IL-2, TNF-alpha and IFN-gamma; the Th2 type inflammatory factors are IL-4 (Interleukin-4), IL-6 (Interleukin-6) and IL-10; the Th17 type inflammatory factor is IL-17 (Interleukin-17).

This invention provides a pharmaceutical composition for treating age-related cognitive impairment in subjects and its use therein, the pharmaceutical composition comprising an antisense oligonucleotide as shown in SEQ ID NO:2. The pharmaceutical composition of this invention is administered via in situ injection, reducing and avoiding the effects of the antisense oligonucleotide on other organs.