431results about How to "Obvious side effects" patented technology

The invention relates to a 2-(2-(2, 6-dichlorophenyl amido) phenyl) methyl acetate, relative synthesis method and application, belonging to the technical field of chemical pharmacy, which comprises that adds acid into diclofenac salt to acidify the salt into diclofenac, reacts diclofenac with methanol, or adds acid into diclofenac salt to acidify the salt into diclofenac, to be reacted with chloracetyl chloride to obtain 2-(2-(2, 6-dichlorophenyl amido) phenyl) methyl acetate. The inventive drug has significant anti-inflammatory and analgesic effects.

The invention relates to an ophthalmic microemulsion/submicron emulsion in situ gel preparation with cyclosporine A and the preparation method. The preparation is prepared through shearing and high pressure homogenization process using cyclosporine A, oil phase, emulsifier, coemulsifier, thickener, isosmotic adjustment agent, bacteriostat, pH regulator and purified water. The invention is characterized in that safe and nonirritant nonionic surface-active material polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, tween or phosphatides are adopted as the emulsifier; macromolecular material with ion and/or pH sensitive properties is used as the thickener. The average particle size of emulsion drops of the ophthalmic microemulsion/submicron emulsion in situ gel preparation is less than 200nm; the cumulative value of 90% particle size is no more than 500nm; as low-viscosity liquid with good fluidity outside the body, the ophthalmic microemulsion/submicron emulsion in situ gel preparation can rapidly form hydrogel after being dropped into eyes, thereby increasing residence time of the medicine and bioavailability. The ophthalmic microemulsion/submicron emulsion in situ gel peparation has the advantages of no stimulation and poison and side effect to eyes and stable quality of the preparation.

The present invention discloses one kinds of ointment for treating piles and other anorectal diseases and its preparation process. The medicine is prepared with Vaseline, bezoars, pearl, calamine, borax and other five kinds of Chinese medicinal materials and through crushing, mixing and other steps. The present invention has simple preparation process and obvious treating effect and is suitable for industrial production.

The invention discloses an anti-tumor traditional Chinese medicine comprising medicinal materials such as astragalus mongholicus, American ginseng, angelica sinensis, sculellaria barbata, oldenlandia diffusa, bighead atractylodes rhizome, endothelium corneum gigeriae galli, grifola, paris polyphylla, Indian strawberry, radix ranunculi ternati, radix curcumae, honey-fried licorice root, scorpion, venenum bufonis and the like. All the medicines supplement each other so that the absorption and operation of the medicines are accelerated and all the medicines are prevented from being cool; and the anti-tumor traditional Chinese medicine has the effects of tonifying Qi of spleens and lungs, tonifying the spleen and promoting dampness, dissolving phlegm, softening hard mass, breaking Qi, clearing away heat and toxic materials, and promoting blood circulation and stopping pain; with regard to patients with a peed tumor and better physique, pseudo-ginseng, leech, the venenum bufonis and the whole scorpion can be added into the medicine to realize the aims of combating poison with poison and enhancing the effect, so as to realize the anti-cancer aim; and the anti-tumor traditional Chinese medicine continually has a better treating effect on the treatment of the tumor.

The invention relates to the field of genetic engineering, and in particular relates to an anti-EGFR ((Epidermal Growth Factor Receptor) chimeric antigen receptor, and a lymphocyte for expressing the antigen receptor. The technical solution of the invention provides a new effective selection for the anti-tumor technical field. The technical scheme is that a single-chain antibody targeting the EGFR is provided. The single-chain antibody is further designed to be constructed into the chimeric antigen receptor by means of a genetic engineering technology, and the structure of the gained chimeric antigen receptor is anti-EGFR (scFv)-IgG2 (Fc)-CD28-CD3 Zeta. According to the genetically engineered lymphocyte targeting the human EGFR, the chimeric antigen receptor is transfected into the lymphocyte by the nucleofaction technology, and thus the nonspecific lymphocyte can be endowed with the capacity of specifically distinguishing the EGFR tumor antigen and targeting and killing the EGFR over-expression tumor cells. According to the technical scheme, the adoptive cell therapy and the genetic therapy are organically combined, so that remarkable effect of killing the tumor is gained, and a novel effective selection is provided for the field.

The invention provides a compound extract for tranquillization, infantile eclampsia resistance and digestion promotion, which comprises 5-95% of iridoid glycosides, 1-90% of saponins, 1-90% of terpenes, 1-90% of flavones and 1-90% of volatile oil.

The invention provides a traditional Chinese medicine contrast medium adjuvant used for B ultrasonic, which comprises the following materials in part by weight: 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 10-20 parts of turmeric, 10-20 parts of tangerine peel, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of radix aucklandiae, 10-20 parts of Rhizoma atractylodis, 10-20 parts of cuttlebone, 10-20 parts of calcined oyster shell, 10-20 parts of Chinese yam, 10-20 parts of charred triplet, 10-20 parts of myristica fragrans, 10-20 parts of gizzard pepsin, 10-20 parts of rhizome cyperi, 10-20 parts of codonopsis pilosula, 10-20 parts of combined spicebush root, 10-20 parts of eclipta, 10-20 parts of jasmine, 10-20 parts of baical skullcap root and 10-20 parts of field pennycress. The traditional Chinese medicine contrast medium adjuvant used for B ultrasonic provided by the invention not only can adapt to stomach hyperfunction type, but also can adapt to decreased stomach function type, and also can be applied to the mixed type of various flatulence and mucinosis, check time is short, imaging rate is high, and preparation process is simple and practical. The contrast medium adjuvant has no obvious toxic side effect and has prospect on further development research.

The invention provides a gargle, wherein each 1000ml of the gargle comprises green tea 60-90g, honeysuckle flower 60-90g, wrinkled gianthyssop 60-90g, peppermint 30-60g, borneol 0.4-0.8g.

The present invention discloses a transcutaneous plaster containing tulobuterol, its preparation method and application. The pressure-sensitive adhesive used by said invention is a hot-melt pressure-sensitive adhesive whose melting point is 50-250 deg.C. the described hot-melt pressure-sensitive adhesive is an adhesive made up by using thermoplastic polymer as main raw material, and hs the hot-melting and pressure-sensitive double characteristics. Said product contains no organic solvent, and its coating speed is quick, and its cost is low.

The invention provides a composition for preventing and treating diabetes, which comprises the following ingredients by weight: 1-100 parts of cinnamon, 1-100 parts of mulberry leaf and 1-100 parts of bitter gourd. The composition has good hypoglycemic effect, and is especially suitable for preventing and treating of spleen and kidney insufficiency type diabetes.

The invention discloses an antineoplastic traditional Chinese medicine. The antineoplastic traditional Chinese medicine comprises the following medicinal materials: milkvetch root, Dangshen, red sage root, Chinese angelica, barbat skullcap, heydyotis, bighead atractylodes rhizome, chicken's gizzard membrane, polyporus, Indian mock strawberry, catclaw buttercup root, turmeric root tuber, honey-fried licorice root, scorpion, toad venom and the like, wherein the above-mentioned medicinal materials supplement each other, so absorption and action of the medicinal materials are benefited, stagnation and cold of the medicinal materials are prevented, and effects on tonifying qi in the spleen and the lung, invigorating the spleen, disinhibiting dampness, dispersing phlegm, softening hardness and dispelling stagnated qi are obtained. The antineoplastic traditional Chinese medicine provided by the invention can both be individually used and be cooperatively used with a surgery, radiotherapy and chemotherapy for treatment of a tumor, has the characteristics of fast action, reliable curative effects, no obvious toxic and side effects, capability of controlling growth of the tumor in a short period and eliminating the tumor and capacity of substantially enhancing the habitus of people and improving disease-resistance and restoration capability of people and is an antineoplastic drug with good effects, comprehensive action and no obvious toxic and side effects.

The invention provides a composition for preventing and treating diabetes, which comprises the following ingredients by weight: 1-100 parts of cinnamon, 1-100 parts of mulberry leaf, 1-100 parts of root of kudzu vine, 1-100 parts of Poria cocos, 1-100 parts of Chinese yam and 1-100 parts of bitter gourd. The composition possesses good hypoglycemic effect, and is especially suitable for preventing and treating of spleen and kidney insufficiency type diabetes.

The invention discloses a traditional Chinese medicine for treating diabetic foot. According to clinical manifestation and syndrome differentiation, the diabetic foot is classified into two types, i.e., toxic heat collateral blocking diabetic foot and blood stasis collateral blocking diabetic foot. Specific to the toxic heat collateral blocking diabetic foot, an internal formula consists of the following raw materials in certain parts by weight: honeysuckle flower, figwort root, coptis root, baical skullcap root, amur corktree bark, philippine violet herb, red paeony root, tree peony bark, earthworm, unprocessed rehmannia root and dahurian angelica root; and specific to the blood stasis collateral blocking diabetic foot, an internal formula consists of the following raw materials in certain parts by weight: suberect spatholobus stem, bupleurum, astragalus, tuber fleeceflower root, bitter orange, peach kernel, yerbadetajo herba ecliptae, common burreed rhizome, zedoary, safflower, szechuan lovage rhizome, Chinese angelica and twotooth achyranthes root. An external foot bathing formula for treating the two types of diabetic foot consists of coptis root, baikal skullcap root, rhubarb, honeysuckle flower, dandelion, safflower, peach kernel, Chinese angelia root tail, suberect spatholobus stem, Chinese taxillus twig, wild celery, cattail pollen, faeces of flying squirrel, wild ginger, fineleaf schizonepeta herb and garden balsam stem. The traditional Chinese medicine is convenient to use and has a remarkable curative effect.

The invention relates to the genetic engineering field, in particular to a human EpCAM targeted genetically engineered lymphocyte, a preparation method and use thereof. Technically, the invention aimsto provide a new effective means for immunotherapy of tumors. The technical scheme for solving the technical problem of the invention firstly provides a single-chain antibody capable of recognizing human EpCAM, a chimeric antigen receptor (CAR) containing the single-chain antibody, a vector carrying the chimeric antigen receptor, and a lymphocyte modified by the chimeric antigen receptor. After specific recognition of EpCAM overexpressed tumor cells, the EpCAM targeted chimeric antigen receptor modified lymphocyte provided by the invention can play an anti-tumor role through cytokine releaseand cytotoxicity, and can remarkably tumor formation, tumor growth and lung metastasis in vivo, thus having good application prospect.

The invention provides a magnetic nano silver antibacterial material for sterilization treatment in medical treatment and/or drinking water and a preparation method thereof. An antibacterial agent provided by the invention takes magnetic nanoparticles coated with silica gel as a core and inlaid with antibacterial particles on the outer layer, is preferably a Fe3O4 magnetic nano antibacterial material which is inlaid with silver nanoparticles and coated with silica gel. The antibacterial agent simultaneously has large special surface area of nano material, magnetic separation capacity and magnetic target of magnetic material, dispersant effect of a silica gel coating layer, protection action on the core and strong antibacterial ability of nano silver. In addition, the antibacterial agent issimple to prepare and convenient to operate and can realize directional sterilization, thereby having wide application prospect in medical care and food sanitation sterilization treatment.

A Chinese medicine for treating the apoplexy sequelae is prepared from 9 Chinese-medicinal materials including astragalus root, Chinese angelica root, Chuan-xiong rhizome, red peony root, etc. Its preparing process is also disclosed.

The present invention relates to preparation process and application in medicine for treating liver fibrosis of curcumin. The medicine treating liver fibrosis has curcumin as main effective component and pharmaceutically acceptable carrier, such as excipient, additive and flavoring agent, and may be prepared into different forms, including medicine powder, tablet, micro pill, etc. Curcumin has obvious effect of treating liver fibrosis, no obvious toxic side effect and rich resource.

The invention relates to an extract method of Chinese traditional medicinal compound rhizoma coptidis alexipharmic soup active part and an application of the active part in preparing medicament resisting vascular dementia. The extract method disclosed by the invention adopts industrialized separating and refining technologies, such as microporous membrane and macroporous resin absorption, greatly decreases cream yield of the preparation, maximally retains effective components, improves transforming rate of effective components in raw materials and purity of effective components in the preparation. The extracted active part comprises three kinds of known chemical components: alkaloids, flavonoid glycosides and iridoid glycosides respectively, and has a vascular dementia resisting function.

The invention discloses genetic recombinant collagen-like peptide MJLGG-34 as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering. Comparedwith the traditional natural collagen, the collagen-like peptide MJLGG-34 obtained through genetic recombination has the advantages that the collagen-like peptide MJLGG-34 is small in molecular weight, easy to prepare and stable biological activity, has better transdermal rate and higher biological activity, and is more easily absorbed by skin while guaranteeing the biological activity; the collagen-like peptide MJLGG-34 is good in biocompatibility and biology safety, has excellent biological activity, such as oxidation resistance, apoptosis resistance and melanogenesis inhibiting, can obviously inhibit oxidative damage of skin, regulate melanogenesis and resist ageing, and does not have obvious toxic or side effects; the collagen-like peptide MJLGG-34 can be applied to food, health care products and cosmetics, and is wide in application range, thereby having the excellent application value and industrial prospect. The preparation method is simple, high in production efficiency, low inproduction cost and wide in application prospect.

The invention discloses Chinese medicinal enema decoction for treating colonitis, which solves the problems of large side effect, high relapse rate, unsatisfactory long-term effect, lasting state of illness, easy relapse after healing and troublesome treatment of the traditional method for treating the colonitis by using Western medicine. The Chinese medicinal enema decoction for treating the colonitis comprises the following medicines serving as raw materials in part by weight: 10 to 35 parts of bletilla, 10 to 35 parts of Chinese pulsatilla root, 10 to 35 parts of sargentgloryvine stem, 10 to 35 parts of amur corktree bark, 15 to 35 parts of lightyellow sophora root, 12 to 35 parts of feverfew, 5 to 25 parts of Chinese gall, 10 to 25 parts of garden burnet root, 5 to 20 parts of dragon's blood, 6 to 15 parts of powdered notoginseng root, 3 to 10 parts of golden thread and 3 to 6 parts of alum. Due to the adoption of the traditional Chinese medicines, the Chinese medicinal enema decoction has the advantages of treatment of both symptoms and root causes, treatment aiming at the root of disease, treatment according to syndrome differentiation and increment/decrement according to syndrome, and the characteristics of simple and understandable treatment method, low price, no toxic or side effect, safety, reliability, wide applicable range, no pain to patients and easy acceptance.

The invention relates to a complex traditional Chinese medicine preparation for treating upper respiratory tract infection and a preparation method thereof. The complex traditional Chinese medicine preparation comprises the following raw materials: 10-25 parts of picria felterrae lour, 5-15 parts of herba sarcandrae, 5-15 parts of senecio, 5-13 parts of pubescent holly root and 1-5 parts of liquorice. The preparation method comprises the following steps: pulverizing a proper amount of picria felterrae lour into fine powders; adding water into residual picria felterrae lour, the herba sarcandrae, the senecio, and the like and extracting to obtain extracts; adding alcohol into the extracts to carry out alcohol deposition, filtration and concentration to form thick paste; uniformly mixing, drying and pulverizing the thick paste and the picria felterrae lour fine powder to form fine powders; and adding a proper number of auxiliary materials and uniformly mixing to prepare particles or adding general preparation auxiliary materials to prepare general solid oral administration preparation. According to clinical observation for many years, the traditional Chinese medicine preparation benzyrin tablet has the obvious treating effects on a patient with upper respiratory tract infection diseases, such as upper respiratory tract inflammation, bronchitis, rhinitis, pharyngolaryngitis, tonsillitis, and the like.

The invention pertains to biomedical technique field, in particular to a TGF-beta induced regulatory T-cell and a synthesis method and the applications thereof. The regulatory T-cell of the invention is formed by combining two cytokines: TGF-Beta and IL-2, and obtained by extrinsically inducing CD4+ cells of autoimmune diseases sufferer, and is recorded as CD4++CD25+Foxp3+ regulatory T-cell, wherein FoxP3 is FoxP3 gene or protein. The regulatory T-cell of the invention can be taken as a medicine preparation that is used for treating the diseases of autoimmune diseases (such as SLE) sufferer.

The invention provides the use of Valeriana jatamansi Jones and its extract in preparing medicaments for treating dysphoria. The invention also discloses a medicinal composition containing Valeriana jatamansi Jones and its extract as the active components, as well as pharmaceutically acceptable medicinal auxiliary materials.

The invention relates to an insectifuge and particularly relates to an environment-friendly insectifuge and a preparation method thereof. The environment-friendly insectifuge is prepared by garlic, pepper, melia azedarach fruit, dark plum fruit, Chinese torreya seed kernel, betel nut, radix sophorae flavescentis and antifeverile dichroa root. The insectifuge adopts natural plant fruits, is wide in material source, does not generate insecticide resistance in the plant body, has no harmful residue or obvious toxic and side actions and is an organic 'green' insect-repellent health-care product.

The invention provides application of a sesquiterpene compound 6-OAP in preparation of STAT3 inhibitors and in treatment of diseases unusually relevant to STAT3, and a pharmaceutical composition for treatment of diseases unusually relevant to STAT3. The pharmaceutical composition contains 6-OAP. 6-OAP can quickly combine with STAT3, can significantly inhibit phosphorylation of STAT3 in a cell and animal tumor-bearing model and significantly inhibit the activity of STAT3 induced by inflammatory factors, and has no significant toxic and side effect on other normal tissues. With the advantages of proper dose, significant curative effect, definite action target, and low toxic and side effects, etc., the 6-OAP has wide anticancer and anti-inflammatory application prospects clinically.