181 results about "Condyloma Acuminatum" patented technology

The invention relates to uses of Bombay canary and its alcohol extract in preparing medicine for treatment of inflammation, specifically, for treating cervical erosion, ulcerative colitis, fig wart after operation, said invention belongs to medicine field.

A composite medicine with skin target for treating pointed condyloma, viral or fungal infection of skin, and eczema is prepared from oil, surfactant, surfactant assistant, osmotic promoter, active medicine and water through proportional mixing, and adding gel matrix.

The present invention provides a puccoon extract-puccoon polysaccharide and its application in preparation of medicine for effectively curing pointed condyloma. Said medicine has effective action for killing human papilloma virus, so that it can effectively cure the pointed condyloma due to human papilloma virus. Besides, said invention also provides a method for preparing said puccoon polysaccharide by using Chinese medicinal material puccoon.

The present invention relates to Periplaneta Americana or its ethanol extract for the treatment of inflammation. Specifically, said inflammation includes cervical erosion, ulcerative colitis, skin ulcer, mucosal ulcer and postoperative condyloma acuminatum. Treating said disorders by Periplaneta Americana or its ethanol extract has the advantages of effectively reducing bleeding, shortering healing time, significant curative effect, no adverse reactions and low cost. Periplaneta Americana or its ethanol extract provides a new selection for the clinical treatment of cervical erosion, ulcerative colitis and postoperative condyloma acuminatum.

The present invention relates to human papillomavirus (HPV) type hybrid virus-like particles and a preparation method thereof. The virus-like particles can be used for preventions two or more HPV infections and diseases caused by HPV infections. The present invention further relates to uses of the protein and the virus-like particles in preparations of drug compositions or vaccines, wherein the drug compositions or the vaccines are provided for preventions of HPV infections and diseases caused by HPV infections, and the diseases comprise cervical cancer, condyloma acuminatum, and the like.

The invention relates to the technical field of medicines and in particular relates to a novel chlorine photosensitizer-pyropheophorbide-a ether amino acid derivative, a preparation method thereof and an application to preparation of antitumor medicines. A chemical structure of the pyropheophorbide-a ether amino acid derivative is shown in a general formula (I) in the specification. The pyropheophorbide-a ether amino acid derivative has the advantages of high efficiency, low toxicity and the like, and can be used for preparing new medicines for photodynamic therapy of cancers, medicines for photodynamic therapy of benign vascular diseases, such as age-related macular degeneration and nevus flammeus and medicines for photodynamic therapy of condyloma acuminate.

The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

An isolated sequence or peptide isolated from an E2, E4, E6, E7 early or late coding region of human papillomavirus (HPV) that is soluble in aqueous medium, and characterized by a linkage to another protein sequence or peptide isolated from the E2, E4, E6, E7 early or late coding region of HPV by a spacer sequence, wherein the isolated protein sequence or peptide consists of more than 50% hydrophilic amino acids, and is recognized by a specific antibody of HPV. Also disclosed are isolated protein sequences or peptides from Harvey Ras (H-Ras), Kirsten Ras (K-Ras), and phosphatase and tensin homologue (PTEN) tumor suppressor proteins and Chlamydia trachomatis heat shock protein 60 (CHSP60 groEL1) and methods for detecting or diagnosing cancer or cellular abnormalities.

The present invention discloses the use of methyltestosterone as a novel pharmaceutical for treatment of anti-HPV infections, especially for treatment of verruca planae, condyloma acuminatum, and the relapse of these disorders. The therapeutic efficacy of the aforementioned indications proves satisfactory.

The invention discloses a quadruple fluorescence quantitive PCR typing detection method for common human papillomavirus infection, which comprises a fluorescence quantitive PCR technology-based quadruple PCR reaction system and contains forward and reverse primers of four kinds of human papillomavirus (HPV) genotypes and AllGlo fluorescence probes, wherein the capacity of carrying DNA at most comprising HPV-6,-11, -16 and -18 can be synchronously detected in a reaction tube under a proper PCR condition. The method comprises the following steps of: designing specific primers and the fluorescence probes; building a standard molecule; preparing a standard curve; and detecting a clinical sample. The method can conveniently, quickly and synchronously detect four types of clinically common HPV infection in the reaction tube, realizes typing detection of the four types of HPV by a single-tube PCR at the same time, can quantitatively detect, is simple and quick in operation, high in sensitivity, good in specificity and repeatability and accurate and reliable in the result, and has very high clinical value on early preventing and treating woman cervical carcinogenesis caused by pointed condyloma and the common HPV, blocking infectious source, decreasing HPV infection and monitoring clinical treatment effect.

The invention relates to a kind of natural medicine of broad spectrum antibiotic. At present, the broad spectrum antibiotic medicine with high effect and safety is at shortage all round the world. The invention is intended to extract laminarinsulphate or sulphonic acid sugar ester or sulphosalts from plant chickweed or other chickweed plant with two resin adsorption methods or a water extraction and alcohol precipition method. The spectrum antibiotic in the invention is distributed under 50,000 in the formula weight formed by carbon glycosidic bond and / or oxide glycosidic bond with phenol, especially the total flavones comprising apigenin. However, the invention mainly acts as total phenolic glycoside with the formula weight under 4,000. Besides, the invention can form brownish compound with the total flavones comprising apigenin and the glycosidic ingredients without sulfur element, so as to be applied as broad spectrum antibiotic drug. Therefore, the compound in the invention can be applied to cure ADIS virus, hepatitis virus, influenza virus and parainfluenza virus comprising SARS, adenovirus, verruca acuminate virus, enterovirus, mumps virus, herpes simplex virus, herpes zoster virus and varicella. No toxic effect has been found in the application. What is more, the invention can be made into 10 sorts of formulation, disinfector and health-improving products.

The invention discloses a composite capable of preventing bacteria, viruses, oxidation and pigment deposition, which is characterized by being prepared from the following raw materials in proportion by weight: 0.1-10 of epigallocatechin gallate (EGCG), 0-10 of chlorogenic acid, 0-10 of asiaticoside and 0-10 of ginkgolide. The invention also discloses application of the composite in preparing drugs, health-care food and cosmetics, which are capable of preventing bacteria, viruses, oxidation and pigment deposition. The composite of the invention has favorable safety, is suitable for curing respiratory tract infection, condyloma acuminatum, herpes progenitalis, chromatosis and other diseases, simultaneously has anti-oxidation and skin whitening functions, protects cells and DNA from being damaged, can prevent and cure dementia and chloasma, and also can be used for cancer adjuvant therapy.

The present invention relates to human papillomavirus type bivalent virus-like particle mixture, and human papillomavirus type bivalent virus-like particle mixing protein antigen and its construction method. The present invention includes one kind of cervical carcinoma virus HPV16 L1 antigen and one kind of condyloma acuminata virus HPV11 L1 antigen. The HPV11 L1 gene is first cloned from condyloma acuminata tissue through molecular geological method, and both HPV16 L1 gene cloned from cervical carcinoma tissue and the HPV11 L1 gene are then expressed in the insect cell expression system of baculovirus, so as to constitute recombinant virus strain Bacmid / HPV16-HPV11L1. Animal immunizing test shows that the constituted recombinant protein has excellent immunogenicity and immunoreactivity, and may be used as candidate antigen of gene engineering multivalent vaccine for preventing condyloma acuminata and cervical carcinoma.

The invention relates to the technical field of medicines and particularly relates to a novel chlorin photosensitizer, i.e., a chlorin p6 amino acid derivative, a preparation method therefor and use of the chlorin p6 amino acid derivative in preparation of antitumor drugs. The chlorin p6 amino acid derivative disclosed by the invention has a chemical structure represented by a general formula (I) shown in the description. The chlorin p6 amino acid derivative disclosed by the invention has the advantages of high efficiency, low toxicity and the like and can be used for preparing novel photodynamic cancer therapy drugs, drugs for photodynamic therapy on benign vascular diseases such as senile macular degeneration and nevus flammeus and drugs for photodynamic therapy on verruca acuminata.

The invention relates to an antiviral medicament which comprises the raw materials of (by weight ratio) seed of Job's tears 39-41, Chinese yam 34-36, dried orange peel 24-26, rhizome of Sichuan lovage 39-41, astragalus root 78-82, basket fern 29-31, herba patriniae 39-41, barbat skullcap 39-41, oldenlandia 19-21, Sedum sarmentosum 29-31, capsule of weeping forsythia 98-102, medicated leaven 39-41, malt 39-41, atractylodes rhizome 39-41, kuh-seng 49-51, root of pilose asiabell 59-61, rhizome smilacis glabrae 39-41, giant knotweed rhizome 29-31, radix isatidis 98-102, zedoary 39-41, glabrous sarcandra herb 39-41 and dyers woad leaf 29-31.

The invention discloses an external ointment for treating herpes zoster, which comprises the following raw materials in proportion by weight: 45 to 55 grams of gamboge, 15 to 25 grams of red orpiment, 8 to 12 grams of camphol, 4 to 6 grams of hydrargyrum, 8 to 12 grams of menthol, and 1,000 grams of vaseline. According to the proportion, the external ointment is prepared by gradually heating the Vaseline to 100 DEG C, lowering the temperature of the Vaseline to 60 DEG C, mixing the powdered red orpiment, the camphol and the menthol into the Vaseline, reducing the temperature of a mixture to 50 DEG C, adding the gamboge and the hydrargyrum into the mixture, grinding the mixture until mercury globules disappear, gradually cooling the temperature of the mixture to 30 DEG C, and bottling the mixture. The ointment can cure the herpes zoster in short time with single treatment, has stable healing efficacy and convenient use, has significant healing effects on patients suffering from xerosis cutis, pruritus and tinea manuum, has cure rate of over 98 percent, and has good healing effects on verruca acuminate, chancroid, syphilis and other venereal diseases.

The invention relates to a medicine for external application and for curing condyloma acuminatum and herpes progenitalis. The medicine is mixed by oleum fructus bruceae and clovirs antiviral drugs (such as acyclovir, ganciclovir, etc.) by a certain ratio, which are prepared into externally applicable dosage forms, such as liniment, ointment, etc. by a specific process with medicinally acceptable optional bases. The medicine for external application is characterized by low cost, good curative effect, high recovery rate, and low recurrence rate after recovery, as well as convenient use, safety, reliability and small side-effects during the therapeutic process.

The invention relates to a new preparation process of 5-aminolevulinic acid (5-ALA) hydrochloride. The 5-ALA is a second-generation photosensitizer, and has a structure shown in the specification. The 5-ALA hydrochloride has been used for treating photosensitive keratosis in America. The 5-ALA hydrochloride is used for treating dermatological condyloma acuminatum in China. Indications related to the 5-ALA are also extended in clinical application. According to the new preparation process, 4-alkenylbenzyl valerate is used as a starting raw material and is subjected to oxidation, addition, oxidation and catalytic hydrogenation to successfully synthesize the 5-ALA.

The invention discloses a pharmaceutical composition for treating condyloma acuminatum and herpes, mainly comprising mixtures of effective components of 100 parts of periplaneta Americana extractive and 2-300 parts of granatum. The method for preparing the pharmaceutical composition for treating condyloma acuminatum and herpes comprises the following steps of: extracting the periplaneta Americana extractive and the effective components of the granatum, and mixing to prepare the medicine. The preparation method of the invention is simple, gives full play to the periplaneta Americana extractive, and effectively improves the healing effect of condyloma acuminatum and herpes; the pharmaceutical composition is a new medicine worth of promoting, is convenient to use and has little toxic and side-effect.

The invention discloses a podophyllotoxin preparation formula for external use for the treatment of condyloma acuminatum and genital herpes, a series of formulations and a preparation method, and belongs to the field of pharmacy. The weights or the volumes of all the ingredients of the formula of 100ml of the podophyllotoxin preparation for external use are as follows: 0.5g of podophyllotoxin, 20ml-80ml of main solvent, 1ml-3ml of penetration enhancer 1, 0.5g-2.5g of penetration enhancer 2, 20ml-80ml of cosolvent and 0.03-0.5g of preservative. The podophyllotoxin preparation for external use has the advantages that the types and the amount of excipients and the proportion of main drugs are reasonable, the drug administration is carried out by a liniment, a spray or other formulations which are applicable to the external use, the main drug can be rapidly absorbed by the horny layer and the epidermis, the efficacy is significant, the local toxicity or side effects are small, the skin acute toxicity is very low, and the podophyllotoxin preparation has no irritation and weak allergy and does not hinder the skin normal functions; the podophyllotoxin preparation has no systemic toxicity or side effects, thereby being safe and effective. The preparation prepared by the formula has the advantages of good appearance, moderate viscosity, easy coating, spraying drug administration, feasible process, controllable quality, simple preparation process, and suitability for industrial batch production.

The invention discloses a highly effective antiviral medicinal composition of chickweed, a preparation method and an application thereof. Presently, highly effective, safe and universal antiviral medicine is lacking all over the world. A plant, chickweed, or other stellaria plant is extracted, by two resin adsorption methods, one water-alcohol extraction and ultra-filtration, into a dark brown composition that has a molecular distribution ranging from 2,000 to 900,000 Dolton and comprises total sulfate peptidoglycan phenolic acidic components and flavonoid components; the composition is used as a safer, more highly effective universal antiviral natural medicine. Total peptides account to 15-25 percent of the chemical structures of dark brown total sulfate peptidoglycan phenolic-acidic components, and include totaling 17 amino acids by proportion: aspartic acid, glutamic acid, serine, histidine, cystine, methionine, isoleucine; the polysaccharides essentially consist of glucose, galactose and arabinose and form sulfate polysaccharides. The composition can be used for treating virus diseases, including AIDS virus, hepatitis virus, respire virus such as influenza virus including highly pathogenic bird flu virus, para influenza virus and adenovirus, and papovavirus, enterovirus, mumps virus, herpes simplex virus, herpes zoster virus, and varicella-zoster virus, and on the like, does not show toxicity, and can be prepared into more than 10 medicinal dosage forms and healthcare products, and the production process does not cause pollution to the environment.

The invention relates to a medicament for treating verruca wart, which is specifically prepared from the following raw materials: 30g of radix isatidis, 20g of lithospermum, 10g of liquorice, 20g of peach kernel, 20g of rhizoma cyperi and 20g of herba equiseti hiemalis, wherein the dosage accuracy of the traditional Chinese medicine is + / - 10 percent of each Chinese herbal medicine. The medicament for treating the verruca wart mainly treats verruca vulgaris, verruca plana and condyloma acuminatum, has obvious efficacy and is safe and effective without toxic and side effects.

The invention relates to a dysosma versipellis extract, a medicine composite containing the extract as well as a preparation method and application thereof. The dysosma versipellis extract with specific chemical components contains active components, such as general lignans, general flavones and the like; and the impurities of the extract are reduced, and contents of effective components are high. The dysosma versipellis extract comprises the following components in percentage by weight: 20-50 percent of podophyllotoxin, 3-8 percent of kaempferol and 8-15 percent of general flavones. The dysosma versipellis extract is high in contents of the effective components and low in impurities; and the dysosma versipellis extract or the medicine composite containing the extract is obvious in effect and low in side effects during skin sterilization and treatment in verruca acuminate. Compared with the prior art, the preparation method has the advantages of advanced process, high production, high practicability, relatively low cost and low environment pollution.

The invention relates to a kit for high-sensitivity detection of low-risk human papilloma virus (HPV) 6,11 type nucleic acid with the application of a fluorescent PCR technology. The invention discloses a specific amplification primer and a fluorescent probe for detection, a PCR reaction buffer solution, a reference substance and a nucleic acid extracting reagent. The invention also provides a preparing method and a using method of the kit for detecting the HPV 6,11 type. The invention is applicable to qualitative detection of the HPV 6,11 type virus in a human condyloma acuminatum urogenital tract secretion sample; and the kit is simple and rapid to operate, the kit can facilitate automatic operations of instruments, and the kit can solve problems of the prior art which is low in detection sensitivity, capable of causing missing inspection and misdiagnosis easily and the like.

The invention relates to capsules for clearing away damp toxin. The capsules are prepared from the following raw materials: capillary wormwood herb, plantain seed, herba houttuyniae, rhizoma smilacis glabrae, atractylodes rhizome and phellodendron. The preparation method of the capsules comprises the following steps: crushing the atractylodes rhizome and one third of the quantity of rhizoma smilacis glabrae into fine powder, and evenly mixing the fine powder for use; respectively decocting the capillary wormwood herb, the plantain seed, the herba houttuyniae, the phellodendron and the rest ofrhizoma smilacis glabrae for extraction, combining decoction, filtering and concentrating filtered liquor into thick paste for later use; and mixing the thick paste with the fine powder, drying, crushing, evenly mixing and encapsulating to finally obtain the capsules. According to the invention, the preparation process is simple, cost is low, traditional Chinese herbal medicines are matched scientifically, and the capsules have high bioavailability, high stability, obvious curative effect and no obvious toxic and side effects; moreover the capsules have the efficacy of clearing away heat and toxic materials and removing dampness and can be used for treating damp-toxin patients suffering from gonorrhoea, condyloma acuminatum, nongonococcal urethritis (cervicitis and colpitis), herpes progenitalis, chronic prostatitis and the like. Therefore the invention provides a more convenient and faster Chinese traditional medical treatment mode for clinical treatment of skin diseases.

The present invention relates to a mutant HPV 39 L1 protein (or a mutant thereof), a coding sequence and a preparation method thereof, and a virus-like particle comprising HPV. The protein (or the mutant thereof) can induce neutralizing antibodies against at least two types of HPVs (e.g., HPV 39 and HPV 68, or HPV 39, HPV 68 and HPV 70), thereby being used for preventing infections by the at leasttwo types of the HPVs and diseases caused by the infections, such as cervical cancer and condyloma acuminatum. The present invention also relates to uses of the protein and virus-like particle for preparation of drug compositions or vaccines, the drug compositions or vaccines can be used for preventing at least two types of the HPV infections and diseases caused by the infections, such as the cervical cancer and condyloma acuminatum.

The invention relates to the application of paraben and paraben analog for preparing medicine used for preventing and curing viral infection, in particular to the application for preparing the medicine used for curing the HBV, HPV and HSV viral diseases of human and animal. The viral diseases comprise Hepatitis B, herpes simplex, condyloma acuminate, vaginitis, cervicitis and cervical erosion. The application is as follows; the paraben, the paraben analog and the various auxiliary materials of pharmacy are made into different drugs or personal care products.