Application of hydroxyl benzoate and analogue in preparing medicament for preventing and treating hepatitis B virus

A technology of hydroxybenzoate and hepatitis B virus, which is applied to the application field of hydroxybenzoate and its analogs in the preparation of medicines for preventing and treating hepatitis B virus, and can solve temporary effects and large toxic reactions. , Zidovudine due to poor efficacy and other problems

Active Publication Date: 2009-01-14
SHENGHUA GUANGZHOU PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Antiviral drugs for hepatitis B virus (HBV), vidarabine, vidarabine phosphate, acyclovir, and zidovudine, which were tested in the 1980s, have been used abroad because of their poor efficacy and high toxicity. no longer used to treat hepatitis B
In recent years, a variety of nucleoside drugs have been developed, which have obvious inhibitory effects on HBV, such as lamivudine, famciclovir, lobucavir, adefovir, FTC, FMAU, FDDC, BMS 200475, etc., but long-term For these drugs, the virus may mutate and tolerate, and long-term medication is required, and short-term application has only temporary effects

Method used

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  • Application of hydroxyl benzoate and analogue in preparing medicament for preventing and treating hepatitis B virus
  • Application of hydroxyl benzoate and analogue in preparing medicament for preventing and treating hepatitis B virus
  • Application of hydroxyl benzoate and analogue in preparing medicament for preventing and treating hepatitis B virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of anti-HPV virus microemulsion

[0049] Mix 20 ml of 1,2-propanediol, 8015 ml of Tween, and 5 ml of azone, and add sterile distilled water to a total volume of 100 ml to obtain an external preparation solution. Take benzoic acid, salicylic acid, benzoic acid + salicylic acid, p-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, p-hydroxybenzene Ethyl formate, methyl 3,4-dihydroxybenzoate, gallic acid, lauryl gallate, octyl gallate, propyl gallate, ethyl gallate, methyl gallate, 2,4-di Each 10g of methyl hydroxybenzoate was added with 50ml of external preparation solution to adjust the pH to 5.5, and then the external preparation solution was added to 100ml to obtain 10% anti-HPV virus microemulsion of the present invention and control microemulsion.

Embodiment 2

[0050] Example 2 Preparation of anti-HBV virus propyl gallate injection

[0051] Take 10g of propyl gallate, 8.5g of sodium chloride, 10ml of 1,2-propanediol, and 8010ml of Tween. After mixing, add sterile distilled water to dissolve, and add sterile distilled water to 100ml, adjust the pH to 7.4, and filter. Potting and sterilizing at 100°C for 30 minutes. Get Propyl Gallate Injection.

Embodiment 3

[0052] Example 3 Preparation of compound ethyl gallate effervescent tablets

[0053] Take 0.25 g of ethyl gallate, 0.01 g of polyinositides, and 0.45 g of tartaric acid, respectively, and pass through an 80-mesh sieve, and use 95% ethanol to make a soft material, pass through a 12-mesh sieve to make wet granules, and dry at 50° C. for use. Take another 0.65g of sodium bicarbonate, 0.02g of dextrin and sterile distilled water to make soft material, pass through a 12-mesh sieve to make wet granules, dry at 50℃, then mix with the above dry granules, sizing, add appropriate amount of sterilized distilled water, and bake After a while, add 0.01g PEG6000. Mix well, press tablets, and get ready.

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PUM

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Abstract

The invention relates to the application of paraben and paraben analog for preparing medicine used for preventing and curing viral infection, in particular to the application for preparing the medicine used for curing the HBV, HPV and HSV viral diseases of human and animal. The viral diseases comprise Hepatitis B, herpes simplex, condyloma acuminate, vaginitis, cervicitis and cervical erosion. The application is as follows; the paraben, the paraben analog and the various auxiliary materials of pharmacy are made into different drugs or personal care products.

Description

[0001] This application is a divisional application with the application number 200510012287.0. The original application date is August 2, 2005, the application number is 200510012287.0, and the title of the invention is "Hydroxybenzoate and its analogues are used in the preparation of prevention and treatment of viral infections. Application in medicine". Technical field [0002] The present invention relates to the application of hydroxybenzoate and its analogues in the preparation of drugs for the prevention and treatment of viral infections. Such drugs can be used to treat human and animal HBV, HPV, HSV viral diseases, such as hepatitis B, acute Condyloma, herpes simplex, vagina, cervicitis and cervical erosion and adjuvant treatment of cervical cancer. Background technique [0003] Among parabens and their analogs, parabens are known to be used as preservatives for foods and medicines; gallic acid esters (3,4,5-trihydroxybenzoic acid esters) can inhibit thrombosis A2 (TXA2) i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/235A61P1/16A61P31/12
Inventor 张庆民秦卫华
Owner SHENGHUA GUANGZHOU PHARMA SCI & TECH
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