6 results about "Famciclovir" patented technology

Human herpesviruses can infect barrier and immune cells of the intestinal tract to cause microbiome dysbiosis and inflammation. Microbiome dysbiosis can affect the availability of nutrients required for normal brain function. Inflammation can compromise the intestinal barrier and lead to microbial translocation. Microbial translocation can cause brain infection or a mimicry auto-immune response. The embodiments restrict herpesvirus activity and injury by 1) the oral administration of exosomes containing factors to inhibit viral activity and restore homeostasis, and 2) the oral administration of recombinant bacteria that produce exosomes containing factors to inhibit viral activity and restore homeostasis. Another embodiment is the treatment of alpha-HHVs mediated intestinal dysfunction by nucleoside analogs, such as famciclovir, which may be combined with anti-viral exosome therapy.

The invention relates to the technical field of sludge conditioners, in particular to a pharmaceutical composition for preventing and treating oropharyngeal mucosal injury caused by radiotherapy and chemotherapy, which is prepared from forsythin, radix ophiopogonis total saponins, L-glutamine, famciclovir, yeast beta-glucan, recombinant human epidermal growth factors, glutathione and glycine. The oral pharyngeal mucosal injury caused by chemoradiotherapy can be prevented and treated. According to the traditional Chinese medicine composition, multiple components have a synergistic effect, and the traditional Chinese medicine composition has prevention and treatment effects and is free of incompatibility and good in tolerance; the mucous membrane adhesive force is enhanced, the administration frequency is reduced, the dosage forms are diversified, different injury degrees and medication scenes are adapted, and the clinical prevention and control requirements are comprehensively met.

This invention provides a traditional Chinese medicine composition for treating herpes zoster, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. The active ingredients of the traditional Chinese medicine composition include the following two parts: (1) Traditional Chinese medicine active ingredients: by weight, prepared from the following traditional Chinese medicinal materials: 10-15 parts of Isatis root; 10-15 parts of Isatis leaf; 10-15 parts of Astragalus; 8-12 parts of Angelica sinensis; 8-12 parts of white peony root; 6-10 parts of Ligusticum chuanxiong; 5-8 parts of safflower; 5-8 parts of red peony root; 5-8 parts of Salvia miltiorrhiza; 4-7 parts of cicada slough; 4-7 parts of earthworm; 4-7 parts of Saposhnikovia divaricata; and 3-5 parts of licorice; (2) Western medicine active ingredients: composed of acyclovir and famciclovir in a weight ratio of 1:1-3. This invention is a traditional Chinese and Western medicine combined drug developed based on the traditional Chinese medicine treatment of herpes zoster and combined with modern pharmaceutical technology. It adopts bio-enzymatic hydrolysis technology and nano-level drug delivery system, which significantly improves the bioavailability and targeting of the drug. It has a unique therapeutic effect on shingles, and its advanced preparation process results in significant efficacy, short onset time, convenient administration, few adverse reactions, safety and effectiveness. It can also prevent and relieve postherpetic neuralgia, providing a new option for the treatment of shingles.

The invention discloses a preparation method of famciclovir. The preparation method comprises the following steps: reacting diethyl malonate serving as a starting material with ethylene oxide to obtain an intermediate 1, reacting the intermediate 1 with paratoluensulfonyl chloride to generate an active ester side chain intermediate 2, and performing high-selectivity substitution reaction on the active ester side chain intermediate 2 and the ninth site of 2-amino-6-chloropurine to obtain a key intermediate 3; the intermediate 3 is subjected to ester bond reduction and ester formation through an existing mature famciclovir process, and finally pd / C dechlorination is performed to obtain the famciclovir. Compared with methods reported in existing literatures, the method has the advantages that raw materials are simple and easy to obtain, reaction conditions are simple, 9-site selectivity is larger than 99%, the total reaction yield is high, and industrial large-scale production is facilitated.

The invention belongs to the field of medicine preparation, and particularly relates to a preparation method of a sustained-release famciclovir tablet for treating feline herpes virus infection, the preparation method is used for preparing the sustained-release famciclovir tablet, and the preparation method comprises the following steps: preparation of quick-release layer particles, preparation of sustained-release layer particles, double-layer tabletting and coating. Three-stage drug release is realized by preparing the double-layer tablet core containing the quick release layer and the slow release layer and combining the pH responsive coating layer. The quick-release layer and the slow-release layer are granulated by adopting specific auxiliary materials according to a certain ratio, and are subjected to fluidized bed coating by using a coating solution containing hydroxypropyl methylcellulose acetate succinate after double-layer tabletting. The prepared sustained-release tablet is not released or is released in a small amount in the stomach, is continuously released in the small intestine and maintains drug release in the colon for 12 hours, the in-vitro release degree conforms to an ideal curve, the blood concentration can be maintained for a long time, meanwhile, in-vivo drug conversion supersaturation caused by excessive drug release in a short time is avoided, and the drug utilization efficiency is improved.

The invention relates to the field of food detection, in particular to an analysis and detection method for antiviral drug residues in eggs, which comprises the following steps: S1, sample pretreatment: 1.1, sample preparation: shelling eggs, homogenizing, and storing at 4 DEG C; 1.2, extracting: weighing a homogenate sample, extracting twice by using 90% acetonitrile-1% formic acid solution, and merging supernate; 1.3, purifying and redissolving: purifying the supernate through an EMR-Lipid solid-phase extraction column, collecting eluent, blowing the eluent to be nearly dry at 40 DEG C by nitrogen, redissolving by using a formic acid-methanol solution, and filtering to obtain a matrix extracting solution; s2, preparing a standard solution; s3, instrument detection: performing chromatography-tandem mass spectrometry detection; s4, quantitative analysis: calculating the residual quantity of the eight antiviral drugs in the eggs according to the quantitative ion peak area by adopting a matrix matching standard curve external standard method. The precise detection of eight viruses, namely nevirapine, peramivir, famciclovir, rimantadine, amantadine, oseltamivir, imiquimod and memantine, is realized.