Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Famciclovir sustained-release granules and production method thereof

A technology of sustained-release granules and famciclovir, which is applied in the field of medicine, can solve the problems of unfavorable patient compliance, does not solve the problem of frequent taking of famciclovir, etc., and achieves the effect of reducing the frequency of taking medicine, improving compliance and good taste.

Active Publication Date: 2017-07-14
武汉人福药业有限责任公司
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In summary, the existing famciclovir preparations do not solve the frequent problem of famciclovir medication (adults each 0.25g, 3 times a day), which is not conducive to patient compliance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Famciclovir sustained-release granules and production method thereof
  • Famciclovir sustained-release granules and production method thereof
  • Famciclovir sustained-release granules and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 famciclovir sustained-release granules

[0035]

[0036] The raw and auxiliary materials are respectively passed through a 100-mesh sieve, and the raw materials and hydroxypropyl methylcellulose are weighed, and the raw and auxiliary materials are preliminarily mixed by an equal-volume increasing method, and then the prescribed amount of polyvinylpyrrolidone and microcrystalline cellulose are added, and an appropriate amount of 95% ethanol, made of soft material, granulated through a 16-mesh sieve, dried at 50°C for 2 hours, then granulated through a 16-mesh sieve, added with 5% magnesium stearate and 35% lactose and mixed evenly.

Embodiment 2

[0037] The preparation of embodiment 2 famciclovir sustained-release granules comparative example 1

[0038]

[0039]

[0040] The raw and auxiliary materials are respectively passed through a 100-mesh sieve, the bulk drug and hydroxypropyl methylcellulose are weighed, the raw and auxiliary materials are preliminarily mixed by an equal increase method, then the prescribed amount of microcrystalline cellulose is added, and an appropriate amount of 95% ethanol is added, Make soft material, pass through a 16-mesh sieve to granulate, dry at 50°C for 2 hours, pass through a 16-mesh sieve for granulation, add magnesium stearate and lactose and mix well.

Embodiment 3

[0041] The preparation of embodiment 3 famciclovir sustained-release granules comparative example 2

[0042]

[0043] The raw and auxiliary materials were respectively passed through a 100-mesh sieve, and the bulk drug was weighed, and the prescribed amount of polyvinylpyrrolidone and microcrystalline cellulose was added, and an appropriate amount of 95% ethanol was added to make a soft material, passed through a 16-mesh sieve for granulation, dried at 50°C for 2 hours, and then Sieve through a 16-mesh sieve for granulation, add magnesium stearate and lactose and mix well.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides famciclovir sustained-release granules and a production method thereof. The famciclovir sustained-release granules comprise the following components in percentage by weight: 20-30% of famciclovir, 20-40% of adhesives, 2-5% of disintegrants, 2-5% of lubricants and 20-40% of filler. The famciclovir sustained-release granules are low in administration dosage, stable in quality and simple and easily operable in production process, and are suitable for industrial production.

Description

[0001] 1. Technical field [0002] The invention belongs to the technical field of medicine, and in particular relates to a famciclovir sustained-release granule and a preparation method thereof. [0003] 2. Background technology [0004] Famciclovir (Famciclovir) is the diethyl acyl ester of the 6-deoxy derivative of penciclovir (penciclovir), its structure is shown in formula I, oral absorption is good, and bioavailability is high, so replace penciclovir. [0005] Famciclovir (Famciclovir) is a second-generation ring-opening nucleoside anti-herpes virus drug. It is a diethyl acyl lipid prodrug of the 6-deoxy derivative of penciclovir (penciclovir). On March 29, it was approved by the U.S. Food and Drug Administration (FDA) for marketing, and the trade name is Famvir. Famciclovir is a prodrug of the antiviral drug penciclovir, which is used to treat herpes zoster and genital tract and cold sores, and is also used to treat recurrent herpes simplex attacks in AIDS patients. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/52A61P31/22
CPCA61K9/0002A61K9/1623A61K9/1635A61K9/1652A61K31/52
Inventor 邓霞飞刘艳红方智唐维刘红华
Owner 武汉人福药业有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com