499results about How to "Mild experimental conditions" patented technology

The invention discloses a synthesis method of an alkali metal salt containing sulfonyl chloride or phosphorus imide: the alkali metal salt is prepared by subjecting compound (V-2) and sulfuryl chloride or phosphorus oxychloride to nucleophilic substitution under the presentation of acid binding agents; the invention further discloses a synthesis method of an alkali metal salt containing fluorine sulfonyl or phosphorus imide, the alkali metal salt is prepared by reacting (sulfonyl chloride) (perfluorinated alkyl) imide salt (V-1) or (dichloro phosphoryl) (perfluorinated alkyl sulfonyl) imide salt (V-2) with fluorinated reagents. The synthesis methods have the advantages that the experiment condition is mild, and the used materials are convenient to store and prepare; the preparation rate is high, the purification is simple, the preparation cost is low, and the methods are suitable for mass industrial preparation. The preparation rate and the purity of the resultants are high, and the resultants can be used as lithium salt electrolyte materials for lithium batteries, or for preparing catalytic agents, and for synthesizing high-performance ionic liquids.

The invention discloses a preparation method of a graphene composite aerogel absorbing material and application thereof. The material is obtained by one-step reduction self-assembled reaction on reduced graphene oxide, a polymer A and magnetic nano particles which wrap a polymer B. The absorbing material is low in density and high in absorbing strength, effectively absorbs bandwidth, and has excellent absorbing property on an X wave band. In the absorbing material, the content of graphene is low, the cost is low, and therefore, the graphene composite aerogel absorbing material has wide application potential and market prospect in the field of invisibility of aircrafts, electromagnetic shielding of radar and communication equipment, and electromagnetic safety protection.

The invention belongs to an alloy nano-particle preparation method based on a protein reduction method. Firstly, 3-50mg ML<-1> of purified protein solution is prepared; 10-30 mM of precious metal salt solution formed by one of silver, gold, platinum or palladium or mixing any two of the silver, the gold, the platinum or the palladium is prepared; 20-30 mM of metal salt solution of copper, nickel, ferrous iron or aluminum is prepared; the purified protein solution, the precious metal salt solution and the metal salt solution are mixed to prepare a nano alloy precursor solution, the pH of the nano alloy precursor solution is adjusted to an alkaline range through a sodium hydroxide solution, the precursor solution is evenly mixed and then high-purity nitrogen is introduced for deoxygenization, then the mixture is placed in water bath to be heated, and nano alloy quickly reduced by protein can be obtained. Time for preparing precious metal nano-particles reduced by the protein is shortened from 1-5 h to 5-30 min, nano alloy with properties of target nano-particles can be quickly and effectively synthesized, the synthesis rate is greatly increased, and commercial application is facilitated.

The invention relates to a water-soluble metal ion loaded hybrid material and a method for preparing the same. The water-soluble metal ion loaded hybrid material comprises carrier molecules A, stabilizer molecules B and metal ions. The method includes steps of stirring and mixing aqueous solution of the carrier molecules A and aqueous solution of the stabilizer molecules B with each other to obtain mixed solution; regulating a pH (potential of hydrogen) value of the mixed solution; adding metal ion salt solution into the mixed solution drop by drop; continuously stirring the mixed solution and the metal ion salt solution; adding precipitants into the mixed solution and the metal ion salt solution; filtering the mixed solution and the metal ion salt solution to obtain precipitates; drying the precipitates by the aid of a vacuum drying oven to obtain the dry-state metal ion loaded hybrid material. The water-soluble metal ion loaded hybrid material and the method have the advantages that the metal ions in the metal ion loaded hybrid material are stably and effectively connected onto molecular chains of the carrier molecules in ionic bond and coordination bond forms, so that the water-soluble metal ion loaded hybrid material is good in water solubility, and the metal ion loading capacity of the water-soluble metal ion loaded hybrid material can be adjusted; the method for preparing the hybrid material is free of pollution and easy to implement, and products rarely contain impurities; the water-soluble metal ion loaded hybrid material prepared by the aid of the method can be widely applied to the aspects such as antibacterial finishing liquid, self-assembly stock solution and intermediates prepared from metal nano-materials.

The invention discloses a hepatic targeted temperature sensitive microsphere and a preparation method therefor, and belongs to the functional polymer material field, and especially relates to a drug sustained release and targeted drug delivery material and a preparation method therefor. The temperature response range of the material is 25 DEG C-37 DEG C, and the particle size of the microsphere is about 500nm. The microsphere can be prepared through the following method: glycyrrhetinic acid (GA) is modified by ethylene diamine and acrylic acid (AAc) and vinyl monomers are generated; ammonium persulfate (APS) is employed as an initiator, N,N-methylene bisacrylamide (MBA) is employed as a cross-linking agent, hepatic targeted temperature sensitive microspheres are prepared through a semicontinuous soap-free emulsion polymerization method. The preparation method has simple technological processes, and mild experiment conditions, needs no special devices, has a low investment cost, and has good operability. The reagents are all common reagents. The reaction residues are easy to remove. The preparation method is convenient for industrial implementation.

The invention discloses a drug nanoparticle preparation based on complexing coating, a preparation method and an application. The preparation comprises a complex formed by a poorly-soluble drug, a polyphenol compound, and metal ions; Firstly, a suspension of the poorly-soluble drug particles is obtained by solvent exchange; then with the rapid complexation effect of the polyphenol compound and metal ions, a stable coating layer is formed on the drug particle surfaces, so as to obtain the stable poorly-soluble drug nanoparticle preparation. The invention also discloses a monodisperse nanoparticle preparation of the poorly-soluble drug obtained by the method, and an application thereof. The poorly-soluble drug nanoparticle preparation of the invention is controllable in particle size, uniform in distribution, high in drug loading ratio, and good in stability.

The invention relates to a beta-cyclodextrin-modified polyamide-dendrimer and a preparation method of a gold nanoparticle compound of the beta-cyclodextrin-modified polyamide-dendrimer. The preparation method includes: mixing DMSO (dimethyl sulfoxide) solutions in which beta-CD and CD I are dissolved, respectively, adding DMSO solution of G5PAMAM after reacting, performing stirring at room temperature for 3 d, and performing dialysis and freeze-drying to obtain G5.NH2-beta-CD; adding HauCl4.4H2O solution into the obtained G5.NH2-beta-CD solution, adding NaBH4 solution after stirring, performing stirring for 2-4 h, and performing dialysis and freeze-drying to obtain a target compound {(Au0)25-G5.NH2-beta-CD}. The prepared compound is a good gene carrier, capable of successfully carrying and expressing pDNA-transfected human embryonic kidney cells, transfection conditions are mild, operating is easy, transfection efficiency is high, and the compound has a promising application in terms of biomedicine such as gene therapy.

The invention discloses an epirubicin loaded graphene quantum dot drug carrying system and a preparation method thereof. The preparation method includes the following steps: preparation of graphene quantum dots by a hydrothermal method; loading an anti-cancer drug with the graphene quantum dots; and performing a drug slow-release experiment, and performing a cytotoxicity test on the drug carrying system. The graphene quantum dots prepared by the hydrothermal method are used as a drug carrier for being loaded with epirubicin, greatly improve the drug loading rate, and show a quite good inhibitory effect on tumor HeLa cells. The preparation method of the drug carrying system is simple to operate, mild in reaction conditions and high in drug loading rate, and is expected to have a broad application prospect in the field of biological medicine.

The present invention discloses a host-guest explosive embedded with small molecule gas, and a preparation method thereof, wherein N2O gas is continuously introduced into a CL-20 solution, and the CL-20 and the N2O are subjected to co-crystallizing by using a solution re-crystallization method so as to obtain the CL-20 and N2O co-crystallized host-guest explosive crystal. According to the present invention, the method is based on the host-guest chemical thought, and the gas-liquid co-crystallization method is used to co-crystallize the small molecule gas and the explosive in the solution so as to obtain the CL-20 host-guest explosive crystal embedded with the N2O gas; the method has characteristics of simple preparation process and mild experiment condition, wherein the small molecule gas can be embedded into the explosive crystal without the high pressure gas; and the new idea can be provided for the structural optimization and the performance control of the high energy explosives, and the basic support can further be provided for the design and the manufacture of the advanced weapon.

The invention relates to the process for preparing cadmium selenide and cadmium telluride nano sticks , wherein cadmium oxide is used as the monomer, and tetradecanoic acid is used as ligand, by controlling the nucleation and growth procedure of the nanocrystalline, and injecting selenium or tellurium precursor solution into the cadmium precursor solution at the temperature of 190 deg. C to 230 deg. C, the nano sticks can be prepared at the temperature of 160-180 deg. C. The advantages of the cadmium selenide and cadmium telluride nano sticks are high yield, narrow dimension distribution, uniform shapes and fine repeatability for experiment.

The invention relates to a photosensitizer nanoparticle as well as a preparation method and application thereof. The photosensitizer nanoparticle comprises components of photosensitizer molecules and regulation and control molecules for conducting regulation and control on the composition structure of the photosensitizer; the preparation of the photosensitizer nanoparticle is realized through self-composition of the photosensitizer molecules and the regulation and control molecules. The photosensitizer nanoparticle has the advantages that the size is controllable, the distribution is uniform, and the medicine loading capacity are high; the preparation method is simple and quick, and does not need to use any toxic solvent or additive; the photosensitizer nanoparticle can be applied to preparation of medicines for tumor positioning image formation and photodynamic therapy, has the characteristics of being high in biocompatibility and high in tumor tissue gathering, and has excellent application prospects when being used as the anti-tumor and photodynamic therapy medicine.

The invention relates to a preparation method of alpine pine needle active extract and a whitening anti-aging active cosmetic. The whitening anti-aging active cosmetic extract is obtained by carrying out crushing, extracting, filtering, extracting and separating, concentrating and the like on the alpine pine needles, and then is added into a cosmetic for preparing the cosmetic with the whitening anti-aging active cosmetic function. The alpine pine needle extract has the characteristics of restraining tyrosinase, resisting radical and the like, and has the special efficacies of whitening and resisting aging. The raw materials used in the invention are natural and regenerative; the preparation process is environment-friendly, safe, and simple and unique in steps; the obtained extract has good stability and long efficacy, and can be added into cosmetics at the medium and high temperature stages of the preparation process.

The invention discloses a finishing method of a cotton-hydrophobic fabric based on BTCA-TEOS-OA combined treatment and belongs to the technical field of functional textiles. The finishing method is characterized in that 1,2,3,4-butanetetracarboxylic acid is adopted for pretreating the fabric so as to increase the capability of reaction between the fabric and a following chemical reagent and function as a bridge; tetraethoxysilane is hydrolyzed and condensated under the acidic or alkali condition so as to form particulate matters on the surface of the fabric and play a role in roughening the fabric; due to long-chained alkane type octadecylamine, the surface energy of the fabric can be effectively reduced, and further the environmental problem caused by total-fluoride energy is avoided. The finishing method disclosed by the invention has the advantages that the traditional processes of soaking, rolling, drying and baking are adopted, and a product is good in uniformity and repeatability and low in cost. BTCA, TEOS and OA adopted in the finishing process need to be carried out under the condition of weak acid and weak alkaline, the baking temperature is low and the damage on the fabric is less. The finishing method can be used for finishing the hydrophobic function of the cotton fabrics.

The invention relates to a preparation method of a hyaluronic acid targeted carbon nano-tube loaded anti-cancer medicine. The preparation method disclosed by the invention comprises the following steps: (1), chemically bonding a multi-walled carbon nano-tube (MWCNT) with PEI (Polyetherimide) in dimethyl sulfoxide through EDC (Ethylene Dichloride), dialyzing, freeze-drying, and synthesizing MWCNT/PEI; (2), dissolving hyaluronic acid in water, and activating by adding EDC; (3), adding FITC (Fluorescein Isothiocyanate) into MWCNT/PEI to stir, adding activated hyaluronic acid (HA), dialyzing, freeze-drying, and synthesizing MWCNT/PEI-FI-HA; and (4), dissolving the MWCNT/PEI-FI-HA in water, adding an aqueous solution of DOX (Doxycycline), adjusting the pH value, sufficiently stirring, dialyzing, and freeze-drying, thus obtaining a medicine loading compound. The preparation method disclosed by the invention is simple in process and easy to operate; the experiment is carried out at normal temperature and normal pressure; after being loaded with the DOX, the hyaluronic acid targeted carbon nano-tube loaded anti-cancer medicine prepared by the preparation method disclosed by the invention has the effects of releasing and actively locating cells in a pH sensitive manner, and therefore, the preparation method disclosed by the invention has a good practical value.

The invention discloses a method for preparing a graphene aerogel supported carbon nanotube and a ZIF-67 lithium battery electrode material. The method comprises the steps of preparing a graphene oxide by performing a chemical oxidation stripping method on natural graphite powders; adding the graphene oxide into a carbon nanotube (CNTs) to carry out ultrasonic treatment; preparing a compound (GAS@CNTs) of a porous graphene aerogel (GAS) and the CNTs through a hydrothermal method and a freeze-drying method; and stirring the compound with a ZIF-67 solution, stewing, after that, the graphene aerogel (GAS), the supported carbon nanotube (CNTs) and a ZIF-67 lithium battery electrode material (GAS@CNTs@ZIF-67) can be prepared. The key of the method is preparing the compound of the GAS and the CNTs is prepared through the hydrothermal method and the freeze-drying method, and then adding the ZIF-67, stirring evenly and dispersing, vacuum drying and obtaining the GAS@CNTs@ZIF-67 lithium battery electrode material; and besides, an electrochemical test shows that, the relative specific capacity of the novel graphene aerogel supported carbon nanotube and the ZIF-67 lithium battery electrode material is high, the cycling stability is good, and the novel graphene aerogel supported carbon nanotube and the ZIF-67 lithium battery electrode material are commercialized and can be applied to pure electric vehicles.

The invention discloses a responsive chitosan microsphere/cellulose hydrogel drug-loading composite membrane and preparation thereof. The preparation includes: preparing chitosan microspheres that load tetracycline hydrochloride which is an antibacterial drug; dispersing the prepared chitosan microspheres and 5-fluorouracil evenly in three-dimensional network structure formed by crosslinking carboxymethyl cellulose and cystamine dihydrochloride, wherein 5-fluorouracil is an anticancer drug. The responsive chitosan microsphere/cellulose hydrogel drug-loading composite membrane has good biocompatibility and reduction response, can release tetracycline hydrochloride and 5-fluorouracil in controlled manner in cancer tissue areas, and has antibacterial and anticancer functions.

The invention relates to an antibacterial finishing agent and a preparation method and antibacterial application thereof. The antibacterial finishing agent is a hybrid material aqueous solution loaded with silver sulfide nano-particles and is composed of a hybrid material loaded with silver sulfide nano-particles and water, wherein the hybrid material is composed of carrier molecules A, stabilizer molecules B and silver sulfide nano-particles. The preparation method comprises the following steps: stirring and mixing an aqueous solution of A and an aqueous solution of B, regulating the pH value of the mixed solution, sequentially dropwise adding a silver ion salt solution and a metal sulfide sulfur source aqueous solution into the mixed solution, and stirring, thereby obtaining the hybrid material aqueous solution. The silver sulfide nano-particles in the hybrid material loaded with the silver sulfide nano-particles are stably and effectively connected to a molecular chain of the carrier molecules in forms of ionic bonds and coordinate bonds. The water soluble antibacterial finishing agent is very stable, is high in dispersity and has an excellent broad-spectrum antibacterial effect. Moreover, cotton textiles treated by the using method have extremely high inhibition rate on multiple bacteria after standard soaping of over 20 times.

The invention relates to a composite film for guiding bone tissue regeneration and a preparation method of the composite film. The composite film is a double-layer film, wherein a bottom-layer film is an L-lactide and caprolactone copolymer (L-PLCA) cast film with a compact structure, and the molar ratio of monomer components is (50:50) to (95:05); a surface layer is an L-PLCA and hydroxyapatite (HA) or tricalcium phosphate (beta-TCP) compound electrospinning film with a micropore structure, wherein the mass ratio of HA or beta-TCP in the electrospinning film is 10-50wt%, and the particle size of the electrospinning film can be nano-grade or micro-grade. The double-layer composite film is relatively good in mechanical performance and bone-like apatite deposition induction capacity, favorable in flexibility and capable of realizing performance regulation through regulating the molar ratio of L-PLCA, the content of the component HA or beta-TCP and the microstructure of the electrospinning film so as to be a novel degradable double-layer composite film capable of guiding bone tissue regeneration.

The invention discloses a carbon film obtained by self assembly of graphene oxide or its derivatives and a preparation method thereof, and relates to a preparation method for a highly ordered carbon film. The objective of the invention is to solve the problems existing in the prior art that the combination between a carbon film and a substrate is poor, the preparation technology is complex, the cost is high, and the thickness of carbon films is difficult to control in the process of preparation. The carbon film provided in the invention uses graphene oxide or its derivatives as the raw material and is obtained through the process of self assembly. The carbon film is prepared by the following steps: dispersing graphene oxide or its derivatives in a solvent so as to obtain a solution, immersing a substrate into the solution and allowing the solution to stand at a constant temperature for assembly, wherein the temperature is in a range of 50 to 100 DEG C. The carbon film prepared in the invention has smooth surfaces, strong bonding force to the substrate and good light transmittance and mechanical properties; the modulus of the carbon film is 80 to 120 GPa, and the hardness is 7 to 9 Gpa; the carbon film is orderly orientated along the surface of the substrate, and the thickness of the carbon film is 10 nm to 2 mu m. The preparation process is controllable and concise and produces products with controllable thickness. The carbon film provided in the invention has broad application prospects in such fields as electrode materials, electronic chips, solar cells and high efficient catalysis.