Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug nanoparticle preparation based on complexing coating and preparation method and application

A technology of nanoparticles and complexes, which is applied in the field of drug nanoparticle preparations based on complex coating, can solve the problems of difficult promotion and high cost, and achieve controllable size and shape, low cost, good shape and Effects with easy size control

Active Publication Date: 2014-07-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
View PDF12 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of metal Au in this method has the disadvantages of high cost and difficult promotion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug nanoparticle preparation based on complexing coating and preparation method and application
  • Drug nanoparticle preparation based on complexing coating and preparation method and application
  • Drug nanoparticle preparation based on complexing coating and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] It is the ethanol solution of paclitaxel that volume mass concentration is 40mg / mL, the aqueous solution of tannic acid that volume mass concentration is 80mg / mL and the FeCl that volume mass concentration is 20mg / mL 2 Under ultrasonic conditions, the ethanol solution of the above-mentioned paclitaxel of 1ml is added to 100ml water, obtains the dispersion system that contains paclitaxel particle; In the above-mentioned dispersion system, add the tannic acid aqueous solution of 1ml respectively (concentration is 80mg / mL ) and 1ml volume mass concentration is 20mg / mL FeCl 2 aqueous solution; and after continuous ultrasonication for 30 seconds, a stable paclitaxel nanoparticle solution preparation was obtained; the suspension was centrifuged to obtain paclitaxel nanoparticle powder.

[0046] The particle size distribution of the obtained nanoparticles is shown in the attached figure 1 (a); The measured Zeta potential of the nanoparticles is -21.7eV (attached figure 2 In...

Embodiment 2

[0048] Configure the glycerin solution of paclitaxel with a volume mass concentration of 2 mg / mL, the aqueous solution of gallic acid with a volume mass concentration of 200 mg / mL and the CuSO with a volume mass concentration of 2 mg / mL 4 Under ultrasonic conditions, the glycerin solution of the above-mentioned paclitaxel of 10ml is added in 100ml water, obtains the dispersion system that contains paclitaxel particle; Rapidly in above-mentioned dispersion system, add the gallic acid aqueous solution of 1ml respectively (concentration is 200mg / mL) And 1ml volume mass concentration is 2mg / mL CuSO 4 aqueous solution; and after continuous ultrasonication for 5 seconds, a stable paclitaxel nanoparticle solution formulation is obtained;

[0049] The particle size distribution of the obtained nanoparticles is shown in the attached figure 1 (b); The measured Zeta potential of the nanoparticles is -24.3eV (attached figure 2 in b). Scanning electron microscope pictures of the obtain...

Embodiment 3

[0051] It is the ethanol solution of the docetaxel that volume mass concentration is 2mg / mL, the aqueous solution of the catechol of 80mg / mL volume mass concentration and the aqueous solution of the zinc oxalate that volume mass concentration is 20mg / mL; The ethanol solution of the above-mentioned docetaxel was added to 100ml water to obtain a dispersion system containing docetaxel particles; quickly to the dispersion system, add 1ml of catechol aqueous solution (concentration is 80mg / mL) and 1ml volume mass concentration It is an aqueous solution of 20 mg / mL zinc oxalate; and after continuous ultrasonication for 30 seconds, a stable docetaxel nanoparticle solution preparation is obtained;

[0052] The particle size distribution of the obtained nanoparticles is shown in the attached figure 1 (c).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a drug nanoparticle preparation based on complexing coating, a preparation method and an application. The preparation comprises a complex formed by a poorly-soluble drug, a polyphenol compound, and metal ions; Firstly, a suspension of the poorly-soluble drug particles is obtained by solvent exchange; then with the rapid complexation effect of the polyphenol compound and metal ions, a stable coating layer is formed on the drug particle surfaces, so as to obtain the stable poorly-soluble drug nanoparticle preparation. The invention also discloses a monodisperse nanoparticle preparation of the poorly-soluble drug obtained by the method, and an application thereof. The poorly-soluble drug nanoparticle preparation of the invention is controllable in particle size, uniform in distribution, high in drug loading ratio, and good in stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to the application of nanocarriers in the field of biotechnology, and specifically discloses a drug nanoparticle preparation based on complexation coating, its preparation method and application, and the prepared nanomedicine has a high drug loading capacity and good biological properties. technical background [0002] In recent years, the rapid development of high-throughput screening technology has enabled the development and utilization of a large number of active compounds and drugs. However, more than 40% of the drugs have insoluble problems, and this ratio is as high as more than 60% in the synthetic drugs, which has brought great obstacles to clinical drug delivery. As we all know, the solubility and dissolution rate of microparticle drugs will increase with the increase of surface area, so a large number of patent methods that adopt mechanical grinding and precipitation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/48A61K9/14A61K9/19A61P35/00
Inventor 闫学海沈桂芝陈成军邹千里马光辉
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com