Application of nucleoside type antiviral medicine to preparation of medicine for treating infarction diseases
An antiviral drug and nucleoside technology, applied in the field of medicine, can solve problems such as increased risk of thrombosis, achieve the effects of reducing severity and frequency, inhibiting P-selectin expression, and inhibiting activation
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Embodiment 1
[0039] This embodiment combines Figure 1~3 Effects of famciclovir on platelet aggregation, platelet GPIIb / IIIa activation, and P-selectin expression will be described.
[0040] (1) The experimental method for studying the influence of famciclovir on the degree of platelet aggregation is as follows:
[0041] Get male C57BL / 6 mice (25-30g) and divide into random groups (N=6), respectively model control group, model group, famciclovir low-dose group (LFCV, 60mg / kg), famciclovir high-dose group (HFCV, 120mg / kg). kg), administered once a day for seven consecutive days. The model control group was given an equal volume of solvent saline in the same way. On the evening of the seventh day, the C57BL / 6 mice were fasted without water.
[0042] On the day of the experiment, mice were anesthetized by intraperitoneal injection of 3.5% pentobarbital sodium solution, blood was collected by heart puncture, and immediately mixed with 3.8% sodium citrate anticoagulant at a volume ratio of 9...
Embodiment 2
[0048] This embodiment combines Figure 4~6 The effects of famciclovir on arterial and venous thrombosis are described.
[0049] (1) The experimental method for studying the influence of famciclovir on arterial thrombosis is as follows:
[0050] Administration pre-treatment: male C57BL / 6 mice (25-30g) were randomly divided into groups (N=6), respectively model control group, model group, famciclovir low-dose group (LFCV, 60mg / kg), famciclovir high-dose group ( HFCV, 120mg / kg), administered once a day for seven consecutive days. The model control group was given an equal volume of solvent saline in the same way. On the evening of the seventh day, the C57BL / 6 mice were fasted without water.
[0051] On the eighth day, 1 hour after the last administration, C57BL / 6 mice were intraperitoneally injected with 3.5% pentobarbital sodium solution. After anesthesia, the skin was cut with surgical scissors along the midline of the mouse neck, and then the left side of the mouse was blu...
Embodiment 3
[0058] This embodiment combines Figure 7 The effect of famciclovir on cerebral infarction will be described.
[0059] The experimental method for studying the effect of famciclovir on cerebral infarction is as follows:
[0060] Administration pre-treatment: male C57BL / 6 mice (25-30g) were randomly divided into groups (N=6), respectively model control group, model group, famciclovir low-dose group (LFCV, 60mg / kg), famciclovir high-dose group ( HFCV, 120mg / kg), administered once a day for seven consecutive days. The model control group was given an equal volume of solvent saline in the same way. On the evening of the seventh day, the C57BL / 6 mice were fasted without water.
[0061] Modeling: on the eighth day, 1 hour after the last administration, C57BL / 6 mice were intraperitoneally injected with 3.5% pentobarbital sodium solution. After anesthesia, the animals were fixed on the operating table in a supine position, the neck hair was shaved, and the operation area was disin...
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