Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer

a cancer cell and telomere technology, applied in the field of cancer therapy, can solve the problems of no therapeutic composition based on nucleosides, tumors will go into crisis, and eventually di

Inactive Publication Date: 2009-05-28
ALT SOLUTIONS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]The present invention provides methods and compositions involving the use of antiviral nucleoside analogs for modulation, suppression or inhibition of lengthening of telomeres in cells without regard to the telomere lengthening mechanism (telomerase or ALT mechanism). The present invention also discloses methods for prevention and/or treatment of proliferative disorders and all types of cancers using specific nucleoside analogs. More particularly, the present invention discloses that acyclic nucleoside analogs that can interfere with telomerase activity and L-1 (LINE-1) retrotransposon encoded reverse transcriptase (L1RT) activity in proliferating cells including cancer cells (e.g., human cancer cells) at levels that are not cy

Problems solved by technology

Currently, there are no therapeutic compositions in use that are based on nucleoside analogs that are acyclic, anti-telomerase, ant

Method used

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  • Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer
  • Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer
  • Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer

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working examples

[0057]The following working examples are provided to demonstrate preferred embodiments of the invention, but of course, should not be construed as in any way limiting the scope of the present invention. The examples below were carried out using conventional techniques that are well known and routine to those of skill in the art, except where otherwise described in detail. Further, it should be appreciated by those of skill in the art that the techniques disclosed in the examples represent techniques found by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

[0058]Induction of telomere shortening, G2 arrest and apoptosis in telome...

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Abstract

Acyclic nucleoside analogs such as acyclovir, ganciclovir, penciclovir and the corresponding pro-drugs, i.e., valacyclovir, valganciclovir and famciclovir, respectively have been identified as inhibitors or antagonists of both telomerase (encoded by TERT) and reverse transcriptase encoded by L-1 (LINE-1) RT, and as useful for treating or preventing cancers induced or mediated by the two enzymes. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase positive and telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing TERT and L1RT are also disclosed.

Description

[0001]This application claims the benefit of U.S. Provisional Application No. 60 / 682,110 filed May 18, 2005, and the text of application 60 / 682,110 is incorporated by reference in its entirety herewith.FIELD OF THE INVENTION[0002]The present invention is directed to the field of cancer therapy. Specifically, the present invention relates to the regulation of telomere elongation in cancer cells. More particularly, the present invention relates to the use of acyclic nucleoside analogs for treating or preventing cancers.BACKGROUND OF THE INVENTION[0003]An asymmetry in the synthesis of leading and lagging DNA strands creates the “end problem” for replication of linear genomes.1 To overcome this problem, eukaryotic chromosomes have specialized end structures, telomeres, consisting of TTAGGG repeats.2 Telomerase3,4 is a ribonucleoprotein enzyme that elongates telomeres and therefore maintains chromosomal stability in majority of cancer cells during cell doubling5. The gradual loss of DNA ...

Claims

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Application Information

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IPC IPC(8): A61K31/7088C12N5/02A61P35/04
CPCA61K9/0019A61K9/0095A61N5/10A61K45/06A61K31/522A61P5/38A61P11/00A61P15/00A61P17/00A61P19/00A61P35/00A61P35/04A61P43/00
Inventor BONDAREV, IGOR E.
Owner ALT SOLUTIONS INC
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