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99results about "Positive/negative analyte ion analysis/introduction/generation" patented technology

MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection

An ion mobility / mass spectrometry method and instrument using aerosolized samples and dual positive and negative mode detection is described. Sample preparation methods are also described.
Owner:RGT UNIV OF CALIFORNIA +1

Mass spectrometer and reaction cell for ion-ion reactions

The invention relates to a reaction cell for reactions between different types of ion species and a related mass spectrometer to analyze the ion products. The invention consists in an RF-operated straight ion guide with a side inlet, particularly suitable for reactions between positive and negative ion species, one ion species being fed in through the side inlet. Particularly favorable is an ion guide made up of a set of coaxial apertured diaphragms with a slight axial potential gradient. The reactions can be used for a fragmentation of multiply charged protein or peptide ions by electron transfer, or for the removal of excess charges of multiply charged biopolymer ions, for example.
Owner:BRUKER DALTONIK GMBH & CO KG

Capacitive discharge plasma ion source

In a system for chemical analysis, an RF-driven plasma ionization device including a pair of spaced-apart and plasma-isolated electrodes, the electrodes are connected to a power source wherein the electrodes act as plates of a capacitor of a resonant circuit, the gas electrically discharges and creates a plasma of both positive and negative ions, and the voltage is applied as a continuous alternating waveform or as a series of pulses, such as a packet waveform.
Owner:DH TECH DEVMENT PTE

Detection of positive and negative ions

An ion detector comprises an ion guide with electrodes arranged about a first axis; a positive ion detection device with an ion inlet at a first side of the ion output section offset from and at an angle to the first axis; and a negative ion detection device with an ion inlet at a second side opposite the first side, offset from and at an angle to the first axis. A negative voltage bias applied to the positive ion device accelerates positive ions toward the inlet along a path including a component along a second axis orthogonal to the first axis. A positive voltage bias applied to the negative ion detection device accelerates negative ions toward the inlet along a path that includes a component along the second axis orthogonal to the first axis in a direction generally opposite to the path of the positive ions.
Owner:BRUKER DALTONIK GMBH & CO KG

Device for manipulating charged particles

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
Owner:SHIMADZU RES LAB EURO

Mass spectrometric apparatus and ion source

A mass spectrometric apparatus capable of generating and detecting positive and negative ions stably at the same time. The apparatus preferably comprises: an opening through which a sample gas is introduced; an ion source to generate ions of the sample gas; and a mass spectrometer to analyze the mass of the generated ions. The ion source utilized with the mass spectrometric device comprises: a first needle electrode on which a voltage is applied in order to generate positive ions of the sample gas introduced through the opening; a first counter electrode having a first opening through which the sample gas and the positive ions pass; a second counter electrode disposed opposite the first counter electrode having a second opening through which the sample gas and the positive ions pass; a second needle electrode on which voltage is applied in order to generate negative ions of the sample gas; and a vent through which the sample gas is ejected. Generated ions are then introduced into a vacuum region via an aperture and subjected to mass analysis.
Owner:HITACHI LTD

Method for introducing ions into an ion trap and an ion storage apparatus

A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.
Owner:SHIMADZU RES LAB EURO

Mass spectrometer for both positive and negative particle detection

A mass spectrometer suitable to measure both positive and negative particles, such as ions for example in a vacuum chamber. This spectrometer is provided with a turnable permanent magnet segment, which provides the gap of a yoke with adequate magnetic flux having the appropriate direction to separate the positive or the negative particles. Changing the polarity adjusts the flight path of the ions. Thus, negatively charged ions and positively charged ions will follow similar flight paths under opposite polarities, permitting the use of a single array of detectors. One or more coils may be used in place of or in addition to the turnable permanent magnet segment in order to provide the appropriate magnetic flux to the gap, and / or facilitate the turning process of the turnable magnet segment. The turnable magnet and / or the coils may be inside or outside the vacuum chamber. The detector may comprise at least one detector area, two charge mode amplifiers coupled to the detector area, a first CCD shift register coupled to a first one of the charge mode amplifiers and a second CCD shift register coupled to a second one of the charge mode amplifiers.
Owner:O I CORP

Mass Spectrometer With Beam Expander

A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
Owner:MICROMASS UK LTD

Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer

A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND +1

Ion sampling apparatuses in fast polarity-switching ion sources

The present invention provides ion sampling apparatuses that can be used in a fast polarity-switching electric field. In some embodiments, the ion sampling apparatus comprises a capillary made with an insulator, with a resistive inner or outer surface. Devices and systems comprising the ion sampling apparatuses, as well as methods of use thereof, are also provided.
Owner:AGILENT TECH INC

Time-of-flight spectrometry and spectroscopy of surfaces

Described is an analytical method and apparatus for counting and measuring the flight time of secondary electrons, secondary ions and neutrals, scattered ions and / or neutrals and for correlating coincidences between these while maintaining a continuous un-pulsed, micro-focused, primary particle beam for impinging a surface for purposes of microprobe imaging and microanalysis.
Owner:IONWERKS

Correcting phases for ion polarity in ion trap mass spectrometry

In a method and apparatus for adjusting a composite electric field to be applied to an ion trap to accommodate switching the operation of the ion trap between a positive ion mode and a negative ion mode, the composite electric field includes a plurality of component fields including at least one AC trapping field and one or more supplemental AC fields. A phase of one or more of the component fields is adjusted such that a force imparted by the composite field to a negative ion in the ion trap will be substantially the same as the force imparted by the composite field to a positive ion in the ion trap.
Owner:VARIAN INC

Confining ions with fast-oscillating electric fields

The applicants' teachings provide methods, systems, and apparatus useful in operating mass spectrometers and other devices incorporating multipole rod sets or other multi-electrode devices to simultaneously contain ions of both positive and negative charges through the simultaneous application to the rods or other electrodes of both radio-frequency (RF) and alternating (AC) currents.
Owner:DH TECH DEVMENT PTE

Mass spectrometer

In a mass spectrometer according to the present invention, when MRM measurements for a plurality of MRM transitions need to be performed within one cycle, a measurement order rearranger determines an analysis sequence by sorting the measurement in ascending order of the absolute value of an optimum application voltage (an application voltage which gives the highest ionization efficiency) to the nozzle of the ESI probe. An analysis controller performs the analysis by controlling the high-voltage power source and other relevant units according to the determined analysis sequence. Since the voltage applied to the nozzle within one cycle has no period in which the voltage is changed in the decreasing direction with the same polarity, the cycle time becomes shorter than in a conventional device.
Owner:SHIMADZU CORP

Method for introducing ions into an ion trap and an ion storage apparatus

The present invention describes a method of introducing ions into an ion trap and an ion storage device. The first ions are introduced into the ion trap through an entrance aperture to the ion trap by means of introducing means. Operating conditions of said introduction means are adjusted to introduce a second ion having a different polarity than the first ion into the ion trap through said same entrance aperture.
Owner:SHIMADZU RES LAB EURO

Mass spectrometer and mass spectrometry method

An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source (1), an ion guide part (31), and an ion trap (32), while ions are being mass-selectively ejected from the ion trap, ions having a polarity reverse to that of the ions trapped in the ion trap are introduced into the ion guide part.
Owner:HITACHI HIGH-TECH CORP

Efficient detection for ion traps

An apparatus and method are disclosed for efficient detection of ions ejected from a quadrupolar ion trap, in which the ions are ejected as first and second groups of ions having different directions. The first and second groups of ions are received by a conversion dynode structure, which responsively emits secondary particles that are directed to a shared detector, such as an electron multiplier. The conversion dynode structure may be implemented as a common dynode or as two dynodes (or sets of dynodes), with each dynode positioned to receive one of the groups of ions.
Owner:THERMO FINNIGAN
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