30results about "Positive/negative analyte ion analysis/introduction/generation" patented technology

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.

A dual analyser mass spectrometer obtains MS1 / MS2 scans of positive and negative ions by: operating an ion source and processing region at a first polarity; performing, by a first mass analyser (FMA) at the first polarity, MS1 or MS2 scan(s); switching polarity of the FMA to a second polarity; performing, by a second mass analyser (SMA) at the first polarity, MS1 or MS2 scan(s), wherein at least part of the MS1 or MS2 scan(s) performed by the SMA is performed while the FMA is switching polarity. Alternatively, the FMA may be operated at a first polarity and the SMA at a second polarity opposite to the first, and after initiating at least one MS1 scan and / or MS2 scan by the FMA, switching the polarity of the source and ion processing region to a second polarity and performing at least one MS1 scan and / or MS2 scan with the SMA.

The invention belongs to the technical field of analytical instruments, and provides a flat plate type FAIMS analyzer, which comprises a separation area, an upper separation electrode, a lower separation electrode, a flat plate type FAIMS, a flat plate type FAIMS and a flat plate type FAIMS, the separation voltage signal source is used for outputting high-frequency asymmetric voltage; the first compensation voltage source is used for outputting negative compensation voltage, and the high-frequency asymmetric voltage and the negative compensation voltage are superposed and then applied to the upper separation electrode; the second compensation voltage source is used for applying the output positive compensation voltage to the lower separation electrode, the absolute value of the positive compensation voltage and the absolute value of the negative compensation voltage at the same moment are equal, and the positive compensation voltage and the negative compensation voltage enable the equal height of the center of the separation area to be kept in a zero potential state. The negative compensation voltage eliminates potential fluctuation caused by the positive compensation voltage in the center of the separation area, so that the center of the separation area is kept in a zero potential state, more target ions reach the detection area through the zero potential state of the center of the separation area, and therefore the FAIMS detection sensitivity is improved.

To provide a method of operating a dual analyzer mass spectrometer to obtain MS1 scans / MS2 scans of positive and negative ions from a sample.SOLUTION: The method comprises: operating an ion source and a processing region at a first polarity; performing MS1 or MS2 scan(s) by a first mass analyzer at the first polarity; switching the polarity of the first mass analyzer to a second polarity; and performing MS1 or MS2 scans by a second mass analyzer at the first polarity, where at least part of the MS1 or MS2 scans performed by the second mass analyzer are performed during a deadtime in which the first mass analyzer is switching the polarity.SELECTED DRAWING: Figure 2

There is provided a data dependent acquisition (DDA) method of mass spectrometry using a dual analyser mass spectrometer. The method comprises: performing, by a first mass analyser, an MS1 scan of the

A mass spectrometer includes an ion source configured to ionize a sample to produce ions; a mass analyzer configured to separate the ions based on their mass-to-charge ratio; a detector configured to detect ions; an ion optics component configured to direct ions along at least part of the path from the ion source to the mass analyzer to the detector; and a controller. The controller is configured to switch the source at a first time from a first polarity source voltage to a second polarity source voltage; and switch the detector or the ion optics component at a second time from a first voltage to a second voltage, the second time being offset from the first time, the first voltage being the first polarity detector voltage or the first polarity ion optics voltage and the second voltage being the second polarity detector voltage or the second polarity ion optics voltage.

A method of operating an instrument which comprises a first and second ion stores, comprising determining whether a target accumulation time for the second ion store is greater than a threshold accumulation time. When the target accumulation time is less than the threshold accumulation time, ions are accumulated within the second ion store using an accumulation time that is based on the target accumulation time. When the target accumulation time is greater than the threshold accumulation time, ions are accumulated within the first ion store using a first accumulation time, the ions accumulated in the first ion store are passed to the second ion store, and further ions are accumulated within the second ion store using a second accumulation time.

A portable mass spectrometer with improved detection of chemical composition of aerosol particles is provided.

The invention relates to a method and an apparatus for analyzing a sample material on a sample carrier, comprising the following modes of operation: providing a time-of-flight mass analyzer having an ion generating unit, an ion generation unit having a mount for the sample carrier, an ion receiver, a flight path defining a longest flight time therebetween, an ion selector disposed along the path, and a clock generator for repeatedly triggering an ion generation pulse at the sample carrier and a subsequent pulse for accelerating ion species into the flight path; defining one or more mass-to-charge ratio (m / z) ranges, each range upper limit corresponding to a flight time shorter than the longest flight time; selecting the cycle period of the ion generation pulse so that the continuous pulse interval is shorter than the longest flight time but longer than the acceleration time; and using the mass analyzer, selecting a pulse cycle mode and an ion selector to analyze the sample material.

To provide an ion detector capable of detecting an ion having both poles while reducing a circuit scale.SOLUTION: An ion detector 1 comprises: an electron multiplying body 3 for detecting a positive ion; an electron multiplying body 4 for detecting a negative ion; an anode 5 for capturing an electron emitted by the electron multiplying body 3; an anode 6 for capturing an electron emitted by the electron multiplying body 4; and a changeover circuit 9 that includes an input terminal 9a electrically connected to the anode 5, an input terminal 9b electrically connected to the anode 6, and an output terminal 9c and selectively connects either the input terminal 9a or the input terminal 9b to the output terminal 9c.SELECTED DRAWING: Figure 1

A dual-mode ion detector for a mass and / or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and / or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detective negative ions.

The present disclosure of the invention concerns embodiments directed to a multi-pressure chemical ionization multi-ion identification device (MPCI MION device), a system and method using the same to utilize chemical ionization (CI) in multiple adduct formation from the substances in the sampled gas of a gas sample being addressed to be analyzed in a mass analyzer. The multi-pressure multi-ion identification (MPCI MION) device comprises a buffering region to have the sample flow turbulence decayed before the sample flow entrance to the low pressure ionization regions (IR(A)), IR(B), (IR(B′), (IR(C′), IR(D′)) (IR(E′)) utilizing chemical ionization by reagents from an ensemble of reagent ion towers (R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18,).

To provide a multi-reflection time-of-flight (MR-ToF) mass analyzer for a mass spectrometer.SOLUTION: A mass analyzer includes first and second mirror electrodes operating at a first and second polarity, respectively. The mass analyzer further includes: a first regulator coupled to one or more first HV switches and providing an electric potential to first mirror electrode; and one or more second regulators which each provide an electric potential to a respective second mirror electrode. The first and second HV switches swap the polarity supplied to the first regulator and the one or more second regulators. A regulator including a feedback circuit arranged to monitor voltages supplied at an output part includes: a first feedback path to monitor AC coupled currents on the output part; and a second feedback path to monitor DC level on the output part.SELECTED DRAWING: Figure 5A

The present disclosure provides an integrated device for rapid pretreatment-ionization-detection comprising: (a) a fixing device for fixing a sample to be treated; b) a rapid pretreatment-ionization device comprising: a voltage output module for generating an AC voltage; a boost module for boosting and amplifying the voltage to achieve an adjustable pulse voltage of 1mV-100 kV; a delay module for setting a delay time for the voltage output; and a trigger module for receiving a pulse voltage trigger; (c) a mass spectrometer; and (d) a timing control device for controlling the mass spectrometer and the rapid pretreatment-ionization device to collect a signal. According to the integrated device, mutual separation between analytes in a cell sample and separation between an analyte and a complex matrix can be achieved, and the separation time can reach a sub-millisecond level.

A method of operating an instrument which comprises a first and second ion stores, comprising determining whether a target accumulation time for the second ion store is greater than a threshold accumulation time. When the target accumulation time is less than the threshold accumulation time, ions are accumulated within the second ion store using an accumulation time that is based on the target accumulation time. When the target accumulation time is greater than the threshold accumulation time, ions are accumulated within the first ion store using a first accumulation time that is based on a difference between the target accumulation time and the threshold accumulation time, the ions accumulated in the first ion store are passed to the second ion store, and further ions are accumulated within the second ion store using a second accumulation time that is based on the threshold accumulation time.

A dual-mode ion detector for a mass and / or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and / or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detecting negative ions.

The present disclosure of the invention concerns embodiments directed to a multi-pressure chemical ionization multi-ion identification device (MPCI MION device), a system and method using the same to utilize chemical ionization (CI) in multiple adduct formation from the substances in the sampled gas of a gas sample being addressed to be analyzed in a mass analyzer. The multi-pressure multi-ion identification (MPCI MION) device comprises a buffering region to have the sample flow turbulence decayed before the sample flow entrance to the low pressure ionization regions (IR(A)), IR(B), (IR(B'), (IR(C'), IR(D')) (IR(E')) utilizing chemical ionization by reagents from an ensemble of reagent ion towers (R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18,).

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed that enables elemental and molecular analysis of positive and negative polarities within a single instrument. The system includes an ICP torch that generates a plasma with a buffer gas to produce positively and negatively charged ions from a sample. The system has an insert between a sampler and a skimmer of an ICP-MS interface, characterized by having an aperture and a defined geometry forming a reaction chamber. Various embodiments include an insert having a plurality of apertures for pressure regulation, a rotatable disk for regulating the apertures of the insert, a sliding gate between a sampler and a skimmer for pressure control, a circular gate having adjustable radial apertures in a first vacuum stage, and a second vacuum stage for introducing various gases, reagents, bores, etc. And a reaction chamber inlet for dopants or analytes. These innovations provide precise pressure regulation within the reaction chamber, optimizing the functionality of the system in bipolar elemental and molecular mass spectrometry applications.

A mass spectrometer, multi-reflection time-of-flight (MR-ToF) mass analyser (figure 2), comprising first and second mirror electrodes (figure 2 - any of 160,162) operating at a first and second voltag

The invention relates to methods and devices for analyzing sample material on a sample carrier, comprising an operating mode as follows: - providing a time-of-flight mass analyzer comprising an ion generation unit with a holder for the sample carrier, an ion receiver, a flight path between the ion generation unit and the ion receiver which determines a maximum flight time, an ion selector along the flight path, and a clock for repeatedly triggering an ion generation pulse locally at the sample carrier and a subsequent pulse for accelerating ion species directly from the ion generation unit onto the flight path, - defining one or more ranges of mass-to-charge ratios m / z, each with an upper m / z limit corresponding to a flight time that is shorter than the maximum flight time, - selecting a timing of ion generation pulses such thatthat the time interval between two successive ion generation pulses is shorter than the longest flight time and longer than the acceleration time of ion species from the ion generation unit, - Analyzing the sample material using the time-of-flight mass analyzer, the selected timing of ion generation pulses, and the ion selector.

There is provided a data dependent acquisition (DDA) method of mass spectrometry using a dual analyser mass spectrometer. The method comprises: performing, by a first mass analyser, an MS1 scan of the

The invention relates to methods and devices for analysing sample material on a sample carrier, comprising an operating mode as follows: providing a time-of-flight mass analyser with an ion generating unit having a mount for the sample carrier, an ion receiver, a flight route between them determining the longest time-of-flight, an ion selector along the route, and a clock generator for repeatedly triggering an ion generating pulse at the sample carrier and a subsequent pulse for accelerating ion species onto the flight route; defining one or more ranges of mass-to-charge ratios (m / z), each with an upper limit corresponding to a time-of-flight shorter than the longest time-of-flight; selecting a cycling of ion generating pulses such that the duration between successive pulses is shorter than the longest time-of-flight but longer than the acceleration time; and analysing the sample material using the mass analyser, the selected pulse cycling, and the ion selector.

The present disclosure of the invention concerns embodiments directed to a multi-pressure chemical ionization multi-ion identification device (MPCI MION device), a system and method using the same to utilize chemical ionization (CI) in multiple adduct formation from the substances in the sampled gas of a gas sample being addressed to be analyzed in a mass analyzer. The multi-pressure multi-ion identification (MPCI MION) device comprises a buffering region to have the sample flow turbulence decayed before the sample flow entrance to the low pressure ionization regions (IR(A)), IR(B), (IR(B'), (IR(C'), IR(D')) (IR(E')) utilizing chemical ionization by reagents from an ensemble of reagent ion towers (R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18,).

To provide a multi-reflection time-of-flight (MR-ToF) mass analyzer for a mass spectrometer.SOLUTION: A mass analyzer includes first and second mirror electrodes operating at a first and second polarity, respectively. The mass analyzer further includes: a first regulator coupled to one or more first HV switches and providing an electric potential to first mirror electrode; and one or more second regulators which each provide an electric potential to a respective second mirror electrode. The first and second HV switches swap the polarity supplied to the first regulator and the one or more second regulators. A regulator including a feedback circuit arranged to monitor voltages supplied at an output part includes: a first feedback path to monitor AC coupled currents on the output part; and a second feedback path to monitor DC level on the output part.SELECTED DRAWING: Figure 5A

A method of ion detection comprises: (a) setting electrical potentials of a dynode and a scintillator electrode of a Daly detector and of a focusing lens disposed at an ion inlet of the Daly detector so as to detect negatively charged ions received from a mass analyzer or mass filter; (b) transferring the negatively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said negatively charged ions by a photodetector of the Daly detector; (c) setting electrical potentials of the dynode, the scintillator electrode and the focusing lens of the Daly detector so as to detect positively charged ions received from the mass analyzer or mass filter; and (d) transferring the positively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said positively charged ions by the photodetector.

The present disclosure provides an integrated device for rapid pretreatment-ionization-detection comprising: (a) a fixing device for fixing a sample to be treated; b) a rapid pretreatment-ionization device comprising: a voltage output module for generating an AC voltage; a boost module for boosting and amplifying the voltage to achieve an adjustable pulse voltage of 1 mV-100 kV; a delay module for setting a delay time for the voltage output; and a trigger module for receiving a pulse voltage trigger; (c) a mass spectrometer; and (d) a timing control device for controlling the mass spectrometer and the rapid pretreatment-ionization device to collect a signal. According to the integrated device, mutual separation between analytes in a cell sample and separation between an analyte and a complex matrix can be achieved, and the separation time can reach a sub-millisecond level.

Method for operating an analytical instrument comprising a first ion storage and a second ion storage downstream of the first ion storage, wherein the method comprises: Determine whether a target accumulation time for the second ion storage is greater than a threshold accumulation time; If it is determined that the target accumulation time is less than the threshold accumulation time: accumulation of ions within the second ion storage using an accumulation time based on the target accumulation time; and If it is determined that the target accumulation time is greater than the threshold accumulation time: Accumulate ions within the first ion storage using a first accumulation time based on a difference between the target accumulation time and the threshold accumulation time, transfer the ions accumulated in the first ion storage to the second ion storage, and accumulate further ions within the second ion storage using a second accumulation time based on the threshold accumulation time.

A dual-mode ion detector for a mass and / or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and / or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detective negative ions.

The present disclosure provides an integrated device for rapid pretreatment-ionization-detection comprising: (a) a fixing device for fixing a sample to be treated; b) a rapid pretreatment-ionization device comprising: a voltage output module for generating an AC voltage; a boost module for boosting and amplifying the voltage to achieve an adjustable pulse voltage of 1mV-100 kV; a delay module for setting a delay time for the voltage output; and a trigger module for receiving a pulse voltage trigger; (c) a mass spectrometer; and (d) a timing control device for controlling the mass spectrometer and the rapid pretreatment-ionization device to collect a signal. According to the integrated device, mutual separation between analytes in a cell sample and separation between an analyte and a complex matrix can be achieved, and the separation time can reach a sub-millisecond level.

The present invention relates to a time-of-flight mass spectrometer comprising: electrodes to which a high DC voltage is applied in order to form a flight space for ions; and a high-voltage power supply device for applying the high voltage to the electrodes. The high-voltage power supply device includes a high-voltage generating circuit for generating the high voltage; and a voltage control circuit selectively set to a first mode and a second mode, wherein the first mode controls the high-voltage generating circuit so that the high voltage has a first convergence response and a first stability, and the second mode controls the high-voltage generating circuit so that the high voltage has a second convergence response that is lower than the first convergence response and a second stability that is higher than the first stability.