585 results about "Needle electrode" patented technology

An electroporation device which may be used to effectively facilitate the introduction of a macromolecule into cells of a selected tissue in a body or plant. The electroporation device comprises an electro-kinetic device (“EKD”) whose operation is specified by software or firmware. The EKD produces a series of programmable constant-current pulse patterns between electrodes in an array based on user control and input of the pulse parameters and allows the storage and acquisition of current waveform data. The electroporation device also comprises a replaceable electrode disk having an array of needle electrodes, a central injection channel for an injection needle, and a removable guide disk.

A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.

Described herein are devices, systems and methods for treatment of tissue within a lumen of a body. For example, the devices described herein may be used to treat the urethra or gastrointestinal tract, including a sphincter. These devices may provide an expandable element at the distal end of an elongate body and may also include a plurality of electrodes (e.g., needle electrodes) configured to extend from the device and into the tissue to deliver energy to multiple, circumferentially arranged treatment sites. Sufficient energy may be delivered from the device to create a desired tissue effect.

A device for tissue ablation comprises plural arrays of segmented needle electrodes, each of which contains a plurality of electrically conductive segments, a plurality of non-conductive joints, and a needle tip. Each of the electrically conductive segments is wired to a radio-frequency electrical power source and can be connected to and disconnected from the power source. After the needle electrodes of the device are penetrated into a target tissue to be ablated, the intended volume of ablation can be configured in three dimensions. Thus, the device allows physicians to effectively control ablation boundaries.

An object of the invention is to provide a method for delivery of macromolecules into biological cells, such as Langerhans cells (22) in the epidermis (20) of a patient, which includes the steps of coating electodes (16) in an electrode assembly (12) with solid phase macromolecules to be delivered, such as a DNA, and/or RNA vaccine or a protein-based vaccine, attaching the electrode assembly (12) having the coated electrodes (16) to an electrode assembly holder (13), providing a waveform generator (15), establishing electrically conductive pathways between the electrodes (16), and the waveform generator (15), locating the electrodes (16) such that the biological cells are situated therebetween, such as by penetrating the needle electrode (16) into the epidermis (20) above the epidermal basal lamina, and providing pulse waveform from the waveform generator (15) to the electrodes (16), such that macromolecule on the electrodes (16) is driven off of the electrodes (16), and delivered into the biological cells, such as the Langerhans cells (22).

A method for ablating tissue in or around the heart to create an enhanced lesion is provided. The distal end of a catheter including a needle electrode at its distal end is introduced into the heart. The distal end of the needle electrode is introduced into the tissue. An electrically-conductive fluid is infused through the needle electrode and into the tissue. The tissue is ablated after and/or during introduction of the fluid into the tissue. The fluid conducts ablation energy within the tissue to create a larger lesion than would be created without the introduction of the fluid.

An instrument is provided to assess the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes a needle member having an elongated shaft and a distal tip portion adapted to pierce the tissue first surface and into the ablation lesion of the biological tissue. A plurality of needle electrodes are spaced-apart along the elongated shaft. When the needle member pierces the tissue first surface, each the electrode being positioned at different respective depths of the biological tissue from the tissue first surface to the tissue second surface. These electrodes each measure at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue and at the respective depth to determine the transmurality of the ablation lesion.

The disclosure provides a needle-electrode anchor system having a needle and an optional electrode with one or more anchors. The system can provide an electrical cutting current to the needle-electrode to create an opening in a tissue portion. An anchor coupled to the needle-electrode can be pushed through the opening with a pusher and pulled into position to set the anchor on a distal surface of the opening. If the tissue portion is to be approximated to another tissue portion, the system can be relocated to another tissue portion and another opening created with the cutting current with another anchor pushed through the opening and secured on a distal surface. Lines coupled to the anchors can be pulled together, approximating the tissue portions. If the tissue portion is to be retracted, an anchor line can be grasped to retract the tissue portion from an adjacent tissue portion.

An apparatus and method for minimally invasive treatment of deep subcutaneous fat deposits in lieu of cosmetic surgery is disclosed. The apparatus comprises a high voltage pulse generator connected to two or more needle electrodes at least one of which is configured for placement deeply under the skin in a treatment site of the patient's body. High voltage pulses, delivered to the electrodes, create an electric field that kills subcutaneous fat cells.

Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue

A needle electrode deployment shaft includes a central member and a plurality of needle electrodes. The central member has a plurality of needle advancement channels formed therein. The needle electrodes are disposed within the advancement channels and each advancement channel terminates in a ramp portion which deflects the needles radially outwardly as they are axially advanced. The ramps may be spirally or acutely configured in order to increase the distance through which the needles may be bent as they are axially advanced. Additionally, the central member may have a radially reduced distal tip in order to decrease tissue insertion forces.

An electrosurgical needle includes a body having at least one conductive element in the form of a needle that is surrounded by an insulation layer except at a conductor tip portion of the conductive element. The conductor tip portion and insulation layer each have unique geometric shapes and composition of the parts to reduce or eliminate the production of smoke and eschar and reduce tissue damage. The electrosurgical needle electrode is configured to concentrate the flow of electrosurgical energy at the tip region.

An electro-nerve stimulation apparatus includes a pulse generator, a first electrically conductive, insulated lead wire, a second electrically conductive, insulated lead wire, an electrically conductive transcutaneous electrode and an electrically conductive percutaneous needle electrode. Connected to one end of the first and second lead wires is a connector for electrically coupling with the pulse generator. The transcutaneous electrode is operably connected to the other end of the first lead wire. An electrically conductive adaptor is secured to the other end of the second lead wire for electrically coupling to the terminal end of the percutaneous needle electrode. The lead wire set includes a single-use mechanism adapted to effectively discourage reuse of the electrodes. In use, the transcutaneous electrode is adhered to the patient's skin distal from the desired internal stimulation site. The percutaneous needle electrode is inserted through the skin in proximity to the desired internal stimulation site. The pulse generator is activated to pass current pulses between the transcutaneous electrode and the percutaneous needle electrode through the internal stimulation site.

An electrosurgical instrument includes a conductive element in the form of a needle that is surrounded by an insulation layer except at a conductor tip portion of the conductive element. The conductor tip portion and insulation layer each have unique geometric shapes and composition of the parts to reduce or eliminate the production of smoke and eschar and reduce tissue damage. The electrosurgical needle electrode is configured to concentrate the flow of electrosurgical at the tip region.

Ablation probes are provided for perfusing the tissue, while the tissue is ablated. The ablation probe comprises an elongated shaft and an ablative element, such as a needle electrode. The ablation probe further comprises a lumen that extends through the probe shaft, which will be used to deliver an fluid to the distal end of the probe shaft for perfusion into the surrounding tissue. The ablation probe further comprises a porous structure that is associated with the distal end of the shaft in fluid communication with the lumen. For example, the distal end of the shaft, or the entirety of the shaft, can be composed of the porous structure. Or, if the ablative element is an electrode, the electrode can be composed of the porous structure. Because the pores within the porous structure are pervasive, the fluid will freely flow out into the tissue notwithstanding that some of the pores may become clogged.

A modality of electrical twitch obtaining intramuscular stimulation pain relief therapy utilizes a surface probe with a conductive tip to apply surface electrical stimulation of relatively high voltage locally and focally to muscle motor points and regions of adjacent motor end plate zones. The surface-applied electrical stimulation through intact skin readily facilitates the elicitation of forceful twitch responses from muscle fibers associated with the stimulated motor points and motor end plate zones, without requiring needle penetration into the patient's flesh. Rapid movement between multiple treatment sites is possible allowing treatment of a larger number of muscle motor point areas in afflicted muscles and more muscles to be treated in a single treatment session. The therapeutic effect of the twitches increases with the force and number of the twitches. In addition, since physical insertion of the needle electrode is totally unnecessary, patients experience little to no pain during and after the procedure, and the risk of repetitive stress injury to the therapist is reduced. Additionally, significantly less skill is required to effectively elicit pain relieving twitch responses, thus facilitating training of medical and para-medical personnel to perform the procedure.

An ablation electrode system includes a handle assembly; a needle electrode assembly supported in and extending from the handle assembly. The needle electrode assembly includes an outer tube having at least a conductive distal tip and defining a cavity therein; and an inner tube disposed at least partially within the cavity of the outer tube and defining a lumen therein. The ablation electrode assembly includes a hub assembly fluidly connected to the needle electrode assembly. The hub assembly defines a first chamber and a second chamber; wherein the proximal end portion of the inner tube is in fluid communication with the first chamber and the proximal end portion of the outer tube is in fluid communication with the second chamber. The ablation electrode assembly includes a first fluid conduit fluidly connected to the first chamber; and a second fluid conduit fluidly connected to the second chamber.

The invention relates to an atmospheric pressure low-temperature plasma jet reactor with preionization structure, which belongs to plasma discharge reactor technical field, and the reactor is characterized in that: the device main body is a millimeter magnitude main silica tube with one open end; a part is arranged above the open end at the lower part with 15 to 25mm, and the part becomes the thinnest at 20mm part, and a ring-shaped electrode is wound on the part; a thin silica tube is connected at the closed end arranged in the inner part thereof through the closed end arranged at the upper part of the silica tube; and a needle electrode is arranged in the thin silica tube. An earthing electrode is arranged below the open end of the main silica tube; and the argon gas is filled into the needle electrode, and the oxygen gas is filled into the main silica tube. The needle electrode and the ring-shaped electrode can be exerted with the same high voltage; the needle electrode discharge can supply the seed electrons for the ring-shaped electrode discharge, and a stable glowing discharge plasma jet is arranged between the ring-shaped electrode and the earthing electrode. The reactor has the beneficial effects that the obtained plasma jet can generate high-concentration chemical activity species, and the reactor has practical value.

The invention discloses a measuring device and method for a trap parameter of solid dielectric. The solid dielectric material is charged by using a three-electrode corona discharge system; a material sample to be tested is placed below a single-needle electrode and a metal mesh electrode; the sample is adhered to a metal disc electrode through conductive silicone grease and is charged by the three-electrode system; after charging is ended, an external voltage is removed, and short circuit discharge is performed to remove surface free loads; surface potential of the measured sample is attenuated; and the trap energy level and the trap density parameter of the material can be calculated through a signal conditioning circuit and a data acquisition system. The measuring device comprises a constant temperature box, the three-electrode coronate charging system, a surface potential measuring system, a sample preheating system, a rotary electrode and a temperature and humidity control system. The invention provides an effective analysis means for research in representation of an aging condition of a polymer insulating material and an aging rule of polymer by the trap parameter and research in aspects such as a solid dielectric surface electrification phenomenon and surface flashover performance influence.