70 results about "Tissue ablation" patented technology

High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and / or minimize the risk of arcing, such as due to the presence of bubbles, and / or minimize muscle stimulation are described herein.

The utility model provides a visual posterior nasal nerve ablation electrode device. The visual posterior nasal nerve ablation electrode device comprises an electrode tip with a camera, a snake bone pipe and an electrode tip swing assembly. The electrode tip is sleeved on the snake bone pipe and is connected with a moving piece in the electrode tip swinging assembly through a rope beam group of the snake bone pipe; by means of the camera, a doctor can more visually find out target tissue in the ablation nasal cavity, the moving part can move when driven, then the rope beam set is pulled, the snake bone pipe is driven by the rope beam set to swing, then bending of the electrode tip is achieved, the electrode tip can accurately reach the diseased position, and tissue ablation is conducted.

The utility model provides a radiofrequency ablation instrument which comprises an electrode base body, a first electrode, a second electrode, a third electrode and a fourth electrode. The handle is connected with the electrode base body, and the handle can rotate; the bending control assembly is arranged on the handle and is connected with the deformation part; when the handle rotates, the bending control assembly can be driven to rotate, and the bending control assembly drives the deformation part to bend. According to the radiofrequency ablation instrument, the bending amplitude of the deformation part can be controlled by rotating the handle, so that the position of the deformation part can be adjusted according to different patients, the matching degree of different patients is improved, the treatment effect is improved, and the operation risk is reduced.

Waveform characteristics of pulses in a pulse train configured to cause pulsed field tissue ablation may be varied in a manner that improves electromagnetic compatibility while retaining treatment efficacy. Such waveform characteristics may include pulse-to-pulse initiation intervals, inter-pulse delays, pulse on-times, pulse widths, inter-phase delays in the case of biphasic pulses, or a combination thereof. Such waveform characteristics may be varied in a random manner. Variations of waveform characteristics may be bounded by minimum, maximum, or both minimum and maximum differences between various pulses or pulse groups, or between various pulse trains or pulse train groups, for example, to help ensure sufficient stability of treatment signal waveforms while allowing sufficient variability, for example, to improve electromagnetic compatibility.

This application discloses a high-voltage pulsed ablation technique (PFA) with variable pulse width based on the ablation site, belonging to the field of high-frequency pulse control technology. The method includes selecting and confirming the ablation site on the ablation device display; switching and matching the corresponding pulse width parameters based on the confirmed ablation site; initiating and controlling ablation based on the switched and matched pulse width parameters; determining whether ablation is complete after completion; if not, restarting and controlling ablation again; if complete, determining the end of the current ablation; determining whether the ablation site needs to be changed; if not, restarting and controlling ablation again; if so, reselecting the ablation site for the next ablation. This method allows for ablation with different parameters based on different sites, resulting in less muscle tremor, more thorough tissue ablation, and a reduced recurrence probability. It does not require changes to the original hardware layout or catheter shape, only modifications to the software and algorithm.

The application provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which comprises an energy storage device, a switch, a transmission line group and a load. The main feature is that the transmission line group is composed of multiple parallel or series transmission lines, the input end of the transmission line group is connected with the energy storage device in series through the switch, and the inner conductors at the output end of the transmission line group form different polarities of ground potential. The transmission lines can independently drive the load and output different polarities of steep pulses on different loads; two transmission lines with opposite polarities of inner conductor potential can cooperatively drive the load in series and output synchronous bipolar steep pulses on different loads. The application creatively provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which can be widely applied to the treatment of various tumor and lesion tissues in human body. Compared with the prior art, in the specific implementation, the synchronous multi-channel multi-polarity steep pulse output can realize the ablation of larger tumor tissues or irregularly shaped tissues at one time, and at the same time, it can actively shield the adjacent important tissues to prevent them from being damaged by the electric field.

An arthroscopic cutting probe includes an outer sleeve having a longitudinal bore and an outer cutting window at its distal end. An inner sleeve is rotationally disposed in a bore of the outer sleeve, and the inner sleeve has a distal end, a proximal end, a longitudinal passageway, and an inner cutting window at its distal. An active electrode sleeve is disposed on an outer surface of the inner sleeve in a position opposed to the inner cutting window. Rotation of the inner sleeve relative to the outer sleeve causes the inner cutting window to rotate past the outer cutting window to resect tissue received through the cutting windows as they pass each other. Radiofrequency current can be applied to the active electrode to enhance tissue cutting then the cutting windows are being rotated or to able or cauterize tissue when the cutting windows are held stationary with the active electrode disposed through the outer cutting window.

The invention discloses a tissue ablation method based on double scanning modules, which comprises the following steps: firstly, acquiring a three-dimensional model and a motion mode of a target tissue, then determining a three-dimensional moving track and a two-dimensional scanning path of an optical focusing module based on the three-dimensional model and the motion mode, and moving the optical focusing module to an initial focusing position; and finally, the laser source is started to emit laser, the optical focusing module is controlled to move along the three-dimensional movement track, meanwhile, the focus of the laser is controlled to scan in the designated area based on the two-dimensional scanning path, the peak power density of the laser is not lower than a nonlinear breakdown threshold value, and the designated tissue is mechanically damaged. By means of multi-stage scanning and synchronous positioning, high-precision, large-area and three-dimensional dynamic focusing treatment can be achieved, and the high-precision and low-heat-damage controllable ablation effect is achieved.

The application provides a tissue ablation electrode connector and device. The tissue ablation electrode connector comprises a connector, a storage device and a damage element. The connector has a core needle. The storage device is arranged in the connector and is electrically connected with the core needle. The storage device is used for storing anti-fake information. The core needle is used for connecting an information reading device. The information reading device comprises a data reading circuit and a protection circuit connected with each other. The protection circuit is used for placing the storage device and the core needle in a suspended state through optical isolation communication and magnetic isolation power supply, so as to realize high-voltage isolation and protection of the data reading circuit and prevent high-voltage pulse energy from damaging the data reading circuit. The damage element is arranged in the connector and is connected with the storage device. The damage element is used for damaging the storage device, so as to ensure one-time use of the tissue ablation electrode. The application solves the problem that the existing ablation needle body cannot simultaneously ensure anti-fake and one-time use.

The application discloses a kind of medical mid-infrared 1720nm pulsed fiber lasers, it is related to laser medical technical field, including the following steps: acquisition pulsed fiber laser data, respectively calculate thulium ion concentration uniformity index, laser energy intensity and each small target tissue ablation area ablation index, and then construct the thermal map matrix of each small thulium-doped fiber section, and draw the anti-fake color coding diagram of each target tissue ablation area, the spectral analysis technique in the method, multiple linear regression algorithm and convolution neural network algorithm are closely combined with modern information technology, the degree of uniformity of thulium ion concentration distribution and target tissue ablation degree are achieved in real time and comprehensive monitoring, so that the monitored data becomes more accurate index under the same conditions, significantly enhance the intelligent degree of medical mid-infrared 1720n pulsed fiber laser in use process.

The application provides a focused ultrasound tissue fragmentation system, belonging to the technical field of medical devices, comprising a transceiving integrated focused ultrasound probe, a multi-degree-of-freedom moving device and a tissue fragmentation workstation. The system acquires images of a region of interest through an image acquisition device, adjusts the position of the focused ultrasound probe by using the multi-degree-of-freedom moving device, receives and processes the images by the tissue fragmentation workstation, controls the focused ultrasound probe to emit pulses, generates a cavitation bubble cloud in a cavitation region, positions the cavitation region and performs cavitation on the tissue in the region of interest. The system adopts a high-intensity focused ultrasound multi-channel phased array probe, can overcome the reflection and refraction problems of ultrasound in tissue, accurately focuses the focal point on the tissue fragmentation region, realizes precise treatment of the target tissue and improves the treatment effect and safety.

The application discloses a natural cavity tissue ablation device and an ablation system. The tissue ablation device comprises an operation handle, a sheath tube and an ablation mechanism. One end of the sheath tube is connected to the operation handle, and the other end is used for entering the body through a natural cavity. The ablation mechanism is arranged in the sheath tube and is arranged to be exposed from the other end of the sheath tube. The ablation mechanism comprises a puncture piece and a sub-puncture needle in the puncture piece. The puncture piece is used for puncturing into the tissue to be ablated. The sub-puncture needle is arranged to be punctured out of the side opening of the puncture piece to puncture other regions of the tissue to be ablated. The sub-puncture needle is connected to an ablation device outside. The ablation device is used for sending an ablation signal to the sub-puncture needle to perform an ablation operation on the tissue to be ablated. The direction of the sub-puncture needle puncturing out of the side opening of the puncture piece can be adjusted. The above scheme can be suitable for precise ablation of tissues with different regular shapes.

The embodiment of the invention provides a Doppler ultrasound argon beam device and a tissue damage method of the Doppler ultrasound argon beam device, a Doppler ultrasound assembly and an argon beam assembly of a Doppler ultrasound argon beam are respectively installed on a tube shell, a host is located outside the tube shell, and the host is electrically connected to the Doppler ultrasound assembly and the argon beam assembly. Thus, the information of the tissue position can be obtained through the Doppler ultrasound assembly, the argon beam assembly can damage the tissue in a targeted mode according to the information, obtained by the Doppler ultrasound assembly, of the tissue position, and the tissue damage effect is improved; and the situation that tissue damage is not in place or excessive damage is caused due to inaccurate information judgment at the tissue position is reduced. Besides, the Doppler ultrasonic assembly and the argon beam assembly are integrated in the tube shell, the compactness of the structure can be improved, the application of two functions of the Doppler ultrasonic argon beam device is facilitated, and the use flexibility and safety of the Doppler ultrasonic argon beam device can be improved.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

In one example, a device includes: an ablation energy generator for transmitting ablation energy to electrodes of a catheter; a processor configured to: calculate a first force signal acting on tissue by the distal end assembly based on a first magnetic signal received from a magnetic emitter coil at the distal end of the catheter by a first magnetic field sensor of the distal end assembly during tissue ablation by the electrodes; calculate a second force signal acting on tissue by the distal end assembly based on a second magnetic signal received from a magnetic emitter coil disposed in a positioning pad by a second magnetic field sensor of the distal end assembly; calculate a third force signal based on the first and second force signals; and render the force value or ablation index value calculated based on the third force signal to a display.

The invention is entitled "Bipolar Organized Ablation According to Predetermined Periodic Sets of Time Slots". A method for applying bipolar ablation pulses, the method comprising positioning a plurality of electrodes of a catheter in contact with tissue of an organ. The tissue is ablated using the plurality of electrodes according to a predetermined pattern comprising periodic sets of time slots. Each of the time slots defines (i) a pair of electrodes (EP), (ii) a waveform of one or more bipolar ablation pulses (BAP) applied to the tissue by the EP, and (iii) a duration of the time slot. The time slots are applied sequentially, and the pattern further comprises at least one empty time slot.

An antenna system for tissue ablation includes an energy transmission member, a conductive hollow coil member coupled to the energy transmission member, and a fluid cooling system coupled to the conductive hollow coil member for providing a flow of cooling fluid through a member lumen of the conductive hollow coil member for cooling the conductive hollow coil member. In some examples, at least one of the antenna body, a choke member, and a hybrid choke member includes the conductive hollow coil member. In some examples, the hybrid choke member includes a choke portion wound around a portion of the energy transmission member, an antenna body portion wound around a portion of the energy transmission member, and an insulator portion extending between the choke portion and the antenna body portion. In some examples, the antenna system includes a sheath extending over the energy transmission member and the conductive hollow coil member.

An ablation system and methods comprising a catheter having an expandable basket and a shaft assembly comprising an outer and inner elongated shaft allowing relative longitudinal movement. The expandable basket comprises filaments braided into a braided mesh including electrodes for ablation, mapping and measurement. An expandable basket at the distal end of the catheter is coupled to both shafts and is deployable from a collapsed to an expanded configuration. The system includes an introducer sheath with a highly abrasion-resistant inner liner designed for smooth catheter deployment. An electrical control circuits regulates the delivery of high-voltage pulses from a pulse generator to the target tissue, enhancing the safety, precision and effectiveness of tissue ablation.

This application relates to the field of medical device technology, providing an ablation catheter and a multimodal ablation device. The ablation catheter includes a tube body, an inner sheath, and an ablation assembly. The tube body has an inlet channel for introducing coolant. The inner sheath is inserted into the tube body and is movable relative to the tube body. The ablation assembly includes multiple elastic tubes and multiple ablation electrodes. One end of each elastic tube is connected to the inner sheath, and the other end is connected to the tube body. Each elastic tube is equipped with an ablation electrode, which can switch between pulse ablation mode and radiofrequency ablation mode under the control of the ablation device's main unit. An outlet is provided on the side wall of each elastic tube, and the outlet is connected to the inlet channel. The ablation catheter enables dual-modal tissue ablation using both pulsed electric field and radiofrequency energy. When facing deep tissues that are difficult to ablate with pulsed electric field energy, it switches to radiofrequency ablation mode, thereby reducing the recurrence of atrial fibrillation.

According to some embodiments, an ophthalmic surgical system for treating presbyopia includes controllable components and a computer. The controllable components include a light source for generating a light beam and a scanner for guiding the focus of the beam. The computer determines an ablation profile to remove tissue from the central and peripheral regions of the cornea of ​​the first eye in a pair of eyes. The ablation profile is designed to: remove tissue from the central region to create a protrusion to provide near vision, and remove tissue from the peripheral region to correct to emmetropia.

An ablation device includes a first jaw, a second jaw including an ablation unit including a protrusion for ablating a tissue and being rotatable with respect to the first jaw under the first jaw, and a signal unit configured to provide a signal to the tissue and receive a reflected signal and disposed on the second jaw, in which the signal unit moves in a longitudinal direction of the ablation unit, the first jaw does not overlap the signal unit in a vertical direction, and the second jaw overlaps the signal unit in the vertical direction.

Methods, systems and adaptors for multiphoton imaging of, and laser-tissue interactions with, non-transparent tissue, such as ocular and periocular tissue, are provided. Aspects of the present invention include methods of imaging a structure through non-transparent tissue, such as ocular or periocular tissue, comprising: deploying an excitation source to transmit light energy to a structure through non-transparent tissue, such as ocular or periocular tissue, detecting light emitted from the structure via multiphoton excitation through the non-transparent tissue, such as ocular or periocular tissue, and imaging the structure based on the detected light. Aspects of the present invention further include methods of treating tissue, such as ocular or periocular tissue or dermatologic tissue, by manipulating an imaged structure, including, for example, providing non-incisional therapy, photo-tissue interactions, multi-photon-mediated damage, such as thermal damage, photo-disruption, photo cross-linking, blood vessel coagulation or ablating tissue. Aspects of the present invention further include methods of imaging dermatologic tissues or providing dermatologic treatments. Aspects of the present invention further include methods of providing cosmetic treatments. Aspects of the present invention further include methods of guiding delivery of gene therapy or cellular therapy in ocular or periocular tissue. Also provided are systems and adaptors for performing the methods described herein.

Described herein are systems and methods for performing optical signal analysis for tissue ablation using a catheter having viewports. A method includes transmitting illumination toward a target tissue via the viewport. The method also includes receiving, at a first viewport, a first scattered illumination from the target tissue and generating a first measurement signal based on the first scattered illumination. The method also includes receiving, at the first viewport, a second scattered illumination from the target tissue after the receiving of the first scattered illumination and generating a second measurement signal based on the second scattered illumination. The method also includes determining whether the viewport is in contact with the target tissue based on a first difference among the plurality of optical measurements meeting or crossing a first threshold value, wherein the first difference comprises a difference between the first and second measurement signals.

The application discloses a PFA combined electrode one-stop ablation catheter and system, relates to the technical field of medical devices, and comprises a catheter body, an electrode ring arranged at the head end of the catheter body, and a plurality of annular electrodes arranged on the electrode ring. The annular electrodes comprise fixed electrodes fixedly installed at fixed positions of the electrode ring, active displacement electrodes capable of moving back and forth along the electrode ring based on electrode moving grooves based on the operation of a control handle, and passive displacement electrodes capable of moving between the fixed electrodes and the active displacement electrodes along with the movement of the active displacement electrodes. The control handle is connected to the proximal end of the catheter body, the electrode form of the electrode ring is controlled, and the electrode ring is switched between a single electrode sequential state and a combined electrode state. The application improves the homogeneity and treatment effect of target tissue ablation on the basis of improving the tissue abutting quality.

The invention discloses a double-frequency phased array composite pulse histotripsy system and a double-frequency phased array composite pulse histotripsy method. Comprising a double-frequency phased array transducer, a driving control module, a focus control module and a real-time monitoring module, wherein the double-frequency phased array transducer is a double-frequency hundreds of array element phased array transducer or a double-frequency split array transducer; the double frequency multiplication phased array transducer comprises a fundamental frequency array element group and a frequency multiplication array element group, the driving control module is used for outputting driving signals with corresponding frequencies to two groups of array elements, the focus control module is used for regulating and controlling the positions and the number of focuses, and the real-time monitoring module is used for tracking the effect; the double-frequency phased array composite pulse histotripsy system adopts a four-stage composite pulse time sequence to cooperatively control the working states of a fundamental frequency array element group and a frequency multiplication array element group, and is realized in combination with a multi-focus control strategy; according to the method, the defect of fogging zone front cavitation shielding possibly caused by double-frequency millisecond long-pulse tissue damage and the defect that instant B-ultrasonic monitoring is affected by slow bubble dissipation after treatment are overcome.

The present application provides a tissue ablation apparatus and an electrochemical impedance measurement apparatus and method. In the present application, a Faraday current participating in an electrochemical reaction of a target tissue (800) and a voltage difference between a first output end and a second output end of a high-voltage pulse module (100) are detected in real time, a corresponding electrochemical impedance parameter of the target tissue can be obtained according to an electrochemical impedance fitting function, and the amount of bubbles generated during ablation of the target tissue can be obtained according to the electrochemical impedance parameter of the target tissue, so that feedback control can be implemented for an outputted high-voltage pulse signal, to control the amount of generated bubbles in a timely manner. According to the present application, the status of bubble generation can be obtained while a high-voltage pulse signal is outputted for tissue ablation, there is no need to generate an additional detection signal, and high working efficiency is achieved.

1. The name of the design product: the main machine of therapeutic instrument. 2. The use of the design product: the design product is a medical device for providing treatment, such as the main machine of focused ultrasound tissue ablation system, etc. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

An ablation catheter (20) is provided that includes a shaft (22) including a distal electrode-support portion (26, 126) that includes electrical insulation (30). An electrically- conductive electrode (24) includes an uninsulated electrode surface (40) disposed on an outer surface (42) of the distal electrode-support portion (26, 126), and an insulated electrode surface (44). The electrical insulation (30) insulates the insulated electrode surface (44) with respect to outside the distal electrode-support portion (26, 126), The insulated electrode surface (44) is shaped to define one or more curved surface portions (50) that face only partially radially outward, and do not face even partially radially inward, with respect to a central longitudinal axis (28) of the distal electrode- support portion (26, 126). For each of all points (60) on the one or more curved surface portions (50), a line (62), which is perpendicular to the central longitudinal axis (28) and intersects the central longitudinal axis (28) and the point (60), defines an oblique angle with the curved surface portion (50) at the point (60). Other embodiments are also described.

The application discloses a kind of liquid guide laser bone ablation devices and methods of multi-modal sensing fusion, the liquid guide laser bone ablation device includes: supply module, ablation module, detection module and main control module, supply module includes containing cavity and nozzle, nozzle is located at the bottom of containing cavity, the isotonic solution in containing cavity can be ejected by nozzle and be flushed with liquid beam flow to be ablated tissue.Ablation module includes pulsed laser, pulsed laser is used to emit ablation laser in liquid beam flow, and liquid beam flow guides ablation laser to remove to be ablated tissue.Detection module includes frequency-sweeping laser and balanced optical detector, frequency-sweeping laser is used to emit probe laser in liquid beam flow, and balanced optical detector is used to receive the surface scattering of to be ablated tissue probe laser, and is converted into electrical signal.Main control module is used to determine the phase change data generated by light-heat expansion of to be ablated tissue based on electrical signal, determines the ablation depth of to be ablated tissue and calculates temperature.Realize the deep hole ablation of low taper.