128 results about "Tissue ablation" patented technology

Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A pulse that has an element of decay may be applied to a target for tissue ablation while the decay is modulated. In some examples, apparatus including a controller and switches may be used to modulate the decay and / or selectively apply the pulse to the target. The apparatus may further include resistors and / or other elements to modulate a magnitude of the pulse and / or a slope of a decay of the pulse.

High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and / or minimize the risk of arcing, such as due to the presence of bubbles, and / or minimize muscle stimulation are described herein.

The present disclosure relates to an apparatus for estimating a tissue ablation comprising: means for determining an impedance value associated with an electrode of an ablation catheter in contact with the tissue and connectable to the apparatus for applying one or more ablation pulses to the tissue; means for estimating a dimension of the tissue ablation based at least in part on the impedance value.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and / or minimize the risk of arcing, such as due to the presence of bubbles, and / or minimize muscle stimulation are described herein.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

A medical system may be configured at least to receive a user-selection of a first group of electrodes in a spatial distribution of electrodes; cause, at least in response to the user-selection of the first group of electrodes, a machine-selection of a second group of electrodes in the spatial distribution of electrodes, each electrode in the machine-selected second group of electrodes spaced, according to the spatial distribution, from an electrode in the user-selected first group of electrodes at least by a respective interposed electrode set in the spatial distribution of electrodes; and cause bipolar pulsed field tissue ablation between the user-selected first group of electrodes and the machine-selected second group of electrodes, while omitting at least any electrode of each respective interposed electrode set from causing bipolar pulsed field tissue ablation.

Disclosed are an automatic planning method and a device for tissue ablation. The method includes: obtaining a three dimensional (3D) model of a to-be-ablated tissue through a 3D reconstruction technique; marking a cylindrical ablation point on the 3D model through an ablation planning, an axial direction of the ablation point is the same as a radio frequency direction of thermal ablation; and displaying an ablated area on the 3D model, the reconstruction technique includes: obtaining slice images of the to-be-ablated tissue in a plurality of directions, the slice image in each direction includes a plurality of two dimensional (2D) images; depicting, by a primitive, the to-be-ablated tissue on the 2D images in one direction; and constructing the 3D model of the to-be-ablated tissue through the 3D reconstruction technique based on the original 2D images.

The utility model provides a visual posterior nasal nerve ablation electrode device. The visual posterior nasal nerve ablation electrode device comprises an electrode tip with a camera, a snake bone pipe and an electrode tip swing assembly. The electrode tip is sleeved on the snake bone pipe and is connected with a moving piece in the electrode tip swinging assembly through a rope beam group of the snake bone pipe; by means of the camera, a doctor can more visually find out target tissue in the ablation nasal cavity, the moving part can move when driven, then the rope beam set is pulled, the snake bone pipe is driven by the rope beam set to swing, then bending of the electrode tip is achieved, the electrode tip can accurately reach the diseased position, and tissue ablation is conducted.

According to certain embodiments, an ophthalmic surgical system for treating presbyopia comprises controllable components and a computer. The controllable components comprise a light source that generates a light beam and a scanner that directs a focal point of the light beam. The computer determines an ablation profile to remove tissue from a central region and a peripheral region of a cornea of a first eye of a pair of eyes. The ablation profile is designed to remove tissue from the central region to yield a protrusion to provide for near-vision, and to remove tissue from the peripheral region to correct to emmetropia.

The utility model provides a radiofrequency ablation instrument which comprises an electrode base body, a first electrode, a second electrode, a third electrode and a fourth electrode. The handle is connected with the electrode base body, and the handle can rotate; the bending control assembly is arranged on the handle and is connected with the deformation part; when the handle rotates, the bending control assembly can be driven to rotate, and the bending control assembly drives the deformation part to bend. According to the radiofrequency ablation instrument, the bending amplitude of the deformation part can be controlled by rotating the handle, so that the position of the deformation part can be adjusted according to different patients, the matching degree of different patients is improved, the treatment effect is improved, and the operation risk is reduced.

The utility model relates to the technical field of medical instruments, and provides an ultrasonic ablation system, which comprises an ultrasonic ablation assembly, a handle mechanism and a host, the ultrasonic ablation assembly comprises a carrier and at least two focused ultrasonic transducers, each focused ultrasonic transducer is arranged on the carrier, and each focused ultrasonic transducer has the same energy focus point; the handle mechanism is in driving connection with the carrier and used for driving the carrier to move in the axial direction or rotate in the circumferential direction so as to drive the focused ultrasonic transducers to move synchronously. The host is electrically connected with the focused ultrasonic transducers and used for controlling the focused ultrasonic transducers to work alternately. According to the utility model, a more accurate, safer and more efficient tissue ablation process can be realized, meanwhile, the system design is simplified, the surgical risk is reduced, and the comfort level and the recovery speed of a patient are improved.

Waveform characteristics of pulses in a pulse train configured to cause pulsed field tissue ablation may be varied in a manner that improves electromagnetic compatibility while retaining treatment efficacy. Such waveform characteristics may include pulse-to-pulse initiation intervals, inter-pulse delays, pulse on-times, pulse widths, inter-phase delays in the case of biphasic pulses, or a combination thereof. Such waveform characteristics may be varied in a random manner. Variations of waveform characteristics may be bounded by minimum, maximum, or both minimum and maximum differences between various pulses or pulse groups, or between various pulse trains or pulse train groups, for example, to help ensure sufficient stability of treatment signal waveforms while allowing sufficient variability, for example, to improve electromagnetic compatibility.

This application discloses a high-voltage pulsed ablation technique (PFA) with variable pulse width based on the ablation site, belonging to the field of high-frequency pulse control technology. The method includes selecting and confirming the ablation site on the ablation device display; switching and matching the corresponding pulse width parameters based on the confirmed ablation site; initiating and controlling ablation based on the switched and matched pulse width parameters; determining whether ablation is complete after completion; if not, restarting and controlling ablation again; if complete, determining the end of the current ablation; determining whether the ablation site needs to be changed; if not, restarting and controlling ablation again; if so, reselecting the ablation site for the next ablation. This method allows for ablation with different parameters based on different sites, resulting in less muscle tremor, more thorough tissue ablation, and a reduced recurrence probability. It does not require changes to the original hardware layout or catheter shape, only modifications to the software and algorithm.

The application provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which comprises an energy storage device, a switch, a transmission line group and a load. The main feature is that the transmission line group is composed of multiple parallel or series transmission lines, the input end of the transmission line group is connected with the energy storage device in series through the switch, and the inner conductors at the output end of the transmission line group form different polarities of ground potential. The transmission lines can independently drive the load and output different polarities of steep pulses on different loads; two transmission lines with opposite polarities of inner conductor potential can cooperatively drive the load in series and output synchronous bipolar steep pulses on different loads. The application creatively provides a synchronous multi-channel multi-polarity steep pulse generating device for tissue ablation, which can be widely applied to the treatment of various tumor and lesion tissues in human body. Compared with the prior art, in the specific implementation, the synchronous multi-channel multi-polarity steep pulse output can realize the ablation of larger tumor tissues or irregularly shaped tissues at one time, and at the same time, it can actively shield the adjacent important tissues to prevent them from being damaged by the electric field.

An arthroscopic cutting probe includes an outer sleeve having a longitudinal bore and an outer cutting window at its distal end. An inner sleeve is rotationally disposed in a bore of the outer sleeve, and the inner sleeve has a distal end, a proximal end, a longitudinal passageway, and an inner cutting window at its distal. An active electrode sleeve is disposed on an outer surface of the inner sleeve in a position opposed to the inner cutting window. Rotation of the inner sleeve relative to the outer sleeve causes the inner cutting window to rotate past the outer cutting window to resect tissue received through the cutting windows as they pass each other. Radiofrequency current can be applied to the active electrode to enhance tissue cutting then the cutting windows are being rotated or to able or cauterize tissue when the cutting windows are held stationary with the active electrode disposed through the outer cutting window.

An example medical device is disclosed. The medical device includes a catheter shaft including a distal end portion, wherein the distal end portion includes an ablation assembly. The ablation assembly includes an expandable frame including a base, an end region and a plurality of struts extending between the base and the end region, the struts defining a plurality of apertures along the frame. The ablation assembly also includes an electrical circuit coupled to an inner surface of the second end region of the frame, the electrical circuit including a plurality of ablation electrodes coupled thereto. Further, the expandable frame is designed to shift from a delivery configuration in which the ablation electrodes face inward from the inner surface of the expandable frame to an expanded configuration in which the ablation electrodes face away from the base of the expandable frame.

The invention provides an ablation device and a prostate tissue ablation system.The ablation tissue comprises a head electrode assembly, a needle electrode assembly and a handle assembly, the head electrode assembly comprises a head end main body and an outer tube which are connected with each other, the head end main body is arranged at the far end of the outer tube, a head electrode is arranged at the far end of the head end main body, and the needle electrode assembly is arranged on the outer tube. A needle electrode channel is arranged in the outer tube, the needle electrode assembly is contained in the needle electrode channel, the needle electrode assembly comprises at least one needle electrode, and the needle electrode assembly extends out of the side face of the ablation device based on operation on the handle assembly. According to the embodiment of the invention, the interventional operation of entering the urethra through a natural orifice and operating under a visual working condition and adopting an irreversible electroporation steep pulse electric field with tissue selectivity can be realized, so that the operation efficiency and the operation safety and effectiveness are greatly improved.

A power generator is disclosed for generating ablating energy deliverable to a catheter for treatment of heart rhythm disorders. The power generator includes a first output port configured to deliver ablation energy through a first conductive wire of a catheter and a second output port configured to receive a sensing signal from a thermocouple junction formed at a catheter electrode. The generator includes a first power driver for producing waveforms suitable for radiofrequency ablation (RFA) and a second power driver for generating pulsed waveforms suitable for pulsed field ablation (PFA). A switching circuit selectively couples one of the power drivers to the first output port based on a selected ablation modality. A control circuit receives an input indicating the selected modality and controls the switching circuit accordingly. The system enables dual-modality ablation using a shared catheter interface, facilitating seamless transition between RFA and PFA without requiring hardware reconfiguration.

The invention discloses a tissue ablation method based on double scanning modules, which comprises the following steps: firstly, acquiring a three-dimensional model and a motion mode of a target tissue, then determining a three-dimensional moving track and a two-dimensional scanning path of an optical focusing module based on the three-dimensional model and the motion mode, and moving the optical focusing module to an initial focusing position; and finally, the laser source is started to emit laser, the optical focusing module is controlled to move along the three-dimensional movement track, meanwhile, the focus of the laser is controlled to scan in the designated area based on the two-dimensional scanning path, the peak power density of the laser is not lower than a nonlinear breakdown threshold value, and the designated tissue is mechanically damaged. By means of multi-stage scanning and synchronous positioning, high-precision, large-area and three-dimensional dynamic focusing treatment can be achieved, and the high-precision and low-heat-damage controllable ablation effect is achieved.

The application provides a tissue ablation electrode connector and device. The tissue ablation electrode connector comprises a connector, a storage device and a damage element. The connector has a core needle. The storage device is arranged in the connector and is electrically connected with the core needle. The storage device is used for storing anti-fake information. The core needle is used for connecting an information reading device. The information reading device comprises a data reading circuit and a protection circuit connected with each other. The protection circuit is used for placing the storage device and the core needle in a suspended state through optical isolation communication and magnetic isolation power supply, so as to realize high-voltage isolation and protection of the data reading circuit and prevent high-voltage pulse energy from damaging the data reading circuit. The damage element is arranged in the connector and is connected with the storage device. The damage element is used for damaging the storage device, so as to ensure one-time use of the tissue ablation electrode. The application solves the problem that the existing ablation needle body cannot simultaneously ensure anti-fake and one-time use.

The application discloses a kind of medical mid-infrared 1720nm pulsed fiber lasers, it is related to laser medical technical field, including the following steps: acquisition pulsed fiber laser data, respectively calculate thulium ion concentration uniformity index, laser energy intensity and each small target tissue ablation area ablation index, and then construct the thermal map matrix of each small thulium-doped fiber section, and draw the anti-fake color coding diagram of each target tissue ablation area, the spectral analysis technique in the method, multiple linear regression algorithm and convolution neural network algorithm are closely combined with modern information technology, the degree of uniformity of thulium ion concentration distribution and target tissue ablation degree are achieved in real time and comprehensive monitoring, so that the monitored data becomes more accurate index under the same conditions, significantly enhance the intelligent degree of medical mid-infrared 1720n pulsed fiber laser in use process.

The application provides a focused ultrasound tissue fragmentation system, belonging to the technical field of medical devices, comprising a transceiving integrated focused ultrasound probe, a multi-degree-of-freedom moving device and a tissue fragmentation workstation. The system acquires images of a region of interest through an image acquisition device, adjusts the position of the focused ultrasound probe by using the multi-degree-of-freedom moving device, receives and processes the images by the tissue fragmentation workstation, controls the focused ultrasound probe to emit pulses, generates a cavitation bubble cloud in a cavitation region, positions the cavitation region and performs cavitation on the tissue in the region of interest. The system adopts a high-intensity focused ultrasound multi-channel phased array probe, can overcome the reflection and refraction problems of ultrasound in tissue, accurately focuses the focal point on the tissue fragmentation region, realizes precise treatment of the target tissue and improves the treatment effect and safety.

The application discloses a natural cavity tissue ablation device and an ablation system. The tissue ablation device comprises an operation handle, a sheath tube and an ablation mechanism. One end of the sheath tube is connected to the operation handle, and the other end is used for entering the body through a natural cavity. The ablation mechanism is arranged in the sheath tube and is arranged to be exposed from the other end of the sheath tube. The ablation mechanism comprises a puncture piece and a sub-puncture needle in the puncture piece. The puncture piece is used for puncturing into the tissue to be ablated. The sub-puncture needle is arranged to be punctured out of the side opening of the puncture piece to puncture other regions of the tissue to be ablated. The sub-puncture needle is connected to an ablation device outside. The ablation device is used for sending an ablation signal to the sub-puncture needle to perform an ablation operation on the tissue to be ablated. The direction of the sub-puncture needle puncturing out of the side opening of the puncture piece can be adjusted. The above scheme can be suitable for precise ablation of tissues with different regular shapes.

The present invention discloses a power supply for a tissue ablation, cutting, and fusion system. The power supply outputs a low-frequency DC pulse voltage with a high-level voltage below 24V and a frequency below 500Hz. The duty cycle of the DC pulse voltage output by the power supply can be adjusted based on the thermal conductivity of the tissue to be ablated, cut, or fused. The tissue ablation, cutting, and fusion system of the present invention comprises a power supply for a tissue ablation, cutting, and fusion system of the present invention. The tissue ablation, cutting, and fusion system of the present invention comprises a handle assembly, a shaft assembly, a working portion, a circuit system, and a power supply. The DC pulse voltage output by the power supply periodically switches between high and low levels to cyclically power on and off the electric heating device, maintaining the heating device in a state of heating when powered on and moderate cooling when powered off. This ensures that as heat is continuously transferred deep into the tissue or organ, the temperature at the site of contact between the heating device and the tissue or organ remains within a stable range and does not continue to rise. This effectively prevents accidental damage to the tissue or organ caused by excessive temperatures, making clinical use safer and more reliable.

The embodiment of the invention provides a Doppler ultrasound argon beam device and a tissue damage method of the Doppler ultrasound argon beam device, a Doppler ultrasound assembly and an argon beam assembly of a Doppler ultrasound argon beam are respectively installed on a tube shell, a host is located outside the tube shell, and the host is electrically connected to the Doppler ultrasound assembly and the argon beam assembly. Thus, the information of the tissue position can be obtained through the Doppler ultrasound assembly, the argon beam assembly can damage the tissue in a targeted mode according to the information, obtained by the Doppler ultrasound assembly, of the tissue position, and the tissue damage effect is improved; and the situation that tissue damage is not in place or excessive damage is caused due to inaccurate information judgment at the tissue position is reduced. Besides, the Doppler ultrasonic assembly and the argon beam assembly are integrated in the tube shell, the compactness of the structure can be improved, the application of two functions of the Doppler ultrasonic argon beam device is facilitated, and the use flexibility and safety of the Doppler ultrasonic argon beam device can be improved.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

The present invention is titled "Flush Electrophysiology Catheter with Resolvable Electrodes for Multi-Electrode Identification and Orientation under Two-Dimensional Visualization". An electrophysiology catheter having a balloon with a membrane is disclosed. Electrodes may be disposed on the membrane. Each electrode may include a radiopaque marker. The marker may have different forms, such as alphanumeric or polygonal, to facilitate visualization of the electrodes using a bistable image and to allow selection of the appropriate electrodes to be energized during tissue ablation. The subject matter of the present invention allows for proper orientation of the electrodes on the balloon under a two-dimensional imaging system. This allows an operator or physician to determine whether certain electrodes are adjacent or contiguous to the posterior surface of the left atrium and to ablate such posterior surface for a shorter duration or at a lower power to create an effective transmural lesion on the posterior wall of the left atrium while reducing the chance of damaging adjacent anatomical structures.

In one example, a device includes: an ablation energy generator for transmitting ablation energy to electrodes of a catheter; a processor configured to: calculate a first force signal acting on tissue by the distal end assembly based on a first magnetic signal received from a magnetic emitter coil at the distal end of the catheter by a first magnetic field sensor of the distal end assembly during tissue ablation by the electrodes; calculate a second force signal acting on tissue by the distal end assembly based on a second magnetic signal received from a magnetic emitter coil disposed in a positioning pad by a second magnetic field sensor of the distal end assembly; calculate a third force signal based on the first and second force signals; and render the force value or ablation index value calculated based on the third force signal to a display.