19 results about "Microprobe" patented technology

Provided herein is a method comprising: binding α-synuclein to a biolayer interferometry (BLI) microprobe, contacting the BLI microprobe with a biological sample, contacting the BLI microprobe with α-synuclein, and measuring an optical signal from the BLI microprobe, wherein the optical signal indicates whether α-synuclein aggregates have formed on the microprobe.

The biopsy assembly comprises a cap body and a sampling piece, the cap body is provided with a first opening and a second opening, the first opening and the second opening are arranged in a staggered mode, a containing cavity channel and a pressure adjusting cavity channel are arranged in the cap body, the containing cavity channel is communicated with the first opening, and the pressure adjusting cavity channel is communicated with the second opening. The pressure adjusting cavity channel is communicated with the second opening and the storage cavity channel so as to provide positive pressure or negative pressure into the storage cavity channel; the sampling piece is at least partially arranged in the accommodating cavity channel and can move between a first position and a second position relative to the first opening; when the positive pressure in the containing cavity exceeds a first threshold value, the sampling piece moves from the first position to the second position relative to the first opening, so that at least part of the sampling piece penetrates through the first opening and extends out of the cap body. According to the utility model, the biopsy component and the intracavitary detector can be inserted into a cavity or an instrument channel at the same time after being matched, so that the sampling is prevented from deviating from the actual position, and the sampling accuracy is improved.

The application belongs to the technical field of electrostatic measurement, and particularly relates to a non-contact electrostatic potential tester based on a micro probe. The non-contact electrostatic potential tester comprises a shielding shell, an induction electrode, a conductor plate, a conductor filament, a test module and an insulating medium. The shielding shell is a columnar structure with two open ends. The two ends of the shielding shell are respectively provided with the insulating medium. The induction electrode is fixed to the insulating medium at one end of the shielding shell. The test module and the conductor plate are respectively fixed to the insulating medium at the other end of the shielding shell. The test module is provided with a test electrode. The conductor filament is located in the shielding shell and is respectively connected to the induction electrode and the conductor plate at two ends. The insulating medium is arranged on the two sides of the conductor filament. The insulating medium is arranged between the conductor plate and the test module.

The application provides a method for in-situ monitoring of active ion deintercalation in an active material. The method comprises: thinning a sample to be tested to below 150 nm by using a FIB technology to obtain a sample to be tested; determining an angle between a preferential orientation path of active ion intercalation and an electron beam by using an EBSD technology, and selecting a grain with an angle of 85°-95° as an in-situ monitoring object; transferring the active metal to a conductive microprobe, oxidizing part of the active metal on the conductive microprobe to form an active metal oxide, and obtaining a negative electrode and an electrolyte attached to the conductive microprobe; fixing the sample to be tested at a fixed end of a sample rod of an in-situ TEM tester, fixing the negative electrode and the electrolyte at a moving end thereof, and building a solid-state battery in a field of view of the tester; connecting the sample to be tested with a negative electrode of an external power supply, connecting the negative electrode with a positive electrode of the external power supply, applying a voltage to the solid-state battery, and collecting electron energy loss spectra at different positions in the grain of the active material to be tested.

The application discloses a preparation method of a flexible array microprobe in the field of semiconductors and microelectronics, and comprises the following steps: step S1, providing a quartz glass substrate, performing organic cleaning treatment, the cleaning process comprising three-step ultrasonic cleaning of acetone-isopropyl alcohol-deionized water, ultrasonic power being 50-200 W, time being 5-15 minutes, and drying in a 80 DEG C vacuum oven for 30 minutes after cleaning; step S2, preparing an ultraviolet narrow-band filter film on the quartz glass substrate, and the filter film adopting an HfO2 / SiO2 alternating film layer structure. The application designs an ultraviolet narrow-band filter for a wide-spectrum photoetching machine (mercury lamp spectrum range 300-600 nm) exposure light source, realizes specific wavelength selective transmission, improves diffraction light field definition of the narrow-band filter, and improves micro-needle sidewall smoothness; moreover, without complex mask exposure equipment or gray-scale mask plate preparation, through ultraviolet narrow-band filter design and diffraction light field regulation technology, the process flow is simplified, micro-needle geometric precision is improved, and process cost is reduced.

This invention discloses a neural microprobe for bimodal functional localization and precise electrical stimulation of deep brain nuclei in non-human primates. It comprises a basal layer, a conductive metal layer, and an insulating layer. The conductive layer includes a set of detection sites and stimulation sites. This invention employs a dry etching process on the back of the silicon basal layer using two insulating layers with opposite stresses, balancing the stress differences between the different materials. This overcomes the technological challenges of extending silicon microprobes and solves the problems of probe bending and low mechanical stress caused by the large aspect ratio of silicon probes in non-human primates. The detection sites acquire bimodal signals using modified nanomaterials and polymer anti-interference ion-exchange membranes as localization markers for functional localization. The detection sites are arranged between the positive and negative electrodes of the electrical stimulation, controlling the stimulation range to be near the detection sites, thus achieving precise electrical stimulation. This invention provides a new research method and means for deep brain stimulation therapy of diseases such as Parkinson's disease.

The invention relates to the technical field of planetary science and celestial body material analysis, and particularly discloses a lunar soil micron-sized particle sample capturing method which comprises the following steps: on an original substrate containing target particles, performing in-situ identification and phase classification on the particles by adopting a non-destructive spectrum means, generating a particle positioning map with serial number marks; preparing a microprobe with a flexible adhesion tip, and coating the flexible adhesion tip with an adhesion medium; the microprobe is controlled to make contact with target particles, the target particles are captured in a lossless mode through the adhesion force of the adhesion medium, and the target particles are separated from the substrate; transferring the microprobe capturing the target particles into a packaging medium, performing unique identification on a packaging body, and establishing a traceable file; a mild adhesion mode of the fiber tip and the embedding medium is adopted, the physical capture success rate of nearly 100% is achieved, and one-by-one independent treatment of single particles can be achieved.

The invention relates to a high-speed optical detection platform for a microprobe. The high-speed optical detection platform comprises a machine base, the electromagnetic chuck is located above the machine table base and comprises a magnetic conductive frame and a magnetic conductive cover plate, a hollow structure is arranged in the magnetic conductive frame, an electromagnetic coil is installed in the hollow structure, an opening is formed in the upper portion of the magnetic conductive frame, and the magnetic conductive cover plate covers the opening side of the magnetic conductive frame. Magnetic lines of force generated by the electromagnetic coil form a closed magnetic circuit in the magnetic conductive frame and the magnetic conductive cover plate; and the detection lens is positioned above the magnetic conductive cover plate and can move up and down. According to the detection platform of the scheme, accurate focusing of the probe and efficient detection of the quality of the probe can be achieved.

The invention aims to provide an ion source for mass spectrum in-situ ionization, which is used for qualitative and quantitative analysis of mass spectrum and comprises an ionization cavity, a grooving needle, a capillary spray needle fixed in the ionization cavity, a liquid phase pump for supplying liquid to the capillary spray needle and a laser heating source. The method comprises the following steps: dipping 0.5-1 [mu] L of a sample solution into a grooving needle, heating the grooving needle to evaporate the sample solution in a grooving groove to dryness to obtain sample dry residues, extending the grooving needle into an ion source at a distance of 05-20 mm from an inlet of a mass spectrometer, conveying methanol, acetonitrile, water or other spray liquid to a capillary spray needle by a liquid phase pump at a speed of 10-200 [mu] L / min, and simultaneously applying 2-6 KV high voltage to the capillary spray needle to atomize the spray liquid, a grooving part of the grooving needle is connected with a ground wire, fog is gathered to the grooving part to wet sample dry residues, then direct-current high voltage of the flat spraying capillary tube and the grooving needle are disconnected at the same time, then direct-current high voltage of 3-7 KV is applied to the grooving needle, aerosol generated by human analysis is excited by discharging of the grooving needle to generate ions, and the ions are removed; and the mass spectrometer inlet potential collects the generated ions into the mass spectrometer for separation and determination so as to generate a mass spectrum signal. The ion source has the sensitivity and stability of a common chemical ionization ion source under atmospheric pressure, and can be used for qualitative and quantitative analysis of mass spectrum.

Provided is an inspection device including: a light source generating and outputting a femtosecond laser beam; a beam splitter configured to split the femtosecond laser beam into a first light and a second light; a first optical array configured to separate the first light into a first sub-light and a second sub-light and to provide the first and the second sub-lights to an inspection target, wherein the first sub-light and the second sub-light are polarized in different directions; a microprobe configured to detect a photoelectric signal caused by incidence of the first and the second sub-lights on the inspection target, the microprobe including a first microprobe configured to detect the first sub-light and a second microprobe configured to detect the second sub-light; and a second optical array configured to provide the second light to the microprobe.

The invention provides a detection device and method for power plant metallographic authenticity discrimination, belongs to the technical field of material detection, and can at least partially solve the problems that the existing comparison result highly depends on the integrity of a database, the slight editing sensitivity of an algorithm to a photo is low, the algorithm is only based on static visual characteristics, the dynamic characteristics are ignored, an active verification mechanism is lacked, and the detection efficiency is low. The device comprises a sample positioning platform, a resonant cavity module, an electrochemical microprobe module, an optical polarization modulation module and a signal processor, and has the beneficial effects that the device is provided with the resonant cavity module, the electrochemical microprobe module and the optical polarization modulation module; through multi-mode cooperation, the limitation of single visual comparison is broken through, vibration, electrochemical and optical signatures are actively generated, and the anti-counterfeiting capability is enhanced; the device does not depend on a huge database and adapts to a power plant complex environment; all the modules work cooperatively to form a closed-loop verification mechanism.

The present disclosure provides a metal microprobe array and an electroforming method thereof, and relates to the technical field of microfabrication, and comprises the following steps: constructing a photocured resin mask model with a microprobe cavity; preparing a photocured resin mask; placing the photocured resin mask into a dopamine mixed solution to form a self-assembled polydopamine molecular layer on the surface of the photocured resin mask, thereby obtaining a photocured resin mask with surface hydrophilicity; adhering the photocured resin mask with surface hydrophilicity to a metal substrate by mechanical bonding, and using the photocured resin mask as an assembled cathode for electrodeposition; immersing the assembled cathode into an electroforming solution as a cathode for vacuum boiling electrodeposition; when the microprobe array is filled with metal and fills the cavity of the photocured resin mask with surface hydrophilicity, removing the cathode to obtain a filled photocured resin mask; and performing high-temperature ashing treatment on the filled photocured resin mask, and then performing ultrasonic cleaning to obtain a metal microprobe array. The present disclosure can improve the preparation efficiency of the metal microprobe array.

The invention discloses a laser-assisted MCED electrochemical deposition method and an inclined cantilever beam preparation method, and the method comprises the steps: S1, carrying out laser-assisted experiment simulation on a glass microprobe tip in an MCED system through COMSOL software to obtain correlation characteristics of temperature field change and deposition rate of the glass microprobe tip under different laser parameters; s2, after a stable electrolyte droplet bridge is formed in the MCED system, a laser-assisted assembly is started; s3, the droplet bridge form, the deposition point form and the deposition area temperature are observed in real time based on a temperature-vision system; and S4, the MCED central controller realizes regulation and control on the shape of the liquid drop at the tip of the glass microprobe based on coordination in the step S3, the shape of the liquid drop bridge is kept consistent, and the preparation of the micro-nano structure is rapidly completed on the substrate. According to the MCED electrochemical deposition method based on laser assistance and the inclined cantilever beam preparation method, the deposition rate is increased while the process stability is guaranteed, micro-nano manufacturing is completed, and the MCED technology is promoted to be applied and developed to industrialization.

This invention discloses a single-crystal organic phototransistor based on anthracene nuclei with single or double-sided substitution, its fabrication method, and applications, belonging to the field of active layer semiconductor design and synthesis of organic phototransistors. The fabrication method of the single-crystal organic phototransistor based on anthracene nuclei with single or double-sided substitution includes the following steps: single-crystal growth using single-sided or double-sided substituted anthracene nuclei small molecules as raw materials to prepare organic semiconductor micro / nano single crystals; preparing gold electrodes; and using a microprobe transfer method to attach the organic semiconductor micro / nano single crystals onto the gold electrodes to construct a bottom-gate top-contact structure single-crystal organic phototransistor. This invention limits anthracene to the molecular core, fabricating a series of organic phototransistors constructed using anthracene nuclei-based single / double-sided substituted small molecule semiconductor materials as the active layer, and controlling the photoresponse speed according to the single or double-sided substitution form of the anthracene nuclei small molecules.

According to the spiral ultrasonic thrombolysis micro-probe, the system, the control method, the equipment and the medium, the spiral ultrasonic thrombolysis micro-probe is precisely cut into a plurality of independent array elements, and the working time sequence and the phase of each array element are independently controlled by a circuit system, so that the synthesis of hurricane spiral ultrasonic fields in different modes is realized. According to the structure, while the processing complexity of the probe is remarkably reduced, drugs and microbubbles act on thrombus through a spiral sound field, and the cavitation effect and mechanical disturbance are effectively enhanced, so that the thrombolysis efficiency is greatly improved. According to the invention, two reliable phase control implementation paths are provided, a specific and feasible circuit implementation scheme is provided for realizing fine and stable phase adjustment, and the requirements of different application scenes are met. According to the invention, the phase of each array element is dynamically regulated and controlled through a circuit system, and the switching of a clockwise scanning mode and an anticlockwise scanning mode of a spiral sound field at different rates is realized.

The invention discloses a nanometer platform real-time pose calibration method fusing laser interference and multi-sensor data, and relates to the technical field of nanometer positioning and precision measurement. The method comprises the following steps: establishing a sensor system comprising a laser interference measurement module, a capacitive displacement sensor, a visual sensor and a high-precision optical fiber microprobe sensor (FMS), and completing initialization; multi-source data space-time synchronization is realized by taking a sampling clock of the laser interferometer as a reference; performing layered preprocessing on the synchronized data and extracting multi-dimensional key features; constructing a fusion weight adaptive distribution model, and outputting a dynamic fusion weight through an optimization objective function containing cutting operation and KL divergence penalty; pose fusion estimation is completed based on a multi-scale sliding window, hierarchical constraint, robust iteration and error feedback correction four-level framework; and finally, parameter self-optimization is realized through closed-loop feedback calibration. The method does not need an external auxiliary device, gives consideration to the pose calibration precision and robustness, improves the dynamic response capability, and is suitable for the real-time pose calibration of the nano platform under a complex working condition.

The invention provides a terahertz near-field spectral signal measurement system and a measurement method. The invention relates to the technical field of terahertz spectrum detection and imaging, and in particular relates to a terahertz near-field spectral signal measurement system which comprises a sample bearing plate, the sample bearing plate is provided with a through hole and a cooling channel, a sample to be detected is arranged in the through hole, and a cooling medium flows through the cooling channel; the emission source module is used for emitting detection light pulses and terahertz waves and guiding the terahertz waves to penetrate through the sample to be detected through the through hole; the light guide microprobe module is configured to be arranged in a near-field area of a sample to be detected; wherein under the condition that the cooling medium flows through the cooling channel to enable the temperature of the near-field region to be lower than the preset temperature, the light guide microprobe module is configured to receive the terahertz wave penetrating through the sample to be detected under the action of the detection light pulse, and a terahertz spectrum signal of the sample to be detected is obtained.

This invention belongs to the field of radiation detector technology and relates to an array detector for coded spectral dispersion and a method for acquiring response depth information. The array detector includes: a scintillator array composed of multiple microprobes, with a light-reflecting layer disposed between adjacent pixel scintillators; a photoelectric channel array optically coupled to the scintillator array for converting detected scintillating light into electrical signals; and a light guide block array optically coupled to the first end face of the scintillator array, with adjacent light guide channels separated by a light-reflecting layer. The light guide block array is used to partially distribute light emitted from one pixel scintillator and entering the corresponding light guide channel to an adjacent pixel scintillator crystal, so that the light signal generated by the same scintillating event can be received by at least two photoelectric devices. Its advantages include high energy measurement accuracy and accurate timing, high linearity of DOI correlation, and more accurate measurement.

This invention discloses a magnetic field microprobe based on the anomalous Nernst effect, along with its calibration and usage methods. The magnetic field microprobe includes a magnetic field sensing unit, a laser heating unit, a microprobe support structure, and a voltage detection and processing unit. The magnetic field sensing unit comprises a substrate, a ring-shaped or near-ring-shaped magnetic thin-film microstructure, and a voltage electrode. The laser heating unit heats the magnetic thin-film microstructure towards its heated center to create a radial temperature gradient. The voltage detection and processing unit acquires the anomalous Nernst voltage and obtains the information of the magnetic field to be measured. This invention eliminates the need for an external bias magnetic field and electric heating source, offering advantages such as low power consumption, high linearity, adjustable sensitivity, and suitability for micrometer-scale magnetic field measurements.