Optical tweezers type optical fiber Raman microprobe and manufacturing method

A Raman probe and optical fiber technology, which is applied in the field of optical tweezers fiber Raman probe production, can solve the problems of inability to intervene in living tissue, difficult living tissue Raman measurement, poor flexibility, etc., and achieves small size and measurement process. Stable, high spatial resolution effects

Active Publication Date: 2017-05-31
GUILIN UNIV OF ELECTRONIC TECH
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Problems solved by technology

However, the traditional optical tweezers are realized based on a relatively large microscope system, so the flexibility of

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  • Optical tweezers type optical fiber Raman microprobe and manufacturing method
  • Optical tweezers type optical fiber Raman microprobe and manufacturing method
  • Optical tweezers type optical fiber Raman microprobe and manufacturing method

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Embodiment Construction

[0041] The present invention is described in more detail below in conjunction with accompanying drawing example:

[0042] figure 1 It is a schematic diagram of the optical tweezers fiber Raman probe and its working method. The Raman excitation light output by the laser light source 5 is first transmitted by the ordinary single-mode fiber 2, and the single-mode fiber 2 is coupled with the coaxial dual waveguide channel fiber 1 after side throwing, and then the excitation light can be coupled to the coaxial dual waveguide channel Inside the annular core 1-1 of the optical fiber 1. When the excitation light is transmitted to the fiber end of the probe, the finely ground rotationally symmetrical reflective optical structure 1-3 will converge the excitation light, capture and interact with particles 4 such as microbes or cells to be detected , to generate Raman scattered light, wherein the backscattered light is collected and transmitted by the intermediate core 1-2, and then the...

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Abstract

The invention provides an optical tweezers type optical fiber Raman microprobe and a manufacturing method. The probe has two optical channels which are coaxial, wherein an annular optical fiber core provides a Raman exciting light channel and a channel in the coaxial center is used for receiving Raman probe light; and by performing fine taper angle grinding on the fiber ends of coaxial dual waveguide channel optical fibers, a rotary symmetrical plane (or chambered surface) structure is formed. The structure can converge Raman exciting light transmitted by the annular core in a micron order, and on the one hand, the converged exciting light has an ability of capturing micron-order and nanoscale particles and on the other hand, the converged exciting light interacts with the particles, so that a back scattering Raman optical signal generated by the exciting light converged by the Raman scattering light can be collected and transmitted to a Raman spectrometer through an intermediate large-core fire cores. The microprobe provided by the invention can capture micro living matters of cell living bodies to effectively excite the Raman spectrum of the matters in cells and to obtain the Raman spectrum so as to achieve Raman measurement of micro liquids, single cells in living bodies and inner substances thereof.

Description

technical field [0001] The invention relates to an optical tweezers fiber Raman probe. The invention also relates to a manufacturing method of an optical tweezers type optical fiber Raman probe. Background technique [0002] Raman spectroscopy is a technology that generates Raman scattering spectra to reflect the internal structure and molecular vibration information of substances through the interaction of light and substances. It is widely used in biomedicine, environmental testing, food safety and other fields. The design and manufacture of Raman probes is one of the key technologies in the development of Raman spectroscopy. [0003] In order to accurately realize the diagnostic accuracy of Raman spectroscopy in living cells and to improve the research of Raman spectroscopy in living cells and in somatic cells to the level of molecules inside single cells, two technical problems must be solved: [0004] (1) Since the size of the cells is in the micron scale, the Raman ...

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Application Information

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IPC IPC(8): G01N21/65
Inventor 苑立波杨世泰
Owner GUILIN UNIV OF ELECTRONIC TECH
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