35 results about "Stratum basale" patented technology

The invention relates to a pigment-containing artificial skin detection model and a preparation method thereof. The artificial skin detection model is an epidermal layer structure with activity, which is constructed by compositely inoculating cutin formative cells and melanophores to the surface of a support membrane made from a biodegradable material through culture and comprises a stratum basale, a stratum spinosum, a stratum granulosum and a stratum corneum, and a basilar membrane structure is formed between the epidermal layer and the biodegradable material positioned below the epidermal layer. Compared with the conventional product, the invention can better simulate the pigment components of natural skin and more accurately reflect the whitening and sunscreen effect of cosmetics because of containing the melanophores, nourish the cutin formative cells by using the support membrane made from the biodegradable material as an enderonic layer, control the contraction of the epidermal layer with the strength and enhance the stability of the detection model and has low raw material cost, short manufacturing period and mass production; and in addition, the prepared artificial skin detection model can be directly used for the efficacy detection of the cosmetics and the skin irritation detection of textiles, the cosmetics and chemicals.

The invention discloses a skin care composition with a wrinkle removing and resisting function. The composition comprises a phase A and a phase B, wherein the phase A comprises oil, and the phase B comprises traditional Chinese medicine extracts. In the invention, raw materials are all selected from natural soothing components, have little stimulation to the skin, permeate into the skin stratum basale through various approaches and can be used for recovering skin activity and removing free radicals so as to fundamentally play the roles of removing and resisting wrinkles. Experiments prove that the preparation of the skin care composition has an obvious wrinkle removing function, and can obviously improve the texture of the skin, make the texture fine and smooth, simultaneously enhance skin glossiness and make the skin fin, mellow and white after being used for 30 days. The skin care composition disclosed by the invention is prepared from the raw materials which are easy to obtain by a convenient preparation method, is easy to accept by the massive consumers and has good application prospects and market prospects.

The invention discloses a biological electric impedance measuring electrode, which is characterized in that the electrode comprises a viscous stratum basale, an electrically conductive adhesive layer, a connecting fastener and a laying, wherein the electrically conductive adhesive layer, the viscous stratum basale and the laying are connected in turn, the connecting fastener is off-center designed, the electrically conductive adhesive layer has a cylindrical shape, and the connecting fastener is electrically connected with the electrically conductive adhesive layer. The invention can ensure the tight contact of the electrode and measured body surface, avoids the conditions that the electrode moves or looses or falls off the measured body, thereby effectively improving the precision and repeatability of the measurement value when the biological electric impedance is measured, additionally, the invention can receive consistent electrical characteristics when measuring the biological electric impedance, decrease the possibility of generating error, and ensure the consistency of contact electrical impedance which is measured in each time. Further more, the invention can further avoid the inference to the biological electrical impedance which is caused by the movement of the measured body, and guarantees the precision of the measured value.

The invention discloses tissue engineering skin constructed by a sodium alginate hydrogel scaffold. The tissue engineering skin comprises a cuticular layer and a corium layer from top to bottom, wherein the cuticular layer is a layer of seed cells positioned above the corium layer; and the corium layer comprises seed cells and a sodium alginate hydrogel scaffold; the seed cells are positioned in the surface and body of the sodium alginate hydrogel scaffold to form a skin appendage. Since the hydrogel scaffold cross-linked network contains a great amount of moisture, can be used for supplying nutrition to cells, and is crosslinked with EGF to adjust growth and differentiation of cells, so that the hydrogel scaffold can be used for well simulating tissue-like physical and spatial structures essential to cell growth, a three-dimensional cultural space of cells can be provided, culture and function maintenance of stratum basale epidermidis cells can be benefited, and a tissue engineering skin substitute with biological activity can be constructed. When the tissue engineering skin is applied to a wound surface, and recovery of a normal tissue structure of the wound is benefited.

The invention provides a semiconductor device etching method and a semiconductor device formation method. The semiconductor device etching method comprises a main etching process and at least one auxiliary etching process. The main etching process comprises steps of forming a polycrystal layer on an oxide layer on a stratum basale of a semiconductor device, performing etching on the polycrystal layer through a first etching fluid, and finishing the main etching flow and leaving a first preset thickness on the polycrystal layer when a preset first etching end point detection condition is met. The auxiliary etching process comprises steps of performing the etching on the residual polycrystal layer through a second etching fluid, wherein the etching speed of the second etching fluid is slower than that of the first etching fluid, finishing the auxiliary etching process when the preset second etching end point detection condition is met and leaving a second preset thickness on the oxide layer. The semiconductor device etching method increases the adjustable range of the etching amount of the oxide layer without changing the main etching process, and the adjustment of the thickness of the lower oxide layer does not affect the etching feature.

A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin.

The invention provides a facial mask with excellent moisturizing and repairing effects. The facial mask comprises the following components: polypeptide and a humectant, and the polypeptide is a mixedactive protein peptide formed by mixing a small molecular active protein peptide with an amino acid sequence shown as SEQ ID NO: 2 and a small molecular cell-penetrating peptide with an amino acid sequence shown as SEQ ID NO: 3. The TAT-EL mixed active protein peptide is compounded in the formula of the mask to replace tissue/collagen/blood capillaries to accept attack of free radicals, so that the effect of protecting the blood capillaries and collagen is achieved; and the facial mask has excellent effects of promoting cell proliferation and differentiation and accelerating self-renewal and self-repair of skin epidermal cells, and has a good effect on damaged pox muscle/medical beauty wound repair. Acetylated hyaluronic acid is used as one of humectants, so that the solubility, permeability and hyaluronidase resistance of the hyaluronic acid are enhanced; and acetylated hyaluronic acid is amphiphilic, can be dissolved in water and oil, can permeate into a basal layer of skin by takingintercellular substances as carriers, and plays a role in moisturizing.

The invention discloses a transdermal delivery nano-preparation, containing kojic dipalmitate, a polymer material, agouti protein and oleic acid, wherein the polymer material is formed into a nano-preparation carrier; the agouti protein and oleic acid are modified on the surface of the carrier; and the kojic dipalmitate is loaded in the carrier. The invention also discloses a preparation method and application of the transdermal delivery nano-preparation. The transdermal delivery nano-preparation disclosed by the invention is capable of effectively penetrating through the cuticle and also can be located at the melanocyte of the epidermis stratum basale; and besides, the transdermal delivery nano-preparation has good stain treatment effect and is suitable for treating hyperpigmentation diseases such as chloasma, freckle and the like.

The invention discloses a five-dimensional stereo repair system, relating to the technical field of skincare and beauty. A repair method of the system comprises the following steps: (I) the first dimension: stratum corneum repair; (II) the second dimension: stratum basale repair; (III) the third dimension: superficial-layer repair of dermis; (IV) the fourth dimension: deep-layer repair of dermis; and (V) the fifth dimension: soft tissue repair. The five-dimensional stereo repair system improves the sensitivity and fragility, redness, red blood, drying and aging, lines and under-eye puffiness, dull skin, sunburn, acnes and laxity and aging, realizes after-sun repair, repair after various high-technology beauty and early and later repair of various pigments, dredges and shrinkages the pores, brightens the skin and effectively repairs the lax outline so that the apple muscle is sweet and the silkworm comes back again, the tear lines, bitter lines and nasolabial folds shallow or disappear, the muscle layer is stimulated to become tight, the fat fades away and the bottommost layer of the skin is improved.

The invention discloses a gold nanometer wafer, and belongs to the technical field of a nanometer wafer. The gold nanometer wafer comprises a silicon substrate, wherein microneedles are arranged on the silicon substrate; each microneedle comprises an upper section and a lower section; the upper section of the microneedle is in a cylindrical shape; the lower section of the microneedle is in a pointed cone shape; a groove is formed in each microneedle; and a gold layer is plated on the outer wall of each microneedle. The gold nanometer wafer has the advantages that by using an independent research and development technology, 99.999-percent gold materials are combined with 99.999-percent monocrystalline silicon materials; through a fine engraving process, the nanometer level microneedles areintegrated onto the wafer; the use effect is obvious; and effective active substances can be conveyed to positions above the stratum basale, so that the seepage of a skin care product is greatly enhanced, and the skin care product fast works; and the corium layer, nerves and blood vessels cannot be touched, so that no harm is caused on the skin.

The invention discloses a model for simulating dermatophyte infection in vitro and an establishment method and application thereof, and belongs to the technical field of bioengineering. The model forsimulating dermatophyte infection in vitro comprises matrix glue, an epidermal analogue embedded in the solidified matrix glue and dermatophyte hyphae, the epidermal analogue is of a relatively complete solid sphere structure, and the exterior of the epidermal analogue is a cell layer which is composed of substrate layer cells and substrate upper layer cells and distributed in a surrounding mode,and a keratinization sample non-cell layer is arranged inside; hyphae invade basal layer cells outside the sphere structure and do not invade or only invade a small amount of basal layer cells, and donot invade the keratinization sample non-cell layer inside the sphere structure; the model can effectively simulate the state that dermatophyte infects normal skin tissue, the infection process of the model can be directly observed under a phase contrast microscope, the infection situation can be detected through omics methods such as high-throughput RNA sequencing, and the model can be effectively used for researching the pathogenic mechanism of dermatophyte infection and screening anti-dermatophyte drugs.

The invention discloses a skin-beautifying skin-cleansing spot-regulating facial mask as well as a preparation method and a use method thereof. The skin-beautifying skin-cleaning spot-adjusting facial mask is mainly prepared from the following components: peach kernels, red peony roots, rhizoma cyperi, angelica sinensis, cordyceps sinensis, radix scrophulariae, radix rehmanniae, rhizoma typhonii, white poria, radix paeoniae alba, ginseng, saffron crocus, codonopsis pilosula, saussurea involucrata, moutan bark, pseudo-ginseng, golden cypress, medlar, bitter apricot seed, semen cuscutae, bighead atractylodes rhizome, deionized water, essence, a water replenishing agent and honey. According to the facial mask, the decomposition and metabolism speed of melanin, lead mercury and garbage on a skin basal layer is increased, the problems of melanin accumulation and poor metabolism are solved fundamentally, the skin is not red or swollen, the skin cuticle is not damaged, melanin is metabolized from the basal layer to inhibit the activity of tyrosinase, rebounding is avoided after melanin is removed, and all dirt is discharged from inside to outside.

The invention discloses a multi-point microinjection device for a uterine neck. The multi-point microinjection device comprises a hollow injection disc, an inner core of the injection disc and multiple hollow microinjection needles. The injection disc is composed of a first cylinder and a second cylinder as a whole. The microinjection needles are secured on one surface, away from the second cylinder, on the first cylinder. One end of the inner core of the injection disc is fixedly connected with a piston head. The piston head is located into the first cylinder and closely combined with the cylindrical wall of the first cylinder and performs up-down motion in the first cylinder. The multi-point microinjection device for the uterine neck is capable of accurately injecting medicine for treating uterine neck lesions to the stratum basale of a cervical leather and keeping medicine in high concentration partially so that uterine neck lesions induced by an HPV virus are favorably treated; a patient may recover from uterine neck lesions; and the new medication therapy for treating uterine neck lesions can be applied; and the multi-point microinjection device is simple, viable, cost-effective and practical and is convenient for clinic use.

The invention relates to the technical field of plant extracts and discloses application of platycladus orientalis. The invention finds that a natural plant platycladus orientalis extract can significantly up-regulate genes sirt1, nidi1 and igf1 contributing to skin cell and tissue repair and remarkably increase thickness of epidermis to make arrangement of cells on basal layers more closely and differentiation of the cuticle more perfected, which indicates that the platycladus orientalis extract can enhance overall vitality and health conditions of skin, has skin tissue repair capacity, can further continuously promote skin cell proliferation and skin tissue regeneration and delay declination phenomena caused by reduced viability and decreased number of existing skin cells.

The invention provides freckle-removing and whitening traditional Chinese medicine mask powder. The mask powder is prepared from the following raw materials in parts by weight: 15-20 parts of white poria, 15-20 parts of silkworm larva, 10-15 parts of ginseng roots, 10-15 parts of licorice roots, 10-15 parts of bighead atractylodes rhizomes, 10-13 parts of coix seeds, 8-10 parts of wax gourd seeds,5-10 parts of pseudo-ginseng, 5-10 parts of flos magnoliae liliflorae, 5-10 parts of peach kernels, 5-8 parts of tuber bletillae, 5-8 parts of moutan bark and 5-8 parts of pearl powder. According tothe invention, all the components produce a synergistic effect through combination according to a certain ratio, and can effectively whiten skin and remove freckles, fully supplement nutrition required by the skin, promote blood circulation of the skin, enhance metabolic activity of skin cells and effectively inhibit generation of melanin and self-free radicals on the basal layer of skin epidermis.