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37 results about "Stratum basale" patented technology
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The stratum basale (basal layer, sometimes referred to as stratum germinativum) is the deepest layer of the five layers of the epidermis, the outer covering of skin in mammals. The stratum basale is a single layer of columnar or cuboidal cells. The cells are attached to each other and to the overlying stratum spinosum cells by desmosomes and hemidesmosomes. The nucleus is large, ovoid and occupies most of the cell. Some basal cells can act like stem cells with ability to divide and produced new cells, whereas others serve to anchor the epidermis glabrous skin (hairless), and hyper-proliferative epidermis (from a skin disease).
Micro-invasive method for painless detection of analytes in extracellular space
InactiveUS6904301B2Reduces and eliminates delay timeAvoid destructionAdditive manufacturing apparatusSurgeryAnalyteStratum basale
A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
Owner:BECTON DICKINSON & CO
Pigment-containing artificial skin detection model and preparation method thereof
The invention relates to a pigment-containing artificial skin detection model and a preparation method thereof. The artificial skin detection model is an epidermal layer structure with activity, which is constructed by compositely inoculating cutin formative cells and melanophores to the surface of a support membrane made from a biodegradable material through culture and comprises a stratum basale, a stratum spinosum, a stratum granulosum and a stratum corneum, and a basilar membrane structure is formed between the epidermal layer and the biodegradable material positioned below the epidermal layer. Compared with the conventional product, the invention can better simulate the pigment components of natural skin and more accurately reflect the whitening and sunscreen effect of cosmetics because of containing the melanophores, nourish the cutin formative cells by using the support membrane made from the biodegradable material as an enderonic layer, control the contraction of the epidermal layer with the strength and enhance the stability of the detection model and has low raw material cost, short manufacturing period and mass production; and in addition, the prepared artificial skin detection model can be directly used for the efficacy detection of the cosmetics and the skin irritation detection of textiles, the cosmetics and chemicals.
Owner:GUANGDONG BOXI BIO TECH CO LTD
Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof
ActiveCN102048666ADPPH free radical scavenging ability is strongPromote absorptionCosmetic preparationsToilet preparationsIrritationStratum basale
The invention discloses a skin care composition with a wrinkle removing and resisting function. The composition comprises a phase A and a phase B, wherein the phase A comprises oil, and the phase B comprises traditional Chinese medicine extracts. In the invention, raw materials are all selected from natural soothing components, have little stimulation to the skin, permeate into the skin stratum basale through various approaches and can be used for recovering skin activity and removing free radicals so as to fundamentally play the roles of removing and resisting wrinkles. Experiments prove that the preparation of the skin care composition has an obvious wrinkle removing function, and can obviously improve the texture of the skin, make the texture fine and smooth, simultaneously enhance skin glossiness and make the skin fin, mellow and white after being used for 30 days. The skin care composition disclosed by the invention is prepared from the raw materials which are easy to obtain by a convenient preparation method, is easy to accept by the massive consumers and has good application prospects and market prospects.
Owner:NEW ERA HEALTH IND GRP +2
Culture method for acquisition of tissue-engineered epidermis and application of culture method
ActiveCN105132358AEasy to integrateQuality assuranceArtificial cell constructsVertebrate cellsTreatment effectCuticle
The invention provides a culture method for acquisition of tissue-engineered epidermis and application of the culture method. By means of co-culture of epidermal cells and melanocytes, an epidermis membrane with a stratum bassale, a stratum spinosum, a stratum granulosum and a stratum corneum can be acquired, and large area, avoidance of rejection reaction, structural similarity to natural epidermis, excellent treatment effects and the like are realized.
Owner:NOVAPRINT THERAPEUTICS SUZHOU CO LTD
Bio-electrical impedance measuring electrode and apparatus
InactiveCN101194835AGuaranteed adhesionPrevent movementDiagnostic recording/measuringSensorsElectricityElectrical resistance and conductance
The invention discloses a biological electric impedance measuring electrode, which is characterized in that the electrode comprises a viscous stratum basale, an electrically conductive adhesive layer, a connecting fastener and a laying, wherein the electrically conductive adhesive layer, the viscous stratum basale and the laying are connected in turn, the connecting fastener is off-center designed, the electrically conductive adhesive layer has a cylindrical shape, and the connecting fastener is electrically connected with the electrically conductive adhesive layer. The invention can ensure the tight contact of the electrode and measured body surface, avoids the conditions that the electrode moves or looses or falls off the measured body, thereby effectively improving the precision and repeatability of the measurement value when the biological electric impedance is measured, additionally, the invention can receive consistent electrical characteristics when measuring the biological electric impedance, decrease the possibility of generating error, and ensure the consistency of contact electrical impedance which is measured in each time. Further more, the invention can further avoid the inference to the biological electrical impedance which is caused by the movement of the measured body, and guarantees the precision of the measured value.
Owner:CHONG QING BORN FUKE MEDICAL EQUIP CO LTD
Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof
The invention discloses tissue engineering skin constructed by a sodium alginate hydrogel scaffold. The tissue engineering skin comprises a cuticular layer and a corium layer from top to bottom, wherein the cuticular layer is a layer of seed cells positioned above the corium layer; and the corium layer comprises seed cells and a sodium alginate hydrogel scaffold; the seed cells are positioned in the surface and body of the sodium alginate hydrogel scaffold to form a skin appendage. Since the hydrogel scaffold cross-linked network contains a great amount of moisture, can be used for supplying nutrition to cells, and is crosslinked with EGF to adjust growth and differentiation of cells, so that the hydrogel scaffold can be used for well simulating tissue-like physical and spatial structures essential to cell growth, a three-dimensional cultural space of cells can be provided, culture and function maintenance of stratum basale epidermidis cells can be benefited, and a tissue engineering skin substitute with biological activity can be constructed. When the tissue engineering skin is applied to a wound surface, and recovery of a normal tissue structure of the wound is benefited.
Owner:朱家源 +1
Semiconductor device etching method and semiconductor device formation method
ActiveCN104900515ALarge adjustment rangeDoes not affect etched topographySemiconductor/solid-state device manufacturingEtchingStratum basale
The invention provides a semiconductor device etching method and a semiconductor device formation method. The semiconductor device etching method comprises a main etching process and at least one auxiliary etching process. The main etching process comprises steps of forming a polycrystal layer on an oxide layer on a stratum basale of a semiconductor device, performing etching on the polycrystal layer through a first etching fluid, and finishing the main etching flow and leaving a first preset thickness on the polycrystal layer when a preset first etching end point detection condition is met. The auxiliary etching process comprises steps of performing the etching on the residual polycrystal layer through a second etching fluid, wherein the etching speed of the second etching fluid is slower than that of the first etching fluid, finishing the auxiliary etching process when the preset second etching end point detection condition is met and leaving a second preset thickness on the oxide layer. The semiconductor device etching method increases the adjustable range of the etching amount of the oxide layer without changing the main etching process, and the adjustment of the thickness of the lower oxide layer does not affect the etching feature.
Owner:CSMC TECH FAB2 CO LTD
Micro-invasive method for painless detection of analytes in extracellular space
InactiveUS20050283057A1Reduces and eliminates delay timeAvoid destructionAdditive manufacturing apparatusInvestigating moving fluids/granular solidsAnalyteStratum basale
A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
Owner:BECTON DICKINSON & CO
Freckle dispelling composition
InactiveCN111228158AImprove permeabilityEffectiveCosmetic preparationsToilet preparationsBiotechnologyStratum basale
The invention provides a freckle dispelling composition. The freckle dispelling composition comprises the active components of troxerutin, a radix cynanchi atrati extract, salicylic acid and 4-Butyl-resorcinol. Experiments prove that the active components can achieve the basal layer of skin, and can effectively act on melanocyte; through efficacy test and assessment, after freckle dispelling essence of the embodiment of the invention is used for 1 week, 4 weeks and 8 weeks, individual typology angle values present gradual upward trend, which has notable statistics significance. After the product is used, the individual typology angle values are increased, which indicates that the freckle dispelling essence provided by the embodiment of the invention can notably change the skin color, and has the effect of dispelling freckle. The freckle dispelling composition provided by the invention is found to be free from irritation to skin, is free from additional addition water and is high in active matter content.
Owner:斑敏痘(广东)皮肤研究院
Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin
InactiveUS20160089319A1Improve uniformityReduce color contrastCompounds screening/testingCosmetic preparationsStratum basaleSkin hyperpigmentation
A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin.
Owner:ELC MANAGEMENT LLC
Facial mask with excellent moisturizing and repairing effects
ActiveCN112545915AImprove securityThe process is proven to be feasibleCosmetic preparationsToilet preparationsStratum basaleActive protein
The invention provides a facial mask with excellent moisturizing and repairing effects. The facial mask comprises the following components: polypeptide and a humectant, and the polypeptide is a mixedactive protein peptide formed by mixing a small molecular active protein peptide with an amino acid sequence shown as SEQ ID NO: 2 and a small molecular cell-penetrating peptide with an amino acid sequence shown as SEQ ID NO: 3. The TAT-EL mixed active protein peptide is compounded in the formula of the mask to replace tissue / collagen / blood capillaries to accept attack of free radicals, so that the effect of protecting the blood capillaries and collagen is achieved; and the facial mask has excellent effects of promoting cell proliferation and differentiation and accelerating self-renewal and self-repair of skin epidermal cells, and has a good effect on damaged pox muscle / medical beauty wound repair. Acetylated hyaluronic acid is used as one of humectants, so that the solubility, permeability and hyaluronidase resistance of the hyaluronic acid are enhanced; and acetylated hyaluronic acid is amphiphilic, can be dissolved in water and oil, can permeate into a basal layer of skin by takingintercellular substances as carriers, and plays a role in moisturizing.
Owner:四川省恩乐生物工程有限公司
Transdermal delivery nano-preparation, and preparation method and application thereof
InactiveCN103099783AGood for spot treatmentInhibition of secretionPowder deliveryOrganic active ingredientsDiseaseStratum basale
The invention discloses a transdermal delivery nano-preparation, containing kojic dipalmitate, a polymer material, agouti protein and oleic acid, wherein the polymer material is formed into a nano-preparation carrier; the agouti protein and oleic acid are modified on the surface of the carrier; and the kojic dipalmitate is loaded in the carrier. The invention also discloses a preparation method and application of the transdermal delivery nano-preparation. The transdermal delivery nano-preparation disclosed by the invention is capable of effectively penetrating through the cuticle and also can be located at the melanocyte of the epidermis stratum basale; and besides, the transdermal delivery nano-preparation has good stain treatment effect and is suitable for treating hyperpigmentation diseases such as chloasma, freckle and the like.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Stem Cell Introduction Device
ActiveCN105477769BSimple and fast operationImprove reproductive functionMedical devicesDiseaseProximal point
Owner:PEKING UNIV SHENZHEN HOSPITAL
Five-dimensional stereo repair system
InactiveCN103655222AImprove sensitivity and vulnerabilityImprove dry agingCosmetic preparationsElectrotherapyNasolabial foldStratum basale
The invention discloses a five-dimensional stereo repair system, relating to the technical field of skincare and beauty. A repair method of the system comprises the following steps: (I) the first dimension: stratum corneum repair; (II) the second dimension: stratum basale repair; (III) the third dimension: superficial-layer repair of dermis; (IV) the fourth dimension: deep-layer repair of dermis; and (V) the fifth dimension: soft tissue repair. The five-dimensional stereo repair system improves the sensitivity and fragility, redness, red blood, drying and aging, lines and under-eye puffiness, dull skin, sunburn, acnes and laxity and aging, realizes after-sun repair, repair after various high-technology beauty and early and later repair of various pigments, dredges and shrinkages the pores, brightens the skin and effectively repairs the lax outline so that the apple muscle is sweet and the silkworm comes back again, the tear lines, bitter lines and nasolabial folds shallow or disappear, the muscle layer is stimulated to become tight, the fat fades away and the bottommost layer of the skin is improved.
Owner:徐红意
Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof
ActiveCN102048666BEasy accessLess irritatingCosmetic preparationsToilet preparationsWrinkle skinIrritation
Owner:NEW ERA HEALTH IND GRP +2
Preparation method of human 3D structure epidermal cell sheet and clinical application thereof
InactiveCN104906634AArtificial cell constructsArtificially induced pluripotent cellsDiseaseStratum basale
The invention discloses a preparation method of a human 3D structure epidermal cell sheet and a clinical application thereof. The preparation method is characterized by comprising the following steps that (1), human epidermal stem cells, base layer horn cells, melanocyte stem cells and the like are separated at a time through a Wbbase mixed enzyme; (2), two-step culture is carried out, wherein the two-step culture comprises a) non-serum mixing single-layer culture of three kinds of cells and b) induced differentiation of cells and culture of the 3D structure epidermal cell sheet; (3), the cell sheet is stripped; and (4), the cell sheet is clinically applied to treat leucoderma, burn and other skin pigment depigmentation diseases. The creativity of the preparation method of the human 3D structure epidermal cell sheet and the clinical application thereof is that three kinds of cells are separated simultaneously, the effective time is prolonged by 150-300 times compared with that of traditional trypsin separation methods, activity of the enzyme does not need to be neutralized, the activity of separated cells is greater than 95%, and the total yield is greater than 1-5*107 / g of skin; the two-step culture method amplifies the three kinds of cells at the same time, so that the amplification fold is improved by five times; the melanin forming unit is close to a normal person; and the compound color effect of transplanted skin is close to or consistent with the skin of a person.
Owner:武汉北度生物科技有限公司
Skin lightening composition
InactiveUS20160243015A1Reduced activityAbsence of hyperpigmentationCosmetic preparationsToilet preparationsIrritationSkin color
Desired skin colour is a major unmet consumer need around the world and especially in Asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone. One solution is to use biological actives that reduce the activity of melanocyte cells in skin. These cells, present in the basal layer of the epidermis, make the dark coloured pigment melanin and export it, in small export vesicles called melanosomes, to the neighbouring keratinocytes. It is well described in the literature that compounds which reduce melanin synthesis when topically applied to the skin will reduce skin darkness over time and can generate a more even skin tone. Tyrosinase is a very popular target for the regulation of melanocyte pigment production. However effective inhibitors of tyrosinase are bedevilled by safety issues causing, for example, melanocyte cell death, permanent depigmentation, irritation and allergic reactions. Often effective inhibitors kill melanocytes (for example hydroquinone) or cause sensitisation reactions. There is therefore a great need for safe and effective inhibitors of skin pigment production that work through an alternative safe mechanism. The inventors have observed that selected compounds of the same generic structure: or a salt thereof; wherein R1, R2, R3, R4 and R5 may be independently selected from the group consisting of —H, -halide, and methyl, ethyl, propyl, iso-propyl, butyl, and t-butyl moieties, inhibit melanin production in Melanoderms™.
Owner:CONOPCO INC D B A UNILEVER
Gold nanometer wafer
PendingCN110585585AImprove contact effectExtended service lifeMicroneedlesMedical devicesEngravingStratum basale
The invention discloses a gold nanometer wafer, and belongs to the technical field of a nanometer wafer. The gold nanometer wafer comprises a silicon substrate, wherein microneedles are arranged on the silicon substrate; each microneedle comprises an upper section and a lower section; the upper section of the microneedle is in a cylindrical shape; the lower section of the microneedle is in a pointed cone shape; a groove is formed in each microneedle; and a gold layer is plated on the outer wall of each microneedle. The gold nanometer wafer has the advantages that by using an independent research and development technology, 99.999-percent gold materials are combined with 99.999-percent monocrystalline silicon materials; through a fine engraving process, the nanometer level microneedles areintegrated onto the wafer; the use effect is obvious; and effective active substances can be conveyed to positions above the stratum basale, so that the seepage of a skin care product is greatly enhanced, and the skin care product fast works; and the corium layer, nerves and blood vessels cannot be touched, so that no harm is caused on the skin.
Owner:丁丽丽
Model for simulating dermatophyte infection in vitro and establishment method and application thereof
PendingCN112574943AProne to immune responsePromote infectionCompound screeningFungiMatrigelCell layer
The invention discloses a model for simulating dermatophyte infection in vitro and an establishment method and application thereof, and belongs to the technical field of bioengineering. The model forsimulating dermatophyte infection in vitro comprises matrix glue, an epidermal analogue embedded in the solidified matrix glue and dermatophyte hyphae, the epidermal analogue is of a relatively complete solid sphere structure, and the exterior of the epidermal analogue is a cell layer which is composed of substrate layer cells and substrate upper layer cells and distributed in a surrounding mode,and a keratinization sample non-cell layer is arranged inside; hyphae invade basal layer cells outside the sphere structure and do not invade or only invade a small amount of basal layer cells, and donot invade the keratinization sample non-cell layer inside the sphere structure; the model can effectively simulate the state that dermatophyte infects normal skin tissue, the infection process of the model can be directly observed under a phase contrast microscope, the infection situation can be detected through omics methods such as high-throughput RNA sequencing, and the model can be effectively used for researching the pathogenic mechanism of dermatophyte infection and screening anti-dermatophyte drugs.
Owner:深圳钰捷生物医学科技有限公司
Preparation method of strontium chloride and polypeptide composite preparation and application thereof
InactiveCN111195213AGood moisturizing effectReduce sensitivityCosmetic preparationsToilet preparationsEpitheliumHydroxamic acid
The invention discloses a medical product and an application thereof, and particularly relates to a preparation method of a strontium chloride and polypeptide composite preparation and an applicationthereof. In order to solve the problems, the invention provides the preparation method of the strontium chloride and polypeptide composite preparation and the application of the strontium chloride andpolypeptide composite preparation in repairing skin barriers. The preparation method comprises the following components: 50-80 parts of deionized water, 5-10 parts of strontium chloride, 5-10 parts of collagen, 5-10 parts of hyaluronic acid, 1-5 parts of glycerol, 1-5 parts of propylene glycol, 1-5 parts of oligopeptide-2, 1-5 parts of oligopeptide-5, 0.1-1 part of capryloyl hydroxamic acid and 0.1-1 part of 1, 2-hexanediol. The research is developed from a more microscopic level, oligopeptide with a small molecular structure can penetrate through pores to enter a basal layer of skin, the epidermal stem cell division and differentiation process is promoted, layer-by-layer outward updating of cells is regulated, metabolism of epithelial tissues is promoted, and a skin barrier is repaired by changing a cell expression mode. The strontium chloride and human-like collagen are added, so that the polypeptide has a better synergistic effect.
Owner:广州市阳光美域日用品有限公司
A double-course compound cell growth factor hydrogel and its preparation method and application
InactiveCN104225577BNo stimulationNo side effectsPeptide/protein ingredientsAerosol deliveryStratum basaleHealing time
The invention discloses a hydrogel containing human fibroblast growth factor hFGF‑21 and human epidermal growth factor hEGF components, which can repair and heal the dermis and basal layer; the invention also discloses a hydrogel containing human keratinocytes A hydrogel of the growth factor hKGF‑2, human epidermal growth factor hEGF component, which targets the repair and healing of the epidermis and stratum corneum. The invention also discloses the preparation method and application of the two hydrogels. The invention optimizes the healing mechanism of wound tissue in different layers of the skin, so that the repairing ingredients of the formula have no irritation to the skin, no toxic and side effects, are easy to absorb, shorten the healing time, and are safe and effective.
Owner:王悦
A kind of red wolfberry nano-eye cream for improving eyesight and preparation method for adults
ActiveCN113368012BOptimizing Process ParametersAntioxidantCosmetic preparationsToilet preparationsPhenolic content in teaStratum basale
The invention relates to a red wolfberry nano-eye cream for improving eyesight for adults and a preparation method. The raw material components of the eye cream are: red wolfberry zeaxanthin dipalmitate, wolfberry polysaccharide, wolfberry seed oil, tea polyphenol extract, honeysuckle extract, ginsenoside, lecithin, niacinamide, hyaluronic acid, sodium hyaluronate , Trehalose, Sodium Alginate, Xanthan Gum, Phenoxyethanol, Sodium Benzoate, Propylene Glycol, Glycerol, Collagen, Distilled Water. The present invention is rich in natural plant extract components, uses liposome nanotechnology to encapsulate various red wolfberry extracts, on the one hand improves the dispersibility of red wolfberry extracts in water, and on the other hand, liposomes can carry active ingredients through the skin From the stratum corneum to the basal layer, it exerts its effect, so that dry eyes can achieve the effect of brightening and moisturizing, and it is green and healthy without artificial coloring.
Owner:宁夏全通枸杞供应链管理股份有限公司
Stem cell introduction device
ActiveCN105477769ASimple and fast operationImprove reproductive functionMedical devicesDiseaseProximal point
The invention discloses a stem cell introduction device. The stem cell introduction device comprises a hollow outer cannula, a hollow needle core and a hollow catheter. A vernier is arranged along one side on the outer wall of the outer cannula. The other side of the outer wall of the hollow outer cannula is provided with digit scale marks protruding from the outer wall surface. When moving to the digit scale mark, the vernier is rotated to be secured between digit scale marks or above them. The head of the needle core is provided with a piercing part. The tail of the needle core is connected with one end of a first injector joint. The piercing part is exposed by two millimeters when the needle core is completely inserted into the hollow part of the outer cannula. The near end of the cannula is connected to the other end of the first injector joint. The distal end of the cannula is connected to a second injector joint. The stem cell introduction device has following beneficial effects: the stem cell introduction device can accurately introduce stem cells into the stratum basale of the endometrium such that the damaged endometrium of a patient can be repaired; the reproduction function is improved so that diseases related to endometria can be treated; and the stem cell introduction device is easy and convenient to operate, cost-effective and practical and is convenient for clinic use.
Owner:PEKING UNIV SHENZHEN HOSPITAL
Traditional Chinese medicine mask for removing and fading spots
PendingCN109248136APromote circulationHas the effect of removing acne and blemishesCosmetic preparationsToilet preparationsCuticleAdemetionine
The invention discloses a traditional Chinese medicine mask for removing and fading spots. The traditional Chinese medicine mask is mainly prepared from the following raw materials in parts by weight:dahurian angelica root 7g, a traditional Chinese medicine named Baipaizi 6g, poria alba 20g, danshen root 14g, safflower 24g, Chinese angelica 14g, common yam rhizome 18g, radix pseudostellariae 18g,milkvetch root 18g, hyacinth bletilla 12g, ampelopsis radix 18g, ginkgo seed 24g, stiff silkworm 24g, largehead atractylodes rhizome 18g, white peony root 10g, and excrementum passeris 10g. The traditional Chinese medicine mask for removing and fading spots is prepared by grinding and mixing a dozen kinds of Chinese herbal medicines, the medicines penetrate into the basal layer of skin through epidermis to accelerate blood circulation (redness and hotness of a face are normal phenomena), thereby eliminating melanin in the skin through metabolism. The milkvetch root makes the skin white and clear every day. The traditional Chinese medicine mask for removing and fading spots has the effects of removing acnes and fading spots.
Owner:杨洪宁
Skin-beautifying skin-cleansing spot-regulating facial mask as well as preparation method and use method thereof
InactiveCN113520973ASpeed up decompositionIncrease metabolic rateCosmetic preparationsToilet preparationsBiotechnologyAngelica Sinensis Root
The invention discloses a skin-beautifying skin-cleansing spot-regulating facial mask as well as a preparation method and a use method thereof. The skin-beautifying skin-cleaning spot-adjusting facial mask is mainly prepared from the following components: peach kernels, red peony roots, rhizoma cyperi, angelica sinensis, cordyceps sinensis, radix scrophulariae, radix rehmanniae, rhizoma typhonii, white poria, radix paeoniae alba, ginseng, saffron crocus, codonopsis pilosula, saussurea involucrata, moutan bark, pseudo-ginseng, golden cypress, medlar, bitter apricot seed, semen cuscutae, bighead atractylodes rhizome, deionized water, essence, a water replenishing agent and honey. According to the facial mask, the decomposition and metabolism speed of melanin, lead mercury and garbage on a skin basal layer is increased, the problems of melanin accumulation and poor metabolism are solved fundamentally, the skin is not red or swollen, the skin cuticle is not damaged, melanin is metabolized from the basal layer to inhibit the activity of tyrosinase, rebounding is avoided after melanin is removed, and all dirt is discharged from inside to outside.
Owner:龚秀梅
A method for isolating and culturing skin keratinocytes
ActiveCN105154388BImprove proliferative abilityIncrease vitalityMicrobiological testing/measurementArtificial cell constructsStratum basaleProliferative capacity
Owner:NOVAPRINT THERAPEUTICS SUZHOU CO LTD
Transdermal delivery nano-preparation, and preparation method and application thereof
InactiveCN103099783BGood for spot treatmentInhibition of secretionPowder deliveryCosmetic preparationsDiseaseStratum basale
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Multi-point microinjection device for uterine neck
ActiveCN105477770AConvenient treatmentEasy to push and pullMedical devicesHigh concentrationStratum basale
The invention discloses a multi-point microinjection device for a uterine neck. The multi-point microinjection device comprises a hollow injection disc, an inner core of the injection disc and multiple hollow microinjection needles. The injection disc is composed of a first cylinder and a second cylinder as a whole. The microinjection needles are secured on one surface, away from the second cylinder, on the first cylinder. One end of the inner core of the injection disc is fixedly connected with a piston head. The piston head is located into the first cylinder and closely combined with the cylindrical wall of the first cylinder and performs up-down motion in the first cylinder. The multi-point microinjection device for the uterine neck is capable of accurately injecting medicine for treating uterine neck lesions to the stratum basale of a cervical leather and keeping medicine in high concentration partially so that uterine neck lesions induced by an HPV virus are favorably treated; a patient may recover from uterine neck lesions; and the new medication therapy for treating uterine neck lesions can be applied; and the multi-point microinjection device is simple, viable, cost-effective and practical and is convenient for clinic use.
Owner:PEKING UNIV SHENZHEN HOSPITAL
Application of platycladus orientalis
PendingCN110680776AHigh activityGood for healthCosmetic preparationsToilet preparationsBiotechnologyTissue repair
The invention relates to the technical field of plant extracts and discloses application of platycladus orientalis. The invention finds that a natural plant platycladus orientalis extract can significantly up-regulate genes sirt1, nidi1 and igf1 contributing to skin cell and tissue repair and remarkably increase thickness of epidermis to make arrangement of cells on basal layers more closely and differentiation of the cuticle more perfected, which indicates that the platycladus orientalis extract can enhance overall vitality and health conditions of skin, has skin tissue repair capacity, can further continuously promote skin cell proliferation and skin tissue regeneration and delay declination phenomena caused by reduced viability and decreased number of existing skin cells.
Owner:JALA GROUP CORPORATION
Freckle-removing and whitening traditional Chinese medicine mask powder and preparation method thereof
InactiveCN111450034ATo promote metabolismIncrease elasticityCosmetic preparationsAnthropod material medical ingredientsBiotechnologyBletilla striata
The invention provides freckle-removing and whitening traditional Chinese medicine mask powder. The mask powder is prepared from the following raw materials in parts by weight: 15-20 parts of white poria, 15-20 parts of silkworm larva, 10-15 parts of ginseng roots, 10-15 parts of licorice roots, 10-15 parts of bighead atractylodes rhizomes, 10-13 parts of coix seeds, 8-10 parts of wax gourd seeds,5-10 parts of pseudo-ginseng, 5-10 parts of flos magnoliae liliflorae, 5-10 parts of peach kernels, 5-8 parts of tuber bletillae, 5-8 parts of moutan bark and 5-8 parts of pearl powder. According tothe invention, all the components produce a synergistic effect through combination according to a certain ratio, and can effectively whiten skin and remove freckles, fully supplement nutrition required by the skin, promote blood circulation of the skin, enhance metabolic activity of skin cells and effectively inhibit generation of melanin and self-free radicals on the basal layer of skin epidermis.
Owner:耿硕
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