40 results about "Skin hyperpigmentation" patented technology

A method for reducing an occurrence of hyperpigmentation in human skin includes applying to the skin a topical preparation including an amount of an agent effective to reduce an occurrence of hyperpigmentation in human skin. The agent includes idebenone or a derivative of idebenone.

The invention relates to a method for cosmetically treating dark spots on the skin, wherein said method is intended for eliminating at least one of said dark spots located in a region of the hand, the face, the limbs or the chest area of a person suffering from such skin hyperpigmentation, characterised in that said method includes a step of applying a spray of cryogenic fluid to said region, which brings the skin temperature to a temperature of between −4° C. and −15° C. for a consecutive application period of from 2 to 10 seconds, in order to selectively act on the melanocytes, and to a device for carrying out said method.

The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

The invention discloses a vegetable fat composition cosmetic with a whitening effect and a preparation method of the cosmetic. The whitening vegetable fat with the whitening effect of the cosmetic is vegetable fat without any chemical synthetic grease, mineral oil, animal oil or the like; the contained vegetable fat includes citron fruit peel oil, erythropappa branch/leaf oil, camellia japonica seed oil, oxalis vidacea oil and the like. According to the test, the whitening vegetable fat composition cosmetic disclosed by the invention is nonirritant, safe and efficient. Moreover, the vegetable fat composition cosmetic has good effects of brightening skin and improving skin hyperpigmentation, has good compatibility with the skin, and has a refreshing sweet smell on the condition that no essences are added.

A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent. The system also includes a programmable computer with computer-readable instructions that allow the computer to accessing the instances and a hyperpigmentation-relevant gene expression signature stored on the computer readable medium, comparing the hyperpigmentation-relevant gene expression signature to the plurality of the instances, and/or assigning a connectivity score to each of the plurality of instances.

A cosmetic and dermatological composition comprises 2, 3-dihydro-4-hydroxy-2-oxo-1-H-indole-3-acetic acid (4-hydroxy-1-oxindole-3-acetic acid) as an active ingredient for use as a melanin inhibitor and as an anti-tyrosinase enzyme inhibitor. This composition is excellent as a skin whitening agent. Since it also has potent antioxidant and anti-irritant activities it is useful in a cosmetic composition for improving hyperpigmentation disorders of the skin.

The present invention provides cosmetic compositions comprising Ficus serum fraction derived from fresh Ficus cell juice of fresh Ficus leaves. The cosmetic composition also comprises a cosmetically acceptable carrier. The Ficus serum fraction is present in the composition at a cosmetically effective amount for achieving the desired skin lightening result.

The invention discloses a chenopodium quod fermentation object and application thereof in cosmetics. The chenopodium quod fermentation object disclosed by the invention is manufactured by taking shelled chenopodium quod particles as a raw material and taking lactic acid bacteria and/ or saccharomycetes as a fermentation culture through a biological fermentation method. A preparation process is that smashed chenopodium quod powders are evenly mixed with water, after a series of working procedures, including liquification, saccharification and the like, sealing is carried out after the culture is added, and a fermentation product is subjected to centrifugal filtration to obtain chenopodium quod fermentation liquor. The chenopodium quod fermentation object disclosed by the invention can effectively resist injury to skin cells by free radicals, the melanin generation of melanin cells is reduced, and the chenopodium quod fermentation object performs functions of regulating skin hyperpigmentation and brightening skin. A series of product obtained in a way that chenopodium quod fermentation object is compounded with other active ingredients, including oligopeptides and collagen, has the obvious efficacy on whitening and brightening the skin.

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises at least one acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes. Such types of abnormal biological conditions, diseases or disorders include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

The present invention provides bioactive compositions comprising Ficus serum fraction derived from Ficus cell juice of fresh Ficus leaves and a process of preparing the Ficus serum fraction. The compositions have biological activity capable of reducing skin hyperpigmentation.

A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin.

Hyperpigmentary skin disorders, notably those associated with psoriasis or eczema, are prevented/treated by administering to individuals in need of such treatment, thus effective amounts of medicaments containing a combination of fluocinolone acetonide, hydroquinone and tretinoin, formulated into a physiologically acceptable medium therefor.

The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent. And is effective against a plethora of superficial lesions selected from the group consisting of viral warts, verrucae, water warts (molluscum contagiosum), corns and calluses, and skin hyperpigmentation: age spots, solar lentigo, senial lentigo, acne, keratosis pilaris, actinic keratosis, mouth ulcers (canker sores), cold sores, ingrown toenails, onychomycosis, eyelid xanthelasma.

The invention discloses an active peptide skin care product capable of relieving skin hyperpigmentation and a preparation process of the active peptide skin care product. The active peptide skin care product comprises the following raw materials of, in parts by weight, 5-8 parts of fish skin gelatin peptide, 1-1.5 parts of a whitening micro-capsule, 1-3 parts of vitamin E, 0.5-1 part of fatty acid methyl ester, 4-6 parts of glycerol, 15-20 parts of deionized water and 5-8 parts of white oil. The surface of the whitening micro-capsule contains a large amount of molecules capable of absorbing ultraviolet light, the molecules contain a large amount of hindered amine that can convert light energy into heat energy to be released; after the ultraviolet light is absorbed, molecular electronics are transferred from oxygen atoms to nitrogen atoms of a triazole ring, so that the nitrogen atoms are alkaline, protons are transferred to the nitrogen atoms, and an unstable tautomer is formed; and the tautomer is in an unstable state to release the absorbed energy as heat energy to return to a stable state, so that 4-methylresorcinol is prevented from being oxidized by the ultraviolet light, and the skin care product can well relieve skin hyperpigmentation.

A composition for inhibiting lipofuscin accumulation or removing lipofuscin is disclosed. A Chryseobacterium sp. strain, a lysate of the Chryseobacterium sp. strain, a culture of the Chryseobacterium sp. strain, or an extract of the lysate or culture is included in the composition. The composition provides an anti-aging effect by inhibiting lipofuscin accumulation or removing lipofuscin. The composition also provides an effect of preventing, ameliorating or treating the diseases caused by the lipofuscin accumulation, such as skin hyperpigmentation, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, myocardial infarction and age-related macular degeneration.

A composition to improve hyperpigmentation is disclosed. The composition has one or more active ingredients such as tranexamic acid, niacinamide, arbutin, and Vitamin C. The composition has water, caprylic/capric triglyceride, C12-15 Alkyl Benzoate, Isononyl Isononanoate, Silica, Glyceryl Stearate and PEG-100 Stearate, Cetearyl Alcohol and Ceteareth-20, Xylitylglucoside and Anhydroxylitol and Xylitol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Phenoxyethanol and Ethylhexylglycerin, Citric Acid, Titanium Dioxide, Citrus oil, sh-Polypeptide-22, and sh-Oligopeptide-1. The composition is a non-HQ formulation that provides equal or greater efficacy with a reduced adverse reaction profile to improve skin hyperpigmentation, such as melasma, post-inflammatory hyperpigmentation, and solar lentigines. The composition reduces skin damage and provides toning to the skin.

The peptides of the invention have a sequence having at least 85% identity to the sequence SEQ ID NO: 1 or SEQ ID NO: 2. These peptides modulate melanocyte activity in terms of melanin proliferation and production. Therefore, these peptides can be used in the treatment of melanoma, as well as in the treatment of cosmetic hyperpigmentation or hypopigmentation of the skin.

Provided are pharmaceutical compositions for skin lightening, which are particularly useful in treating skin hyperpigmentation, together with methods for their use. The compositions comprise glutathione conjugated to a peptide having a sequence comprising PKEK and cysteamine or a pharmaceutical salt thereof.