58 results about "Melasma" patented technology

The invention provides application of UBR5 in preparation of drugs for treating pigmented skin diseases, and further the pigmented skin diseases comprise various types of pigmented nevus (mainly congenital pigmented nevus and megalous with the risk of malignant transformation). Various pigmented spots (mainly chloasma, freckles, Taitian nevus, post-inflammation hyperpigmentation and the like) and hypopigmentation / depigmentation spots (mainly leucoderma, post-inflammation hypopigmentation and the like). Experimental results show that UBR5 is highly expressed in disease tissues such as pigmented nevus. The UBR5 expression level and the melanogenesis ability are in significant positive correlation, targeted knockout / knockdown of UBR5 in melanocytes can significantly inhibit the expression level of melanogenesis related genes such as MITF, TRP1, TRP2, TYR and other proteins, the melanin content of melanocytes and tyrosinase activity, vice versa, and the melanogenesis ability of melanocytes after overexpression of UBR5 is significantly increased.

The invention relates to a fused exosome-like vesicle based on stem cell exosomes and application thereof, and the fused exosome-like vesicle is prepared by a method comprising the following steps: mixing stem cell exosomes and aloe exosome-like vesicles under an ultrasonic condition, and incubating to obtain the fused exosome-like vesicle. The fused exosome-like vesicle can effectively promote percutaneous penetration of stem cell exosome, and can effectively improve cell damage caused by ultraviolet rays, regenerate and repair skin damage barriers such as basilar membranes and the like, resist inflammation and oxidation, effectively remove melanin, and improve the skin quality. The composition has good repair potentials for chloasma and skin damage, aging and melanin deposition related to chloasma. Sufficient data support and technical support are provided for research and development of stem cell exosome innovative drugs, and clinical application of the stem cell exosome innovative drugs is accelerated.

The invention discloses an external preparation of a microsphere-loaded medicine for treating chloasma and a preparation method of the external preparation. The preparation method comprises the following steps: preparing polyvinyl alcohol acrylate microspheres, loading a tranexamic acid medicine and adding a matrix to prepare the external preparation of the microsphere-loaded medicine. By means of oleophylic and hydrophilic segments on the polyvinyl alcohol acrylate microspheres, fusion with skin lipid components is increased, permeability of the medicine is improved, meanwhile, due to the large specific surface area of the microspheres, the medicine can be more evenly loaded on the microspheres, and due to the hydrophilicity of the microspheres, moisture can be kept for a longer time; and the problem of crystallization of tranexamic acid caused by moisture volatilization is well solved. The ointment or gel external preparation prepared by the invention is relatively good in character and stability, good in in-vitro permeation and in-vitro release performance and remarkable in treatment effect on chloasma of mice.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The present disclosure is a peptide (Inpén SEQ ID N ° 1) with whitening action for melasma, a cosmetic or dermopharmaceutic composition containing this peptide as active ingredient and the use of this composition in the treatment of melasma or skin hyperpigmentation, developed from a peptide bioinspired from the venom of Brazilian wasps. Melasma is an acquired chronic dermatologic disorder characterized by the emergence of hyperpigmented skin spots. Although it is a common condition, a definitive cure has not been developed so far, due to the complexity of multifactorial causes. Because it is a cosmetic composition, of topic and painless application, the present disclosure can be applied daily, with no need for a specialist in the field of aesthetics, besides not being expensive as the known to date techniques for treating melasma are. The peptide SEQ ID N° 1 acts inhibiting melanogenesis.

The invention provides a soft capsule helpful for improving the function of chloasma as well as a preparation method and application thereof, and relates to the technical field of health care products. The soft capsule comprises a mulberry leaf extract, a seville orange flower extract, a grape seed extract, an almond extract, donkey-hide gelatin powder, vitamin C and vitamin E. The soft capsule provided by the invention exerts the overall effect of improving chloasma through a multi-target synergistic mechanism from inside to outside: the mulberry leaf extract and the grape seed extract block melanogenesis from the source and resist ultraviolet damage by inhibiting tyrosinase activity and strongly resisting oxidation; the seville orange flower extract is used for soothing liver and regulating qi, and regulating internal pathogenesis; the almond extract and the donkey-hide gelatin powder have the effects of promoting blood circulation to remove blood stasis and nourishing yin and blood, improve microcirculation and nourish skin; vitamin C and vitamin E form an anti-oxidation cycle, so that melanin intermediates are directly reduced, and cell membranes are protected. All the raw materials supplement each other to jointly achieve the comprehensive effects of fading stains, brightening the skin color and improving the skin quality.

Provided herein are methods for treating skin-related diseases or disorders (e.g., melasma). Also provided are pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof formulated for topical administration. Also described are methods for preparing such topical pharmaceutical compositions and methods for using the topical pharmaceutical compositions to treat a subject.

According to the dermatosis medicine based on xanthoxylin WGX-50 and the preparation method thereof, WGX-50 has a strong anti-oxidation characteristic and is crucial to the anti-aging process of skin, and meanwhile, it is found that WGX-50 has the effects of promoting regeneration of collagen, elastin and lipid droplets, inhibiting expression of key genes participating in melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis and inhibiting melanogenesis. Due to the characteristics, the WGX-50 can effectively repair skin injury related to the natural aging process, and meanwhile, the WGX-50 has remarkable whitening and antioxidant effects. Compared with the effect of an asiaticoside cream ointment, the WGX-50 is effective on chloasma by reducing skin pigmentation, the effect of the WGX-50 is better than that of asiaticoside, and in the treatment of chloasma, the WGX-50 can be used as another method for relieving pigmentation and improving skin quality.

The invention relates to a whitening composition containing oxidized resveratrol and capable of deeply fading stains and application of the whitening composition, the composition is prepared from the following components: oxidized resveratrol, VC ethyl ether, a verbascos extract and a spearmint extract, and the weight ratio of the oxidized resveratrol to the VC ethyl ether to the verbascos extract to the spearmint extract is (0.11-2): (1-5): (0.01-1.2): (0.01-2). The whitening composition provided by the invention constructs an inhibition-removal-protection-repair system for chloasma, dermis plaque, post-inflammation pigmentation and other stubborn color spots caused by basement membrane zone injury, and performs multi-target repair.

The invention discloses a soluble microneedle array transdermal drug delivery freckle-removing mask and a preparation method of the soluble microneedle array transdermal drug delivery freckle-removing mask. The mask comprises a backing layer and a soluble micro-needle array arranged on the backing layer, the micro-needle array is composed of a needle tip and a base, and the needle tip comprises a freckle-removing active component, a nano-carrier material, a micro-needle matrix material and a stabilizer. The freckle-removing active components comprise tranexamic acid, sodium ascorbyl phosphate, Maojian green tea extract, licoflavone and nicotinamide; the nano carrier material is selected from hydroxyl cyclodextrin, chitosan nanoparticles and alginic acid-chitosan nanoparticles; the microneedle matrix material comprises hyaluronic acid, polyvinylpyrrolidone and polyvinyl alcohol. Through combination of a nano-carrier technology and a micro-needle system, the drug loading capacity, stability and transdermal efficiency of freckle-removing active ingredients are remarkably improved, and the freckle-removing micro-needle has the advantages of being good in freckle-removing effect, painless, noninvasive, convenient to use and the like, and is suitable for prevention and treatment of chloasma, freckles, hyperpigmentation after inflammation and other pigmented skin diseases.

A composition for inhibiting generation of melanin and the use thereof is provided, the composition includes platelets and / or growth factors isolated from blood, the composition for inhibiting generation of melanin has the abilities for inhibiting activity of tyrosinase and alleviating inflammation, and the composition for inhibiting generation of melanin is able to be used to manufacture of preparation for improving skin pigmentation or alleviating melasma.

The invention belongs to the technical field of biological medicine, and particularly relates to a composite whitening preparation containing liquid CGF and tranexamic acid and a preparation method of the composite whitening preparation. The preparation method of the composite whitening preparation containing the liquid CGF and the tranexamic acid comprises the following steps: performing differential centrifugation on blood to obtain a liquid CGF mixture, and mixing the liquid CGF mixture with a tranexamic acid injection according to a specific proportion to obtain the composite whitening preparation. According to the compound whitening preparation, the compound whitening preparation is injected to the chloasma in a subcutaneous injection mode, through the synergistic interaction effect of the liquid CGF and tranexamic acid, the compound whitening preparation can effectively relieve the chloasma and also can improve the transparency of the whole skin color and the darkness of local skin blocks, so that the skin has the whitening effect that the skin is white and red, and the whitening effect is good. The effect of the tranexamic acid injection is far better than that of conventional pure tranexamic acid injection or liquid CGF, and the tranexamic acid injection can be well applied to the freckle removing market and is safer and milder.

The present patent application is characterized essentially by a chemical formulation based on papain, urea, zinc sulfate and ubiquinol, the aim of which is to treat and heal skin affected by melasma, the formulation being composed of: 10% papain; 5% urea; 6% zinc sulfate and 5% ubiquinol, in a cream base q.s. 100g. This formulation must be produced by a trained professional who understands chemical processes and the use of each composition for proper handling. The product is for nighttime topical use, for any type of skin, and must be applied to clean, dry skin. The formulation should be applied to the area of the melasma and, once absorbed into the skin, sunscreen should be used on top of the product. The minimum period of treatment should be 6 to 12 months. Said formulation is considered to combat cellular senescence, repair the stratum corneum and the phospholipid bilayer of the cells, combat lipidic peroxidation and local inflammation, eliminate excess free radicals in the intracellular environment, reorganize the structure of internal organelles and preserve DNA, thereby maintaining homeostasis and skin health, healing and reducing dark spots, and leaving the skin healthier, soft, bright and moisturized.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

The invention discloses an application of a compound gel preparation in preparation of a product for treating chloasma. The compound gel disclosed by the invention is prepared from polypeptide gel capable of opening tight connection of skin through a self-assembly method. Finally, the hydrogel with certain flowability is formed. The polypeptide gel formed by the invention can penetrate through the surface layer of the skin, tranexamic acid, vitamin C and reduced glutathione are transferred to the basal layer of the skin through one-time operation, and then tranexamic acid is competitively combined with tyrosinase to inhibit the activity of the tyrosinase, so that the formation of melanin is reduced; the vitamin C inhibits the formation of melanin by reducing the formation of o-quinone and reducing oxidized melanin; the reduced glutathione is used as an antioxidant component, can inhibit the generation of free radicals, helps to stabilize the skin and restore the skin whiteness, can be used for treating chloasma, and provides a new solution for the field of skin health treatment.

Disclosed is a composition that is advantageously cosmetic, and preferably ecobiological, comprising: - glabridin, or an extract containing same; and - a compound of general formula (I); and the uses thereof, in particular cosmetic and non-therapeutic uses, for preventing and / or treating skin hyperpigmentation, and / or a hyperpigmentary disorder, advantageously actinic lentigo, melasma and / or post-inflammatory hyperpigmentation (PIH).

L'OREAL The present invention relates to methods for obtaining a plant extract from flowering tops of Inula helenium, as well as plant extracts of Inula helenium, compositions comprising them, and their implementation to prevent and / or treat a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular linked to a scar or an unsightly disorder following an inflammatory skin manifestation, in particular a scar or an acne mark or (iii) a melasma.

This invention provides a composition for suppressing melanin production and its use. [Solution] The composition contains platelets and / or growth factors isolated from blood and has the ability to suppress tyrosinase activity and alleviate inflammation. Furthermore, the composition of the present invention can be used in the manufacture of formulations for improving skin pigmentation or alleviating melasma.

The present invention provides the use of a compound represented by formula I, a pharmaceutically acceptable salt, hydrate, isomer, prodrug, or a mixture thereof, for manufacturing a product for improving pigmentation. This compound is very promising for the treatment of melasma. [Chemical 1] JPEG2025518798000031.jpg31169

The invention belongs to the technical field of biological materials, and particularly relates to a chloasma skin organ pathological model constructed on the basis of a 3D printing technology and a construction method and application of the chloasma skin organ pathological model. The model has a three-layer bionic structure, has high anatomical reducibility, can realize gradient positioning of melanocytes on a substrate layer, keeps long-term functions of the melanocytes, and breaks through the problem that a traditional model is difficult to maintain functions of the melanocytes; by adopting an endothelial cell co-printing technology and combining with a dynamic perfusion culture method, a microcirculation network with functionality is successfully established, a vascularization structure of chloasma skin is effectively simulated, the physiological simulation of the pathological model is improved, and the accuracy of the pathological model for simulating chloasma diseases is also greatly improved; in addition, the invention also develops a two-factor pathologic induction scheme, accurately simulates a light injury-hormone disorder synergistic pathogenic mechanism of chloasma, and solves the defect that a traditional model cannot fully show a complex pathogenic mechanism.

The present application relates to a method, device, and storage medium for early warning of aspiration and melasma during femtosecond corneal refractive surgery. This application employs a deep learning model consisting of an encoder and a decoder, and utilizes the trained deep learning model to output a predicted frame at the current moment. By comparing the predicted frame with the actual frame at the current moment, the application determines that the actual frame has deviated from the predicted direction when a deviation occurs between the predicted and actual frames. This application then determines that aspiration or melasma has occurred based on the deviation of the actual frame from the predicted direction. This method enables timely detection of aspiration and early warning before aspiration occurs during all-femtosecond corneal refractive surgery, thereby reducing the incidence of aspiration and improving safety.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The application provides a traditional Chinese medicine gel for treating stubborn skin color spots and a preparation method thereof, and the traditional Chinese medicine gel is prepared from the following raw materials in mass parts: aloe extract 25-30 parts, opuntia dillenii Haw extract 10-15 parts, safflower 5-10 parts, radix lithospermi 5-8 parts, herba portulacae 5-8 parts, purified water 60-65 parts, carbomer 1-5 parts, fish scale glue 5-8 parts, hydrogenated castor oil 100-110 parts, ethanol 120-140 parts and monoglyceride 4-10 parts. The prepared traditional Chinese medicine gel can clear heat and cool blood, remove blood stasis and remove spots, promote skin metabolism, repair damaged skin cells, and can treat stubborn skin color spots such as chloasma, melasma and age spots, and has no side effects.

The invention particularly relates to a traditional Chinese medicine composition for treating chloasma and an external preparation. At present, the mode of treating chloasma by western medicine has obvious adverse reaction, the traditional Chinese medicine believes that the formation of chloasma mainly lies in liver and kidney malnutrition, the invention provides a traditional Chinese medicine composition with chloasma treatment effect on the basis of formula principles of nourishing essence and blood, promoting blood circulation to remove blood stasis, regulating qi-flowing for eliminating phlegm, removing freckles and whitening, and the traditional Chinese medicine composition comprises 30-100 parts of dark plum, 20-80 parts of Chinese angelica and 2-8 parts of pseudo-ginseng. The invention further provides an external preparation of the composition. Through verification, the external preparation can be used for effectively treating various types of chloasma, has a remarkable improvement effect on the facial state, is simple in preparation process and free of obvious side effects, and has a good market prospect.

The present invention relates to the use of a mixture of tranexamic acid, hydroquinone, arbutin and a concentrated extract solution of the brown seaweed Ascophyllum nodosum in the preparation of a medicament for treating melasma, wherein said medicament is associated with the use of a CO2 laser with cold pulse for the treatment of melasma.

Provided herein are formulations for topical and / or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and / or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

The present invention belongs to the field of biomedicine technology, and discloses a carbazole derivative and its application. The carbazole derivative is a structural formula shown in formula (1) or a salt thereof, and is applied in medicines or cosmetics for the treatment or prevention of freckles, pregnancy spots, chloasma, coffee spots, nevus, ultraviolet-induced pigmentation and hereditary dark skin, and has a significant effect. Formula (1).

The present invention relates to the use of botulinum toxins for the treatment of hyperpigmentation conditions. The use includes intracutaneously injecting botulinum toxin into the skin of a patient with hyperpigmentation at a specific depth, volume and dose to specifically target the epidermal layer and the upper dermal layer. For example, an intradermal injection of botulinum toxin according to the invention may be used to treat chloasma.

The utility model discloses a repair mask for sensitive skin or chloasma. The repair mask comprises a mask body, a mask cover and a mask cover, the lamp panel is arranged on the mask body, a plurality of lamp beads are arranged on the lamp panel, the lamp beads emit visible light and / or infrared light, the light rays emitted by the lamp beads are suitable for irradiating the face of a user for repairing, the wavelength of the light rays emitted by the lamp beads is lambda, the light density of the light rays emitted by the lamp beads is rho, and lambda and rho meet the conditions that lambda is larger than or equal to 500 nm and smaller than or equal to 1200 nm, and rho is larger than or equal to 50% and smaller than or equal to 100%. According to the repairing mask, phototherapy can be carried out, the repairing mask can be used at home, using convenience is improved, and sensitive skin and chloasma of skin can be effectively repaired.

The invention discloses a traditional Chinese medicine compound for preparing skin external medicine, a preparation method and application, and belongs to the technical field of skin external medicine. The traditional Chinese medicine composition is prepared from the following components in percentage by weight: 1 to 3 percent of tranexamic acid, 10 to 15 percent of radix angelicae, 5 to 10 percent of radix angelicae sinensis, 3 to 10 percent of flos carthami, 3 to 8 percent of rhizoma atractylodis macrocephalae, 2 to 5 percent of radix scutellariae, 3 to 8 percent of poria cocos, 2 to 5 percent of liquorice root and 40 to 70 percent of matrix. The traditional Chinese medicine composition can effectively fade facial chloasma, freckles and other hyperpigmentation symptoms, improves the skin color, is convenient for long-term external use of patients, and avoids the problems of irritation and possible skin barrier injury caused by traditional freckle-removing chemical preparations. By combining the action mechanism of the modern medicine tranexamic acid and through the multi-target synergistic effect of the traditional Chinese medicine composition and the tranexamic acid, melanin deposition can be intervened in multiple links such as pigmentation generation, metabolism and excretion, and the freckle removing effect is remarkably improved.