45 results about "Melasma" patented technology

The invention relates to a fused exosome-like vesicle based on stem cell exosomes and application thereof, and the fused exosome-like vesicle is prepared by a method comprising the following steps: mixing stem cell exosomes and aloe exosome-like vesicles under an ultrasonic condition, and incubating to obtain the fused exosome-like vesicle. The fused exosome-like vesicle can effectively promote percutaneous penetration of stem cell exosome, and can effectively improve cell damage caused by ultraviolet rays, regenerate and repair skin damage barriers such as basilar membranes and the like, resist inflammation and oxidation, effectively remove melanin, and improve the skin quality. The composition has good repair potentials for chloasma and skin damage, aging and melanin deposition related to chloasma. Sufficient data support and technical support are provided for research and development of stem cell exosome innovative drugs, and clinical application of the stem cell exosome innovative drugs is accelerated.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The present disclosure is a peptide (Inpén SEQ ID N ° 1) with whitening action for melasma, a cosmetic or dermopharmaceutic composition containing this peptide as active ingredient and the use of this composition in the treatment of melasma or skin hyperpigmentation, developed from a peptide bioinspired from the venom of Brazilian wasps. Melasma is an acquired chronic dermatologic disorder characterized by the emergence of hyperpigmented skin spots. Although it is a common condition, a definitive cure has not been developed so far, due to the complexity of multifactorial causes. Because it is a cosmetic composition, of topic and painless application, the present disclosure can be applied daily, with no need for a specialist in the field of aesthetics, besides not being expensive as the known to date techniques for treating melasma are. The peptide SEQ ID N° 1 acts inhibiting melanogenesis.

The invention provides a soft capsule helpful for improving the function of chloasma as well as a preparation method and application thereof, and relates to the technical field of health care products. The soft capsule comprises a mulberry leaf extract, a seville orange flower extract, a grape seed extract, an almond extract, donkey-hide gelatin powder, vitamin C and vitamin E. The soft capsule provided by the invention exerts the overall effect of improving chloasma through a multi-target synergistic mechanism from inside to outside: the mulberry leaf extract and the grape seed extract block melanogenesis from the source and resist ultraviolet damage by inhibiting tyrosinase activity and strongly resisting oxidation; the seville orange flower extract is used for soothing liver and regulating qi, and regulating internal pathogenesis; the almond extract and the donkey-hide gelatin powder have the effects of promoting blood circulation to remove blood stasis and nourishing yin and blood, improve microcirculation and nourish skin; vitamin C and vitamin E form an anti-oxidation cycle, so that melanin intermediates are directly reduced, and cell membranes are protected. All the raw materials supplement each other to jointly achieve the comprehensive effects of fading stains, brightening the skin color and improving the skin quality.

Provided herein are methods for treating skin-related diseases or disorders (e.g., melasma). Also provided are pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof formulated for topical administration. Also described are methods for preparing such topical pharmaceutical compositions and methods for using the topical pharmaceutical compositions to treat a subject.

According to the dermatosis medicine based on xanthoxylin WGX-50 and the preparation method thereof, WGX-50 has a strong anti-oxidation characteristic and is crucial to the anti-aging process of skin, and meanwhile, it is found that WGX-50 has the effects of promoting regeneration of collagen, elastin and lipid droplets, inhibiting expression of key genes participating in melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis and inhibiting melanogenesis. Due to the characteristics, the WGX-50 can effectively repair skin injury related to the natural aging process, and meanwhile, the WGX-50 has remarkable whitening and antioxidant effects. Compared with the effect of an asiaticoside cream ointment, the WGX-50 is effective on chloasma by reducing skin pigmentation, the effect of the WGX-50 is better than that of asiaticoside, and in the treatment of chloasma, the WGX-50 can be used as another method for relieving pigmentation and improving skin quality.

The invention relates to a whitening composition containing oxidized resveratrol and capable of deeply fading stains and application of the whitening composition, the composition is prepared from the following components: oxidized resveratrol, VC ethyl ether, a verbascos extract and a spearmint extract, and the weight ratio of the oxidized resveratrol to the VC ethyl ether to the verbascos extract to the spearmint extract is (0.11-2): (1-5): (0.01-1.2): (0.01-2). The whitening composition provided by the invention constructs an inhibition-removal-protection-repair system for chloasma, dermis plaque, post-inflammation pigmentation and other stubborn color spots caused by basement membrane zone injury, and performs multi-target repair.

The invention discloses a soluble microneedle array transdermal drug delivery freckle-removing mask and a preparation method of the soluble microneedle array transdermal drug delivery freckle-removing mask. The mask comprises a backing layer and a soluble micro-needle array arranged on the backing layer, the micro-needle array is composed of a needle tip and a base, and the needle tip comprises a freckle-removing active component, a nano-carrier material, a micro-needle matrix material and a stabilizer. The freckle-removing active components comprise tranexamic acid, sodium ascorbyl phosphate, Maojian green tea extract, licoflavone and nicotinamide; the nano carrier material is selected from hydroxyl cyclodextrin, chitosan nanoparticles and alginic acid-chitosan nanoparticles; the microneedle matrix material comprises hyaluronic acid, polyvinylpyrrolidone and polyvinyl alcohol. Through combination of a nano-carrier technology and a micro-needle system, the drug loading capacity, stability and transdermal efficiency of freckle-removing active ingredients are remarkably improved, and the freckle-removing micro-needle has the advantages of being good in freckle-removing effect, painless, noninvasive, convenient to use and the like, and is suitable for prevention and treatment of chloasma, freckles, hyperpigmentation after inflammation and other pigmented skin diseases.

A composition for inhibiting generation of melanin and the use thereof is provided, the composition includes platelets and / or growth factors isolated from blood, the composition for inhibiting generation of melanin has the abilities for inhibiting activity of tyrosinase and alleviating inflammation, and the composition for inhibiting generation of melanin is able to be used to manufacture of preparation for improving skin pigmentation or alleviating melasma.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

The invention discloses an application of a compound gel preparation in preparation of a product for treating chloasma. The compound gel disclosed by the invention is prepared from polypeptide gel capable of opening tight connection of skin through a self-assembly method. Finally, the hydrogel with certain flowability is formed. The polypeptide gel formed by the invention can penetrate through the surface layer of the skin, tranexamic acid, vitamin C and reduced glutathione are transferred to the basal layer of the skin through one-time operation, and then tranexamic acid is competitively combined with tyrosinase to inhibit the activity of the tyrosinase, so that the formation of melanin is reduced; the vitamin C inhibits the formation of melanin by reducing the formation of o-quinone and reducing oxidized melanin; the reduced glutathione is used as an antioxidant component, can inhibit the generation of free radicals, helps to stabilize the skin and restore the skin whiteness, can be used for treating chloasma, and provides a new solution for the field of skin health treatment.

Disclosed is a composition that is advantageously cosmetic, and preferably ecobiological, comprising: - glabridin, or an extract containing same; and - a compound of general formula (I); and the uses thereof, in particular cosmetic and non-therapeutic uses, for preventing and / or treating skin hyperpigmentation, and / or a hyperpigmentary disorder, advantageously actinic lentigo, melasma and / or post-inflammatory hyperpigmentation (PIH).

L'OREAL The present invention relates to methods for obtaining a plant extract from flowering tops of Inula helenium, as well as plant extracts of Inula helenium, compositions comprising them, and their implementation to prevent and / or treat a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular linked to a scar or an unsightly disorder following an inflammatory skin manifestation, in particular a scar or an acne mark or (iii) a melasma.

This invention provides a composition for suppressing melanin production and its use. [Solution] The composition contains platelets and / or growth factors isolated from blood and has the ability to suppress tyrosinase activity and alleviate inflammation. Furthermore, the composition of the present invention can be used in the manufacture of formulations for improving skin pigmentation or alleviating melasma.

The present invention provides the use of a compound represented by formula I, a pharmaceutically acceptable salt, hydrate, isomer, prodrug, or a mixture thereof, for manufacturing a product for improving pigmentation. This compound is very promising for the treatment of melasma. [Chemical 1] JPEG2025518798000031.jpg31169

The invention belongs to the technical field of biological materials, and particularly relates to a chloasma skin organ pathological model constructed on the basis of a 3D printing technology and a construction method and application of the chloasma skin organ pathological model. The model has a three-layer bionic structure, has high anatomical reducibility, can realize gradient positioning of melanocytes on a substrate layer, keeps long-term functions of the melanocytes, and breaks through the problem that a traditional model is difficult to maintain functions of the melanocytes; by adopting an endothelial cell co-printing technology and combining with a dynamic perfusion culture method, a microcirculation network with functionality is successfully established, a vascularization structure of chloasma skin is effectively simulated, the physiological simulation of the pathological model is improved, and the accuracy of the pathological model for simulating chloasma diseases is also greatly improved; in addition, the invention also develops a two-factor pathologic induction scheme, accurately simulates a light injury-hormone disorder synergistic pathogenic mechanism of chloasma, and solves the defect that a traditional model cannot fully show a complex pathogenic mechanism.

The present application relates to a method, device, and storage medium for early warning of aspiration and melasma during femtosecond corneal refractive surgery. This application employs a deep learning model consisting of an encoder and a decoder, and utilizes the trained deep learning model to output a predicted frame at the current moment. By comparing the predicted frame with the actual frame at the current moment, the application determines that the actual frame has deviated from the predicted direction when a deviation occurs between the predicted and actual frames. This application then determines that aspiration or melasma has occurred based on the deviation of the actual frame from the predicted direction. This method enables timely detection of aspiration and early warning before aspiration occurs during all-femtosecond corneal refractive surgery, thereby reducing the incidence of aspiration and improving safety.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The application provides a traditional Chinese medicine gel for treating stubborn skin color spots and a preparation method thereof, and the traditional Chinese medicine gel is prepared from the following raw materials in mass parts: aloe extract 25-30 parts, opuntia dillenii Haw extract 10-15 parts, safflower 5-10 parts, radix lithospermi 5-8 parts, herba portulacae 5-8 parts, purified water 60-65 parts, carbomer 1-5 parts, fish scale glue 5-8 parts, hydrogenated castor oil 100-110 parts, ethanol 120-140 parts and monoglyceride 4-10 parts. The prepared traditional Chinese medicine gel can clear heat and cool blood, remove blood stasis and remove spots, promote skin metabolism, repair damaged skin cells, and can treat stubborn skin color spots such as chloasma, melasma and age spots, and has no side effects.

The present invention relates to the use of a mixture of tranexamic acid, hydroquinone, arbutin and a concentrated extract solution of the brown seaweed Ascophyllum nodosum in the preparation of a medicament for treating melasma, wherein said medicament is associated with the use of a CO2 laser with cold pulse for the treatment of melasma.

Provided herein are formulations for topical and / or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and / or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

The present invention relates to the use of botulinum toxins for the treatment of hyperpigmentation conditions. The use includes intracutaneously injecting botulinum toxin into the skin of a patient with hyperpigmentation at a specific depth, volume and dose to specifically target the epidermal layer and the upper dermal layer. For example, an intradermal injection of botulinum toxin according to the invention may be used to treat chloasma.

The utility model discloses a repair mask for sensitive skin or chloasma. The repair mask comprises a mask body, a mask cover and a mask cover, the lamp panel is arranged on the mask body, a plurality of lamp beads are arranged on the lamp panel, the lamp beads emit visible light and / or infrared light, the light rays emitted by the lamp beads are suitable for irradiating the face of a user for repairing, the wavelength of the light rays emitted by the lamp beads is lambda, the light density of the light rays emitted by the lamp beads is rho, and lambda and rho meet the conditions that lambda is larger than or equal to 500 nm and smaller than or equal to 1200 nm, and rho is larger than or equal to 50% and smaller than or equal to 100%. According to the repairing mask, phototherapy can be carried out, the repairing mask can be used at home, using convenience is improved, and sensitive skin and chloasma of skin can be effectively repaired.

The invention discloses a traditional Chinese medicine compound for preparing skin external medicine, a preparation method and application, and belongs to the technical field of skin external medicine. The traditional Chinese medicine composition is prepared from the following components in percentage by weight: 1 to 3 percent of tranexamic acid, 10 to 15 percent of radix angelicae, 5 to 10 percent of radix angelicae sinensis, 3 to 10 percent of flos carthami, 3 to 8 percent of rhizoma atractylodis macrocephalae, 2 to 5 percent of radix scutellariae, 3 to 8 percent of poria cocos, 2 to 5 percent of liquorice root and 40 to 70 percent of matrix. The traditional Chinese medicine composition can effectively fade facial chloasma, freckles and other hyperpigmentation symptoms, improves the skin color, is convenient for long-term external use of patients, and avoids the problems of irritation and possible skin barrier injury caused by traditional freckle-removing chemical preparations. By combining the action mechanism of the modern medicine tranexamic acid and through the multi-target synergistic effect of the traditional Chinese medicine composition and the tranexamic acid, melanin deposition can be intervened in multiple links such as pigmentation generation, metabolism and excretion, and the freckle removing effect is remarkably improved.

The invention belongs to the technical field of whitening and freckle removing, and discloses a Chinese herbal medicine whitening and freckle removing cream, which comprises the following components: 15% of panax pseudoginseng, 10% of Tibetan angelica, 5% of myrobalan, 3% of rhodiola rosea, 6% of emblic leafflower fruit, 4% of saffron crocus, 10% of meconopsis and 20% of calcined gypsum rubrum. Efficient freckle removal is realized through a multi-target synergistic effect. The traditional path of singly inhibiting tyrosinase is broken through, and the expression of inflammatory factors (IL-6 and TNF-alpha), antioxidant enzymes (SOD and GSH-Px) and vascular endothelial growth factors (VEGF) is synchronously regulated and controlled. Clinical data show that after 30 cases of chloasma patients continuously use the medicine for 8 weeks, the MASI score is reduced by 62.3% (plt, 0.01) which is obviously superior to that of a control group (38.7%), and the recurrence rate is only 15.6% which is lower than that of laser treatment 3 months after the medicine is stopped. The effect is derived from the synergistic effect of components under the guidance of the Tibetan medicine theory, melanin generation is inhibited, the skin microenvironment is improved, and a long-acting treatment mechanism is formed.

Provided herein are methods of treating a skin-related disease or disorder (such as melasma). Also provided are pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof formulated for topical administration. Further described are methods for preparing such topical pharmaceutical compositions and methods of using the same for treating a subject.

At present, diagnosis of the severity of chloasma mainly depends on experience judgment of professional doctors and is related to actual experience of the doctors, and evaluation results often have high subjectivity and are not accurate enough. The invention provides a chloasma severity assessment method based on a neural network, and the method comprises the steps: inputting a face image, firstly, detecting key points of all parts of a face through a face key point detection model, cutting out an area needing the chloasma severity analysis according to the key point information, and carrying out the chloasma severity assessment. According to the method, a chloasma area is cut, such as a left side cheek area, a right side cheek area, a forehead area or a lower jaw area, then the cut area image is loaded into a chloasma severity assessment model to obtain an assessment value, the chloasma area severity is scientifically, objectively and accurately assessed, the whole assessment process is automatically completed by a computer, manual intervention is not needed, and the method is efficient and reliable. And accurate auxiliary information can be provided for subsequent diagnosis and treatment of chloasma.

The invention relates to a device and a method for treating chloasma by implanting a needle into a skin. The device comprises a needle handle and a needle body, the needle handle is connected with the needle body through a short shaft, and the needle handle is parallel to the needle body; the length of the short shaft is 1mm, and the length of the needle body is 10mm; the design of the short shaft is matched with the thicknesses of the epidermal layer and the dermal superficial layer of the face, and it is ensured that the acupuncture depth accurately acts on the melanin generation part. The contact area between the needle body and skin tissue is increased, and the treatment effect is improved. And a needle tip is arranged at the tail end of the needle body. Compared with the prior art, the invention has the advantages of accurate depth control and targeted treatment of chloasma; minimally invasive safety is achieved, and adverse reactions are reduced; the operation is standardized; the treatment repeatability is improved, and the like.

The present patent application is essentially characterized by a chemical formulation based on papain, urea, zinc sulfate, and ubiquinol, the purpose of which is to treat and heal skin affected by melasma; composed of: papain 10%; urea 5%; zinc sulfate 6%; ubiquinol 5%, in a cream base ad 100g, wherein the preparation must be carried out by a person skilled in the art who is familiar with the chemical processes and the use of each composition for correct manipulation; a product for topical nighttime application, suitable for all skin types; the area to be treated must be clean and dry, the formula applied to the melasma area, once it is absorbed into the skin, a sunscreen applied over it; the minimum treatment duration should be 6 to 12 months;In this way, it is determined that this formulation combats cell senescence, regenerates the stratum corneum and the phospholipid bilayer of cells, combats lipid peroxidation and local inflammation, eliminates excess free radicals from the intracellular environment, reorganizes the structures of internal organelles, preserves DNA integrity and maintains skin homeostasis and health, healing, reducing dark spots, and making the skin healthier, softer, more radiant, and more moisturized.