21 results about "Melasma" patented technology

The invention provides a soft capsule helpful for improving the function of chloasma as well as a preparation method and application thereof, and relates to the technical field of health care products. The soft capsule comprises a mulberry leaf extract, a seville orange flower extract, a grape seed extract, an almond extract, donkey-hide gelatin powder, vitamin C and vitamin E. The soft capsule provided by the invention exerts the overall effect of improving chloasma through a multi-target synergistic mechanism from inside to outside: the mulberry leaf extract and the grape seed extract block melanogenesis from the source and resist ultraviolet damage by inhibiting tyrosinase activity and strongly resisting oxidation; the seville orange flower extract is used for soothing liver and regulating qi, and regulating internal pathogenesis; the almond extract and the donkey-hide gelatin powder have the effects of promoting blood circulation to remove blood stasis and nourishing yin and blood, improve microcirculation and nourish skin; vitamin C and vitamin E form an anti-oxidation cycle, so that melanin intermediates are directly reduced, and cell membranes are protected. All the raw materials supplement each other to jointly achieve the comprehensive effects of fading stains, brightening the skin color and improving the skin quality.

Provided herein are methods for treating skin-related diseases or disorders (e.g., melasma). Also provided are pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof formulated for topical administration. Also described are methods for preparing such topical pharmaceutical compositions and methods for using the topical pharmaceutical compositions to treat a subject.

The invention discloses a soluble microneedle array transdermal drug delivery freckle-removing mask and a preparation method of the soluble microneedle array transdermal drug delivery freckle-removing mask. The mask comprises a backing layer and a soluble micro-needle array arranged on the backing layer, the micro-needle array is composed of a needle tip and a base, and the needle tip comprises a freckle-removing active component, a nano-carrier material, a micro-needle matrix material and a stabilizer. The freckle-removing active components comprise tranexamic acid, sodium ascorbyl phosphate, Maojian green tea extract, licoflavone and nicotinamide; the nano carrier material is selected from hydroxyl cyclodextrin, chitosan nanoparticles and alginic acid-chitosan nanoparticles; the microneedle matrix material comprises hyaluronic acid, polyvinylpyrrolidone and polyvinyl alcohol. Through combination of a nano-carrier technology and a micro-needle system, the drug loading capacity, stability and transdermal efficiency of freckle-removing active ingredients are remarkably improved, and the freckle-removing micro-needle has the advantages of being good in freckle-removing effect, painless, noninvasive, convenient to use and the like, and is suitable for prevention and treatment of chloasma, freckles, hyperpigmentation after inflammation and other pigmented skin diseases.

A composition for inhibiting generation of melanin and the use thereof is provided, the composition includes platelets and / or growth factors isolated from blood, the composition for inhibiting generation of melanin has the abilities for inhibiting activity of tyrosinase and alleviating inflammation, and the composition for inhibiting generation of melanin is able to be used to manufacture of preparation for improving skin pigmentation or alleviating melasma.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

The invention discloses an application of a compound gel preparation in preparation of a product for treating chloasma. The compound gel disclosed by the invention is prepared from polypeptide gel capable of opening tight connection of skin through a self-assembly method. Finally, the hydrogel with certain flowability is formed. The polypeptide gel formed by the invention can penetrate through the surface layer of the skin, tranexamic acid, vitamin C and reduced glutathione are transferred to the basal layer of the skin through one-time operation, and then tranexamic acid is competitively combined with tyrosinase to inhibit the activity of the tyrosinase, so that the formation of melanin is reduced; the vitamin C inhibits the formation of melanin by reducing the formation of o-quinone and reducing oxidized melanin; the reduced glutathione is used as an antioxidant component, can inhibit the generation of free radicals, helps to stabilize the skin and restore the skin whiteness, can be used for treating chloasma, and provides a new solution for the field of skin health treatment.

L'OREAL The present invention relates to methods for obtaining a plant extract from flowering tops of Inula helenium, as well as plant extracts of Inula helenium, compositions comprising them, and their implementation to prevent and / or treat a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular linked to a scar or an unsightly disorder following an inflammatory skin manifestation, in particular a scar or an acne mark or (iii) a melasma.

This invention provides a composition for suppressing melanin production and its use. [Solution] The composition contains platelets and / or growth factors isolated from blood and has the ability to suppress tyrosinase activity and alleviate inflammation. Furthermore, the composition of the present invention can be used in the manufacture of formulations for improving skin pigmentation or alleviating melasma.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The application provides a traditional Chinese medicine gel for treating stubborn skin color spots and a preparation method thereof, and the traditional Chinese medicine gel is prepared from the following raw materials in mass parts: aloe extract 25-30 parts, opuntia dillenii Haw extract 10-15 parts, safflower 5-10 parts, radix lithospermi 5-8 parts, herba portulacae 5-8 parts, purified water 60-65 parts, carbomer 1-5 parts, fish scale glue 5-8 parts, hydrogenated castor oil 100-110 parts, ethanol 120-140 parts and monoglyceride 4-10 parts. The prepared traditional Chinese medicine gel can clear heat and cool blood, remove blood stasis and remove spots, promote skin metabolism, repair damaged skin cells, and can treat stubborn skin color spots such as chloasma, melasma and age spots, and has no side effects.

The present invention relates to the use of botulinum toxins for the treatment of hyperpigmentation conditions. The use includes intracutaneously injecting botulinum toxin into the skin of a patient with hyperpigmentation at a specific depth, volume and dose to specifically target the epidermal layer and the upper dermal layer. For example, an intradermal injection of botulinum toxin according to the invention may be used to treat chloasma.

The utility model discloses a repair mask for sensitive skin or chloasma. The repair mask comprises a mask body, a mask cover and a mask cover, the lamp panel is arranged on the mask body, a plurality of lamp beads are arranged on the lamp panel, the lamp beads emit visible light and / or infrared light, the light rays emitted by the lamp beads are suitable for irradiating the face of a user for repairing, the wavelength of the light rays emitted by the lamp beads is lambda, the light density of the light rays emitted by the lamp beads is rho, and lambda and rho meet the conditions that lambda is larger than or equal to 500 nm and smaller than or equal to 1200 nm, and rho is larger than or equal to 50% and smaller than or equal to 100%. According to the repairing mask, phototherapy can be carried out, the repairing mask can be used at home, using convenience is improved, and sensitive skin and chloasma of skin can be effectively repaired.

The present patent application is essentially characterized by a chemical formulation based on papain, urea, zinc sulfate, and ubiquinol, the purpose of which is to treat and heal skin affected by melasma; composed of: papain 10%; urea 5%; zinc sulfate 6%; ubiquinol 5%, in a cream base ad 100g, wherein the preparation must be carried out by a person skilled in the art who is familiar with the chemical processes and the use of each composition for correct manipulation; a product for topical nighttime application, suitable for all skin types; the area to be treated must be clean and dry, the formula applied to the melasma area, once it is absorbed into the skin, a sunscreen applied over it; the minimum treatment duration should be 6 to 12 months;In this way, it is determined that this formulation combats cell senescence, regenerates the stratum corneum and the phospholipid bilayer of cells, combats lipid peroxidation and local inflammation, eliminates excess free radicals from the intracellular environment, reorganizes the structures of internal organelles, preserves DNA integrity and maintains skin homeostasis and health, healing, reducing dark spots, and making the skin healthier, softer, more radiant, and more moisturized.

This disclosure discloses inhibitors of CTGF RNA, MITF RNA, and SRD5A2 RNA and their applications, wherein the inhibitors are gene editing systems. The gene editing systems disclosed herein can knock down CTGF RNA, MITF RNA, or SRD5A2 RNA, and can be used to repair scars, whiten skin, reduce or eliminate melasma, prevent or treat melanoma, and / or prevent or treat androgenetic alopecia. This disclosure also discloses a gene editing system that targets AR RNA encoded by the androgen receptor gene, which can be used to treat androgenetic alopecia and other diseases.

A cosmetic composition comprising: (a) ascorbic acid; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) cationic polymer is described. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The invention relates to an application of a compound Mardepodect in preparation of a product for inhibiting melanogenesis, and a corresponding product. Experimental research proves that the compound has whitening and freckle removing effects, has potential application value in treatment of hyperpigmentation diseases such as post-inflammatory hyperpigmentation or senile freckles besides chloasma, and can be used for being matched with photoelectricity to treat chloasma.

The present application relates to a kind of white composition containing oxidized white resveratrol and deep lightening spot and its application, the composition includes the following components: oxidized white resveratrol, VC ethyl ether, verbascum thapsus extract and spearmint extract, the weight ratio of the oxidized white resveratrol, VC ethyl ether, verbascum thapsus extract and spearmint extract is (0.11-2):(1-5):(0.01-1.2):(0.01-2).The white composition of the present application is aimed at stubborn spots such as chloasma caused by basement membrane zone injury, dermal spots and post-inflammatory hyperpigmentation, constructs "inhibition-removal-protection-repair" system, and carries out multi-target repair.

The present invention relates to a cosmetic skin lightening composition comprising the combination of sclareolide, kojic acid and ascorbyl glucoside, wherein kojic acid is encapsulated within a targeted microcapsule or nanocapsule having a melanocortin 1 receptor (MC1R) agonist peptide bound to the surface. It was found that such combination of active substances provided synergistic kin-whitening effect. The present invention also relates to the cosmetic use of this composition for skin whitening, particularly, for the elimination or reduction of hyperpigmented marks of the skin, such as UV exposure related marks, post-scar marks, post-inflammation marks, melasma marks, lentigo marks or age-related marks.

A cosmetic composition comprising: (a) 2-mercaptonicotinoyl glycine; (b) acyl glycinate surfactant; (c) a salt providing divalent cations having a charge density of about 40 to about 200 C / mm3 and a water solubility of at least 400 g / L; (d) anionic polymer; (e) glycerin; (f) water; and (g) reducing agent. The cosmetic composition is particularly useful in a method for brightening skin, depigmenting skin, treating hyperpigmentation of skin, treating melasmic skin, or evening skin tone.

The present invention relates to processes for obtaining a plant extract of flowering tops of Inula helenium, and also to Inula helenium plant extracts, to compositions comprising same, and to the uses thereof for preventing and / or treating a chronic inflammatory skin disorder, in particular a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular associated with a scar or with an unaesthetic disorder consecutive to an inflammatory skin manifestation, in particular a scar or an acne mark, a scar or a rosacea mark or (iii) melasma.