109 results about "Depigmentation" patented technology

The invention features a method of administering a skin benefit agent to an expanse of skin, wherein the method includes: (a) contacting the expanse of skin with an apparatus, the apparatus including: (i) a skin-contactable element having a skin-contactable surface; (ii) a motor; and (iii) a transfer member for transferring mechanical energy from the motor to the skin-contactable element in order to provide periodic motion to the skin-contactable surface; and (b) after contacting the expanse of skin with the apparatus has ceased, further contacting the expanse of skin with a benefit agent, wherein the benefit agent is selected from the group consisting of retinoids, copper moieties, skin-firming agents, depigmentation agents, and combinations thereof.

The invention relates to a method for extracting raffinate oil and tea saponin from tea seed cake after oil extraction, which belongs to the field of grain and oil processing and byproduct extracting techniques. The technique of the invention mainly comprises the processes: after the extracted tea seek cake is crashed and dried, the raffinate oil is extracted by using industrial hexane or sherwood oil, the extracted raffinate oil is distilled to remove the solvent so as to obtain crude oil; the distilled solvent can be recycled, the tea seed cake after the raffinate oil is adopted to leach tea saponin by 85 to 95 percent ethanol, the tea saponin is subjected to the water bath heat and reflux for 2 to 3 hours at a temperature of between 70 and 80 DEG C, the tea saponin concentrated solution is obtained after filtering, distilling and concentrating processes, the depigmentation treatment is performed by using active carbon or 35 percent H2O2, and certain mount of acetone is added to the processed solution to keep stand for 1 to 2 hours; and after the tea saponin separates out completely, and the product of tea saponin is obtained by filtering and drying processes.

The invention discloses a preparation method for extracting chitosan from hermetia illucens, which comprises the following steps of: extracting chitinous substance from hermetia illucens by steps of decalcification by using hydrochloric acid, protein removal by using dilute alkalis, depigmentation by using sodium hypochlorite and the like, and removing acetyl from chitinous substance so as to obtain chitosan. The preparation method for extracting chitosan from hermetia illucens is a chitosan preparation method designed according to properties of hermetia illucens; since hermetia illucens is taken as the raw material and the sources of hermetia illucens are wide, the source channel of chitosan resources is widened; the method is simple in process, the extracting efficiency of the chitosan is high, and the quality of products is easy to control; and the chitosan prepared by the method can be applied to fields of environment protection, medical treatment, foods, textiles and agriculture.

The invention discloses a tissue engineering material-based culture method and applications of melanophore. In the method of the invention, the tissue engineering technology is used to build carrier material with good biocompatibility and perform culture (co-culture) and transfer of melanophore or melanophore, fibroblast and keratinocyte and the method can be used in depigmentation diseases such as vitiligo and for the regulation of skin color. The invention relates to the preparation of the carrier material with biocompatibility and the building and transplanting of the cell-carrier composite material. The carrier material can be used to provide good carrier for cell culture, maintain cellular activity and solve the problem that the cell suspension is easy to lose in the cellular transplantation process; the inoculum density and culture time of cells can be regulated at the same time, the regulation to the skin colors of different individuals can be realized; and the carrier materialhas good performances such as damage resistance, tear resistance and easy transfer, has good function of promoting wound healing, and satisfies the use requirements of the large-area depigmentation disease and the regulation of skin color.

The invention discloses an extraction and purification method of polysaccharide from Polygonatum kingianum, comprising the following steps: degreasing crude powder of a Polygonatum kingianum medicinalmaterial, carrying out water extraction for three times (40 min for each time), mixing filtrates, carrying out reduced pressure concentration at 60 DEG C to 1: 1.5, and carrying out alcohol precipitation for two times; mixing precipitates, and freeze-drying to obtain crude polysaccharide from Polygonatum kingianum; preparing a 0.3-0.5 g / mL solution by the use of the crude polysaccharide from Polygonatum kingianum, and carrying out depigmentation by loading the solution into D-101 macroporous resin; removing protein in the crude polysaccharide from Polygonatum kingianum by an isoelectric pointmethod; and carrying out dialysis by placing the protein-removed crude polysaccharide solution into a dialysis bag. By the method of the invention, polysaccharide in Polygonatum kingianum can be extracted effectively, impurities such as pigment, protein, micromolecular substances and the like in polysaccharide can be more thoroughly removed, and the structure of polysaccharide will not be damaged. In addition, use amount of an organic reagent is reduced, and polysaccharide purity is raised. The invention is an innovation of a purification method of polysaccharide from Polygonatum kingianum.

The invention discloses a Xanthomonas amylose culture medium, a method for preparing the culture medium and the application of the culture medium in the production of Xanthomonas amylose; the raw materials used for preparing the culture medium comprises starch waste water, amylase, active medical stone granule and yeast extract; the preparation method comprises the steps of wastewater disposal, pH value control, zymohydrolysis and saccharification, as well as depigmentation and adding nutrientsubstance; the method has the advantages that the starch waste water is transformed into the culture medium for producing the Xanthomonas amylase, thus greatly reducing the production cost and realizing the technological innovation of the industry of the Xanthomonas amylose; meanwhile, the method can turn harm into good and change waste into valuable, so as to reduce the pollution of organic wastewater of starch for the environment and develop circular economy in 'second panning' of the starch waste water.

The invention discloses a preparation method of nanometer fibril enteromorpha cellulose. By taking marine biomass enteromorpha as a raw material, waste residue after polysaccharide extraction is subjected to a chemical treatment, and is then subjected to a nanometer fibril treatment after desalination, deproteinization and depigmentation, thus preparing enteromorpha algae nanometer fibril. The enteromorpha cellulose nanometer fibril prepared by the preparation method is long and uniform in fiber diameter distribution. The prepared cellulose nanometer fibril can have great application prospects in biological scaffolds, inorganic templates, optical transparent flexible films, drug controlled release, water purification, efficient heat insulation and sound insulation materials, rechargeable batteries, super-capacitors, catalysts and carriers, gas filtering materials, adsorption materials, cosmetics, food additives and the like.

Topically applicable skin depigmenting compositions, suited for treatment of such hyperpigmentary disorders as melasma and chloasma, contain a thus effective amount of at least one skin depigmenting active agent, for example hydroquinone or 4-hydroxyanisole, in admixture with a depigmentation-accelerating amount of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthanoic acid), and optionally with at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

The invention discloses a method for determining the content of gamma-aminobutyric acid in red yeast through a high-efficient liquid chromatography. The method comprises the steps of (1) extracting the gamma-aminobutyric acid: adding the measured red yeast sample into water, ultrasonically extracting, centrifuging, and collecting the supernatant; (2) precipitating alcohol: adding ethanol and salt solution into the supernatant to execute alcohol precipitation, centrifuging the solution, and collecting the alcohol precipitation supernatant; (3) carrying out enzyme treatment: separating the solvent from the alcohol precipitation supernatant, and adding a composite enzymic preparation to execute enzyme treatment; (4) carrying out depigmentation: adsorbing the enzyme treated concentrated solution onto a column, adsorbing the solution with resin, eluting the solution with ammonia water; filtering the elution solution by utilizing a micro-pore filter membrane, wherein the filtered liquid is the detected liquid; (5) executing pre-column derivatization on the detected liquid, i.e. determining the content of the gamma-aminobutyric acid by adopting the liquid chromatography. By adopting the steps of alcohol precipitation, enzyme treatment and depigmentation, the content of impurities in the gamma-aminobutyric acid can be effectively removed, the interference in the detection process can be reduced, the detection accuracy can be effectively improved, and the detection result is reliable and stable.

A composition for treating skin pigmentation, a method of forming the composition, and a method of treating skin pigmentation are disclosed. The composition comprises at least one pharmaceutically acceptable additive. The composition further comprises at least one melanin production inhibitor, which may be a depigmentation agent. The melanin production inhibitor is present in an amount effective to inhibit melanin production in human skin cells of a subject that is administered the composition. The melanin production inhibitor is selected from the group consisting of cyclovirobuxine D, lipoic acid, nuciferine, peimisine, oleuropein, Rhodiola algida extract, Rhodiola kirilowii (Regel) Maxim extract, Glycyrrhizae Radix et Rhizoma extract, Cirsii japonici herba extract, Platycladi semen extract, Synotis erythropappa extract, Astragali complanati semen extract, Plantaginis semen extract, Lycopi herba extract, Euryales semen extract, Cuscutae semen extract, Amomi fructus extract, Tara seed extract, Platycladi cacumen extract, Eucommiae cortex extract, Dioscoreae rhizoma extract, Cirsii herba extract, and combinations thereof.

The invention pertains to the food color protection technology field, which relates to a color protection compound modifier for cooked meat products. The modifier is prepared by the following raw materials based on portions by weight: 40-80 portions of emulsifier, 5-20 portions of acidity regulator, 3-20 portions of antioxidant, 5-20 portions of chelating agent and 2-6 portions of anti-caking agent. The invention can remarkably postpone the depigmentation degree of the cooked meat products, facilitating the cooked meat products to keep florid color during sale and circulation processes for a long time, thereby improving the freshness of the cooked meat products.

The present invention relates to a cosmetic kit for depigmenting human skin comprising a multi-unit receptacle containing a first unit containing a microdermabrasion composition; a second unit containing a skin depigmenting composition; a third unit containing ascorbic acid in powder form; a fourth unit containing a skin soothing composition; optionally, a fifth unit containing a maintenance composition, and optionally a sixth unit containing a photoprotective composition. The present invention also relates to a method for treating human skin in need of depigmentation comprising the successive application, to an area of skin, of the compositions contained in the multi-unit receptacle.

at least one aurone or a natural or synthetic derivative of aurone, or an analogue of aurone, in which the independent phenyl ring can be substituted by a heterocycle of pyrrole, imidazole, triazole, pyridine, furan, or thiophene type, is disclosed as a cosmetic agent, or as an active substance, for the manufacture either of a cosmetic composition, or of a pharmaceutical composition, notably a dermatological composition, having a melanogenesis-inhibiting activity or a depigmenting activity, or an anti-tyrosinase activity.

The invention relates to a method for preparing polysaccharide instant powder by extraction, purification and spray drying; the dendrobium officinale polysaccharide is extracted with the ultrasonic assisted negative pressure cavitation method, and NKA-2 macroporous resin is optimized to purify the dendrobium officinale polysaccharide; the spray drying parameters and the formula of the dendrobium officinale polysaccharide are optimized, and an optimization technology of the preparing polysaccharide instant powder is formulated. A set of technology for preparing polysaccharide instant powder by extraction, purification and spray drying of the dendrobium officinale polysaccharide is formulated, compared with traditional methods, the dendrobium officinale polysaccharide is extracted efficiently and rapidly, with the adoption of the preparation technology, the extraction amount, the purity, the deproteinization rate and the depigmentation rate of crude polysaccharide are high, the prepared dendrobium officinale polysaccharide has excellent fluidity, larger stacking density, stable dispersity and rapid solubility and has an important significance for deep processing of the dendrobium officinale polysaccharide.

Topically applicable, stable and non-irritating aqueous-alcoholic cosmetic / dermatological gels suited for cutaneous depigmentation contain water, at least one alcohol, at least one gelling agent, at least one phenolic compound, at least one retinoid, and, optionally, at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;

Cosmetic method in which: a) a color is acquired from a region of the body of an individual, by using a device (20) equipped with a color camera (21) and by placing a color reference chart (30) in the field of said camera during the acquisition; and b) using the device, and the color acquired in a), and optionally knowledge of the tanning pathways of various skin colors, at least one indication is delivered concerning skin type and / or at least one indication is delivered concerning at least one skin color obtainable by the individual via the pigmentation or depigmentation process and / or at least one indication is delivered concerning photoprotection and / or application or administration of a product intended to temporarily modify the color of the skin.

The present invention relates to the field of medicines, and in particular discloses a child tuberous sclerosis treatment drug including rapamycin, the child tuberous sclerosis includes child tuberous sclerosis combined intractable epilepsy, child tuberous sclerosis combined cardiac rhabdomyoma, child tuberous sclerosis combined depigmentation, facial steatadenoma, and child tuberous sclerosis combined renal angioleiomyolipoma, and the drug use method is as follows: the initial dose of the rapamycin is 1mg / (m2.d), and the blood drug concentration is maintained at 5-10ng / mL.

The invention discloses a method for culturing human melanocyte based on a nano-fiber scaffold. Melanocyte or melanocyte, fibroblast and keratinocyte can be (co-cultured) cultured and transferred by utilizing a nano-fiber scaffold which is constructed by utilizing a tissue engineering technology and has an excellent biocompatibility, and the method is applicable to depigmentation (such as leukoderma) and can be used for regulating skin color. The invention also relates to preparation of the nano-fiber scaffold and construction of a cell-nano-fiber scaffold composite material. Because the nano-fiber scaffold has a porous structure, cell culture and activity maintenance can be promoted.

The invention belongs to the field of traditional Chinese medicine modernization, and particularly relates to a grub polysaccharide component and a preparation method and application thereof. The grub polysaccharide component has one or more of the following characteristics that monosaccharide is prepared from rhamnose, xylose, glucose and galactose according to the mole ratio of 1:(2.8-3.4):(11.6-12.5):(12.6-13.1), the weight-average molecular weight is 7*10<3>-10*10<3> Da, the total sugar content is 40%-55%, the protein content is 10%-20%, the uronic acid content is 25%-37%, and the sulfuric group content is 8%-11%. The preparation method comprises the steps that after grubs are crushed into coarse powder, total polysaccharide is extracted through alkaline water extraction and alcohol liquid precipitation methods; after deproteinization, depigmentation and dialysis are conducted, grading is conducted with an anion exchange column; the acidic part is separated and purified through size exclusion chromatography, and the obtained component with the molecular weight of 20 kD or below is dialyzed and then concentrated and dried. The grub polysaccharide component has the obvious effect of resisting tumors or reducing blood glucose or reducing blood pressure or resisting oxidation or resisting senescence or enhancing the immunity.

The invention provides an extracting and separating process of leccinum extremiorientale antioxidant polysaccharides. The method includes the following steps of firstly, conducting degreasing treatment on leccinum extremiorientale sporocarp to obtain leccinum extremiorientale sporocarp powder; secondly, extracting the degreased leccinum extremiorientale sporocarp powder through hot water, sequentially conducting concentration, alcohol precipitation, deproteinization, depigmentation and dialysis on aqueous extracts in sequence, and then conducting drying to obtain crude polysaccharide products; thirdly, conducting ion-exchange column chromatography and sieve chromatography to purify the crude polysaccharide products, collecting eluant, and conducting freezing and drying to obtain the leccinum extremiorientale antioxidant polysaccharides. Through in-vitro free radical scavenging capacity experiments, the result shows that polysaccharide components with molecular weight of 342375 Da have a remarkable anti-oxidation effect. The developed products are safe, and the leccinum extremiorientale antioxidant polysaccharides can be widely used as food additives.

The invention relates to a method for optimizing the ultrasonic-assisted extraction of tuber salep polysaccharide based on response surface methodology. The method includes: crushing tuber salep, thenconducting sieving to separate impurities, performing degreasing with petroleum ether, conducting depigmentation with ethanol, carrying out natural air drying, then using water as a solvent, utilizing Design Expert 8.0.6 software for Box-Behnken design, taking the polysaccharide yield as the response value, adopting three-factor and three-level response surface analysis process to optimize the ultrasonic-assisted extraction of tuber salep polysaccharide, then centrifuging and concentrating the extracted liquid, performing precipitation with anhydrous ethanol, then conducting centrifugation, and subjecting the polysaccharide precipitate to vacuum freeze drying, thus obtaining the tuber salep polysaccharide. Compared with the traditional method, the method provided by the invention has obviously shortened time, significantly lowered temperature and higher antioxidation activity, is easy for scale-up production, and is one of the ideal methods for preparation of tuber salep polysaccharide. The study can provide reference for application and development of tuber salep polysaccharide in anti-oxidation and anti-aging functional food.

Methods and apparatuses are disclosed for assessing pigmentation of skin based on images thereof. In disclosed implementations, a cross-polarized blue image of skin is obtained and processed to extract pigment distribution information. Useful applications include assessing depigmentation, as in the skin condition vitiligo, as well as assessing re-pigmentation such as due to treatment. In addition to the spatial extent of depigmentation, implementations of the present disclosure can also provide the degree of depigmentation. The degree and area of depigmentation can be measured with better accuracy and sensitivity than known techniques.

The invention discloses application of resveratrol in preparing a medicament for preventing and treating radiation induced depigmentation skin disease. A path for treating occurrence and development of ionizing radiation induced leucoderma is established by treating a radiation induced IRM-2 mouse leucoderma model with resveratrol. Mice irradiated by 6Gy after 30 days orally take the medicament for 15 days, and then the result shows that the depigmentation inhibiting rate of the medicament administration group reaches 40% compared with the control group, so the medicament has remarkable effect. Pathological detection results show that hair follicles of the pathological change part of the mice of the resveratrol administration group are distributed more densely, and the distribution of melanin is obviously wider than that of an irradiation group and a normal group. The immune indexes of the mice of the resveratrol administration group, such as peripheral blood leukocyte number, femoral nucleated cell number, CFU-S (colony forming unit-spleen), CFU-GM (colony forming unit-granulocyte and monocyte) and the like, are slightly higher than those of the irradiation group, so the resveratrol has certain protection effect on hematopoiesis and immunologic function of the irradiated mice. The results show that the resveratrol has positive prevention and treatment effect on the occurrence and development of the radiation induced mice leucoderma.

The invention discloses a preparation method of inonotus obliquus polysaccharides. The method comprises the following steps: firstly, carrying out superfine grinding on inonotus obliquus, then breaking walls, extracting with hot water and performing centrifugation to obtain an extracting solution, and carrying out the steps of microfiltration and ultrafiltration on the extracting solution, aqueoustwo-phase extraction, macroporous adsorption resin decolorization, nanofiltration desalting and concentration, freeze-drying and the like to obtain an inonotus obliquus polysaccharide product. The preparation method of the inonotus obliquus polysaccharides disclosed by the invention has the advantages that 1, the release of polysaccharide substances in the inonotus obliquus is obviously improvedby using a low-temperature micro-nano wall breaking technology to destroy the cell walls, 2, most of proteins can be separated from the polysaccharides by using an aqueous two-phase extraction technology, to avoid causing influence on the polysaccharides, 3, depigmentation is performed by using macroporous adsorption resin to make the color of the polysaccharide finished product lighter, 4, sodiumcitrate and other inorganic salts mixed in a polysaccharide solution can be removed by using a nanofiltration membrane technology, and the polysaccharide solution is concentrated to avoid the effectof high temperature on polysaccharide activity, and 5, the solvent is safe and pollution-free, the yield is high, and the preparation method is convenient to operate and low in cost.

The invention belongs to the field of the production process of extracting the active ingredients of Chinese herbs and in particular relates to a response surface analysis-optimized and cellulase-catalyzed method for extracting spreading hedyotis herb polysaccharides and optimum extraction process conditions. The spreading hedyotis herb polysaccharides are extracted by use of the cellulase-catalyzed method which comprises the steps of cellulase-catalyzed hot water extraction, enzyme deactivation, concentration, alcohol precipitation, deproteinization, alcohol precipitation, depigmentation, alcohol precipitation, extraction rate measurement and the like, namely carrying out hot water extraction twice according to the material-to-liquid ratio of 1: (8-12) and by adding about 2% of cellulase, triple precipitation by use of an 80% alcohol, deproteinization twice by use of trichloroacetic acid and twice depigmentation by use of activated carbon adsorption. The following optimum extraction process conditions for extracting the spreading hedyotis herb polysaccharides are obtained by virtue of a response surface three-dimensional diagram: pH of about 7, a temperature at 55 DEG C and the dosage of the cellulase of 2%; the extraction rate of the spreading hedyotis herb polysaccharides under the conditions is 9.83%.

The present invention relates to a composition comprising at least an aminophenol derivative and at least an isoflavonoid in a physiologically acceptable medium. The invention also relates a usage of the composition in producing the decolorization and / or the bleaching preparation for the skin. These combinations of active agents show synergism in the depigmentation and / or bleaching of the skin.

The present invention relates to the use of an extract of Alchemilla vulgaris in a depigmenting cosmetic composition. The present invention also relates to a cosmetic treatment method for depigmenting the skin, by application to the skin of a cosmetic composition containing an extract of Alchemilla vulgaris.

The invention discloses a preparation technology of a compound ulva extract with an auxiliary anti-tumor effect. The process is characterized in that ultrasonic-assisted extraction is utilized, crudepolysaccharide ingredients are separated by adopting a water-extraction and alcohol-precipitation method, then deproteinization and depigmentation are carried out, ulva active polysaccharide with highpurity is obtained after purification, then hydrogen peroxide and ascorbic acid are used for oxidizing and degrading the ulva polysaccharide, ulva active oligosaccharide with high purity is obtainedafter purification, and the ulva polysaccharide and the ulva oligosaccharide are mixed for use. Through the verification of animal pharmacodynamics, the compound ulva extract has an exact killing ability against an H22 hepatocarcinoma tumor in KM mice, can inhibit the growth and spread of the tumor, has a certain repair effect on the diseased tissue, and does no have obvious side effects. The compound ulva extract is a biologically active substance which has no toxicity, has few side effects and is very safe, and can be conveniently prepared into drugs of various dosage forms with pharmaceutically acceptable carriers.