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Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof

A tissue-engineered skin and sodium alginate technology, applied in medical science, prostheses, etc., can solve problems such as wound repair that cannot be effectively solved, and achieve the effects of being conducive to cultivation and function maintenance, fast production, and simple production process

Inactive Publication Date: 2016-11-16
朱家源 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Surgical repair is currently the main method for treating wounds. However, whether it is traditional skin grafting, skin flap transplantation, stamp skin grafting, micro-skin grafting, mesh skin grafting, composite skin grafting, etc., or the current tissue engineered skin, currently failed to effectively solve the problem of wound repair

Method used

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  • Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof
  • Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof
  • Tissue engineering skin constructed by sodium alginate hydrogel scaffold and preparation method thereof

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Embodiment Construction

[0030] The present invention will be described in further detail below in conjunction with specific examples.

[0031] (1) As shown in the following formula, dissolve 4 to 6 g of BLG-NCA monomer in 80 to 100 mL of benzene-dioxane mixed solvent, use ω-amino-terminated polyethylene glycol as the initiator, and react at room temperature for 60 After ~72 hours, the reaction solution was poured into absolute ethanol to precipitate, filtered, and vacuum-dried to obtain a light yellow translucent solid, and PEG-PBLG (PEG was polyethylene glycol, and PBLG was poly-γ-benzyl L-glutamine acid) block copolymer,

[0032] The volume ratio of benzene and dioxane in the benzene-dioxane mixed solvent is 4:1, the molar ratio of BLG-NCA monomer to ω-terminal amino polyethylene glycol is 70-80:1, and the reaction solution and The volume ratio of absolute ethanol is 1:20~30;

[0033]

[0034] (2) Dissolve the PEG-PBLG block copolymer obtained in step (1) in water to make its concentration gre...

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Abstract

The invention discloses tissue engineering skin constructed by a sodium alginate hydrogel scaffold. The tissue engineering skin comprises a cuticular layer and a corium layer from top to bottom, wherein the cuticular layer is a layer of seed cells positioned above the corium layer; and the corium layer comprises seed cells and a sodium alginate hydrogel scaffold; the seed cells are positioned in the surface and body of the sodium alginate hydrogel scaffold to form a skin appendage. Since the hydrogel scaffold cross-linked network contains a great amount of moisture, can be used for supplying nutrition to cells, and is crosslinked with EGF to adjust growth and differentiation of cells, so that the hydrogel scaffold can be used for well simulating tissue-like physical and spatial structures essential to cell growth, a three-dimensional cultural space of cells can be provided, culture and function maintenance of stratum basale epidermidis cells can be benefited, and a tissue engineering skin substitute with biological activity can be constructed. When the tissue engineering skin is applied to a wound surface, and recovery of a normal tissue structure of the wound is benefited.

Description

technical field [0001] The invention relates to the field of tissue skin dressings, and also relates to a preparation method of the skin dressings. Background technique [0002] The skin is the largest organ in the human body, an important protective barrier, and also has important physiological functions such as sensation, protection, and temperature regulation. When normal skin tissue is damaged by external injury factors (burns, trauma, etc.) and internal factors (malnutrition, hypoxia, infection, etc.) Loss of skin function. [0003] Clinically common wounds include major diseases such as burns and trauma, acute wounds such as skin defects formed after surgical resection such as scars, skin pigmented diseases, and benign and malignant tumors, as well as diabetic ulcers, vascular ulcers, pressure ulcers, and radiation ulcers. , tumorous ulcers, cicatricial ulcers, neurogenic ulcers and other chronic wounds. [0004] Surgical repair is currently the main method for trea...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/38A61L27/20
CPCA61L27/20A61L27/3804A61L27/3834A61L27/60C08L5/04
Inventor 朱家源唐冰胡志成
Owner 朱家源
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