25 results about "Skin appendage" patented technology

The present invention relates to a cosmetic or dermatological ingredient or a cosmetic or dermatological composition comprising the peptide of sequence SEQ ID N ° 1 and / or a derivative thereof and / or a salt thereof, and to the uses thereof for improving the condition and / or appearance and / or comfort of healthy skin and / or healthy mucous membranes and / or healthy skin appendages.

The invention relates to the cosmetic and non-therapeutic use of a composition consisting essentially of a compound of formula I below: (I) or its enantiomers, isomers or diastereoisomers, or a mixture thereof, or a salt or a solvate thereof, wherein R1 and R2, independently of each other, are a C3-C6 sugar, a uronic acid, or a glucoside, for bleaching or whitening the skin and skin appendages of a healthy individual.

The present invention relates, in particular, to a cosmetic composition for makeuping and / or caring for the skin and / or lips and / or eyelashes and / or hair, especially the skin, comprising in a physiologically acceptable aqueous medium: a) natural chitosan having a molecular weight strictly greater than 3,000 daltons, in an amount of at least 0.01% by mass relative to the total mass of the composition, and this amount being strictly less than 15% by mass; and b) at least one natural resin. The present invention also relates to a method for makeuping and / or caring for the skin and / or skin appendages, wherein the composition according to the present invention is applied to the skin and / or skin appendages.

This invention relates to a cosmetic composition, in particular make-up and / or treatment intended to be applied on the skin, lips and skin appendages of humans such as hair, eyelashes, eyebrows or nails, comprising glyceryl trihydroxystearate, at least 50% by weight with respect to the total weight of the composition of at least one vegetable oil and at least one pigmentary coloring material. Another object of the invention is a method for making up and / or treating the skin and / or lips and / or cheeks, in particular lips and / or cheeks, wherein the composition according to the invention is applied.

The invention discloses a sheep tail fat active component as well as a separation method and application thereof in skin wound healing, and relates to the technical field of natural product separation and biological medicine. According to the method, through ultrasonic-assisted enzymolysis extraction and silica gel column gradient elution, efficient separation of different polar components is achieved, and high-polarity components rich in high-activity unsaturated fatty acid are obtained; the invention also provides application of the component in skin wound healing. The sheep tail fat active component has excellent free radical scavenging ability, can significantly down-regulate the levels of pro-inflammatory factors such as IL-1beta and TNF-alpha in wound tissues, up-regulate the expression of TGF-beta1, promote the deposition and remodeling of collagen and accelerate the regeneration of skin appendages such as hair follicles and sebaceous glands by regulating and controlling a TGF-beta1 / Smad3 signal channel, and has the effects of promoting the healing of the skin and the like. The method can effectively shorten the wound healing time and reduce scar formation, can be used for preparing a natural wound healing agent, and provides a new way for high-value utilization of Lanzhou big-tailed sheep resources.

The invention discloses a method for scar-free healing in treatment of wounds / wounds by miR-185-5p, relates to the field of biological medicine and plastic surgery and beauty repair, and comprises application of scar-free healing in acute / subacute / chronic wounds related to any skin injury (including burn, laceration, bruise, operation, perforation and vaccination) of deep dermis. Wound healing is a series of complex and elaborately-planned overlapping stages arranged according to a time sequence, wherein the stages comprise four stages of hemostasis, inflammation, proliferation and remodeling. No matter at any stage, the skin stability after wound healing and whether scars are formed or not can be directly influenced. The miR-185-5p is used in an animal skin model caused by an acute wound, so that the wound healing time is integrally shortened, the reepithelization formation of the wound is promoted, the number of skin appendages is increased, and the regeneration of hair follicles is promoted. The secretion amount of the collagen I is reduced, and the formation of the collagen III is improved.

The invention relates to a cosmetic composition, in particular for making up and / or caring for skin and / or lips and / or eyelashes and / or hair, in particular skin, the invention relates to a composition comprising, in a physiologically acceptable aqueous medium, a) at least 0.01% by weight, relative to the total weight of the composition, of a natural chitosan having a molecular weight strictly greater than 3000 Daltons in an amount strictly less than 15% by weight, and b) at least one natural resin. The invention also relates to a method for making up and / or caring for the skin and / or skin appendages, wherein a composition according to the invention is applied to the skin and / or skin appendages.

The invention belongs to the technical field of medical dressings, and relates to a DNA hydrogel dressing with a skin-like structure and function as well as a preparation method and application of the DNA hydrogel dressing. The dressing is structurally characterized in that a skin-like three-layer structure, namely an epidermal layer, a corium layer and a subcutaneous tissue layer, is constructed by regulating and controlling the cross-linking degree of chain segments and combining a directional freezing technology, and an extracellular matrix microenvironment is provided for physiological activities of cells. In function, an aptamer sequence with a specific function is introduced, and stem cells are induced to directionally differentiate into cells required by tissue repair; the subcutaneous tissue-like layer is loaded with resveratrol, and fascia is activated to induce regeneration of skin appendages; in view of the fact that chronic ulcerative wounds are easily attacked by bacteria, the antibacterial peptide and a functional DNA sequence of targeted bacteria form an antibacterial peptide-DNA composite chain segment through a click reaction, and the dressing is endowed with targeted antibacterial performance. The prepared dressing has a skin-imitating three-dimensional structure and performance, can guide skin appendages such as regeneration of hair follicles and sweat glands, and can be widely applied to repair treatment of chronic wounds.

The present invention relates to a composition, in particular for making up and / or caring for the skin and / or the lips and / or skin appendages, comprising, in a physiologically acceptable aqueous medium: a) 0.01% to 15% by weight, relative to the total weight of the composition, of natural chitosan having a molecular weight strictly greater than 3000 Daltons, and b) at least one crystallizable fat. The invention also relates to a method for making up and / or caring for the skin and / or lips and / or skin appendages, wherein a composition according to the invention is applied to the skin and / or lips and / or skin appendages.

The invention relates to a topical composition that is advantageously ecobiological and that comprises i) at least one compound of general formula (I) or one of the salts thereof, wherein said formula is ii) at least one compound of general formula (IIA) or one of the salts thereof, or of general formula (IIB) or one of the salts thereof, and the mixture thereof, and use of same for protecting the skin, mucous membranes, skin appendages and / or scalp against UV radiation.

The application discloses a radial multilayer microneedle sensing system and method for single follicular unit microenvironment analysis, and belongs to the field of skin appendage detection and biological micro-electro-mechanical systems. The system comprises a positioning hole integrated with an optical collimation unit, concentric ring microneedles with a length ratio within a certain range, ring compression protruding structures between the microneedles, a differential negative pressure sampling module and a detection electrode modified with an aptamer probe, which can accurately position the follicle, perform layered puncture, construct a hydraulic barrier to prevent cross-flow, isolate and extract interstitial fluid between deep and shallow layers and target detection of disease markers such as androgen alopecia. The method comprises the steps of optical targeting positioning, compression sealing puncture, differential sampling, in-situ detection and gradient index calculation. The application can improve the spatial detection resolution of the markers, solve the problems of signal dilution and subcutaneous cross-flow, and provide a quantitative tool for follicular pathological research and drug non-diagnostic screening.

The invention relates to the cosmetic and non-therapeutic use of a composition consisting essentially of a compound of formula I below: (I) or its enantiomers, isomers or diastereoisomers, or a mixture thereof, or a salt or a solvate thereof, wherein R1 and R2, independently of each other, are a C3-C6 sugar, a uronic acid, or a glucoside, for bleaching or whitening the skin and skin appendages of a healthy individual.

[Problem] There is no gene transduction method with high efficiency and high specificity for skin, subcutaneous tissue, skin ulcer surfaces, and their constituent cells. More generally, achieving high gene transduction efficiency in vivo is challenging. Additionally, it is difficult to morphologically and functionally regenerate skin appendages and to regenerate lost peripheral tissues of the upper and lower limbs (upper arm, forearm, hand, fingers, thigh, lower leg, foot, toes).[Solution] This invention provides solutions to these challenges through a novel AAV (adeno-associated virus) capsid with high gene transduction efficiency and high specificity for skin, subcutaneous tissue, and skin ulcer surface cells, as well as a novel AAV capsid with high gene transduction efficiency and high specificity for epidermal tissue and its constituent keratinocytes. Additionally, the invention provides a novel tissue-specific promoter with high gene expression efficiency and high specificity for epidermal tissue and its constituent keratinocytes, and a pharmaceutical composition that enhances gene transduction efficiency by co-administering steroids alongside in vivo gene transduction. The invention further includes a pharmaceutical composition that promotes the regeneration, neogenesis, and functional enhancement of skin appendages through in vivo gene transduction, thereby compensating for functional impairments of skin appendages. Additionally, it provides a research and development platform for developing methods to regenerate peripheral and missing tissues of the upper and lower limbs, as well as a pharmaceutical composition for achieving tissue regeneration. Thus, the present invention provides methods for overcoming these challenges.

The present invention relates to a cosmetic or dermatological ingredient or a cosmetic or dermatological composition comprising the peptide of sequence SEQ ID N ° 1 and / or a derivative thereof and / or a salt thereof, and to the uses thereof for improving the condition and / or appearance and / or comfort of healthy skin and / or healthy mucous membranes and / or healthy skin appendages.

The invention relates to an aqueous topical make-up remover composition which advantageously is ecobiological, having a dynamic viscosity, measured at 25 degrees centigrade, greater than 2000 cP, preferably greater than 3000 cP, advantageously greater than 4000 cP, even more advantageously greater than 5000 cP, said composition comprising: - at least one surfactant; - at least one citric acid ester. The invention also relates to the use of the composition, in particular in a method for removing make-up or for cleansing the skin, lips and / or skin appendages.

Embodiments of the present disclosure disclose a scar organoid and a method for constructing, passaging, cryopreserving and drug screening thereof. The specific implementation of the method comprises: a scar organoid comprising an epidermal cell cluster, fibroblasts and residual skin appendage structures, wherein the residual skin appendage structures are sebaceous gland-like lobular structures. The embodiment can improve the authenticity of cell heterogeneity and drug sensitivity reflecting pathological scars, and improve the accuracy of reacting to the biological characteristics of human scars.

The present invention relates to a composition containing a combination of biologically active ingredients that inhibit the glycogen phosphorylase enzyme and improve the glycogen metabolism in the hair follicle stimulating the growth of hair, and improving their aesthetic appearance.

The present invention relates to a cosmetic composition comprising, in a physiologically acceptable aqueous medium, a) natural chitosan having a molecular weight strictly greater than 3000 daltons and present in an amount of at least 0.01% by mass of the total mass of the composition, and this amount being strictly less than 15% by mass, and b) at least one surface-treated inorganic pigment having a size of 100 nm or less. The present invention also relates to a method for cosmeticizing and / or caring for the skin and / or skin appendages, wherein the composition according to the present invention is applied to the skin and / or skin appendages.

The present invention relates to an extract from flowers of Ceiba trichlosta, preferably from the calyx of Ceiba trichlosta, a process for preparing it, and the extract obtained by said process. The present invention also relates to a composition comprising said extract, said composition being advantageously a cosmetic, pharmaceutical or dermatological composition. The present invention also relates to said composition or said extract for use in the prevention or treatment of diseases or pathological conditions of the skin, mucosae or hair and nails, and of imbalances or diseases associated with a microbial imbalance of the skin, mucosae, hair, nails and related cutaneous appendages. Finally, the present invention relates to a cosmetic care method for the skin, hair and nails or mucosae to improve their condition or appearance, said method comprising the application of said composition or said extract.

The application belongs to the technical field of biological medicine and wound repair, and particularly relates to application of Anji small salamander in skin wound healing. The application has good ability of promoting wound healing by using the biological active substances in the ecdysis of Anji small salamander, can effectively improve the skin wound healing efficiency, shorten the exuviation time, inhibit the scar formation in the wound healing process, promote the regeneration of skin appendages in the wound healing process and the like.

The present invention relates to compositions, particularly compositions for makeuping and / or caring for the skin and / or lips and / or skin appendages, comprising in a physiologically acceptable aqueous medium: a) 0.01 to 15% by mass of natural chitosan having a molecular weight strictly greater than 3000 daltons, relative to the total mass of the composition; and b) at least one crystalline fat. The present invention also relates to methods for makeuping and / or caring for the skin and / or lips and / or skin appendages, wherein the compositions according to the present invention are applied to the skin and / or lips and / or skin appendages.

Cosmetic Uses of a Hydrolyzed Extract of Silybum marianum Seed Cake: The invention relates to the cosmetic use of a hydrolyzed extract of Silybum marianum seed cake to maintain and / or enhance the biomechanical properties of skin appendages. Another object of the invention is a cosmetic treatment method comprising the topical application of the hydrolyzed seed cake extract or a composition containing it.

The present invention relates to a composition containing a combination of biologically active ingredients that inhibit the glycogen phosphorylase enzyme, improve the glycogen metabolism in the hair follicle and stimulating the growth of hair and skin appendages, and improving their aesthetic appearance.

Cleaning composition containing a non-modified clay and a polyglyceryl surfactant. The object of the invention is a cosmetic composition, especially for cleansing the skin and / or the skin appendages, which comprises, in an aqueous physiologically acceptable medium: at least one non-modified clay chosen from trioctahedral smectites, and at least one ester chosen from esters of fatty acids comprising from 4 to 16 carbon atoms and of polyglycerols comprising from 2 to 10 glycerol units, the weight ratio of the ester:clay being strictly greater than 1.

The invention belongs to the technical field of biological medicine and wound repair, and particularly relates to application of Anji giant salamander in skin wound healing. Bioactive substances in molting of the Anji giant salamander are utilized, so that the Anji giant salamander has good capacity of promoting wound healing, the skin wound healing efficiency can be effectively improved, the decrustation time is shortened, and the wound healing effect is improved. The scar formation in the wound healing process is inhibited, and the regeneration of skin appendage organs in the wound healing process is promoted.