46 results about "Skin appendage" patented technology

The invention provides application of a turbellarian worm extract in preparation of a product for promoting wound healing, a biological agent for promoting the proliferation activity and / or migration ability of fibroblast NIH3T3, a biological agent for improving the wound healing rate and the decrustation time and a biological agent for improving the collagen fiber deposition type in the wound healing process. The biological preparation is used for promoting regeneration of skin appendage organs in the wound healing process. Wherein the extraction of the turbellarian worm extract comprises the steps of turbellarian worm cleaning, tissue crushing, alcohol extraction, centrifugal separation and concentration drying. The turbellarian worm extract has good capacity of promoting wound healing, and has the effects of effectively improving skin wound healing efficiency, shortening decrustation time, inhibiting scar formation in the wound healing process, promoting regeneration of skin appendage organs in the wound healing process and the like.

The present invention relates to a cosmetic or dermatological ingredient or a cosmetic or dermatological composition comprising the peptide of sequence SEQ ID N ° 1 and / or a derivative thereof and / or a salt thereof, and to the uses thereof for improving the condition and / or appearance and / or comfort of healthy skin and / or healthy mucous membranes and / or healthy skin appendages.

The invention relates to the cosmetic and non-therapeutic use of a composition consisting essentially of a compound of formula I below: (I) or its enantiomers, isomers or diastereoisomers, or a mixture thereof, or a salt or a solvate thereof, wherein R1 and R2, independently of each other, are a C3-C6 sugar, a uronic acid, or a glucoside, for bleaching or whitening the skin and skin appendages of a healthy individual.

The present invention relates, in particular, to a cosmetic composition for makeuping and / or caring for the skin and / or lips and / or eyelashes and / or hair, especially the skin, comprising in a physiologically acceptable aqueous medium: a) natural chitosan having a molecular weight strictly greater than 3,000 daltons, in an amount of at least 0.01% by mass relative to the total mass of the composition, and this amount being strictly less than 15% by mass; and b) at least one natural resin. The present invention also relates to a method for makeuping and / or caring for the skin and / or skin appendages, wherein the composition according to the present invention is applied to the skin and / or skin appendages.

This invention relates to a cosmetic composition, in particular make-up and / or treatment intended to be applied on the skin, lips and skin appendages of humans such as hair, eyelashes, eyebrows or nails, comprising glyceryl trihydroxystearate, at least 50% by weight with respect to the total weight of the composition of at least one vegetable oil and at least one pigmentary coloring material. Another object of the invention is a method for making up and / or treating the skin and / or lips and / or cheeks, in particular lips and / or cheeks, wherein the composition according to the invention is applied.

The invention discloses a sheep tail fat active component as well as a separation method and application thereof in skin wound healing, and relates to the technical field of natural product separation and biological medicine. According to the method, through ultrasonic-assisted enzymolysis extraction and silica gel column gradient elution, efficient separation of different polar components is achieved, and high-polarity components rich in high-activity unsaturated fatty acid are obtained; the invention also provides application of the component in skin wound healing. The sheep tail fat active component has excellent free radical scavenging ability, can significantly down-regulate the levels of pro-inflammatory factors such as IL-1beta and TNF-alpha in wound tissues, up-regulate the expression of TGF-beta1, promote the deposition and remodeling of collagen and accelerate the regeneration of skin appendages such as hair follicles and sebaceous glands by regulating and controlling a TGF-beta1 / Smad3 signal channel, and has the effects of promoting the healing of the skin and the like. The method can effectively shorten the wound healing time and reduce scar formation, can be used for preparing a natural wound healing agent, and provides a new way for high-value utilization of Lanzhou big-tailed sheep resources.

The present invention relates to a liquid composition intended to be applied to the skin, the skin appendages or the mucous membranes, the composition containing at least two grades of hydroxypropyl cellulose, at least one of which has a molecular weight of at least 800,000 and the other of which has a molecular weight of less than 400,000, at least ethyl cellulose, at least one hydroxypropyl cellulose plasticiser, at least one ethyl cellulose plasticiser, at least one organic solvent and at least one inorganic solvent. Once applied to the skin, the skin appendages or the mucous membranes, the solvents evaporate and the composition forms a solid protective film on the skin, the skin appendages or the mucous membranes, which film can advantageously be used in the treatment of skin disorders, in particular acne.

The invention discloses a method for scar-free healing in treatment of wounds / wounds by miR-185-5p, relates to the field of biological medicine and plastic surgery and beauty repair, and comprises application of scar-free healing in acute / subacute / chronic wounds related to any skin injury (including burn, laceration, bruise, operation, perforation and vaccination) of deep dermis. Wound healing is a series of complex and elaborately-planned overlapping stages arranged according to a time sequence, wherein the stages comprise four stages of hemostasis, inflammation, proliferation and remodeling. No matter at any stage, the skin stability after wound healing and whether scars are formed or not can be directly influenced. The miR-185-5p is used in an animal skin model caused by an acute wound, so that the wound healing time is integrally shortened, the reepithelization formation of the wound is promoted, the number of skin appendages is increased, and the regeneration of hair follicles is promoted. The secretion amount of the collagen I is reduced, and the formation of the collagen III is improved.

The invention relates to the technical field of animal histological analysis technology and skin appendage application, in particular to a goose skin hair follicle microsection manufacturing and evaluating method, which specifically comprises the following steps: selecting back skin of a Sanhua goose, avoiding dehairing injury, cutting a 5 * 5mm full-thickness skin sample by using a scalpel, and taking out the full-thickness skin sample; a sample is immediately put into 4% paraformaldehyde to be fixed for 24 hours, stepped ethanol dehydration is adopted, tissue brittleness is reduced, paraffin embedding optimization is adopted, so that a hair follicle structure slice is clear in layer, the method is easy and convenient to operate, tissue treatment procedures do not need to be optimized, it is guaranteed that the thickness of the hair follicle slice is more uniform, and the quality of the hair follicle slice is improved. The number of primary hair follicles and hair follicles is uniform, recording is accurate, hair follicle slice observation and number analysis are facilitated, and the method plays an important role in goose breeding and down feather quality evaluation.

The invention discloses a double-bionic wound dressing with seepage management and self-power generation functions as well as a preparation method and application of the double-bionic wound dressing. The double-bionic wound dressing comprises a first electrode layer, a blocking layer, a moisture absorption power generation layer, a diffusion antibacterial layer, an evaporation power generation layer and a second electrode layer which are sequentially stacked from bottom to top. The electrostatic spinning fiber membrane with high biocompatibility is adopted, a liquid transport mechanism of plant transpiration and an ion active transport principle of electric ray power generation cells are combined through bionic design, the triple functions of wound surface antibiosis, efficient seepage management and stable power generation are achieved, the wound surface microenvironment is regulated and controlled, and the wound surface antibacterial effect is achieved. Excessive inflammation caused by seepage accumulation is effectively avoided, fibroblast migration, angiogenesis and skin appendage regeneration are remarkably promoted, wound healing is accelerated, skin function recovery is facilitated, and a new treatment mode is provided for burn wound repair.

The invention belongs to the field of biomedical materials. The method is applied to biological medicine and traditional Chinese medicine. The polymer bioprotein liquid coating is prepared by taking natural silk fibroin with natural human protein as a base material and adding 2-roots alcohol solute and edible plant light oil, is used for repairing deep III-III-degree wounds, and is used for covering and sealing the wounds, easing pain, resisting bacteria and diminishing inflammation. Due to the action of high-content glycine, alanine and serine in the natural silk fibroin, the cells are activated quickly, the wound surface is repaired quickly, and the healing is comprehensive. Neonatal skin and skin appendages (hair, hair follicles, sebaceous glands and sweat glands) are well recovered, and the wound appearance is comfortable. The problems that in the prior art, survival is difficult and the skin repairing effect is poor due to exclusiveness and incompatibility when the wound is repaired through homogeneous or heterogeneous skin transplantation or other skin substitutes are solved. The purpose of solving the medical problem is achieved.

The invention relates to a cosmetic composition, in particular for making up and / or caring for skin and / or lips and / or eyelashes and / or hair, in particular skin, the invention relates to a composition comprising, in a physiologically acceptable aqueous medium, a) at least 0.01% by weight, relative to the total weight of the composition, of a natural chitosan having a molecular weight strictly greater than 3000 Daltons in an amount strictly less than 15% by weight, and b) at least one natural resin. The invention also relates to a method for making up and / or caring for the skin and / or skin appendages, wherein a composition according to the invention is applied to the skin and / or skin appendages.

The invention belongs to the technical field of medical dressings, and relates to a DNA hydrogel dressing with a skin-like structure and function as well as a preparation method and application of the DNA hydrogel dressing. The dressing is structurally characterized in that a skin-like three-layer structure, namely an epidermal layer, a corium layer and a subcutaneous tissue layer, is constructed by regulating and controlling the cross-linking degree of chain segments and combining a directional freezing technology, and an extracellular matrix microenvironment is provided for physiological activities of cells. In function, an aptamer sequence with a specific function is introduced, and stem cells are induced to directionally differentiate into cells required by tissue repair; the subcutaneous tissue-like layer is loaded with resveratrol, and fascia is activated to induce regeneration of skin appendages; in view of the fact that chronic ulcerative wounds are easily attacked by bacteria, the antibacterial peptide and a functional DNA sequence of targeted bacteria form an antibacterial peptide-DNA composite chain segment through a click reaction, and the dressing is endowed with targeted antibacterial performance. The prepared dressing has a skin-imitating three-dimensional structure and performance, can guide skin appendages such as regeneration of hair follicles and sweat glands, and can be widely applied to repair treatment of chronic wounds.

[Problem] To do not have a gene introduction method that has high gene introduction efficiency and high specificity to skin, subcutaneous tissue, skin ulcer surfaces and constituent cells thereof. More generally, it is difficult to achieve high gene introduction efficiency in gene introduction into a living body. The skin appendages are difficult to regenerate in form and function; when the tip tissues (upper arms, forearms, hands, fingers, thighs, shanks, feet, toes) of the upper limbs and the lower limbs are lost, regeneration is difficult. The solution is that: a novel AAV (AAV is an abbreviation of an adeno-associated virus) capsid having high gene introduction efficiency and high specificity to cells of skin / subcutaneous tissues and skin ulcer surfaces, and a novel AAV capsid having high gene introduction efficiency and high specificity to epidermal tissues and cells constituting the epidermal tissues, namely keratinocytes; disclosed is a novel tissue-specific promoter having high gene expression and high specificity against epidermal tissue and keratinocytes constituting the epidermal tissue, and a pharmaceutical product having improved gene introduction efficiency by using a steroid together with gene introduction in a living body. The present invention relates to a pharmaceutical product for inducing regeneration, regeneration and function improvement of a skin appendage by introducing a gene into a living body in order to achieve sufficient skin appendage functions, a research and development platform for developing a regeneration method for peripheral tissues and defective tissues of upper and lower limbs, and a pharmaceutical product for regeneration, and more particularly, to a pharmaceutical product for regeneration for inducing regeneration, regeneration and function improvement of the skin appendage by introducing a gene into the living body in a state where the function of the skin appendage is reduced. Thus, a method for solving the above problem is provided.

The invention belongs to the technical field of biological medicines, and particularly relates to dual-mode antibacterial repair-promoting injectable hydrogel as well as a preparation method and application thereof. The dual-mode antibacterial and repair-promoting injectable hydrogel is prepared by encapsulating PES (Polyethylene Sulfonate)-RSNO (Reverse Synthesized Nitric Oxide) particles into P407 / P188 / Sal hydrogel, wherein the P407 / P188 / Sal hydrogel is the P407 / P188 / Sal hydrogel doped with PDA-MnO2 NPs and loaded with metformin chitosan-vanillin composite microspheres. The invention further discloses a preparation method of the dual-mode antibacterial and repair-promoting injectable hydrogel. The hydrogel disclosed by the invention can be used for promoting generation and reepithelialization of skin collagenous fiber cells at a diabetic wound and generation of skin appendages such as hair follicles, has an angiogenesis promoting effect and a certain anti-inflammatory effect, can be used for promoting the healing process of wound tissues, and can be used as an excellent wound dressing for wound repair.

The present invention relates to a composition, in particular for making up and / or caring for the skin and / or the lips and / or skin appendages, comprising, in a physiologically acceptable aqueous medium: a) 0.01% to 15% by weight, relative to the total weight of the composition, of natural chitosan having a molecular weight strictly greater than 3000 Daltons, and b) at least one crystallizable fat. The invention also relates to a method for making up and / or caring for the skin and / or lips and / or skin appendages, wherein a composition according to the invention is applied to the skin and / or lips and / or skin appendages.

The invention relates to a topical composition that is advantageously ecobiological and that comprises i) at least one compound of general formula (I) or one of the salts thereof, wherein said formula is ii) at least one compound of general formula (IIA) or one of the salts thereof, or of general formula (IIB) or one of the salts thereof, and the mixture thereof, and use of same for protecting the skin, mucous membranes, skin appendages and / or scalp against UV radiation.

The present invention relates to a cosmetic composition comprising, in a physiologically acceptable aqueous medium: a) at least 0.01% by weight, relative to the total weight of the composition, of natural chitosan having a molecular weight strictly greater than 3000 Daltons in an amount strictly less than 15% by weight, and b) at least one surface-treated mineral pigment having a size less than or equal to 100 nm. The invention also relates to a method for making up and / or caring for the skin and / or skin appendages, wherein a composition according to the invention is applied to the skin and / or skin appendages.

The application discloses a radial multilayer microneedle sensing system and method for single follicular unit microenvironment analysis, and belongs to the field of skin appendage detection and biological micro-electro-mechanical systems. The system comprises a positioning hole integrated with an optical collimation unit, concentric ring microneedles with a length ratio within a certain range, ring compression protruding structures between the microneedles, a differential negative pressure sampling module and a detection electrode modified with an aptamer probe, which can accurately position the follicle, perform layered puncture, construct a hydraulic barrier to prevent cross-flow, isolate and extract interstitial fluid between deep and shallow layers and target detection of disease markers such as androgen alopecia. The method comprises the steps of optical targeting positioning, compression sealing puncture, differential sampling, in-situ detection and gradient index calculation. The application can improve the spatial detection resolution of the markers, solve the problems of signal dilution and subcutaneous cross-flow, and provide a quantitative tool for follicular pathological research and drug non-diagnostic screening.

The application discloses a kind of liquid management and spontaneous power generation dual bionic wound dressing and preparation method and application.The dual bionic wound dressing includes first electrode layer, barrier layer, hygroscopic power generation layer, diffusion antibacterial layer, evaporation power generation layer and second electrode layer stacked in order from bottom to top;The application adopts high biocompatibility electrostatic spinning fiber membrane, realizes the triple function of wound antibacterial, seepage efficient management and stable power generation by combining the liquid transport mechanism of plant transpiration with the ion active transport principle of electric ray power generation cell through bionic design, regulates wound microenvironment, effectively avoids excessive inflammation caused by seepage accumulation, significantly promotes fibroblast migration, angiogenesis and skin appendage regeneration, accelerates wound healing, and is beneficial to restore skin function, provides a new treatment for burn wound repair.

The invention relates to the cosmetic and non-therapeutic use of a composition consisting essentially of a compound of formula I below: (I) or its enantiomers, isomers or diastereoisomers, or a mixture thereof, or a salt or a solvate thereof, wherein R1 and R2, independently of each other, are a C3-C6 sugar, a uronic acid, or a glucoside, for bleaching or whitening the skin and skin appendages of a healthy individual.

The invention provides a biological microsphere and a preparation method thereof, and a multi-skin appendage in-situ regeneration method, the biological microsphere is constructed by loading a small molecule compound combination and a protein by using a lipid carrier sphere, the small molecule compound combination and the protein are integrated, and the lipid carrier sphere is used for slow release, so that epigenetics can be deeply changed; the method has the advantages of maintaining cell proliferation, activating hair papilla cell and sweat gland cell fate, greatly promoting the cell fate conversion efficiency, achieving cell reprogramming, being safe, efficient and easy to operate, and avoiding the safety risk of gene editing, thereby effectively solving the problems of wound repairing, scar weakening and skin functional regeneration.

The invention belongs to the technical field of medicines, and particularly relates to an sECM-SIS biological membrane as well as a preparation method and application thereof. According to the present invention, an extracellular matrix (sECM) derived from stem cells is integrated to a small intestine submucosa (SIS) to prepare the sECM-SIS biological membrane; after the sECM-SIS biological membrane is implanted into a full-thickness skin defect, wound healing is remarkably accelerated, and the sECM-SIS biological membrane is characterized by rapid wound reepithelization, strong angiogenesis, approximate normal epidermis thickness recovery, mature collagen deposition, skin appendage regeneration and macrophage polarization adjustment. According to the results, the sECM-SIS has huge potential in the aspect of skin wound repair.

[Problem] There is no gene transduction method with high efficiency and high specificity for skin, subcutaneous tissue, skin ulcer surfaces, and their constituent cells. More generally, achieving high gene transduction efficiency in vivo is challenging. Additionally, it is difficult to morphologically and functionally regenerate skin appendages and to regenerate lost peripheral tissues of the upper and lower limbs (upper arm, forearm, hand, fingers, thigh, lower leg, foot, toes).[Solution] This invention provides solutions to these challenges through a novel AAV (adeno-associated virus) capsid with high gene transduction efficiency and high specificity for skin, subcutaneous tissue, and skin ulcer surface cells, as well as a novel AAV capsid with high gene transduction efficiency and high specificity for epidermal tissue and its constituent keratinocytes. Additionally, the invention provides a novel tissue-specific promoter with high gene expression efficiency and high specificity for epidermal tissue and its constituent keratinocytes, and a pharmaceutical composition that enhances gene transduction efficiency by co-administering steroids alongside in vivo gene transduction. The invention further includes a pharmaceutical composition that promotes the regeneration, neogenesis, and functional enhancement of skin appendages through in vivo gene transduction, thereby compensating for functional impairments of skin appendages. Additionally, it provides a research and development platform for developing methods to regenerate peripheral and missing tissues of the upper and lower limbs, as well as a pharmaceutical composition for achieving tissue regeneration. Thus, the present invention provides methods for overcoming these challenges.

The present invention relates to a cosmetic or dermatological ingredient or a cosmetic or dermatological composition comprising the peptide of sequence SEQ ID N ° 1 and / or a derivative thereof and / or a salt thereof, and to the uses thereof for improving the condition and / or appearance and / or comfort of healthy skin and / or healthy mucous membranes and / or healthy skin appendages.

The invention provides a biological microsphere and a preparation method thereof, and a multi-skin appendage in-situ regeneration method, the biological microsphere is constructed by loading a small molecule compound combination and a protein by using a lipid carrier sphere, the small molecule compound combination and the protein are integrated, and the lipid carrier sphere is used for slow release, so that epigenetics can be deeply changed; the method has the advantages of maintaining cell proliferation, activating hair papilla cell and sweat gland cell fate, greatly promoting the cell fate conversion efficiency, achieving cell reprogramming, being safe, efficient and easy to operate, and avoiding the safety risk of gene editing, thereby effectively solving the problems of wound repairing, scar weakening and skin functional regeneration.

The present invention relates to a composition comprising a combination of bioactive ingredients that inhibits glycogen phosphorylase, improves glycogen metabolism of hair follicles, thereby stimulating the growth of hair and skin appendages and improving their aesthetic appearance.

The invention relates to an aqueous topical make-up remover composition which advantageously is ecobiological, having a dynamic viscosity, measured at 25 degrees centigrade, greater than 2000 cP, preferably greater than 3000 cP, advantageously greater than 4000 cP, even more advantageously greater than 5000 cP, said composition comprising: - at least one surfactant; - at least one citric acid ester. The invention also relates to the use of the composition, in particular in a method for removing make-up or for cleansing the skin, lips and / or skin appendages.

Embodiments of the present disclosure disclose a scar organoid and a method for constructing, passaging, cryopreserving and drug screening thereof. The specific implementation of the method comprises: a scar organoid comprising an epidermal cell cluster, fibroblasts and residual skin appendage structures, wherein the residual skin appendage structures are sebaceous gland-like lobular structures. The embodiment can improve the authenticity of cell heterogeneity and drug sensitivity reflecting pathological scars, and improve the accuracy of reacting to the biological characteristics of human scars.

The present invention concerns cosmetic compositions to inhibit the activity of KLF4, for anti-aging, especially by diminishing or preventing the consequences promoted by the stiffness of the extracellular matrix (ECM) networks located at the epithelial-stromal interfaces of tissues of the skin. Preferably, said inhibition of KLF4 is achieved through at least one compound among phenylpropanoids, flavonoids, lignans, phenols, benzophenone derivative, homoisoflavonoids, stilbenoids, alkaloids, diterpenoids, phloracetophenone glucoside, polyketides, diarylheptanoids and / or adleroL