Method for preparing isolated hair follicle in process of treating scar by hair follicle stem cell transplantation

A technology of hair follicle stem cell transplantation, which is applied in the field of hair follicle treatment in vitro in the process of hair follicle stem cell transplantation to treat scars. It can solve the problems of long recovery time, unsatisfactory effect, and large side effects, and achieve softening of scars and strong in vitro proliferation ability. , Improve the effect of scar blood supply

Pending Publication Date: 2020-05-29
刘景卫
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problems of large damage, long recovery time, unsatisfactory effect, easy recurrence, and large side effects in scar treatment in the above-mentioned background technology.

Method used

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  • Method for preparing isolated hair follicle in process of treating scar by hair follicle stem cell transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step S1, hair follicle extraction, using FUE technology to extract a hair follicle unit;

[0031] Step S2, the separation of hair follicles, the hair follicle units are separated into complete single hair follicles under the electron microscope; the scar in the smooth hairless area is cut off the lower 1 / 3 of the dermal papilla, so that the hair follicles cannot enter the next growth cycle, and the scar area no terminal hair growth;

[0032] Step S3, the in vitro culture of hair follicles, the extracted and isolated single hair follicles are put into a special culture medium for cultivation, and the cultivation is carried out to enhance the activity of hair follicle stem cells and promote their differentiation and proliferation;

[0033] Step S4, hair follicle transplantation, relying on hair follicles to implant hair follicle stem cells into a specific area of ​​the scar, to promote the proliferation and differentiation of hair follicle stem cells and the formation of ...

Embodiment 2

[0039] In this example, the effective rate of treating scars by hair follicle melanocyte stem cell transplantation is more than 100%. Through clinical comparison, the present invention finds that after the treatment of the isolated hair follicles during the treatment of scars by hair follicle stem cell transplantation, the scar repair time is significantly shortened. The curative effect is obviously improved.

[0040] The technical difficulty of the present invention: "the integrity of hair follicle stem cells and skin appendages" refers to whether the hair follicle stem cells can survive directly after planting, which is related to the later treatment effect. The autologous hair follicle stem cells that have been specially isolated and cultured in vitro have the characteristics of slow periodicity, strong self-renewal ability, high proliferation ability, and multi-differentiation potential, and can continue to repair scar tissue after transplantation. For scars in the smooth ...

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Abstract

The invention discloses a method for preparing an isolated hair follicle in a process of treating scar by hair follicle stem cell transplantation. The method comprises the following steps: extractionof hair follicles, separation of the hair follicles, completely separating the hair follicle units into single hair follicles under an electron microscope, and keeping the extracted skin appendages such as sebaceous glands, sweat glands and the like as far as possible; for scars in a smooth hairless area, removing lower 1/3 of hair papilla, so that the hair follicle could not enter the next growthcycle, and no final hair grows in the scar area; in vitro culture of the hair follicles, putting the isolated single hair follicle into a special culture solution for culturing for later use; planting the hair follicle stem cells in a specific area of the scar on the basis of hair follicles. According to the method, through a hair follicle in-vitro culture technology, the single hair follicle isseparated and inactivated by adopting a separation method different from a hair transplantation operation, and is cultured in the special culture solution, so that growth and proliferation of hair follicle stem cells are facilitated. The method can achieve purposes of inhibiting scar hyperplasia, softening and repairing scars, and removing and beautifying scars.

Description

technical field [0001] The invention relates to the technical field of hair follicle transplantation, in particular to a method for treating isolated hair follicles during scar treatment by hair follicle stem cell transplantation. Background technique [0002] The more professional classification of scars can be divided into hypertrophic scars, keloids, and scar cancer. [0003] "Scar" is the damage of physical, biological, chemical and other factors on the human skin and soft tissue, resulting in serious damage to the skin and soft tissue, which cannot be fully repaired normally by itself, and is replaced by fibrous tissue. Local symptoms that affect both appearance and function . What "scars" bring to patients is huge physical pain and mental pain, especially the scars left over from burns, scalds, and severe trauma. The several years of scar hyperplasia almost made the patient miserable. Then the atrophy period makes the patient's face unrecognizable and dysfunction, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61P17/02A61P17/14C12N5/074
CPCA61K35/36C12N5/0628A61P17/14A61P17/02C12N2509/00
Inventor 刘景卫
Owner 刘景卫
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