15 results about "Sebaceous gland" patented technology

A human sebaceous gland carcinoma cell line and use thereof are provided. The human sebaceous gland carcinoma cell line SHNPH-SeC was deposited in the China Center for Type Culture Collection (CCTCC) on Aug. 31, 2023, with an accession number CCTCC NO: C2023113. The human sebaceous gland carcinoma cell line SHNPH-SeC carries a TP53 mutation, and has been identified as a novel single cell line by short tandem repeat (STR) genotyping. This human sebaceous gland carcinoma cell line exhibits strong adherence and stable cellular characteristics, can be stably passaged for multiple generations, and possesses rapid proliferation and migration capabilities, which are in line with the characteristics of malignant tumor cells.

This invention discloses an enzyme-responsive silk fibroin nanovesicle, its preparation method, and its application, comprising the following steps: silk fibroin is mixed with a hydrophobic acylation reagent containing enzymatically cleavable chemical bonds and a catalyst for a grafting reaction to obtain amphiphilic modified silk fibroin; the amphiphilic modified silk fibroin is mixed with hair care active ingredients in an aqueous phase, and self-assembly is induced to form nanovesicles encapsulating the active ingredients through ultrasonic treatment or high-pressure homogenization. This invention uses silk fibroin as the main body to provide a biocompatible framework and self-assembly basis. Hydrophobic groups are introduced through chemical modification, and these hydrophobic groups are connected to the silk fibroin backbone through enzymatically cleavable chemical bonds. These chemical sites can be recognized and cleaved by sebaceous lipase secreted by the scalp sebaceous glands or other specific lipases highly expressed in the hair follicle microenvironment, achieving specific enzymatic release of the nanovesicles in the hair follicle microenvironment.

The invention discloses a sheep tail fat active component as well as a separation method and application thereof in skin wound healing, and relates to the technical field of natural product separation and biological medicine. According to the method, through ultrasonic-assisted enzymolysis extraction and silica gel column gradient elution, efficient separation of different polar components is achieved, and high-polarity components rich in high-activity unsaturated fatty acid are obtained; the invention also provides application of the component in skin wound healing. The sheep tail fat active component has excellent free radical scavenging ability, can significantly down-regulate the levels of pro-inflammatory factors such as IL-1beta and TNF-alpha in wound tissues, up-regulate the expression of TGF-beta1, promote the deposition and remodeling of collagen and accelerate the regeneration of skin appendages such as hair follicles and sebaceous glands by regulating and controlling a TGF-beta1 / Smad3 signal channel, and has the effects of promoting the healing of the skin and the like. The method can effectively shorten the wound healing time and reduce scar formation, can be used for preparing a natural wound healing agent, and provides a new way for high-value utilization of Lanzhou big-tailed sheep resources.

The invention provides a composition with oil-controlling and pore-shrinking effects and application thereof. The composition with the oil-controlling and pore-shrinking effects comprises a phellinus linteus extract and a litchi peel extract. The phellinus igniarius extract and the litchi peel extract in the composition are matched for use, have a synergistic effect, can inhibit sebaceous gland cell grease secretion and reduce grease oxidation through an oil control channel, and repair cell oxidative damage caused by grease secretion and grease oxidation. And inflammatory reaction caused by sebum oxidation and flora imbalance can be relieved, so that the effects of controlling oil and shrinking pores are remarkably realized.

The invention provides an anti-hair loss and hair growth composition based on cyclic polypeptide c8DSS as well as a preparation method and application of the anti-hair loss and hair growth composition, and relates to the technical field of anti-hair loss and hair growth compositions. The hair loss preventing and hair growing composition based on the cyclic polypeptide c8DSS is prepared from the following components in percentage by mass: 0.45 percent to 1.36 percent of the cyclic polypeptide c8DSS, 0.45 percent of a stable protective agent, 2.73 percent of a penetration enhancer, 2.912 percent of a moisturizing stabilizer and the balance of purified water. The straight-chain 8DSS polypeptide is cyclized into c8DSS, so that the stability and the biological activity of the c8DSS polypeptide are remarkably improved; meanwhile, the annular structure keeps the optimal spatial configuration, the binding capacity with a cell receptor is enhanced, the hair follicle growth cycle can be regulated and controlled through hair follicle sebaceous gland deep penetration, and hair follicles are promoted to enter a growth period from a resting period in advance. The traditional Chinese medicine composition is scientific and reasonable in formula, can be prepared into various dosage forms, is convenient to use, good in safety, free of obvious side effects and wide in application range, and has good market application prospects.

The invention relates to an acne-removing gel containing a plantain fruit extract and a preparation method of the acne-removing gel. The acne-removing gel is prepared from the following components: the plantain fruit extract, a skin conditioner, picolinin, a thickening agent, a preservative, a neutralizing agent, propylene glycol, allantoin and deionized water. Through selection of the effective components and reasonable matching of the use amounts of all the components, by means of the synergistic interaction effect of the Pinonin, the banana fruit extract, the skin conditioner and multiple moisturizing components, generation of acnes is inhibited, water-oil balance is adjusted, healing of acnes is accelerated, acne marks are faded in the aspects of inhibiting pathogenic bacteria of acnes, adjusting secretion of sebaceous glands and promoting keratin metabolism, and the skin care product has the effects of whitening skin, whitening skin and whitening skin. Therefore, a good acne removing effect is achieved, and the product is mild and safe.

The application discloses application of a Bcl-xL, Bcl-2 and Bcl-w inhibitor in preparation of a medicine for treating eyelid sebaceous gland carcinoma, and proposes that ABT-263 or a pharmaceutically acceptable salt thereof is used for preparing the medicine for treating the eyelid sebaceous gland carcinoma, the molecular formula of the ABT-263 is C 47 H 55 ClF3N5O6S3, and a molecular structure is shown as formula (I). The application further provides a medicine composition, which comprises a therapeutically effective amount of ABT-263 or a pharmaceutically acceptable salt thereof, and can be prepared into injection, emulsion, tablet, powder, granule, paste, liposome or oral liquid, in particular, a small-molecule injection preparation. It is found by the application that the ABT-263 can significantly inhibit the growth of eyelid sebaceous gland carcinoma cells, and the drug effect increases with the increase of concentration, so that the ABT-263 used for treating the eyelid sebaceous gland carcinoma can improve the treatment effectiveness, prolong the life of a patient, improve the quality of life, and has important clinical application value.

This invention discloses the application of ordered regenerative biomimetic silk fibroin hydrogel in the preparation of dressings that promote scarless wound repair. First, degummed silk fibroin is used as a raw material to prepare methacryloyl fibroin (SFMA) and silk fibroin nanofibers (BSNF), respectively. Then, SFMA and BSNF solutions are obtained. Finally, the SFMA, BSNF, and photoinitiator aqueous solutions are mixed uniformly to obtain a mixture. The pH of the mixture is adjusted to 10.5, and photocrosslinking is performed to obtain the ordered regenerative biomimetic silk fibroin hydrogel. The ordered regenerative biomimetic silk fibroin hydrogel prepared by this invention can significantly promote scarless wound repair and significantly regenerate hair follicles and sebaceous glands. Furthermore, the materials used in this invention are of a single composition; both SFMA and BSNF are silk fibroin, making it easier to translate into clinical applications and of great significance for the design and clinical application of wound repair materials.

The application discloses a hair loss prevention composition containing Norway spruce leaf extract and application, and relates to the technical field of cosmetics.The composition comprises component A and component B.The component A comprises the following components in parts by weight: 1-5 parts of verbascum thapsus extract, 0.1-1 parts of saw palmetto extract and 1-5 parts of Norway spruce leaf extract.The component B comprises the following components in parts by weight: 2-4 parts of eucommia ulmoides bark extract.The verbascum thapsus extract, the saw palmetto extract, the Norway spruce leaf extract and the eucommia ulmoides bark extract are combined to have a synergistic effect.The composition formed by the specific combination of the components can prevent androgenic alopecia by anti-inflammatory, antibacterial, inhibition of TRPV3 channel and inhibition of the activity of 5alpha-reductase, can inhibit the secretion of lipids by sebaceous cells, and can achieve the purpose of oil control, and the components are all plant components, so the composition is more suitable for men.

The invention discloses a gland nutritional agent for improving fish scale skin and a preparation method thereof, and relates to the technical field of skin nutritional agent preparation. Comprising the following raw materials: an extract, modified seabuckthorn seed oil, modified lactobionic acid, nicotinamide, coenzyme Q10, a phytosterol compound, panthenol sodium phosphate, capryloyl salicylic acid, vitamin H, a ginseng extract, a humectant, oat beta-glucan, sodium hyaluronate, glycerol, propylene glycol, phosphatidylcholine, vitamin E, PEG-100 stearate, carbomer, triethanolamine, a preservative and allantoin. And the balance of deionized water. According to the invention, by adding the modified seabuckthorn seed oil, sebaceous gland can be nourished more efficiently, damaged skin barrier can be repaired, and percutaneous moisture loss can be reduced; meanwhile, the fish scale skin care product has an anti-oxidation effect, can protect skin cells from being damaged by free radicals, delays dryness and roughness aggravation of fish scale skin, and maintains normal physiological functions of glands.

The application discloses a Norway spruce leaf-containing oil control and repair composition and application, and relates to the technical field of cosmetics. The application provides a Norway spruce leaf-containing oil control and repair composition, which comprises the following components in parts by weight: Norway spruce leaf extract 0.1-2 parts, Spermacoce latifolia extract 0.1-0.5 parts, yeast / kelp sugar fermentation product 1-5 parts, Usnea barbata extract 0.1-0.5 parts and Hamamelis virginiana extract 0.1-2 parts. The Norway spruce leaf extract, the Spermacoce latifolia extract, the yeast / kelp sugar fermentation product, the Usnea barbata extract and the Hamamelis virginiana extract are synergistic, the components synergize, and the components jointly play effects in aspects of oil control, barrier repair, anti-inflammatory and antibacterial effects, microenvironment stability maintenance and sebum gland abnormal activation reduction, so that instant oil control can be realized, compensatory secretion can be relieved through long-acting stability maintenance, and the application is suitable for skin which needs long-term oil control and is sensitive.

The application discloses a composition containing yeast / rice fermentation product filtrate with oil control and hair quality repairing effects. The composition comprises yeast / rice fermentation product filtrate, rice husk extract, black truffle extract and millet seed extract. The application also provides application of the composition in preparation of oil control and repairing hair care products, a shampoo containing the composition and a preparation method of the shampoo. Experimental results show that the composition can significantly inhibit secretion of oil by human sebaceous gland cells, repair hair, and improve smoothness and gloss of hair. The composition has strong synergistic effect of components, is safe and non-irritating, has simple preparation process, and is suitable for industrial production.

The invention relates to a composition for controlling oil, shrinking pores and tightening skin as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition with the effects of controlling oil, shrinking pores and tightening skin, provided by the invention, is prepared from EGCG (epigallocatechin gallate) nanocrystals, a phellinus igniarius extract, a lactobacillus / pomegranate fruit fermentation product and cardamom seed ketone, the EGCG nanocrystal is prepared from an EGCG solution in a micro-channel reactor through an anti-solvent crystallization method by taking supercritical CO2 as an anti-solvent. The composition synchronously inhibits the activity of 5alpha-reductase, regulates sebaceous gland secretion, enhances keratinocyte metabolism and promotes barrier repair through a multi-target synergistic mechanism, and improves the stability and transdermal absorption efficiency of active ingredients by means of a specific fermentation process. Therefore, the long-acting and mild oil control, tightening and pore repairing effects with skin health promotion significance are realized.

This invention belongs to the field of skincare products and discloses an oil-controlling and soothing plant-based compound emulsion and its preparation method. The compound emulsion includes the following raw materials: deionized water, 1,3-propanediol, glycerin, trehalose, squalane, decanoic acid triglyceride, emulsifier, tocopherol, kudzu zinc liposomes, *Polyporus puerariae* and *Centella asiatica* ferment, tetrahydromethylpyrimidine carboxylic acid, thickener, and preservative. The kudzu zinc liposomes are made by enzymatically deglycosylating kudzu extract and then complexing it with zinc ions, followed by encapsulation with PEGylated liposomes and sebaceous gland-targeting ligands. The *Polyporus puerariae* and *Centella asiatica* ferment is made by stepwise symbiotic fermentation of *Polyporus puerariae* and *Centella asiatica*, followed by enzymatic hydrolysis to break the cell wall, and then sequentially separating and enriching small molecule active substances through coarse filtration, ultrafiltration, and nanofiltration. This invention constructs an oil-controlling and soothing system that targets oil, soothes and repairs, and strengthens the skin barrier by combining kudzu zinc liposomes and *Polyporus puerariae* and *Centella asiatica* ferment, meeting the core needs of oily and oily sensitive skin.

The present application provides a plant composition for oil control, dandruff removal and nourishment and a hair product thereof, and belongs to the field of medical, dental or cosmetic preparations. The composition is composed of Sophora flavescens, Radix Angelicae Sinensis, Sapindus, Anemarrhena asphodeloides, and optional extracts of Scutellaria baicalensis and Passiflora incarnata, and is prepared by precise processes such as directional extraction of liposoluble alkaloids, directional extraction of water-soluble saponins and gradient solvent extraction. Through multi-target synergistic action, the components can significantly inhibit the proliferation of Malassezia, regulate the secretion of sebaceous glands, and improve the microcirculation of the scalp. The present application has multiple effects of oil control, dandruff removal, itching relief and nourishment, and is mild and non-irritating, and is suitable for various hair washing and care products.