33 results about "Sebaceous gland" patented technology

The invention discloses herbal oil control essence. A component A comprises deionized water and sodium hyaluronate; the component B comprises methylpropanediol, a hyperforin perforatum flower / leaf / stem extract, cyclodextrin and a rehmannia chinensis root extract; the component C is prepared from water, butanediol, amur corktree bark extract, coptis root extract, radix sophorae flavescentis extract, rhus chinensis insect gall extract, cnidium monnieri fruit extract, zanthoxylum bungeanum fruit extract and camphor tree leaf extract; and the component D comprises 1, 2-hexanediol. The preparation method of the herbal oil-control essence comprises the following steps: S1, preparing raw materials; s2, preparing the component A; s3, preparing the component B; s4, preparing a component C; s5, a mixing process; and S6, adding a component D and carrying out post-treatment. The herbal components form a synergistic effect network and act on a skin grease secretion system in a targeted manner, grease secretion is balanced from the source by adjusting the biological activity of sebaceous gland cells, meanwhile, biological signal channels related to skin anti-inflammation, moisturizing and tightening are activated, and the multiple-effect-in-one skin care effect is achieved.

The invention relates to the technical field of scalp detection, in particular to a scalp detection method and system based on deep learning, and the method comprises the following steps: extracting the light intensity value distribution and spatial position value of image pixel points based on scalp image data, analyzing the regional feature boundaries of an epidermal layer, a corium layer and a hair follicle layer, and carrying out the partitioning processing of the whole region, and generating a scalp layering segmentation result. According to the method, through combined analysis of a light intensity value and a spatial position in scalp image data, layered region division is refined, and through quantification of sebaceous gland distribution area, a relation between hair follicle spacing and density and corium layer thickness characteristics, interaction characteristics of sebaceous gland secretion value, hair follicle spacing and thickness value are dynamically analyzed; the fluctuation trend of the health state in the time sequence is disclosed, the accuracy of health state analysis is improved, the efficiency and comprehensiveness of anomaly positioning are enhanced, and more scientific support is provided for medical diagnosis and beauty care.

The invention discloses a refreshing oil-control composition as well as a preparation method and application thereof, and belongs to the field of daily cosmetic preparations. The refreshing and oil-control composition is prepared from the following components: a skin conditioning component, Lignum seu Fructus Liu Citri sodium oleate, sodium cocoyl aminopropionate, disodium lauroyl glutamate, lauramide propyl betaine and a solvent, the skin conditioning component consists of a hyperforin perforatum flower / leaf / stem extract, a capparis spinosa fruit extract and a sanguisorba officinalis root extract. The refreshing oil-control composition provided by the invention has excellent performance of inhibiting grease secretion of human sebaceous gland cells, and has an excellent deep oil-control effect on skin; according to the present invention, the stellaria mellea L sodium oleate, the cocamidopropyl sodium propionate, the disodium lauroyl glutamate and the lauramide propyl betaine are matched to use so as to provide effects of good foaming power and stable and lasting foam; the refreshing oil-control cleaning product provided by the invention can obviously reduce the grease content of skin, improve oily skin and realize an oil-control effect.

The invention discloses an anti-hair loss composition containing picea norvegensis leaf extract and application, and relates to the technical field of cosmetics. The composition disclosed by the invention comprises a component A and a component B, wherein the component A comprises the following components in parts by weight: 1-5 parts of a verbasci extract, 0.1-1 part of a saw palmetto extract and 1-5 parts of a picea norvegensis leaf extract; the component B is prepared from the following ingredients in parts by weight: 2 to 4 parts of eucommia ulmoides bark extracts. According to the composition, the verbasci extract, the saw palmetto extract, the picea norvegensis leaf extract and the eucommia ulmoides bark extract are combined to have a synergistic effect, and the composition formed by specific compatibility of the components can prevent androgenetic alopecia from resisting inflammation and bacteria, inhibiting a TRPV3 channel and inhibiting the activity of 5 alpha-reductase; in addition, the plant components are selected, so that the oil-control composition is more suitable for men to use.

The application relates to a kind of acne-removing compositions and its preparation method, application, cosmetics.The acne-removing composition comprises: coptis chinensis, magnolia officinalis extract and costus root extract, the coptis chinensis and magnolia officinalis extract are extracted from the mixture of coptis chinensis and magnolia officinalis as extraction raw material, and the costus root extract is extracted from costus root as extraction raw material.The acne-removing composition provided in the application can inhibit sebaceous gland excessive secretion of oil and inhibit the growth of propionibacterium acnes, thereby can reduce skin inflammation and infection, and play the effect of preventing and treating acne.

The invention discloses a traditional Chinese medicine composition of hair cleaning, nourishing and strengthening shampoo and hair care essence and a preparation method of the traditional Chinese medicine composition. According to the hair cleaning, nourishing and strengthening shampoo, the multiple hair care effects are achieved through the synergistic effect of the saponin, the soapberry, the folium mori and the cortex phellodendri. The Chinese honeylocust fruit and the Chinese soapberry fruit are used as natural cleaning components and can mildly remove redundant grease and dirt on the scalp, and hair follicle blockage is avoided; the folium mori and the cortex phellodendri play roles in clearing heat and drying dampness, reducing excessive secretion of sebaceous gland and radically relieving the problem of greasy scalp, and the hair care essence adopts compatibility of multiple traditional Chinese medicines such as fructus cnidii, fructus kochiae, cortex dictamni and radix sophorae flavescentis to form a comprehensive scalp care system. The fructus cnidii and the fructus kochiae can inhibit harmful flora of scalp, improve the unbalance state of the flora and relieve scalp itching; cortex dictamni and radix sophorae flavescentis further enhance the antibacterial effect and reduce inflammatory response. The Chinese arborvitae twig, the prepared fleece-flower root, the eclipta and other components have a synergistic effect, so that the hair follicle can be nourished, the scalp blood circulation can be promoted, the hair root fixation force can be enhanced, and the alopecia can be reduced.

A human sebaceous gland carcinoma cell line and use thereof are provided. The human sebaceous gland carcinoma cell line SHNPH-SeC was deposited in the China Center for Type Culture Collection (CCTCC) on Aug. 31, 2023, with an accession number CCTCC NO: C2023113. The human sebaceous gland carcinoma cell line SHNPH-SeC carries a TP53 mutation, and has been identified as a novel single cell line by short tandem repeat (STR) genotyping. This human sebaceous gland carcinoma cell line exhibits strong adherence and stable cellular characteristics, can be stably passaged for multiple generations, and possesses rapid proliferation and migration capabilities, which are in line with the characteristics of malignant tumor cells.

This invention discloses an enzyme-responsive silk fibroin nanovesicle, its preparation method, and its application, comprising the following steps: silk fibroin is mixed with a hydrophobic acylation reagent containing enzymatically cleavable chemical bonds and a catalyst for a grafting reaction to obtain amphiphilic modified silk fibroin; the amphiphilic modified silk fibroin is mixed with hair care active ingredients in an aqueous phase, and self-assembly is induced to form nanovesicles encapsulating the active ingredients through ultrasonic treatment or high-pressure homogenization. This invention uses silk fibroin as the main body to provide a biocompatible framework and self-assembly basis. Hydrophobic groups are introduced through chemical modification, and these hydrophobic groups are connected to the silk fibroin backbone through enzymatically cleavable chemical bonds. These chemical sites can be recognized and cleaved by sebaceous lipase secreted by the scalp sebaceous glands or other specific lipases highly expressed in the hair follicle microenvironment, achieving specific enzymatic release of the nanovesicles in the hair follicle microenvironment.

The invention discloses a sheep tail fat active component as well as a separation method and application thereof in skin wound healing, and relates to the technical field of natural product separation and biological medicine. According to the method, through ultrasonic-assisted enzymolysis extraction and silica gel column gradient elution, efficient separation of different polar components is achieved, and high-polarity components rich in high-activity unsaturated fatty acid are obtained; the invention also provides application of the component in skin wound healing. The sheep tail fat active component has excellent free radical scavenging ability, can significantly down-regulate the levels of pro-inflammatory factors such as IL-1beta and TNF-alpha in wound tissues, up-regulate the expression of TGF-beta1, promote the deposition and remodeling of collagen and accelerate the regeneration of skin appendages such as hair follicles and sebaceous glands by regulating and controlling a TGF-beta1 / Smad3 signal channel, and has the effects of promoting the healing of the skin and the like. The method can effectively shorten the wound healing time and reduce scar formation, can be used for preparing a natural wound healing agent, and provides a new way for high-value utilization of Lanzhou big-tailed sheep resources.

The invention provides a composition with oil-controlling and pore-shrinking effects and application thereof. The composition with the oil-controlling and pore-shrinking effects comprises a phellinus linteus extract and a litchi peel extract. The phellinus igniarius extract and the litchi peel extract in the composition are matched for use, have a synergistic effect, can inhibit sebaceous gland cell grease secretion and reduce grease oxidation through an oil control channel, and repair cell oxidative damage caused by grease secretion and grease oxidation. And inflammatory reaction caused by sebum oxidation and flora imbalance can be relieved, so that the effects of controlling oil and shrinking pores are remarkably realized.

The invention relates to a method for constructing an animal model of acne-like skin lesion caused by a propionibacterium acnes biofilm, which comprises the following steps of: constructing the propionibacterium acnes biofilm in vitro, and intracutaneously injecting a propionibacterium acnes biofilm suspension into ear skin of an ICR mouse, so as to construct the animal model of acne-like skin lesion caused by the propionibacterium acnes biofilm. The problems that an existing acne vulgaris animal model can only be used for evaluating some aspects of the pathogenesis of acne vulgaris, but cannot reveal the complexity of interaction of the acne vulgaris, the reactivity of local inflammation caused by propionibacterium acnes in a hair follicle sebaceous gland unit resident bacterium and free bacterium state is small, and the pathogenesis of the acne vulgaris cannot be evaluated are solved. The common acne inflammatory skin lesion is difficult to restore on an in-vitro animal model. The model established by the invention is simple and easy to operate, can be widely popularized and applied, and provides an experimental tool for research and development of common acne pathogenesis and medicines.

The invention belongs to the field of biomedical materials. The method is applied to biological medicine and traditional Chinese medicine. The polymer bioprotein liquid coating is prepared by taking natural silk fibroin with natural human protein as a base material and adding 2-roots alcohol solute and edible plant light oil, is used for repairing deep III-III-degree wounds, and is used for covering and sealing the wounds, easing pain, resisting bacteria and diminishing inflammation. Due to the action of high-content glycine, alanine and serine in the natural silk fibroin, the cells are activated quickly, the wound surface is repaired quickly, and the healing is comprehensive. Neonatal skin and skin appendages (hair, hair follicles, sebaceous glands and sweat glands) are well recovered, and the wound appearance is comfortable. The problems that in the prior art, survival is difficult and the skin repairing effect is poor due to exclusiveness and incompatibility when the wound is repaired through homogeneous or heterogeneous skin transplantation or other skin substitutes are solved. The purpose of solving the medical problem is achieved.

The invention belongs to the technical field of cosmetics, and discloses a composition with effects of controlling oil, shrinking pores and soothing skin as well as a preparation method and application of the composition. The composition comprises the following components in percentage by mass: 1%-30% of an artemisia apiacea extract and a derivative thereof, 1%-40% of a red clover extract, 1%-30% of a baobuki extract and 0.1%-40% of PCA zinc. The composition disclosed by the invention can synchronously inhibit sebaceous gland cell differentiation, reduce sebum synthesis, regulate a secretion function, control excessive secretion of grease from the source, also can regulate keratinocyte metabolism to realize visual obvious reduction of pores, and also can relieve various discomfort of skin caused by inflammation; meanwhile, the composition is mild and non-irritant, is suitable for sensitive skin and damaged skin, and is particularly suitable for people with oily sensitive skin.

The invention provides an anti-hair loss and hair growth composition based on cyclic polypeptide c8DSS as well as a preparation method and application of the anti-hair loss and hair growth composition, and relates to the technical field of anti-hair loss and hair growth compositions. The hair loss preventing and hair growing composition based on the cyclic polypeptide c8DSS is prepared from the following components in percentage by mass: 0.45 percent to 1.36 percent of the cyclic polypeptide c8DSS, 0.45 percent of a stable protective agent, 2.73 percent of a penetration enhancer, 2.912 percent of a moisturizing stabilizer and the balance of purified water. The straight-chain 8DSS polypeptide is cyclized into c8DSS, so that the stability and the biological activity of the c8DSS polypeptide are remarkably improved; meanwhile, the annular structure keeps the optimal spatial configuration, the binding capacity with a cell receptor is enhanced, the hair follicle growth cycle can be regulated and controlled through hair follicle sebaceous gland deep penetration, and hair follicles are promoted to enter a growth period from a resting period in advance. The traditional Chinese medicine composition is scientific and reasonable in formula, can be prepared into various dosage forms, is convenient to use, good in safety, free of obvious side effects and wide in application range, and has good market application prospects.

The invention relates to an acne-removing gel containing a plantain fruit extract and a preparation method of the acne-removing gel. The acne-removing gel is prepared from the following components: the plantain fruit extract, a skin conditioner, picolinin, a thickening agent, a preservative, a neutralizing agent, propylene glycol, allantoin and deionized water. Through selection of the effective components and reasonable matching of the use amounts of all the components, by means of the synergistic interaction effect of the Pinonin, the banana fruit extract, the skin conditioner and multiple moisturizing components, generation of acnes is inhibited, water-oil balance is adjusted, healing of acnes is accelerated, acne marks are faded in the aspects of inhibiting pathogenic bacteria of acnes, adjusting secretion of sebaceous glands and promoting keratin metabolism, and the skin care product has the effects of whitening skin, whitening skin and whitening skin. Therefore, a good acne removing effect is achieved, and the product is mild and safe.

The application discloses application of a Bcl-xL, Bcl-2 and Bcl-w inhibitor in preparation of a medicine for treating eyelid sebaceous gland carcinoma, and proposes that ABT-263 or a pharmaceutically acceptable salt thereof is used for preparing the medicine for treating the eyelid sebaceous gland carcinoma, the molecular formula of the ABT-263 is C 47 H 55 ClF3N5O6S3, and a molecular structure is shown as formula (I). The application further provides a medicine composition, which comprises a therapeutically effective amount of ABT-263 or a pharmaceutically acceptable salt thereof, and can be prepared into injection, emulsion, tablet, powder, granule, paste, liposome or oral liquid, in particular, a small-molecule injection preparation. It is found by the application that the ABT-263 can significantly inhibit the growth of eyelid sebaceous gland carcinoma cells, and the drug effect increases with the increase of concentration, so that the ABT-263 used for treating the eyelid sebaceous gland carcinoma can improve the treatment effectiveness, prolong the life of a patient, improve the quality of life, and has important clinical application value.

The invention belongs to the technical field of make-up products, and particularly relates to a preparation method for improving skin friendliness and stability of make-up spray. The makeup fixing product coated with a film is prepared by compounding active ingredients and adopting O / W / O multiple emulsification and microencapsulation technologies, anti-inflammatory, anti-ultraviolet, anti-blue-light and skin barrier repair are realized on skin friendliness, meanwhile, protein impurities are reduced in the fermentation process, sensitive skin is adapted, and the retention rate of skin moisture in 24 hours exceeds 99%; in the aspect of durability, the product is resistant to migration, sweat and water, and in the aspect of stability, an O / W / O system is subjected to optimized process treatment, so that multiple stabilities of high-temperature storage, low-temperature circulation without crystallization and centrifugation without layering are realized; on the aspects of moisturizing, oil control and balance, 24-hour moisture retention is guaranteed, and excessive sebaceous gland secretion is inhibited. Multiple breakthroughs of moisturizing, oil control, anti-inflammation, protection and stability are achieved, and practical application value is achieved.

The invention discloses an acne-removing composition and a preparation method thereof, and relates to the technical field of cosmetics, and the acne-removing composition comprises 0.1-10 parts of a sophora flavescens extract, 0.1-10 parts of a cortex dictamni extract, 0.1-10 parts of a radix saposhnikoviae extract, 0.1-10 parts of a herba schizonepetae extract and 1-10 parts of a white willow bark extract. According to the acne-removing composition and the preparation method thereof disclosed by the invention, salicylic acid in the white willow bark extract can be used for dissolving constitutive substances among skin cuticles, softening skin cuticles, enabling the cuticles to fall off, opening sebaceous gland duct orifices blocked by grease substances and promoting metabolism of the skin to achieve grease balance; the radix sophorae flavescentis, the dictamnus dasycarpus, the radix saposhnikoviae and the herba schizonepetae have the effects of inhibiting and killing various aerobic bacteria and anaerobic bacteria in skin acne and the like, are resistant to oxidation and inflammation, and can synergistically enhance the oil-controlling and acne-removing effects of the acne-removing composition on the skin.

The invention discloses an application of ordered regeneration mechanical bionic silk fibroin hydrogel in preparation of dressing for promoting scar-free wound repair, degummed silk fibroin is used as a raw material, methacrylated silk fibroin SFMA and silk fibroin nanofiber BSNF are prepared respectively, and then an SFMA solution and a BSNF solution are obtained; and finally, uniformly mixing the SFMA solution, the BSNF solution and the photoinitiator aqueous solution to obtain a mixed solution, adjusting the pH value of the mixed solution to 10.5, and carrying out photo-crosslinking to obtain the ordered regenerated mechanical bionic silk fibroin hydrogel. The ordered regeneration mechanical bionic silk fibroin hydrogel prepared by the invention can remarkably promote scar-free repair of wound surfaces and remarkable regeneration of hair follicles and sebaceous glands. Besides, the used material is single in component, and the used SFMA and BSNF are silk fibroin, so that clinical transformation is easier, and the preparation method has important significance on design and clinical application of wound repair materials.

This invention discloses the application of ordered regenerative biomimetic silk fibroin hydrogel in the preparation of dressings that promote scarless wound repair. First, degummed silk fibroin is used as a raw material to prepare methacryloyl fibroin (SFMA) and silk fibroin nanofibers (BSNF), respectively. Then, SFMA and BSNF solutions are obtained. Finally, the SFMA, BSNF, and photoinitiator aqueous solutions are mixed uniformly to obtain a mixture. The pH of the mixture is adjusted to 10.5, and photocrosslinking is performed to obtain the ordered regenerative biomimetic silk fibroin hydrogel. The ordered regenerative biomimetic silk fibroin hydrogel prepared by this invention can significantly promote scarless wound repair and significantly regenerate hair follicles and sebaceous glands. Furthermore, the materials used in this invention are of a single composition; both SFMA and BSNF are silk fibroin, making it easier to translate into clinical applications and of great significance for the design and clinical application of wound repair materials.

Compositions and methods for treating congenital epidermal or dermal hyperplasia by using topically administered oncokinase inhibitors such as trametinib, pyrrole derivatives, TAK-733, CH4987655, RDEA119 / BAY 869766, cobimetinib, binimetinib, selumetinib, and the like are described herein.

The application discloses a hair loss prevention composition containing Norway spruce leaf extract and application, and relates to the technical field of cosmetics.The composition comprises component A and component B.The component A comprises the following components in parts by weight: 1-5 parts of verbascum thapsus extract, 0.1-1 parts of saw palmetto extract and 1-5 parts of Norway spruce leaf extract.The component B comprises the following components in parts by weight: 2-4 parts of eucommia ulmoides bark extract.The verbascum thapsus extract, the saw palmetto extract, the Norway spruce leaf extract and the eucommia ulmoides bark extract are combined to have a synergistic effect.The composition formed by the specific combination of the components can prevent androgenic alopecia by anti-inflammatory, antibacterial, inhibition of TRPV3 channel and inhibition of the activity of 5alpha-reductase, can inhibit the secretion of lipids by sebaceous cells, and can achieve the purpose of oil control, and the components are all plant components, so the composition is more suitable for men.

The invention relates to a topical composition, advantageously an ecobiological topical composition, comprising: - succinic acid or a salt thereof; and - at least one phenylpropanoid glycoside, or an extract containing same, and to the use thereof for preventing and / or treating acne, advantageously inflammatory acne; and also to a method for cleaning or providing cosmetic care for greasy and / or acne-prone skin.

To provide a pharmaceutical composition for use in a method of treating a skin condition.SOLUTION: Provided is a pharmaceutical composition for use in a method of treating a skin condition of a subject. The method comprises administering intradermally to the subject a botulinum neurotoxin: herein, following administration, the botulinum neurotoxin induces secretion of one or more sebaceous lipid(s) selected from a squalene, a fatty acid, a cholesterol, and a wax ester to an epidermal layer of skin; and the skin condition is selected from a group consisting of xerosis, dehydrated, dry or cracked skin, eczema, atopic eczema, type 2 Gaucher disease, Sjogren-Larsson syndrome, ichthyosis, lamellar ichthyosis, X-linked ichthyosis, bullous ichthyosiform erythroderma, essential FFA deficiency, aged dry skin, anhidrotic ectodermal dysplasia, Netherton syndrome, actinic keratosis, carbuncle, cellulitis, skin cancer, and lichen pilaris.SELECTED DRAWING: Figure 3

The invention discloses a gland nutritional agent for improving fish scale skin and a preparation method thereof, and relates to the technical field of skin nutritional agent preparation. Comprising the following raw materials: an extract, modified seabuckthorn seed oil, modified lactobionic acid, nicotinamide, coenzyme Q10, a phytosterol compound, panthenol sodium phosphate, capryloyl salicylic acid, vitamin H, a ginseng extract, a humectant, oat beta-glucan, sodium hyaluronate, glycerol, propylene glycol, phosphatidylcholine, vitamin E, PEG-100 stearate, carbomer, triethanolamine, a preservative and allantoin. And the balance of deionized water. According to the invention, by adding the modified seabuckthorn seed oil, sebaceous gland can be nourished more efficiently, damaged skin barrier can be repaired, and percutaneous moisture loss can be reduced; meanwhile, the fish scale skin care product has an anti-oxidation effect, can protect skin cells from being damaged by free radicals, delays dryness and roughness aggravation of fish scale skin, and maintains normal physiological functions of glands.

To provide a topical composition useful for the treatment of hair disorders such as androgenetic alopecia, hirsutism, alopecia of the eyebrow and eyelashes, and hypotrichosis.SOLUTION: Provided is a composition for topical treatment of diseases or conditions affecting the pilosebaceous unit or its components, the composition comprising a prostaglandin analogue as an active ingredient, and further comprising a co-solvent and a semi-fluorinated alkane.SELECTED DRAWING: None

The invention discloses a recombinant IV type collagen capable of being used for adjuvant therapy of xerodermia. The amino acid sequence of the recombinant IV type collagen is as shown in SEQ ID No. 1. The novel recombinant IV type collagen provided by the invention has the advantages that the yield is high; in addition, synthesis of lipid-related enzymes is adjusted, synthesis and secretion of lipid in sebaceous gland cells are adjusted, completeness of skin barriers is maintained, keratinocyte gaps are filled, and hydrophobic barriers are formed; the biological activity or the effect related to moisturizing and skin dryness relieving such as moisture loss prevention is obviously superior to that of commercialized human IV type collagen or other truncated proteins of the human IV type collagen alpha1 chain.

The application discloses a Norway spruce leaf-containing oil control and repair composition and application, and relates to the technical field of cosmetics. The application provides a Norway spruce leaf-containing oil control and repair composition, which comprises the following components in parts by weight: Norway spruce leaf extract 0.1-2 parts, Spermacoce latifolia extract 0.1-0.5 parts, yeast / kelp sugar fermentation product 1-5 parts, Usnea barbata extract 0.1-0.5 parts and Hamamelis virginiana extract 0.1-2 parts. The Norway spruce leaf extract, the Spermacoce latifolia extract, the yeast / kelp sugar fermentation product, the Usnea barbata extract and the Hamamelis virginiana extract are synergistic, the components synergize, and the components jointly play effects in aspects of oil control, barrier repair, anti-inflammatory and antibacterial effects, microenvironment stability maintenance and sebum gland abnormal activation reduction, so that instant oil control can be realized, compensatory secretion can be relieved through long-acting stability maintenance, and the application is suitable for skin which needs long-term oil control and is sensitive.

The application discloses a composition containing yeast / rice fermentation product filtrate with oil control and hair quality repairing effects. The composition comprises yeast / rice fermentation product filtrate, rice husk extract, black truffle extract and millet seed extract. The application also provides application of the composition in preparation of oil control and repairing hair care products, a shampoo containing the composition and a preparation method of the shampoo. Experimental results show that the composition can significantly inhibit secretion of oil by human sebaceous gland cells, repair hair, and improve smoothness and gloss of hair. The composition has strong synergistic effect of components, is safe and non-irritating, has simple preparation process, and is suitable for industrial production.

The invention relates to a composition for controlling oil, shrinking pores and tightening skin as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition with the effects of controlling oil, shrinking pores and tightening skin, provided by the invention, is prepared from EGCG (epigallocatechin gallate) nanocrystals, a phellinus igniarius extract, a lactobacillus / pomegranate fruit fermentation product and cardamom seed ketone, the EGCG nanocrystal is prepared from an EGCG solution in a micro-channel reactor through an anti-solvent crystallization method by taking supercritical CO2 as an anti-solvent. The composition synchronously inhibits the activity of 5alpha-reductase, regulates sebaceous gland secretion, enhances keratinocyte metabolism and promotes barrier repair through a multi-target synergistic mechanism, and improves the stability and transdermal absorption efficiency of active ingredients by means of a specific fermentation process. Therefore, the long-acting and mild oil control, tightening and pore repairing effects with skin health promotion significance are realized.