13 results about "Wound healing agent" patented technology

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

The invention provides a phoebe bournei needle-broadleaf mixed tending and improving method, and belongs to the technical field of forest cultivation and artificial forest management. Comprising the following steps that (1) phoebe bournei and cunninghamia bournei which are arranged in a spaced mode serve as a unit, a plurality of units are arranged, and phoebe bournei and cunninghamia bournei rows among the units are vertically arranged; (2) digging holes to transplant phoebe bournei seedlings and Chinese fir seedlings, applying a base fertilizer during soil returning, and starting to expand the holes, hilling and apply fertilizer in the second year after transplanting; (3) felling is started in the fourth year of afforestation, phoebe bournei is cultivated with cunninghamia bournei, and wound healing agents are adopted for treatment after the cunninghamia bournei According to the method, the phoebe bournei and the Chinese fir which are arranged in an interlaced mode serve as one unit, multiple units are arranged, so that forest stand arrangement is rationalized through the scheme that the phoebe bournei and the Chinese fir between the units are vertically arranged in a row mode, base fertilizer is accurately applied in the soil returning process, the tending frequency is increased, sanitary cutting is conducted, and tree body management is refined; and the double purposes of rapid growth of phoebe bournei, high-quality dry material cultivation and large-diameter material cultivation of Chinese fir are achieved.

The invention discloses a sheep tail fat active component as well as a separation method and application thereof in skin wound healing, and relates to the technical field of natural product separation and biological medicine. According to the method, through ultrasonic-assisted enzymolysis extraction and silica gel column gradient elution, efficient separation of different polar components is achieved, and high-polarity components rich in high-activity unsaturated fatty acid are obtained; the invention also provides application of the component in skin wound healing. The sheep tail fat active component has excellent free radical scavenging ability, can significantly down-regulate the levels of pro-inflammatory factors such as IL-1beta and TNF-alpha in wound tissues, up-regulate the expression of TGF-beta1, promote the deposition and remodeling of collagen and accelerate the regeneration of skin appendages such as hair follicles and sebaceous glands by regulating and controlling a TGF-beta1 / Smad3 signal channel, and has the effects of promoting the healing of the skin and the like. The method can effectively shorten the wound healing time and reduce scar formation, can be used for preparing a natural wound healing agent, and provides a new way for high-value utilization of Lanzhou big-tailed sheep resources.

The object of this invention is to provide novel pharmaceutical agents that can be used for various treatments. The pharmacological compositions of this invention are characterized by comprising extracellular vesicles derived from equine mesenchymal stem cells. The pharmacological compositions of this invention are tissue repair agents, anti-inflammatory agents, angiogenic agents, or wound healing agents.

The invention relates to the field of biological pharmacy, and particularly discloses a preparation method and application of a cartilage extract. The invention relates to a preparation method of a cartilage extract, which comprises the following steps: pretreatment, boiling, alkaline hydrolysis and enzymolysis: adjusting the pH value of an alkaline hydrolysis product to 7-11 at 50-65 DEG C, adding alkaline protease, carrying out enzymolysis for 1-2 hours, adjusting the pH value to 6-8, adding neutral protease, carrying out enzymolysis for 4-6 hours, adjusting the pH value to 5-7 after the enzymolysis is finished, heating to 60-70 DEG C, standing, filtering, washing, and drying to obtain the cartilage extract. Discharging the material liquid, performing primary filtration, performing nanofiltration, sterilizing, performing secondary filtration, and performing spray drying. The preparation method has the advantages that waste is turned into wealth, natural resources are reasonably and fully utilized, the cartilage extract is fully utilized, environmental pollution is reduced, the extraction rate of the cartilage extract is increased, and the cartilage extract can be used for a wound healing agent and has the advantages of being anti-inflammatory, antibacterial, analgesic and capable of effectively promoting wound healing.

Pharmaceutical composition comprising a Pickering oil-in-water emulsion containing an aqueous phase, a vegetable oil phase, and an organomodified phyllosilicate, particularly for its use in increasing TAFA4 production, and possibly for increasing serotonin production, for its use as a cutaneous anti-inflammatory agent and / or wound-healing agent and / or as a cutaneous anti-allergy agent. Figure to be published with the abstract: none.

The invention discloses a mangrove forest big tree transplanting method for a dredging disturbance area, which comprises the following steps: trimming a selected big tree crown, smearing a wound healing agent, digging a soil ball by taking a trunk base as a center, placing the soil ball of the big tree into a root system container, filling and compacting with a nutrient medium, implanting microcapsules into the trunk, and transplanting the big tree into the root system container. Carrying out tolerance culture on the big tree in two stages, putting a root system container in which the big tree is planted into a planting pit of the dredging area, additionally arranging a temporary hollow triangular pyramid or net cage at the periphery of the big tree, and regularly checking the integrity of the root system container, the growth condition of the root system and the physiological state of the big tree. According to the transplanting method, a revolutionary forest nutrition conveying mode is created through deep integration of material science and plant physiology, the transplanting method is particularly suitable for dredging areas and other scenes where the root system environment is severe and traditional maintenance is difficult, the survival rate and the recovery speed of mangrove forest big tree transplanting can be remarkably increased, and the survival rate of mangrove forest big tree transplanting is increased. The device is an edge tool for precise forestry and difficult site ecological restoration in the future.

It is known that during the wound healing process, when pH in blood decreases, oxygen is released from hemoglobin, blood oxygen concentration rises, division of regenerated epithelial cells, and healing is promoted . Wound healing agents such as creams and ointments are generally weakly acidic, and therefore can be expected to lower pH in blood and to promote wound healing. However, the wound healing agents such as creams and ointments are inferior in terms of workability, and there is a risk of presenting further damage to the wound when applied. An object of the present invention is to provide a material for promoting oxygen release from red blood cells, which has excellent workability and can promote division of regenerated epithelial cells in order to facilitate the wound healing. The material for promoting oxygen release from red blood cells according to the present invention is characterized in that the material for promoting oxygen release from red blood cells is a sheet-like material containing an acid-type carboxyl group-containing material, wherein the amount of acid-type carboxyl groups contained in the sheet-like material is 0.05 mmol / g or more and 10.0 mmol / g or less.

This invention provides a method for cultivating grafted kiwifruit seedlings with two root systems, comprising the following steps: S1, Rootstock acquisition: Select one one-year-old *Actinidia cuspidatum* and one *Actinidia deliciosa* seedling as rootstocks, and prune the main roots of both rootstocks to a length of 10-15 cm, retaining 4-5 cm of stem; S2, Scion acquisition: Select branches of the *Actinidia deliciosa* variety as scions, with a length of 8-12 cm. Seal the upper end with wax or wound healing agent, and smooth the lower end with a flat cut; S3, Grafting: Using bark grafting or cleft grafting, graft the two rootstocks in opposite directions onto the lower end of the same scion, and wrap the grafting area with grafting film to form a grafted kiwifruit seedling. The grafted seedlings cultivated by this invention have two sets of root systems, one for *Actinidia cuspidatum* and one for *Actinidia deliciosa*, thus exhibiting strong resistance to waterlogging, drought, and pests and diseases, and absorbing nutrients comprehensively, resulting in high-quality and high-yield fruit with significant economic benefits.

This invention discloses a method for planting industrial chili peppers in Cd-contaminated areas, belonging to the field of crop cultivation technology in contaminated soil. 20-40 days before planting, apply 200-300 kg of biochar and 1000-1500 kg of well-rotted organic fertilizer per mu (approximately 0.067 hectares), and allow the soil to mature after tilling. Use Cd-free nutrient soil for seedling cultivation, and transplant when the seedlings are 35-40 days old, applying rooting and seedling strengthening agents and antibacterial and insecticides. During the inter-cultivation period, drip apply 5-8 kg / mu of selenium-containing water-soluble fertilizer every 7-10 days; after a 7-day seedling establishment period, apply seedling-promoting fertilizer, insecticides, and herbicides; after pruning, apply wound-healing agents and antibacterial agents; apply virus disease control agents every 10 days; and from 30 days after transplanting, apply balanced compound fertilizer every 20 days. During the flowering and fruiting period, spray 1-2 kg / mu of silicon-containing water-soluble fertilizer every 10 days; apply antibacterial and insecticides every 10 days, adjusting the type and dosage according to the pest and fungal infestation situation. Harvest the fruit after it matures. This method uses biochar to passivate Cd in the soil, uses selenium fertilizer to inhibit the absorption of Cd by plants, and combines silicon fertilizer to block the transport of Cd to the above-ground parts of the plant. The Cd content of industrial pepper fruits is <0.08mg / kg, and the yield is >630kg / mu.

The application discloses a preparation method of traumatic drugs, which comprises the following steps: preparing a lithospermum root extract; water-extracting medicine materials of a, biliardae and gardenia to obtain a a-material extract; water-extracting medicine materials of b, radix scutellariae to obtain a b-material extract; water-extracting medicine materials of c, cortex phellodendri to obtain a c-material extract; pretreating the lithospermum root extract to obtain an emulsified phase containing a lithospermum root fat-soluble filtrate and a lithospermum root water-soluble filtrate; diluting and filtering the a-material extract, the b-material extract and the c-material extract after heating, stirring and homogenizing the filtrate of the a-material extract in the emulsified phase, stirring and homogenizing the filtrate of the b-material extract and the filtrate of the c-material extract, and stirring and homogenizing after cooling to obtain the traumatic drugs. The precipitate generated can be reduced by extracting the radix scutellariae and the cortex phellodendri respectively. The black spots can be removed by pretreating the lithospermum root extract through the heating and filtering steps. The traumatic drugs prepared can still remain stable after being placed for a long time by adding new auxiliary materials, i.e., sodium dodecyl sulfate and polyethylene glycol, in the water phase matrix.

The invention discloses a wound healing agent for promoting healing of chronic, slow healing and foul smelling wounds comprising zeolite doped alginate fibers comprising alginate and zeolite, characterised in that the zeolite is embedded and dispersed homogeneously within the alginate fibers.