130 results about "Wound healing agent" patented technology

Methods and devices transmit micromechanical forces locally on the millimeter to micron scale for promoting wound healing. Micromechanical forces can selectively be applied directly to tissue, in some embodiments, by using microchambers fluidically connected to microchannels. Each chamber, or in some cases, group of chambers, may be associated with a valve to control vacuum pressure, positive pressure, liquid delivery, and / or liquid removal from each chamber or group of chambers. Application of embodiments of the invention may shorten wound-healing time, reduce costs of therapy, enable restoration of functional tissue, and reduce the need for more invasive therapies, including surgery.

A method and apparatus for the introduction to a wound under negative pressure therapy of a wound healing agent, generally comprises a foam pad (11) for insertion substantially into a wound site (12), and a wound drape (13) for sealing enclosure of the foam pad at the wound site. The foam pad is placed in fluid communication with a vacuum source for promotion of fluid drainage. Additionally, the foam pad is predisposed, through grafting or other techniques known to those of ordinary skill in the art, with basic fibroblast growth factor (bFGF), anti-microbial or other factors, also known to those of ordinary skill in the art, for the promotion of increased wound healing.

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and / or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.

A device for providing improved wound healing is described. The device includes a vacuum system for applying a sub-atmospheric pressure to the wound, a gas supply system for applying a gaseous wound healing agent to the wound, and a controller connected with the vacuum system and the gas supply system that controls the applications of the sub-atmospheric pressure and the application of the gaseous wound healing agent to the wound. A method of using the device for improved wound healing is also described.

The present invention provides a method and device for exposing injured mammalian tissues, in a non-abrasive manner, to an effective amount of exogenous gaseous nitric oxide (gNO) in order to promote healing by reducing the size, duration and severity of wounds as well as controlling the infection by reducing number of pathogens at the site and the surrounding area. The present invention also provides methods of cosmetically treating the skin wherein a cosmetic agent in combination with gNO is applied to the skin.

The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.

The invention relates to a medical wound surface hemostatic and wound healing agent, which is characterized in that the invention consists of two parts of water solution, one part is the oxidative polysaccharide water solution containing dialdehyde, and the other part is the water-soluable chitosan water solution. The medical wound surface hemostatic and wound healing agent can be applied in the preparation of drugs or medical devices for wound surface sealing and wound surface hemostasis, and the invention can also be applied in the preparation of drugs or medical devices for the promotion of wound surface healing and the prevention of postoperative tissue adhesion. The medical wound surface hemostatic and wound healing agent of the invention has significant effects on wound surface sealing, hemostasis, promotion of wound surface healing, prevention of postoperative tissue adhesion and other aspects, at the same time, the biocompatibility is good, which can not cause the tissue immune response, and the polysaccharides can not generate side effects on organisms after the in vivo degradation, so the safety is good.

This invention relates to an improved Lyophilized platelet rich plasma used to make a platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises therapeutically effective amounts of activated growth factors, platelet ghost, plasma (know as the plasma back bone), white blood cells with optional none, one or more additional anti-oxidant such as vitamin A and / or C and / or E, and / or none one or more antibiotics and / or GHK-Cu (produced by ProCyte Inc.)

The present invention relates to pharmaceutical compositions containing fragments of alpha-1 proteinase inhibitor (API) or chimeric proteins of API and insulin-like growth factor for use in stimulating wound healing.

The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

A method for rapidly growing a tree includes obtaining a cultivating material by cutting a length of a trunk or a bough from a tree. Twigs are removed from the cultivating material. A wound healing agent is applied on a severed end and on wounds of the cultivating material. A periphery of the lower section of the cultivating material is cut to form a plurality of grooves. The severed end is cut to obtain an oblique face. A root-growing agent is applied on the periphery of the lower section and the oblique face. The lower section of the cultivating material is planted into earth. A shield is wrapped around an intermediate section of the cultivating material. The cultivating material is cultivated for a plurality of months for growing roots from the lower section of the cultivating material and growing branches and leaves from a top section of the cultivating material.

The invention relates to the field of protection and restoration of trees, and discloses a wound restoration and protection agent for damaged trees. The wound restoration and protection agent comprises the following components by weight portion: 10-30 portions of adhesive, 5-10 portions of bactericide, 10-20 portions of insecticide, 5 portions of wound healing agent and 20-30 portions of efficacy retention agent. The preparation method of the wound restoration and protection agent comprises the following steps: step1, respectively weighing the components according to the weight proportion, and uniformly mixing the insecticide, the bactericide and the wound healing agent; step2, adding the insecticide, the bactericide and the wound healing agent into the efficacy retention agent, and uniformly stirring; and step3, taking the adhesive, uniformly mixing the adhesive with the efficacy retention agent, and putting into a container. The wound restoration agent has a wide range of application, can be used for various damaged trees, quickly becomes effective, and has a simple application process.

The invention relates to a plant wound healing agent containing sodium alginate oligosaccharide. The healing agent contains 0.001%-0.02% of sodium alginate oligosaccharide and one or more of a resistance inducer, a nutrient, a bactericide, a pesticide and a film forming agent. The plant wound healing agent can be used for spraying or smearing. The plant wound healing agent is used for treating wounds before and after trimming, girdling or grafting, so that the morbidity of the wounds can be reduced, and the healing of the wounds can be promoted. The plant wound healing agent is applicable to fruit trees and flowers.

The present invention relates to compounds that are two-part molecules, and compositions containing such compounds, in which one part is designed to become covalently bonded to the skin (bonding agent) and the other part (a characteristic use agent) is designed to impart some characteristic use, such as emolliency, moisturizing effect, anti-acne, anti-wrinkle, anti-pain, antimicrobial, antifungal, antiviral, anti-irritation, skin tanning and skin lightening effects, extended protection of the skin (e.g., from ultraviolet light, by incorporation of a sunscreen component; from toxic and / or irritating substances; from insects and skin parasites, by incorporation of insecticides and / or insect repellants; from free radicals or other agents, as in aging, by incorporation of antioxidants), or dyeing of hair, skin nails, wool or fuir. The covalently bonded part may also be useful to impart skin strengthening effect (e.g., from shear forces) or as wound healing agents.

An improved platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises a therapeutically effective amount of activated growth factors and ascorbic acid with optional one or more additional anti-oxidant such as vitamin A and / or E, and optional one or more antibiotics.

The invention discloses a cutting propagation method for tree spinach and relates to the technical field of fast and effective propagation of special plant resources. The method comprises the following steps: (1) preparing a cutting matrix and a container; (2) collecting cuttings; (3) leaving spikes to stand; (4) sterilizing and disinfecting the spikes; (5) carrying out rooting hormone treatment; (6) inserting the treated spikes 2-3 cm into the matrix; cutting the tops of the spikes and uniformly smearing the cuts by using a tree wound healing agent; (7) carrying out rooting management; and (8) carrying out hardening-seedling management. The method disclosed by the invention not only can provide a nursery stock guarantee for scaled planting of tree spinach imported from the USA in China, but also can provide a propagation method for breeding high-yield single plants of tree spinach, and moreover, the offspring better retains excellent characteristics of the parents. Therefore, the method has a good market application prospect.

The present document describes methods of use of photo activated compositions for oral disinfection and / or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.

A wound healing agent and a radix astragali composite freeze-dried platelet gel kit for preparing the wound healing agent. The kit comprises a radix astragali extract solution which is stored separately, freeze-dried thrombin and freeze-dried platelets. The preparation method of the wound healing agent mainly comprises the following steps: step one, mixing freeze-dried platelets and sterile injection water, placing the mixture in a water bath with a temperature of 30-37 DEG C, fully dissolving the freeze-dried platelets to obtain a freeze-dried platelet solution; adding freeze-dried thrombin into the radix astragali extract solution to obtain a composite thrombin solution; step two, well mixing the freeze-dried platelet solution and the composite thrombin solution to obtain the wound healing agent. In the invention, after the radix astragali extract solution is mixed with thrombin, the mixture has the effect of activating fibrinogen to become fibrin glue in vitro, and thus reaches theeffect of wound healing.

The invention belongs to the field of biological materials and interdiscipline of polymer chemistry and biochemistry and discloses a gelatin / nano silver composite material decorated by microbial transglutaminase and a preparation method and an application thereof. The gelatin / nano silver composite material decorated by microbial transglutaminase is prepared by utilizing a gelatin / nano silver composite material as main material and utilizing the microbial transglutaminase as a modifier, the material has good biocompatibility, non-toxicity and strong antibacterial activity, the mechanical properties and water stability of the material are good, and meanwhile, the material is simple in preparation process, mild in reaction conditions, easy to control and low in production cost, thereby having good application prospect and very extensive usage in biomedical materials and biomedicine field, such as antibacterial and biodegradable skin dressing capable of reducing infection and inflammation and protecting wound, wound healing agent and artificial skin, and the like.

The invention provides a fast propagation method for seed konjak. According to the invention, corm and rhizome of konjak are distributed with a great number of latent buds; when the corm of the konjak is used as a seed, only terminal buds are germinated into seedlings, while one part of the latent buds are differentiated into a root system, and the other part of the latent buds are latent and do not germinate. The method provided by the invention stimulates the latent buds to germinate into seedlings mainly through stripping and slicing of the corm, matches with seedbed management measures like use of a cut healing agent, fine adjustment of physicochemical environment of soil, improvement of microbial communities and control of the occurrence of soft rot disease, improves an original propagation coefficient of 3 to 5 times to 15 to 20 times, realizes fast propagation of the seed konjak, and is applicable to industrial production.

A method of treating diseases and conditions associated with dry ear comprising topically applying to the ear canal of a subject that is suffering therefrom a liquid composition comprising an anti-irritant agent, a wound healing agent; and an anti-inflammatory agent dissolved in a polyhydroxy liquid solvent.

The invention relates to the technical field of fruit tree planting, in particular to a red pulp honey pomelo seedling raising method. The red pulp honey pomelo seedling raising method comprises the following steps that tree trunks free of diseases, insect pests and mechanical damage and coordinal and congeneric with scion saplings are selected as tree stocks, and the combining parts of the tree stocks are cut by using a sterilized knife; scion grafting is performed, 3-4 branches with full buds and full tissues and free of diseases and insect pests are selected from the pomelo tree stocks to be grafted and are cut into branches of 30-50 cm, the 1-1.5 cm parts at the lower ends of the branches are cut off to expose formation layers, scion cuts are put in a healing agent for soaking, bundling is performed by using plastic films after grafting, reinforcement and fixing are performed, the combined parts of the tree stocks and the scions are coated with a layer of wound healing agent, timely watering is performed after grafting, and nursing is performed by adopting a conventional method. The relative formation layers of the tree stocks and the scions are tightly combined, and the survival rate of the tree stocks is improved and is above 90%.

The present invention relates to pharmaceutical compositions containing fragments of alpha-1 proteinase inhibitor (API) or chimeric proteins of API and insulin-like growth factor for use in stimulating wound healing.

The present invention relates to a wates-soluble aerosol made up by using chitosan as main raw material and a chitosan wound mounting block made up by using basic layer, skeleton layer and mounting layer through a certain hot-pressing and integrally-forming process. The nano-grade oligosaccharide in the aerosol is a chitosan wound healing agent with bio-activity, the polyvinyl alcohol is the hydrophilic thickening, film-forming and slow release agent and the glycerine is the flexibilizing and toughening agent of polyvinyl alcohol medicine film.

The invention discloses a gelling agent for prevention and treatment of apple tree diseases and a preparation method thereof. The gelling agent comprises the following components in percentage by mass: 0.1-10% of carbendazim, 0.01-0.5% of a wound healing agent, 3-10% of a binder, 0.1-10% of a wetting dispersant, 1-10% of a brightening agent and the balance of distilled water. The preparation method comprises the following steps: weighing and taking active ingredients carbendazim, the wetting dispersant, the brightening agent and the distilled water according to the measuring requirement of the formula, fully wetting and stirring uniformly, adding the mixture into a sand mill for sanding, discharging into a mixing kettle, adding the wound healing agent, the binder and the rest of the distilled water, mixing uniformly to obtain the gelling agent. According to the gelling agent for prevention and treatment of apple tree diseases and the preparation method thereof, provided by the invention, the low-toxicity medicaments are taken as the active ingredients and have an obvious prevention and control effect on valsa ceratosperma of apple trees; besides, a layer of uniform medicinal film is formed at wounds of the apple trees after the gelling agent is used, the ventilation effect is good, autonomous respiration of apple trees is not influenced, wound infection of apple trees caused by exotic germs can be effectively reduced, the rain washing resisting performance is improved, and the effective duration is prolonged.

The invention discloses a plant bud grafting wound healing agent. The plant bud grafting wound healing agent is prepared from, by weight, 6-8 parts of polyvinyl alcohol, 10-16 parts of water, 3-5 parts of sodium humate, 2-4 parts of nutrient element additive, 0.01-0.05 part of chitooligo saccharide, 0.5-0.9 part of iron vitriol, 1-2 parts of bactericide, 12-14 parts of a protective agent, 2-3 parts of a tackifier, 2-4 parts of nutrient and 0.1-0.3 part of auxin. The healing agent can effectively avoid bud grafting incisional wound infection and rotting, bacterium infection is avoided, water evaporation is reduced, wound healing is promoted, the bud grafting success rate is increased, the healing agent integrates sterilization, nourishment and moisturizing, use is flexible and convenient, the effect is outstanding, the safety is high, and rain wash resistance is good; meanwhile the preparation method is low in material cost, raw materials are easy to obtain, the technology is simple, and the high practical value and the good application prospect are achieved.