The invention relates to the technical field of bacteriostatic agents, in particular to a radix scutellariae extract with a bacteriostatic effect and a preparation method. The preparation method comprises the following steps: weighing
scutellaria baicalensis root
powder, putting the
scutellaria baicalensis root
powder into a
polyethylene bag, adding a hydroxypropyl-beta-
cyclodextrin aqueous solution into the bag, sealing by a sealing
machine, and putting a sample into ultrahigh pressure equipment. The preparation method comprises the following steps: after ultrahigh-pressure extraction is completed, transferring a material into a centrifugal tube, centrifuging to take supernate which is an extracting solution of
baicalin and
baicalein, heating and stirring the supernate in a water bath kettle, converting the
baicalin into the
baicalein under the action of endogenous
enzyme, and performing vacuum
freeze drying after the reaction is completed to obtain the hydroxypropyl-beta-
cyclodextrin clathrate extract. According to the invention,
baicalin and
baicalein in
scutellaria baicalensis are simultaneously extracted by adopting an ultrahigh pressure assisted hydroxypropyl-beta-
cyclodextrin aqueous solution, and an extract (UP-HP-beta-CD extract) clathrated by hydroxypropyl-beta-cyclodextrin is prepared by cooperating an endogenous
enzyme enzymolysis method with a hydroxypropyl-beta-cyclodextrin clathration technology. The extraction efficiency,
solubility,
biological activity and other properties of effective components in
scutellaria baicalensis are improved, the
antibacterial effect of the
scutellaria baicalensis extract is further improved, and the prepared
scutellaria baicalensis antibacterial extract is simple in preparation method, easy and convenient to operate,
environmentally friendly, safe, capable of saving energy in process, good in environmental benefit and capable of being applied to industrial large-scale production.