Yinzhihuang oral liquid and preparation method thereof

Abstract

The invention relates to the technical field of medicine manufacturing, and particularly discloses Yinzhihuang oral liquid and a preparation method thereof. The invention provides a preparation method of a Yinzhihuang oral liquid, which comprises the following steps: mixing oriental wormwood, cape jasmine and honeysuckle, adding water for decocting, and filtering to obtain a first filtrate; adding an ethanol water solution into filter residues obtained by filtering the water decoction, heating, refluxing and extracting, combining alcohol extracts, and filtering to obtain a second filtrate; combining the first filtrate and the second filtrate, and concentrating to obtain a herba artemisiae scopariae-fructus gardeniae-honeysuckle flower extract; decocting scutellaria baicalensis with water, filtering and concentrating; adding ethanol, refrigerating, filtering and concentrating to obtain a scutellaria baicalensis extract; taking the herba artemisiae scopariae-fructus gardeniae-honeysuckle flower extract and the radix scutellariae extract, adding water, and uniformly stirring; and then adding a sweetening agent, uniformly stirring, refrigerating, adjusting the pH value, uniformly stirring, standing, filtering, filling and sealing, and sterilizing to obtain the beverage. The Yinzhihuang oral liquid provided by the technical scheme of the invention has the advantages of good liquid medicine clarity, no obvious precipitate and good stability.

Description

Technical Field

[0001] The present application relates to the technical field of pharmaceutical manufacturing, and in particular to a Yinzhihuang oral liquid and a preparation method thereof. Background Art

[0002] Yinzhihuang oral liquid is a Chinese patent medicine with the main effects of clearing away heat and detoxifying, promoting dampness and relieving jaundice. It is suitable for jaundice caused by liver and gallbladder dampness and heat, with symptoms such as yellow face, chest and flank pain, nausea and vomiting, yellow and red urine, and acute and chronic hepatitis. Its main ingredients include extracts of Artemisia capillaris, Gardenia jasminoides, Scutellaria baicalensis and Honeysuckle, which work together to achieve the therapeutic effect. In addition, the properties of Yinzhihuang oral liquid are brown-red liquid, sweet and slightly bitter.

[0003] At present, the preparation method of Yinzhihuang oral liquid is relatively complicated, involving multiple steps and ingredients, so there may be certain instability. This instability may come from many aspects, including the quality of raw materials, extraction reagents during the preparation process, temperature, pH value and other conditions, as well as the storage and transportation conditions of the product. If the quality of the raw materials is poor or the extraction method is inappropriate, it may lead to the loss or change of the active ingredients, thus affecting the stability of the product.

[0004] Therefore, it is necessary to provide a new method for preparing Yinzhihuang oral liquid to improve the overall stability and long-term storage performance of the oral liquid. Summary of the invention

[0005] In order to solve the above technical problems, the present application provides a Yinzhihuang oral liquid and a preparation method thereof.

[0006] The present application provides a method for preparing Yinzhihuang oral liquid, which is characterized by comprising the following steps in sequence: S1: Mix Artemisia capillaris, Gardenia jasminoides, and Honeysuckle, add water and boil for 3-4 times, add 8-12 times the weight of water each time, and boil for 120-180 minutes each time; combine the decoctions, and filter to obtain the first filtrate; Add 8-12 times by weight of ethanol aqueous solution to the residue obtained by filtering the decoction, heat and reflux for extraction 2-3 times under closed conditions, combine the alcohol extracts, and filter to obtain a second filtrate; The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of the concentrated solution of 1.15-1.20 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract; S2: Take Scutellaria baicalensis, add water and boil three times, each time adding 8-12 times the weight of water; combine the decoctions, filter, concentrate the filtrate to a concentrated solution with a specific gravity of 1.10-1.20 / 60°C, add ethanol to make the alcohol content reach 60-80%, refrigerate for 8-16 hours, filter, recover the filtrate, and concentrate it to a concentrated solution with a specific gravity of 1.15-1.20 / 60°C to obtain a Scutellaria baicalensis extract; S3: Take 23-31 parts by weight of Artemisia capillaris-gardenia-honeysuckle extract and 35-45 parts by weight of Scutellaria baicalensis extract, add 850-950 parts by weight of water, and stir well; then add 0.05-0.15 parts by weight of sweetener, stir well, refrigerate for 12-36 hours, adjust the pH value to 6.7-7.3, stir well, let stand, filter, fill, and sterilize to obtain.

[0007] The present application selects to prepare the Artemisia capillaris-gardenia-honeysuckle extract by mixing Artemisia capillaris, Gardenia jasminoides and honeysuckle, and prepares the Scutellaria baicalensis extract by decocting Scutellaria baicalensis alone, and then mixes 35-45 of the Artemisia capillaris-gardenia-honeysuckle extract and Scutellaria baicalensis extract to prepare the Yinzhihuang oral liquid, so that the prepared Yinzhihuang oral liquid can effectively keep the solution clear and stably ensure the stability of the baicalin and gardenoside contents when placed at 40°C for 6 months, thereby solving the problems existing in the existing products.

[0008] In order to improve the stability of Yinzhihuang oral liquid, the present application considers improving it by optimizing the extraction process. First, the mixed extraction of Artemisia capillaris, Gardenia jasminoides and honeysuckle is carried out, and the decocted filter residue is subjected to ethanol extraction during the extraction process, which can fully integrate the effective ingredients of these three medicinal materials, form a complex component system, and produce a new stabilizing effect. At the same time, the scutellaria extract is extracted separately from the scutellaria extract, which can maximize the retention of its medicinal ingredients and avoid unnecessary chemical reactions with other medicinal materials during the extraction process. When preparing Yinzhihuang oral liquid, the mixed extract of Artemisia capillaris-gardenia jasminoides-honeysuckle and the scutellaria extract are carefully proportioned, which may form a more stable dispersion system. In summary, the stability of Yinzhihuang oral liquid can be effectively improved by optimizing the extraction process and carefully proportioning. These measures can not only extend the shelf life of the oral liquid, but also ensure the lasting stability of the drug effect, providing patients with better therapeutic effects.

[0009] Preferably, in step S1, in the method for preparing the Artemisia Capillaris-Gardenia Jasminoides-Honeysuckle Flos extract, the weight ratio of Artemisia Capillaris, Gardenia Jasminoides and Honeysuckle Flos is 10-14:6-7.2:4.5-5.5.

[0010] Preferably, in step S1, in the method for preparing the Artemisia Capillaris-Gardenia Jasminoides-Honeysuckle Flos extract, the weight ratio of Artemisia Capillaris, Gardenia Jasminoides and Honeysuckle Flos is 11-13:6.4-6.8:4.8-5.2.

[0011] Preferably, in step S1, the concentration of the ethanol aqueous solution is 45-55 wt%.

[0012] Preferably, in step S2, the specific method of decocting three times is: the first time, adjusting the pH value to 6.0-6.6 with 8-12wt% sodium hydroxide solution, and decocting for 60-90min; the second time, adjusting the pH value to 6.8-7.4 with 8-12wt% sodium hydroxide solution, and decocting for 120-180min; the third time, adjusting the pH value to 7.6-8.2 with 8-12wt% sodium hydroxide solution, and decocting for 200-260min.

[0013] Preferably, in step S2, the specific method of decocting three times is: the first time, the pH value is adjusted to 6.2-6.4 with 8-12wt% sodium hydroxide solution, and the decocting is 70-80min; the second time, the pH value is adjusted to 7.0-7.2 with 8-12wt% sodium hydroxide solution, and the decocting is 140-160min; the third time, the pH value is adjusted to 7.8-8.0 with 8-12wt% sodium hydroxide solution, and the decocting is 220-240min.

[0014] In the process of preparing the Scutellaria baicalensis extract, the present application ensures the stable extraction of the ingredients by carefully designing the pH value and extraction time of three decoctions, thereby further improving the stability of the Yinzhihuang oral liquid.

[0015] Preferably, in S3, the amount of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract is 25-29 parts by weight, and the amount of the Scutellaria baicalensis extract is 37-40 parts by weight.

[0016] Preferably, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-1.5:0.5-1.5.

[0017] Preferably, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-0.8:1.2-1.5.

[0018] Through experimental analysis, it is known that the existing Yinzhihuang oral liquid uses aspartame as a sweetener. Although it can improve the taste, aspartame is chemically unstable under a neutral environment (the residual aspartame in the finished product is only 0.82-6.20% of the added amount, with an average of only 2.5% residual), and it is easy to decompose to produce aspartic acid, phenylalanine and methanol, which is a potential risk for patients with phenylketonuria. In addition, the instability of aspartame will also affect the overall stability and long-term storage performance of the oral liquid. The present application uses erythritol and monk fruit extract in the above weight ratio as sweeteners to further improve the stability of Yinzhihuang oral liquid.

[0019] In a second aspect, the present application provides a Yinzhihuang oral liquid, which is prepared using the above-mentioned preparation method of Yinzhihuang oral liquid.

[0020] In summary, the technical solution of this application has the following effects: The Yinzhihuang oral liquid provided by the technical solution of the present application not only retains a good taste, but is also more stable, not easily decomposed by heat, and extends the shelf life of the product.

[0021] After 6 months of acceleration, the content of active ingredients in the Yinzhihuang oral liquid product provided by the technical solution of the present application decreased less than that in 0 months, the clarity of the liquid was maintained well, there was no obvious precipitation, and it had good stability. DETAILED DESCRIPTION

[0022] The present application is further described in detail below in conjunction with examples, comparative examples and performance testing experiments. These examples should not be construed as limiting the scope of protection claimed in the present application. Example

[0023] Examples 1-5 Examples 1-5 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0024] The difference between the above embodiments is that in step S1, in the method for preparing the Artemisia Capillaris-Gardenia Jasminoides-Honeysuckle Flos extract, the weight ratios of Artemisia Capillaris, Gardenia Jasminoides and Honeysuckle Flos are different, as shown in Table 1.

[0025] The preparation method of Yinzhihuang oral liquid in the above embodiment is: S1: According to Table 1, take Artemisia capillaris, Gardenia jasminoides, and Honeysuckle, mix them, add water and boil them for 3 times, add 10 times the weight of water each time, and boil them for 150 minutes each time; combine the decoctions, filter and obtain the first filtrate; The residue obtained by filtering the decoction is added with 10 times by weight of a 50 wt% ethanol aqueous solution, and the mixture is heated under reflux and extracted twice under a closed condition, and the alcohol extracts are combined and filtered to obtain a second filtrate; The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of the concentrated solution of 1.17 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract; S2: Take 1 kg of Scutellaria baicalensis, add water and boil three times, add 10 times the weight of water each time; combine the decoctions, filter, concentrate the filtrate to a concentrated solution with a specific gravity of 1.15 / 60°C, add ethanol to make the alcohol content reach 70%, refrigerate for 12 hours, filter, recover the filtrate, and concentrate it to a concentrated solution with a specific gravity of 1.17 / 60°C to obtain a Scutellaria baicalensis extract; The specific method of decocting three times is as follows: the first time, the pH value is adjusted to 6.2-6.4 with 10wt% sodium hydroxide solution, and decocted for 75 minutes; the second time, the pH value is adjusted to 7.0-7.2 with 10wt% sodium hydroxide solution, and decocted for 150 minutes; the third time, the pH value is adjusted to 7.8-8.0 with 10wt% sodium hydroxide solution, and decocted for 230 minutes.

[0026] S3: Take 27g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 40g of Scutellaria baicalensis extract, add 900g of water, and stir well; then add 0.1g of sweetener (the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.7:1.3), stir well, refrigerate for 24h, adjust the pH value to 7.0, stir well, let stand, filter, fill, and sterilize.

[0027] Table 1 Weight ratio of Artemisia capillaris, Gardenia jasminoides and Flos Lonicerae in Examples 1-5 example The weight ratio of Artemisia capillaris, Gardenia jasminoides and Honeysuckle Example 1 80g:78g:40g Example 2 100g:72g:45g Example 3 120g:66g:50g Example 4 140g:60g:55g Example 5 160g:54g:60g Embodiment 6-10 Examples 6-10 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0028] The difference between the above embodiment and embodiment 3 is that in step S2, the specific method of decocting three times is different, as shown below.

[0029] In Example 6: 1 kg of Scutellaria baicalensis was taken, decocted three times with water, each time adding 10 times the weight of water; the decoctions were combined, filtered, and the filtrate was concentrated to a concentrate with a specific gravity of 1.15 / 60°C, ethanol was added to make the alcohol content reach 70%, refrigerated for 12 hours, filtered, the filtrate was recovered, and concentrated to a concentrate with a specific gravity of 1.17 / 60°C to obtain a Scutellaria baicalensis extract (without pH adjustment).

[0030] In Example 7: The specific method of decocting three times is: the first time, the pH value is adjusted to 7.8-8.0 with 10wt% sodium hydroxide solution, and decocted for 75min; the second time, the pH value is adjusted to 7.0-7.2 with 10wt% sodium hydroxide solution, and decocted for 150min; the third time, the pH value is adjusted to 6.2-6.4 with 10wt% sodium hydroxide solution, and decocted for 230min.

[0031] In Example 8: The specific method of decocting three times is: the first time, the pH value is adjusted to 6.0 with 10wt% sodium hydroxide solution, and decocted for 230min; the second time, the pH value is adjusted to 7.4 with 10wt% sodium hydroxide solution, and decocted for 90min; the third time, the pH value is adjusted to 7.6 with 10wt% sodium hydroxide solution, and decocted for 75min.

[0032] In Example 9: The specific method of decocting three times is: the first time, the pH value is adjusted to 6.0-6.2 with 10wt% sodium hydroxide solution, and decocted for 60min; the second time, the pH value is adjusted to 6.8-7.0 with 10wt% sodium hydroxide solution, and decocted for 180min; the third time, the pH value is adjusted to 7.6-7.8 with 10wt% sodium hydroxide solution, and decocted for 200min.

[0033] In Example 10: The specific method of decocting three times is: the first time, the pH value is adjusted to 6.4-6.6 with 10wt% sodium hydroxide solution, and decocted for 90min; the second time, the pH value is adjusted to 7.2-7.4 with 10wt% sodium hydroxide solution, and decocted for 120min; the third time, the pH value is adjusted to 8.0-8.2 with 10wt% sodium hydroxide solution, and decocted for 260min.

[0034] The other process parameters in the above embodiment are the same as those in embodiment 3.

[0035] Examples 11-12 Examples 11-12 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0036] The difference between the above embodiment and embodiment 3 is that in step S3, the dosage of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and Scutellaria baicalensis extract is different, as shown below.

[0037] In Example 11: 23 g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 45 g of Scutellaria baicalensis extract.

[0038] In Example 12: 31 g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 35 g of Scutellaria baicalensis extract.

[0039] The other process parameters in the above embodiment are the same as those in embodiment 1.

[0040] Examples 13-16 Examples 13-16 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0041] The difference between the above embodiment and embodiment 3 is that the types of sweeteners are different, as shown below.

[0042] In Example 13: the sweetener is obtained by mixing sucrose and monk fruit extract in a weight ratio of 0.7:1.3.

[0043] In Example 14: the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 1.3:0.7.

[0044] In Example 15: the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5:1.5.

[0045] In Example 16: the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.8:1.2.

[0046] The other process parameters in the above embodiment are the same as those in embodiment 3.

[0047] Comparative Example Comparative Example 1 Comparative Example 1 provides a Yinzhihuang oral liquid and a preparation method thereof.

[0048] The preparation method of Yinzhihuang oral liquid in this comparative example is prepared by the method recorded in the Chinese Pharmacopoeia.

[0049] Comparative Example 2 Comparative Example 1 provides a Yinzhihuang oral liquid and a preparation method thereof.

[0050] The preparation method of Yinzhihuang oral liquid in this comparative example is specifically as follows: S1: According to Table 1, take Artemisia capillaris, Gardenia jasminoides, Honeysuckle and Scutellaria baicalensis in a weight ratio of 120g:66g:50g:100g, add water and boil for 3 times, add 10 times the weight of water each time, and boil for 150 minutes each time; combine the decoctions and filter to obtain the first filtrate; The residue obtained by filtering the decoction is added with 10 times by weight of a 50 wt% ethanol aqueous solution, and the mixture is heated under reflux and extracted twice under a closed condition, and the alcohol extracts are combined and filtered to obtain a second filtrate; The first filtrate and the second filtrate are combined to obtain a mixed solution, and concentrated to a concentrated solution with a specific gravity of 1.17 / 60° C. to obtain an extract; S2: Take 37g of the extract, add 900g of water, and stir well; then add 0.1g of sweetener (the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.7:1.3), stir well, refrigerate for 24h, adjust the pH value to 7.0, stir well, let stand, filter, fill, and sterilize.

[0051] Comparative Example 3 Comparative Example 3 provides a kind of Yinzhihuang oral liquid and its preparation method The difference between Comparative Example 3 and Example 3 is that the preparation method of the Artemisia Capillaris-Gardenia jasminoides-Lonicera japonica extract is different, as shown below.

[0052] In Comparative Example 3: The filter residue of the decoction in the preparation method of Artemisia Capillaris - Gardenia - Honeysuckle extract was not subjected to alcohol extraction, specifically: Artemisia Capillaris, Gardenia, and Honeysuckle were mixed, decocted with water 3 times, adding 10 times the weight of water each time, and decocted for 150 minutes each time; the decoctions were combined, filtered to obtain a filtrate, and concentrated to a concentrate with a specific gravity of 1.17 / 60°C to obtain Artemisia Capillaris - Gardenia - Honeysuckle extract.

[0053] The other process parameters in Comparative Example 3 are the same as those in Example 3.

[0054] Performance testing Stability test method: The samples of Yinzhihuang oral liquid were placed in a constant temperature and humidity chamber at the same time, and the temperature was controlled at 40±2℃ and the relative humidity was controlled at 75±5%. The clarity of Yinzhihuang oral liquid and the content of baicalin and gardenia were tested at 0, 3, and 6 months respectively. The specific method for testing the content of baicalin and gardenia was as follows: the test was carried out with reference to the test method of the Chinese Pharmacopoeia. The test results are shown in Table 2.

[0055] Table 2 Performance test results of Yinzhihuang oral liquid in Examples 1-17 and Comparative Examples 1-3 Combined with Table 2, by comparing the test results of the examples and the comparative examples, it can be seen that in Comparative Example 1, the method of the Chinese Pharmacopoeia was used to prepare the Yinzhihuang oral liquid, and the amount of baicalin and gardenia glycoside effective ingredients in the oral liquid was small, and the stability was poor. In Comparative Example 2, Artemisia capillaris, Gardenia jasminoides, honeysuckle, and Scutellaria baicalensis were mixed together for extraction, and the prepared Yinzhihuang oral liquid had poor stability. In Comparative Example 3, the filter residue of the water decoction in the preparation method of the Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract was not subjected to alcohol extraction, and the prepared Yinzhihuang oral liquid had poor stability.

[0056] In contrast, in the process of preparing Yinzhihuang oral liquid, the present application uses Artemisia capillaris, Gardenia jasminoides and honeysuckle to mix to prepare Artemisia capillaris-gardenia-honeysuckle extract, and the filtrate of the Artemisia capillaris-gardenia-honeysuckle decoction is subjected to alcohol extraction, and at the same time, Scutellaria baicalensis is decocted separately to prepare Scutellaria baicalensis extract, and then the Artemisia capillaris-gardenia-honeysuckle extract and Scutellaria baicalensis extract are mixed to prepare Yinzhihuang oral liquid, so that the prepared Yinzhihuang oral liquid can effectively keep the solution clear and stably ensure the stability of baicalin and gardenoside content when placed at 40°C for 6 months, solving the problems existing in existing products and achieving unexpected results.

[0057] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A method for preparing Yinzhihuang oral liquid, characterized in that: Specifically, the following steps are performed in sequence: S1: Mix Artemisia capillaris, Gardenia jasminoides, and Honeysuckle, add water and boil for 3-4 times, add 8-12 times the weight of water each time, and boil for 120-180 minutes each time; combine the decoctions, and filter to obtain the first filtrate; The residue obtained by filtering the decoction is added with 8-12 times by weight of a 40-60wt% ethanol aqueous solution, and the mixture is heated under reflux for 2-3 times under closed conditions, and the alcohol extracts are combined and filtered to obtain a second filtrate; The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of the concentrated solution of 1.15-1.20 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract; S2: Take Scutellaria baicalensis, add water and boil three times, each time adding 8-12 times the weight of water; combine the decoctions, filter, concentrate the filtrate to a concentrated solution with a specific gravity of 1.10-1.20 / 60°C, add ethanol to make the alcohol content reach 60-80%, refrigerate for 8-16 hours, filter, recover the filtrate, and concentrate it to a concentrated solution with a specific gravity of 1.15-1.20 / 60°C to obtain a Scutellaria baicalensis extract; S3: Take 23-31 parts by weight of Artemisia capillaris-gardenia-honeysuckle extract and 35-45 parts by weight of Scutellaria baicalensis extract, add 850-950 parts by weight of water, and stir well; then add 0.05-0.15 parts by weight of sweetener, stir well, refrigerate for 12-36 hours, adjust the pH value to 6.7-7.3, stir well, let stand, filter, fill, and sterilize to obtain.

2. The method for preparing the Yinzhihuang oral liquid according to claim 1, characterized in that: In step S1, in the method for preparing the Artemisia capillaris-gardenia jasminoides-honeysuckle extract, the weight ratio of Artemisia capillaris, gardenia jasminoides and honeysuckle is 10-14:6-7.2:4.5-5.

5.

3. The method for preparing the Yinzhihuang oral liquid according to claim 2, characterized in that: In step S1, in the method for preparing the Artemisia capillaris-gardenia jasminoides-honeysuckle extract, the weight ratio of Artemisia capillaris, gardenia jasminoides and honeysuckle is 11-13:6.4-6.8:4.8-5.

2.

4. The method for preparing the Yinzhihuang oral liquid according to claim 1, characterized in that: In step S1, the concentration of the ethanol aqueous solution is 45-55wt%.

5. The method for preparing the Yinzhihuang oral liquid according to claim 1, characterized in that: In step S2, the specific method of decocting three times is: adjusting the pH value to 6.0-6.6 with 8-12wt% sodium hydroxide solution for the first time, and decocting for 60-90min; adjusting the pH value to 6.8-7.4 with 8-12wt% sodium hydroxide solution for the second time, and decocting for 120-180min; adjusting the pH value to 7.6-8.2 with 8-12wt% sodium hydroxide solution for the third time, and decocting for 200-260min.

6. The method for preparing Yinzhihuang oral liquid according to claim 5, characterized in that: In step S2, the specific method of decocting three times is: the first time, the pH value is adjusted to 6.2-6.4 with 8-12wt% sodium hydroxide solution, and the decocting is 70-80min; the second time, the pH value is adjusted to 7.0-7.2 with 8-12wt% sodium hydroxide solution, and the decocting is 140-160min; the third time, the pH value is adjusted to 7.8-8.0 with 8-12wt% sodium hydroxide solution, and the decocting is 220-240min.

7. The method for preparing the Yinzhihuang oral liquid according to claim 1, characterized in that: In step S3, the amount of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract is 25-29 parts by weight, and the amount of the Scutellaria baicalensis extract is 37-40 parts by weight.

8. The method for preparing Yinzhihuang oral liquid according to claim 1, characterized in that: The sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-1.5:0.5-1.

5.

9. The method for preparing Yinzhihuang oral liquid according to claim 8, characterized in that: The sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-0.8:1.2-1.

5.

10. A Yinzhihuang oral liquid, characterized in that: The Yinzhihuang oral liquid is prepared by the preparation method of any one of claims 1 to 9.

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