External use cream of gaultheria yunnanensis and preparation method and application thereof

Abstract

This invention provides a topical ointment containing Yunnan white pearl powder, its preparation method, and its application, belonging to the field of traditional Chinese medicine. By incorporating myrrh extract, scutellaria baicalensis extract, and ceramides, the synergistic effect of these active ingredients not only achieves the basic effects of anti-inflammatory, antibacterial, and skin barrier repair, but also unexpectedly enhances the transdermal absorption rate of Yunnan white pearl powder essential oil, strengthens its anti-inflammatory effect, reduces irritation, and extends its shelf life. Furthermore, it can inhibit post-inflammatory hyperpigmentation, with effects far exceeding the combined efficacy of individual ingredients and conventional compound formulations.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine, and in particular relates to a topical ointment for Yunnan white pearl, its preparation method and application. Background Technology

[0002] *Gaultheria leucocarpa* Bl. var. *yunnanensis* (Franch.) TZ Hsuet RC Fang, belonging to the genus *Gaultheria* in the Ericaceae family, is an evergreen shrub and a medicinal plant, with the entire plant used in medicine. It is a very important medicinal plant among traditional Chinese medicines, first recorded in *Diannan Bencao* (Herbal Materia Medica of Yunnan) written by Lan Mao in the early Ming Dynasty. Other names for *Gaultheria leucocarpa* include: Baizhushu (White Pearl Tree), Touguxiang (Penetrating Bone Fragrance), Tougucao (Penetrating Bone Grass), Xiao Tougucao (Small Penetrating Bone Grass), Touguxiao (Penetrating Bone Eliminator), Manshanxiang (Full Mountain Fragrance), Mantianxiang (Full Sky Fragrance), Wanlixiang (Ten Thousand Mile Fragrance), Jiulixiang (Nine Mile Fragrance), Fangxiangcao (Fragrant Grass), Jiguxiang (Chicken Bone Fragrance), Zuangufeng (Drilling Bone Wind), Huotanzi (Fire Charcoal), Meitanzi (Coal), Meitanguo (Coal Fruit), Zaozaoye (Washing Leaf), Soushanhu (Searching for Mountain Tiger), Xiashanhuang (Going Down the Mountain Yellow), Xiashanhu (Going Down the Mountain Tiger), Donglvshu (Winter Green Tree), Jianhuamu (Simple Flower Tree), Laohu Niao (Tiger Noodles), Laohumian (Tiger Face), Niutouyao (Ox Head Medicine), Tuobei Guniang (Huobei Girl), Naoshila (Nao Shi La), Douzhengkong (Fighting the Whole Empty), and Donglian (Winter Lotus). The essential oil extracted from its fresh branches and leaves contains a variety of active ingredients, possessing the effects of dispelling wind and dampness, promoting blood circulation and unblocking meridians, dispelling cold and relieving pain, resolving phlegm and relieving asthma, washing away wind-cold and numbness, relieving muscle and bone pain, and warming the tendons and bones. In traditional medicine, it is often used to relieve rheumatic pain, bruises, minor skin infections, insect bites, and other ailments. When applied externally, it can exert a local therapeutic effect through skin penetration, and it has high safety and few side effects, making it suitable for long-term external use.

[0003] Currently, the variety of topical preparations using Yunnan white pearl as a raw material is relatively limited, with most being single-component preparations. This results in insufficient efficacy and a narrow range of applications. In some compound preparations, the combination of components is unreasonable, making it difficult to achieve synergistic effects. In addition, existing topical ointments often suffer from poor transdermal absorption, insufficient ointment stability, and unsatisfactory user experience, which restricts the development and utilization of Yunnan white pearl resources.

[0004] Based on this, the development of a topical ointment with Yunnan white pearl essential oil as the main active ingredient, reasonable compounding, synergistic efficacy, and convenient use has important practical application value and market prospects. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a topical ointment for Yunnan white pearl, its preparation method and application.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a topical ointment for Yunnan white pearl, comprising the following components in parts by weight: 12-18 parts of active ingredient, 70-90 parts of excipients; The active ingredient comprises the following components in the following mass ratio: Yunnan white pearl essential oil: myrrh extract: scutellaria extract: ceramide = 7~10: 2~3: 2~3: 1~2.

[0007] Preferably, the excipients comprise components in the following mass ratio: Matrix: Emulsifier: Humidifier = 55~75: 3~6: 2~5.

[0008] Preferably, the matrix comprises components in the following mass ratio: Vaseline: Lanolin: Liquid Paraffin = 30~40: 10~15: 15~20.

[0009] Preferably, the emulsifier comprises components in the following mass ratio: Glyceryl stearate: Polysorbate-80 = 2~4: 1~2.

[0010] Preferably, the moisturizer comprises the following components in the following mass ratio: Glycerin: Sodium hyaluronate = 1.5~3: 0.5~2.

[0011] Preferably, the preparation method of the Yunnan white pearl essential oil includes the following steps: Yunnan white pearl is distilled at a temperature of 95~100℃ and a pressure of 0.03~0.07MPa for 1~3 hours to obtain Yunnan white pearl crude oil; Yunnan white pearl crude oil is then subjected to molecular distillation to obtain Yunnan white pearl essential oil. The conditions for molecular distillation are: temperature 60~90℃, vacuum degree 100~300Pa, feed rate 2~5mL / min, scraper rotation speed 100~200rpm, and cooling temperature 5~10℃.

[0012] Preferably, the Yunnan white pearl external ointment includes ointment, cream or plaster.

[0013] This invention provides a method for preparing the Yunnan white pearl external ointment, comprising the following steps: Yunnan white pearl essential oil, myrrh extract, scutellaria baicalensis extract and ceramide were homogenized to obtain the homogenized active ingredients. The homogenized active ingredients and excipients were mixed to obtain Yunnan white pearl external ointment.

[0014] Preferably, the homogenization rotation speed is 300~500 rpm; the homogenization time is 20~60 min; The mixing speed is 300~500 rpm; the mixing time is 20~60 min.

[0015] This invention provides the application of the Yunnan white pearl external ointment in the preparation of external medicines, the external medicines including anti-inflammatory, antipruritic, or skin barrier repair external medicines.

[0016] Compared with the prior art, the present invention has the following beneficial effects: This invention provides a topical ointment containing Yunnan white pearl oil, its preparation method, and its application. It overcomes the limitations of existing technologies that rely on the single use or conventional compounding of Yunnan white pearl oil. By innovatively incorporating myrrh extract, scutellaria baicalensis extract, and ceramides, the synergistic effect of these active ingredients not only achieves the basic effects of anti-inflammatory, antibacterial, and skin barrier repair, but also unexpectedly enhances the transdermal absorption rate of Yunnan white pearl oil, strengthens its anti-inflammatory effect, reduces irritation, and extends its shelf life. Furthermore, it inhibits post-inflammatory hyperpigmentation, with effects far exceeding the combined efficacy of individual ingredients or conventional compound formulations. The optimal ratio of petrolatum, lanolin, and liquid paraffin was selected as the base, combined with a compound emulsifier of glyceryl stearate and polysorbate-80, solving the problem of Yunnan white pearl oil's high oil solubility and difficulty in blending with aqueous excipients. Simultaneously, the addition of moisturizers such as sodium hyaluronate ensures both the stability of the ointment and a good user experience. Detailed Implementation

[0017] This invention provides a topical ointment for *Phyllostachys edulis*, which preferably comprises an ointment, cream, or plaster; the topical ointment for *Phyllostachys edulis* comprises the following components in parts by weight: The active ingredient is 12 to 18 parts, preferably 13 to 16 parts, and more preferably 15 parts; The excipients are 70-90 parts, preferably 75-85 parts, and more preferably 80 parts; In this invention, the active ingredient comprises components in the following mass ratio: Yunnan white pearl essential oil: myrrh extract: scutellaria extract: ceramide = 7~10: 2~3: 2~3: 1~2, preferably 8~9: 2.2~2.8: 2.2~2.8: 1.2~1.8, and even more preferably 8.5: 2.5: 2.5: 1.5.

[0018] In this invention, the excipients preferably comprise the following components in the following mass ratio: The matrix: emulsifier: humectant ratio is 55~75:3~6:2~5, more preferably 60~70:4~5:3~4, and even more preferably 65:4.5:3.5; the matrix preferably comprises the following components in the following mass ratio: petrolatum: lanolin: liquid paraffin = 30~40:10~15:15~20, more preferably 32~38:11~14:16~19, and even more preferably 35:12.5:17. 5; The emulsifier preferably comprises the following components in the following mass ratio: glyceryl stearate: polysorbate-80 = 2~4: 1~2, more preferably 2.5~3.5: 1.2~1.8, and even more preferably 3: 1.5; The moisturizer preferably comprises the following components in the following mass ratio: glycerin: sodium hyaluronate = 1.5~3: 0.5~2, more preferably 2.0~2.7: 0.7~1.5, and even more preferably 2.5: 1.

[0019] In this invention, the preparation method of the Yunnan white pearl essential oil preferably includes the following steps: Yunnan white pearl is distilled to obtain Yunnan white pearl crude oil; Yunnan white pearl crude oil is then subjected to molecular distillation to obtain Yunnan white pearl essential oil; In this invention, the distillation temperature is preferably 95~100℃, more preferably 98~100℃, and even more preferably 100℃; the distillation pressure is preferably 0.03~0.07MPa, more preferably 0.04~0.06MPa, and even more preferably 0.05MPa; the distillation time is preferably 1~3h, more preferably 1.5~2.5h, and even more preferably 2h.

[0020] In this invention, the molecular distillation temperature is preferably 60-90°C, more preferably 70-85°C, and even more preferably 80°C; the vacuum degree is preferably 100-300 Pa, more preferably 150-200 Pa, and even more preferably 180 Pa; the feed rate is preferably 2-5 mL / min, more preferably 3-5 mL / min, and even more preferably 5 mL / min; the scraping speed is preferably 100-200 rpm, more preferably 120-180 rpm, and even more preferably 160 rpm; and the cooling temperature is preferably 5-10°C, more preferably 6-9°C, and even more preferably 8°C.

[0021] This invention provides a method for preparing the Yunnan white pearl external ointment, comprising the following steps: Yunnan white pearl essential oil, myrrh extract, scutellaria baicalensis extract and ceramide were homogenized to obtain the homogenized active ingredients. The homogenized active ingredients and excipients were mixed to obtain Yunnan white pearl external ointment.

[0022] In this invention, the homogenization speed is preferably 300-500 rpm, more preferably 350-450 rpm, and even more preferably 400 rpm; the homogenization time is preferably 20-60 min, more preferably 30-50 min, and even more preferably 40 min; the mixing speed is preferably 300-500 rpm, more preferably 350-450 rpm, and even more preferably 400 rpm; the mixing time is preferably 20-60 min, more preferably 30-50 min, and even more preferably 40 min.

[0023] This invention provides the application of the Yunnan white pearl external ointment in the preparation of external medicines, the external medicines including anti-inflammatory, antipruritic, or skin barrier repair external medicines.

[0024] Myrrh extract was purchased from Jinjinle (Hunan) Chemical Co., Ltd.; Scutellaria baicalensis extract was purchased from Hainan Hanhai Zhiyuan Biotechnology Co., Ltd. The ginger oil and peppermint oil were purchased from the Shangshengmei flagship store; Ceramide, glyceryl stearate, polysorbate-80, petrolatum, lanolin, liquid paraffin, glycerin and sodium hyaluronate were purchased from Shanghai Maclean Biochemical Technology Co., Ltd. Rats weighing 150-250 g were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0025] Example 1

[0026] Preparation of Yunnan white pearl essential oil: Fresh, mold-free, and impurity-free branches and leaves of *Pterocarya yunnanensis* were selected, washed with deionized water, drained, and then chopped to a particle size of 1-2 cm using a chopper to obtain *Pterocarya yunnanensis* fragments. These fragments were placed in a distillation vessel, and distilled water was added at a mass ratio of 1:5 for steam distillation under the following conditions: temperature 100℃, time 1.5 h, and pressure 0.03 MPa. The distillation product was collected and condensed to obtain a condensate. The condensate was allowed to stand at 25℃ for 30 min to separate the layers into oil and water. The upper aqueous phase was *Pterocarya yunnanensis* hydrosol, and the lower oil phase was *Pterocarya yunnanensis* crude oil. The *Pterocarya yunnanensis* crude oil was subjected to molecular distillation at 80℃, a vacuum of 180 Pa, a feed rate of 5 mL / min, a scraper rotation speed of 160 rpm, and a cooling temperature of 8℃ to obtain *Pterocarya yunnanensis* essential oil. The main compounds in the *Pterocarya yunnanensis* essential oil are shown in Table 1. Table 1. Main compounds in Yunnan white pearl essential oil

[0027] The Influence of Base Composition Ratio on the Quality of Topical Ointments

[0028] Three matrix ratios were studied: matrix 1, matrix 2, and matrix 3.

[0029] Matrix 1: 40kg petroleum jelly, 5kg lanolin, 20kg liquid paraffin; Matrix 2: 35kg petroleum jelly, 10kg lanolin, 20kg liquid paraffin; Matrix 3: 35kg petrolatum, 12.5kg lanolin, and 17.5kg liquid paraffin.

[0030] Preparation method of Yunnan white pearl external ointment: Preparation of homogenized active ingredients: Take 8.5 kg of Yunnan white pearl essential oil, 2.5 kg of myrrh extract, 2.5 kg of scutellaria baicalensis extract and 1.5 kg of ceramide, homogenize at 400 rpm for 40 min to obtain homogenized active ingredients; Preparation of the aqueous phase: 1.5 kg of polysorbate-80, 2.5 kg of glycerol and 1 kg of sodium hyaluronate were heated to 72°C and stirred at 150 rpm until completely dissolved to obtain the aqueous phase; Oil phase preparation: Matrix 1, matrix 2 and matrix 3 were mixed with 3 kg of glyceryl stearate and heated to 78 °C, and stirred at 200 rpm until completely melted to obtain the oil phase; Emulsification and mixing: The aqueous phase is slowly added to the oil phase, stirred at 400 rpm, and emulsified at 72°C for 30 min to obtain the excipient; The excipients and homogenized active ingredients were stirred at 400 rpm for 40 minutes until homogeneous. The mixture was then cooled to room temperature to solidify, demolded, filled, and sealed to obtain an ointment-like Yunnan white pearl external ointment.

[0031] Ointments with different matrices were allowed to stand and equilibrate for 24 hours at room temperature (25℃) and relative humidity (45%-65%). Samples stored at high temperature (45℃ for 1 month) should be removed and allowed to return to room temperature (25℃) for 30 minutes before testing to avoid sudden temperature changes affecting the matrix properties. The sample size for each test is fixed at 1.0g ± 0.05g, and weighed using an electronic balance with an accuracy of 0.001g to ensure that the sample size is consistent for each test. Laboratory personnel requirements: Select 10 individuals aged 18-25, provide specialized training, standardize the application techniques, pressure, and testing time, and have each person complete the testing of the same batch of samples individually to reduce differences in operation among different personnel; wear sterile disposable gloves before testing to avoid interference from hand oils and temperature with sample properties.

[0032] The texture of the base was assessed by evaluating the softness, smoothness, stickiness, oil seepage, and ease of spreading of the ointment. Researchers placed the ointment-like Yunnan Baizhu external application onto a clean, dry white ceramic drop plate to visually observe its appearance and whether it exhibited layering or oil seepage. They then gently pressed the ointment with sterile fingertips to assess its softness and resilience, repeatedly touching it 2-3 times to determine its smoothness and graininess. Finally, they gently rubbed the ointment between their fingertips to assess its stickiness and observe for any oil seepage, oil exudation, or clumping. The results were recorded according to the aforementioned grading standards. Specific scoring criteria are shown in Table 2, and the scoring results are shown in Table 3.

[0033] Table 2 Scoring Criteria

[0034] Table 3 Scoring Results

[0035] The results showed that different proportions of the matrix significantly affected the efficacy of the Dianbaizhu external ointment. The Dianbaizhu external ointment using matrix 1 exhibited layering and oil seepage after high-temperature storage, and also showed some layering on the drop plate. However, the Dianbaizhu external ointments using matrix 2 and matrix 3 did not exhibit this phenomenon. Furthermore, the Dianbaizhu external ointment using matrix 2 and matrix 3 was significantly superior to the one using matrix 1 in terms of softness, smoothness, stickiness, oil seepage, and ease of spreading. Matrix 3 showed the best performance, and matrix 3 was used as the matrix in subsequent experiments.

[0036] Example 2

[0037] Preparation of Yunnan white pearl external ointment

[0038] Preparation of homogenized active ingredients: Take 8.5 kg of Yunnan white pearl essential oil prepared in Example 1, 2.5 kg of myrrh extract, 2.5 kg of scutellaria baicalensis extract and 1.5 kg of ceramide, homogenize at 400 rpm for 40 min to obtain homogenized active ingredients; Preparation of the aqueous phase: 1.5 kg of polysorbate-80, 2.5 kg of glycerol and 1 kg of sodium hyaluronate were heated to 72°C and stirred at 150 rpm until completely dissolved to obtain the aqueous phase; Oil phase preparation: 35 kg petrolatum, 12.5 kg lanolin, 17.5 kg liquid paraffin and 3 kg glyceryl stearate were mixed and heated to 78°C and stirred at 200 rpm until completely melted to obtain the oil phase; Emulsification and mixing: The aqueous phase is slowly added to the oil phase, stirred at 400 rpm, and emulsified at 72°C for 30 min to obtain the excipient; The excipients and homogenized active ingredients were stirred at 400 rpm for 40 minutes until homogeneous. The mixture was then cooled to room temperature to solidify, demolded, filled, and sealed to obtain an ointment-like Yunnan white pearl external ointment.

[0039] Example 3

[0040] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 7 kg, the amount of myrrh extract was replaced with 2 kg, the amount of scutellaria baicalensis extract was replaced with 2 kg, and the amount of ceramide was replaced with 1 kg. The rest were the same as in Example 2, and Yunnan white pearl external ointment was obtained.

[0041] Example 4

[0042] Preparation of Yunnan white pearl external ointment

[0043] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 10 kg, the amount of myrrh extract was replaced with 3 kg, the amount of scutellaria baicalensis extract was replaced with 3 kg, and the amount of ceramide was replaced with 2 kg. The rest were the same as in Example 2, and Yunnan white pearl external ointment was obtained.

[0044] Comparative Example 1

[0045] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 15 kg, and ceramide, myrrh extract and scutellaria baicalensis extract were not used. The rest were the same as in Example 2, and Yunnan white pearl external ointment was obtained.

[0046] Comparative Example 2

[0047] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 8.5 kg, the amount of Scutellaria baicalensis extract was replaced with 2.5 kg, the amount of ceramide was replaced with 4 kg, and myrrh extract was not used. The rest was the same as in Example 2, and Yunnan white pearl external ointment was obtained.

[0048] Comparative Example 3

[0049] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 8.5 kg, the amount of myrrh extract was replaced with 2.5 kg, and the amount of ceramide was replaced with 4 kg. Scutellaria baicalensis extract was not used. All other steps were the same as in Example 2 to obtain Yunnan white pearl external ointment.

[0050] Comparative Example 4

[0051] The amount of Yunnan white pearl essential oil used in Example 2 was replaced with 8.5 kg, the amount of myrrh extract was replaced with 2.5 kg, and the amount of scutellaria extract was replaced with 4 kg. Ceramide was not used. All other steps were the same as in Example 2 to obtain Yunnan white pearl external ointment.

[0052] Comparative Example 5

[0053] Myrrh extract, Scutellaria baicalensis extract and ceramide were removed from Example 2, and 3.5 kg of peppermint oil and 3 kg of ginger oil were added. The rest were the same as in Example 2, and Yunnan Baizhu external ointment was obtained.

[0054] Experimental Example 1

[0055] Linalool is the main characteristic active ingredient of Yunnan white pearl essential oil (see Table 1), and is one of the core components that exert its anti-inflammatory and antipruritic pharmacological effects. Its transdermal absorption efficiency can directly reflect the skin penetration of the effective components of Yunnan white pearl essential oil. At the same time, linalool has stable physicochemical properties, does not degrade significantly in the in vitro transdermal absorption experimental system, and can be accurately qualitatively and quantitatively detected by high performance liquid chromatography with good separation, high detection sensitivity, and mature methodology. In addition, using characteristic terpenoid components in essential oils as transdermal absorption detection indicators is also an industry common practice in the in vitro transdermal research of topical preparations of traditional Chinese medicine essential oils, and the detection results are scientific and comparable.

[0056] The specific experiment was as follows: Hair was removed from the abdominal skin of rats, and subcutaneous fat was removed. The rat abdominal skin was fixed between the supply and receiving cells of a Franz diffusion cell, with the stratum corneum facing the supply cell. 1g of the test ointment prepared in Examples 2-4 and Comparative Examples 1-5 was added to the supply cell, and physiological saline was added to the receiving cell (37℃, magnetic stirring, 300rpm). Samples were taken at 2h, 8h, and 24h, and the linalool content in the receiving cell was detected using high-performance liquid chromatography. The transdermal absorption rate was calculated (transdermal absorption rate = total linalool in the receiving cell / total linalool in the supply cell × 100%). Three parallel samples were taken from each group, and the average value was taken. The results are detailed in Table 4.

[0057] Table 4 Transdermal Absorption Rate

[0058] The results in Table 4 show that the transdermal absorption rates of Examples 2-4 are much higher than those of the comparative examples, proving that the synergistic combination of Yunnan white pearl essential oil with the active ingredients of myrrh extract, scutellaria baicalensis extract and ceramide, as well as the targeted optimization of matrix ratio, can effectively improve the transdermal penetration efficiency of linalool and significantly enhance the skin absorption capacity of the active ingredients.

[0059] Comparative Example 1 (single Yunnan white pearl essential oil) and Comparative Example 5 (simple compounding using existing technology) had the lowest transdermal absorption rates, indicating that formulations lacking synergistic ingredients or conventional compounding schemes cannot effectively promote the penetration of active ingredients.

[0060] The transdermal absorption rate of all samples increased over time and tended to stabilize at 24 hours. The optimized formula had an absorption rate of over 16% in the early 2 hours, which was about 1.14 times that of the control group, demonstrating the practical application value of the optimized formula having a faster onset of action.

[0061] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A topical ointment for Yunnan white pearl, characterized in that, The components include the following parts by mass: 12-18 parts of active ingredient, 70-90 parts of excipients; The active ingredient comprises the following components in the following mass ratio: Yunnan white pearl essential oil: myrrh extract: scutellaria extract: ceramide = 7~10: 2~3: 2~3: 1~2.

2. The Yunnan Baizhu external ointment according to claim 1, characterized in that, The excipients comprise the following components in the following mass ratio: Matrix: Emulsifier: Humidifier = 55~75: 3~6: 2~5.

3. The Yunnan white pearl external ointment according to claim 2, characterized in that, The matrix comprises the following components in the following mass ratio: Vaseline: Lanolin: Liquid Paraffin = 30~40: 10~15: 15~20.

4. The Yunnan white pearl external ointment according to claim 2, characterized in that, The emulsifier comprises the following components in the following mass ratio: Glyceryl stearate: Polysorbate-80 = 2~4: 1~2.

5. The Yunnan white pearl external ointment according to claim 2, characterized in that, The humectant comprises the following components in the following mass ratio: Glycerin: Sodium hyaluronate = 1.5~3: 0.5~2.

6. The Yunnan white pearl external ointment according to claim 1, characterized in that, The preparation method of the Yunnan white pearl essential oil includes the following steps: Yunnan white pearl is distilled at a temperature of 95~100℃ and a pressure of 0.03~0.07MPa for 1~3 hours to obtain Yunnan white pearl crude oil; Yunnan white pearl crude oil is then subjected to molecular distillation to obtain Yunnan white pearl essential oil. The conditions for molecular distillation are: temperature 60~90℃, vacuum degree 100~300Pa, feed rate 2~5mL / min, scraper rotation speed 100~200rpm, and cooling temperature 5~10℃.

7. The Yunnan white pearl external ointment according to any one of claims 1 to 6, characterized in that, The Yunnan white pearl external ointment includes ointment, cream or plaster.

8. The method for preparing the Yunnan white pearl external ointment according to any one of claims 1 to 7, characterized in that, Includes the following steps: Yunnan white pearl essential oil, myrrh extract, scutellaria baicalensis extract and ceramide were homogenized to obtain the homogenized active ingredients. The homogenized active ingredients and excipients were mixed to obtain Yunnan white pearl external ointment.

9. The preparation method according to claim 8, characterized in that, The homogenization speed is 300~500 rpm; the homogenization time is 20~60 min; The mixing speed is 300~500 rpm; the mixing time is 20~60 min.

10. The use of the Yunnan white pearl external ointment according to any one of claims 1 to 7 in the preparation of external medicines, characterized in that, The topical medications include those that are anti-inflammatory, antipruritic, or repair the skin barrier.

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