The invention relates to a cleaning agent for artificial teeth. The cleaning agent is composed of following raw materials in parts by weight: humifuse euphorbia herb, exocarpium benincasae, ovate leaf holly bark, rhizome atractylodis, folium microcotis, fagopyrum dibotrys, ligusticum wallichii, longan aril, kamuning, flos farfarae, quisqualis, gentrin knotweed, fructus polygoni orientalis, rhizome bolbostemmae, scorpion, fructus gleditsiae sinensis, small centipeda herb, psammosilene tunicoides, marmor serpentinatum, tree penoy bark, glechoma hedracea, semen sojae germinatum, celsia cristata, celosia seeds, oriental waterplantain rhizome, beltilla rhizome, chingma abutilon seed, folium turpiniae, spina gleditsjae, sparganium, herba lopatheri, piperis longi, melia toosendan, hedysarum polybotrys, thlaspi arvense, caulis trachelospermi, tabasheer, chlorite schist, ampelopsis japonica, artemisia capillaries, fructus podophylli, stalactitum, zaocys dhumnade, gorgon fruit, pomelo flavedo, pinus tabulaeformis carr, abalone shell, lotus leaf, radix bupleuri, and commelia communis L. The cleaning agent for artificial teeth has the advantages of reasonable formula, low price, and definite curative effect, and is suitable for being applied to the clinic.